DOMINO: Discovery of Modules In Networks using Omic

DOMINO is an active module identification (AMI) algorithm. It recieves a gene network and nodes' activity scores as input and report sub-networks (modules) that are putatively biologically meaningful in the context of the activity data.

In extensive evaluation conducted on gene expression and genome-wide association study data we discovered that AMI algorithms tended to over-reporting of enrichment: GO terms enriched in the modules on real data were often also enriched when the algorithms were run on randomly permuted activity scores.

In constrast, modules retrieved by DOMINO had high rate of empirically validated GO terms.