UCSC Genome Browser Sessions (Figure 2 and Supplemental Figures S5-6)
ChIA-PET loops' anchors and Enhancer/Promoter regions were resized to 1000 bp relative to their center.
Please refer to the 'CT-FOCS predicted enhancer-promoter interactions' table below for the original sizes.
CT-FOCS predicted cell type-specific enhancer-promoter interactions
FANTOM5 data - Human (hg19)
Name (link) |
Description |
Type |
Size |
Promoter-TSSs RLE profiles |
A matrix: rows are promoter-TSSs, columns are samples (Library id) |
rds |
35MB |
Promoter genomic positions (genome build: hg19) |
A GRanges object: entries are promoter-TSSs, each entry contains chromosome, start and end positions, name, and more |
rds |
750KB |
Sample annotation |
A matrix: rows are samples, columns represent sample information (lib_id, cell_type, lib_size, and more) |
rds |
44KB |
Promoter-TSS's candidate enhancers in a fixed window |
A list: entries are Promoter-TSSs. Each entry contains the set of enhancer names within a fixed window around the Promoter-TSS |
rds |
1.7MB |
Enhancer-TSSs RLE profiles |
A matrix: rows are enhancer-TSSs, columns are samples (Library id) |
rds |
8.3MB |
Enhancer genomic positions (genome build: hg19) |
A GRanges list: entries are enhancer-TSSs, each entry contains chromosome, start and end positions, name, and score |
rds |
604KB |
ChIA-PET connected loop sets (CLSs) for GM12878 |
A list: entries are Promoter-TSSs. Each entry contains an n-vector (n=number of candidate enhancers) with TRUE/FALSE, where TRUE is an EP link supported by ChIA-PET CLS. |
rds |
1.9MB |
Enhancer-Promoter links per cell type |
A list. Each entry of a cell type is a list of promoter-TSSs, each is a vector of enhancer names in enhancer GRanges list |
rds |
2.75MB |
ENCODE data - Human (hg19)
Name (link) |
Description |
Type |
Size |
Promoter-DHSs count profiles |
A matrix: rows are promoter-DHSs, columns are GEO samples |
rds |
21.5MB |
Promoter-DHSs RLE (log2) profiles |
A matrix: rows are promoter-DHSs, columns are GEO samples |
rds |
139MB |
Promoter-DHSs RLE profiles |
A matrix: rows are promoter-DHSs, columns are GEO samples |
rds |
27.4MB |
Promoter genomic positions (genome build: hg19) |
A GRanges object: entries are promoter-DHSs, each entry contains chromosome, start and end positions, name, and more |
rds |
4.3MB |
Sample annotation |
A matrix: rows are samples, columns represent sample information (GEO_id, cell_type, lib_size, and more) |
rds |
5.6KB |
Promoter-DHS's candidate enhancers in a fixed window |
A list: entries are Promoter-DHSs. Each entry contains the set of enhancer indices within a fixed window around the Promoter-DHS |
rds |
15MB |
Enhancer-DHSs count profiles |
A matrix: rows are enhancer-DHSs, columns are GEO samples |
rds |
109MB |
Enhancer-DHSs RLE (log2) profiles |
A matrix: rows are enhancer-DHSs, columns are GEO samples |
rds |
139MB |
Enhancer-DHSs RLE profiles |
A matrix: rows are enhancer-DHSs, columns are GEO samples |
rds |
139MB |
Enhancer genomic positions (genome build: hg19) |
A GRanges list: entries are enhancer-DHSs, each entry contains chromosome, start and end positions, name, and score |
rds |
11MB |
ChIA-PET connected loop sets (CLSs) for GM12878 |
A list: entries are Promoter-DHSs. Each entry contains an n-vector (n=number of candidate enhancers) with TRUE/FALSE, where TRUE is an EP link supported by ChIA-PET CLS. |
rds |
16.4MB |
Enhancer-Promoter links per cell type |
A list. Each entry of a cell type is a list of promoter-DHSs, each is a vector of enhancer names in enhancer GRanges list |
rds |
223KB |
Roadmap Epigenomics data - Human (hg19)
Name (link) |
Description |
Type |
Size |
Promoter-DHSs count profiles |
A matrix: rows are promoter-DHSs, columns are GEO samples |
rds |
17.8MB |
Promoter-DHSs RLE (log2) profiles |
A matrix: rows are promoter-DHSs, columns are GEO samples |
rds |
78.5MB |
Promoter-DHSs RLE profiles |
A matrix: rows are promoter-DHSs, columns are GEO samples |
rds |
65MB |
Promoter genomic positions (genome build: hg19) |
A GRanges object: entries are promoter-DHSs, each entry contains chromosome, start and end positions, name, and more |
rds |
2.4MB |
Sample annotation |
A matrix: rows are samples, columns represent sample information (GEO_id, cell_type, lib_size, and more) |
rds |
7.8KB |
Promoter-DHS's candidate enhancers in a fixed window |
A list: entries are Promoter-DHSs. Each entry contains the set of enhancer indices within a fixed window around the Promoter-DHS |
rds |
6.8MB |
Enhancer-DHSs count profiles |
A matrix: rows are enhancer-DHSs, columns are GEO samples |
rds |
149MB |
Enhancer-DHSs RLE (log2) profiles |
A matrix: rows are enhancer-DHSs, columns are GEO samples |
rds |
846MB |
Enhancer-DHSs RLE profiles |
A matrix: rows are enhancer-DHSs, columns are GEO samples |
rds |
572MB |
Enhancer genomic positions (genome build: hg19) |
A GRanges list: entries are enhancer-DHSs, each entry contains chromosome, start and end positions, name, and score |
rds |
9.6MB |
Enhancer-Promoter links per cell type |
A list. Each entry of a cell type is a list of promoter-DHSs, each is a vector of enhancer names in enhancer GRanges list |
rds |
258KB |
Additional data: analysis and external databases
[1] Kulakovskiy I V, Vorontsov IE, Yevshin IS, Sharipov RN, Fedorova AD, Rumynskiy EI, et al. HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-Seq analysis. Nucleic Acids Res. Oxford University Press; 2017;46:D252-D259
[2] Tang Z, Luo OJ, Li X, Zheng M, Zhu JJ, Szalaj P, et al. CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell [Internet]. Elsevier Inc.; 2015;163:1611–27. Available from: http://dx.doi.org/10.1016/j.cell.2015.11.024
[3] Li G, Ruan X, Auerbach RK, Sandhu KS, Zheng M, Wang P, et al. Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell. Elsevier; 2012;148:84–98
[4] Neph S, Vierstra J, Stergachis AB, Reynolds AP, Haugen E, Vernot B, et al. An expansive human regulatory lexicon encoded in transcription factor footprints. Nature. 2012;489:83–90
[5] Sheffield NC, Thurman RE, Song L, Safi A, Stamatoyannopoulos JA, Lenhard B, et al. Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. Genome Res. 2013;23:777–88