Module number 981




Database revision : gnsdb28.10
Date : Tue Feb 25 17:20:27 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n Cond912:(99i1)_S150-2B_YPGL_NormInt\n Cond399:Nitrogen_Depletion_8_h\n mYLR339C:Unknown ,, Unknown\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mRPP1A:Homology to rat P1, human P1, and E.coli L12eIIA,acidic ribo\nsomal protein P1A (YP1alpha) (A1),\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond410:diauxic_shift_timecourse_18.5_h\n mRPS21A:Homology to rat S21,ribosomal protein S21A (S26A) (YS25),\n mFPR4:Homolog of homolog of the nucleolar FKBP, Fpr3,peptidyl-prol\nyl cis-trans isomerase (PPIase),Null mutant is viable\n mRPS21B:Homology to rat S21,ribosomal protein S21B (S26B) (YS25),\n mPUF6:member of the PUF protein family,,\n Cond675:MHY1_(dun1)_+_heat_20_min\n mRPS14A:Homology to mammalian S14, E. coli S11,ribosomal protein S14\nA (rp59A),Cryptopleurine resistance\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n mURA7:Last step in pyrimidine biosynthesis pathway; URA7 is very s\nimilar to URA8 CTP synthase,CTP synthase,Null mutant is viab\nle; ura7 ura8 double deletion mutants are inviable\n mRPS14B:Homology to human S14 and rat S14, E. coli S11,ribosomal pro\ntein S14B (rp59B),Null mutant is viable\n Cond400:Nitrogen_Depletion_12_h\n Cond697:gal2-gal\n mRKI1:Ribose-5-phosphate ketol-isomerase,ribose-5-phosphate ketol-\nisomerase,Null mutant is inviable\n Cond416:YPD_10_h__ypd-2\n Cond810:Na45'\n Calcin.NaNa:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond637:DES460_+_0.02%_MMS_-_60_min\n mRPS8A:Homology to mammalian S8,ribosomal protein S8A (S14A) (rp19)\n (YS9),\n Cond890:G1\n mRPS8B:Homology to mammalian S8,ribosomal protein S8B (S14B) (rp19)\n (YS9),\n mNOP13:Nucleolar Protein 13,,\n mPWP1:Protein with periodic trytophan residues that resembles memb\ners of beta-transducin superfamily because of presence of WD\n-40 repeats,,Null mutants are viable but show severely retar\nded growth\n mNOP15:Nucleolar protein 15,ribosome biogenesis,\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n Cond310:Heat_Shock_000_minutes_hs-2\n Cond873:10min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mRPP2A:Homology to rat P2, human P2, and E.coli L12eIB,60S acidic r\nibosomal protein P2A (L44) (A2) (YP2alpha),Null mutant is vi\nable\n mRPP2B:Homology to rat P2, human P2, and E.coli L12eIA,ribosomal pr\notein P2B (YP2beta) (L45),Null mutant is viable\n mRPA12:A12.2 subunit of RNA polymerase I,RNA polymerase I A12.2 sub\nunit,Null mutant is viable but is temperature sensitive; syn\nthetically lethal with RPA14\n mRPS22A:Homology to rat S15a,ribosomal protein S22A (S24A) (rp50) (Y\nS22),\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond318:37C_to_25C_shock_-_60_min\n mRPS22B:Homology to rat S15a,ribosomal protein S22B (S24B) (rp50) (Y\nS22),\n Cond673:DES460_(wild_type)_+_heat_20_min\n mSSZ1:DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a \nribosome-associated complex (RAC) that is bound to the ribos\nome via the Zuo1p subunit,HSP70 family,Null mutant is viable\n, cold sensitive; SSZ1 overexpression causes increased expre\nssion of some PDR genes\n Cond312:Heat_Shock_015_minutes_hs-2\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond683:MHY1_(crt1)_vs._CRY1_(wild_type)_-_log_phase\n Cond689:gal3+gal\n Cond693:gal7+gal\n Cond849:120_min\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mRPS9A:Homology to rat S9 and E.coli S4,ribosomal protein S9A (S13)\n (rp21) (YS11),\n mRPS9B:Homology to rat S9 and E. coli S4,ribosomal protein S9B (S13\n) (rp21) (YS11),Suppression of nonsense mutations\n mYJR070C:Unknown ,, Unknown\n Cond879:MMC\n mRPL11A:Homology to rat L11 and E. coli L5,ribosomal protein L11A (L\n16A) (rp39A) (YL22),\n mRPL11B:Homology to rat L11 and E. coli L5; involved in protein synt\nhesis,ribosomal protein L11B (L16B) (rp39B) (YL22),Null muta\nnt is viable, rp111b rp111a mutants are inviable. rpl11 muta\nnts are deficient in 60S ribosomal subunits relative to 40S \nsubunits. 43S preinitiation complexes accumulate in half-mer\n polyribosomes in the absence of sufficient 60S subunits.\n mRPS30B:Homology to mammalian S30,ribosomal protein S30B,Null mutant\n is viable, but it shows slow growth; Deletion of both RPS30\nA and RPS30B genes is lethal\n mRPS23A:Homology to rat S23 and E. coli S12,ribosomal protein S23A (\nS28A) (rp37) (YS14),Null mutant is viable; rps23a rps23b dou\nble deletion mutants are inviable. Mutations in different pa\nrts of RPS23 have opposite affects on translational accuracy\n or antibiotic sensitivity.