Integrating Gene Expression, Mutation and Copy Number Data

Integrating Gene Expression, Mutation and Copy Number Data to Identify Driver Genes of Recurrent Chromosome-Arm Losses

Aneuploidy driver detection

Aneuploidy, an abnormal number of chromosomes or chromosome arms in a cell, is a hallmark of cancer.
The recurrence of particular alterations within a given cancer type suggests that these changes are positively selected. However, the genes that drive recurrent aneuploidies remain poorly characterized.
Here we provide a tool for identifying drivers of recurrent chromosome-arm losses in cancer by integrating mutation, copy number, and gene expression data.

Saad R, Shamir R, Ben-David U. Integrating mutation, copy number, and gene expression data to identify driver genes of recurrent chromosome-arm losses. Cell Reports. 2025;44(11):116455. doi:10.1016/j.celrep.2025.116455