\n mRPS23B:Homology to rat S23 and E. coli S12,ribosomal protein S23B (\nS28B) (rp37) (YS14),Null mutant is viable, rps23a rps23b dou\nble deletion mutants are inviable. Mutations in different pa\nrts of RPS23 have opposite affects on translational accuracy\n or antibiotic sensitivity.\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mRPS16A:Homology to rat S16,ribosomal protein S16A (rp61R),\n mRPS16B:Homology to rat S16,ribosomal protein S16B (rp61R),\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond443:DBYyap1_+_0.32_mM_H2O2_(20_min)\n mSIK1:homology to microtubule binding proteins and to X90565_5.cds\n,similar to microtubule binding proteins and to X90565_5.cds\n,wild-type gene suppresses toxicity of GAL4-I-Kappa-B alpha \nin yeast\n Cond653:wt_plus_gamma_30_min\n Calcin.Ca/Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRPL10:similar to members of the QM gene family, which is implicate\nd in differentiation in other eukaryotes and tumorigenesis i\nn humans; homology to rat L10; ubiquinol-cytochrome C reduct\nase complex subunit VI requiring protein,ribosomal protein L\n10,Null mutant is inviable; temperature-sensitive mutant, at\n restrictive temperature (on rich medium), arrests after 1-3\n cell divisions as large budded cells with aberrent septum a\nnd cytoskeleton\n Cond742: mRPL12A:Homology to rat L12(a) and E. coli L11,ribosomal protein L12\nA (L15A) (YL23),Null mutant is viable.\n mRPL12B:Homology to rat L12(a) and E. coli L11,ribosomal protein L12\nB (L15B) (YL23),Null mutant is viable.\n mRPL3:Homology to rat L3,ribosomal protein L3 (rp1) (YL1),Tricoder\nmin resistance\n Cond881:4NQO\n Cond303:Heat_Shock_20_minutes_hs-1\n Cond813:Na+FK30'\n mRPS24A:Homology to rat S24,ribosomal protein S24A,\n mRPL5:Homology to rat ribosomal protein L5; required for assembly \nof stable 60S ribosomal subunits,ribosomal protein L5 (L1a)(\nYL3),Null mutant is inviable.\n mRPA34:RNA polymerase I subunit, not shared (A34.5),,Null mutant is\n viable but its RNA polymerase I lacks subunit A49 (rpa49p);\n synthetically lethal with RPA14; shows synthetic interactio\nns with DNA topoisomerase I (TPO1)\n mMRT4:mRna turnover 4,,Null mutant exhibits slow growth. ts mutat\nion results in decreased decay rates of mRNAs\n Cond960:t5_g/r_ratio\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n mTIF1:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mRPS17A:Homology to rat S17,ribosomal protein S17A (rp51A),Null muta\nnt is viable and grows slowly; rps17A rps17B double null mut\nant is inviable\n mRPS17B:Homology to rat ribosomal protein S17,ribosomal protein S17B\n (rp51B),Null mutant is viable, rp51a (rps17a) rp51b (rps17b\n) deletion mutants are inviable\n mTIF2:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mTIF3:Suppressor of translation mutants,translation initiation fac\ntor eIF-4B,\n mAPT1:Adenine phosphoribosyltransferase,adenine phosphoribosyltran\nsferase,\n mGUA1:GMP synthase,GMP synthase,Null mutant is viable but is a gua\nnine auxotroph\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n mRPL1A:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1B (Ssm2p),ribosomal protein L\n1A, forms part of the 60S ribosomal subunit,Null mutant is v\niable; shows double mutant lethality with rpl1b (ssm2b) null\n mutants\n mRPL1B:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1A (Ssm1p),ribosomal protein L\n1B,\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond397:Nitrogen_Depletion_2_h\n Cond390:aa_starv_0.5_h\n Cond320:heat_shock_17_to_37,_20_minutes\n Cond316:37C_to_25C_shock_-_30_min\n Cond982:pho85D_10_mM_1NaPP1_\n Cond887:t-BuOOH\n mBRX1:Essential nucleolar protein required for biogenesis of the 6\n0S ribosomal subunit,,inviable\n mRPL20A:Homology to rat L18a,ribosomal protein L20A (L18A),\n mYDR417C:Unknown ,, Unknown\n mYOR309C:Unknown ,, Unknown\n mRPL20B:Homology to rat L18a,ribosomal protein L20B (L18B),\n mRPL13A:Homology to rat L13,ribosomal protein L13A,Null mutant is vi\nable.\n mRPL13B:Homology to rat L13,ribosomal protein L13B,\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond941:SK1_YPD\n mNEW1:This gene encodes a protein with an Q/N-rich amino terminal \ndomain that acts as a prion, termed [NU]+.,,Null mutant is v\niable\n mRPL25:Homology to E. coli L23 and rat L23a,ribosomal protein L25 (\nrpl6L) (YL25),\n mYKL056C:Unknown ,, Unknown\n mRPS25A:Homology to rat S25,ribosomal protein S25A (S31A) (rp45) (YS\n23),\n mRPS25B:Homology to rat S25; belongs to the S25E family of ribosomal\n proteins,ribosomal protein S25B (S31B) (rp45) (YS23),\n mRPL28:Homology to rat, mouse L27a,ribosomal protein L28 (L29) (rp4\n4) (YL24),Cycloheximide resistance\n mRPS18A:Homology to rat S18 and E. coli S13,ribosomal protein S18A,\n mRPS18B:Homology to rat S18 and E. coli S13,ribosomal protein S18B,\n mRPA49:49-kDa alpha subunit of RNA polymerase A,RNA polymerase A 49\n kDa alpha subunit,Null mutant is viable but grows slowly an\nd is temperature or cold sensitive; synthetically lethal wit\nh RPA14\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n Cond745: mRPL2A:Homology to rat L8 and E. coli L2,ribosomal protein L2A (L5A\n) (rp8) (YL6),\n Cond463:29_deg_growth_ct-1\n mYHR020W:Unknown ,, Unknown\n mRPL2B:Homology to rat L8 and E. coli L2,ribosomal protein L2B (L5B\n) (rp8) (YL6),\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n mKRE33:Killer toxin REsistant ,,Heterozygous diploid mutant exhibit\n haploinsufficiency K1 killer toxin resistance\n Stress.DTT1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond651:wt_plus_gamma_10_min\n Cond872:Zero1\n mKRR1:Involved in cell division and spore germination,,Null mutant\n is inviable\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mEMG1:Essential for Mitotic Growth,ribosome biogenesis,Lethal\n mYLR198C:Unknown ,, Unknown\n mRPL21A:Homology to rat L21,ribosomal protein L21A,\n mRPL30:Homology to rat and mouse L30,ribosomal protein L30 (L32) (r\np73) (YL38) large subunit,Null mutant is inviable.\n Cond532:GAL-RHO1-Q68H,3hrs.gallog10(intensity)\n mNOP58:57 kDa nucleolar protein involved in the pre-rRNA processing\n steps that lead to formation of 18 S rRNA; interacts with N\nop1p,57 kDa nucleolar protein,Null mutant is inviable; in vi\nvo depletion impairs synthesis of the 40S ribosomal subunit\n mRPL21B:Homology to rat L21,ribosomal protein L21B,\n mRPL32:Homology to rat L32 and mammalian L32,ribosomal protein L32,\n mRPL14A:Homology to mammalian L14,ribosomal protein L14A,\n mRPL14B:Homology to mammalian L14,ribosomal protein L14B,\n mRPS26A:Homology to rat S26,ribosomal protein S26A,Null mutant is vi\nable and grows slowly\n Cond459:YP_sucrose_vs_reference_pool_car-2\n mRPS26B:Homology to rat S26,ribosomal protein S26B,Null mutant is vi\nable\n Cond857:pm38-gtoe\n mRPL38:Homology to rat L38,ribosomal protein L38,\n mRPS19A:Homology to rat S19,ribosomal protein S19A (S16aA) (rp55A) (\nYS16A),\n mRPL39:Homology to rat L39,ribosomal protein L39 (L46) (YL40),Null \nmutant is viable, cold-sensitive in some genetic backgrounds\n, exhibits reduced levels of 60S subunits; rpl39 mutations s\nuppress mutations in poly-A binding protein (PAB1)\n mRPS19B:Homology to rat S19,ribosomal protein S19B (rp55B) (S16aB) (\nYS16B),\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n mCBF5:major low affinity 55 kDa Centromere/microtubule binding pro\ntein,major low affinity 55 kDa centromere/microtubule bindin\ng protein,Null mutant is inviable\n Cond317:37C_to_25C_shock_-_45_min\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n RapamycinDip.dip_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond419:YPD_2_d_ypd-2\n Cond431:YPD_stationary_phase_13_d_ypd-1\n Cond882:zero3\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n mRPL22A:Homology to rat L22,ribosomal protein L22A (L1c) (rp4) (YL31\n),\n mDBP2:ATP-dependent RNA helicase of DEAD box family,ATP dependent \nRNA helicase , dead box protein,Null mutant is inviable\n mRPL15A:Homology to rat L15,ribosomal protein L15A (YL10) (rp15R) (L\n13A),\n mDBP3:ATP-dependent RNA helicase CA3 of the DEAD/DEAH box family,A\nTP dependent RNA helicase , dead/deah box protein CA3,Null m\nutant is viable\n Cond886:g-ray\n mRPS27A:Homology to mammalian S27,ribosomal protein S27A (rp61) (YS2\n0),\n mYLR076C:Unknown ,, Unknown\n Cond811:Na60'\n mBUD19:Hypothetical ORF,,Null mutant is viable; random budding in d\niploid null mutants.\n Cond372:1.5_mM_diamide_(30_min)\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond336:constant_0.32_mM_H2O2_(20_min)_redo\n Cond743: mRPL4A:Homology to rat L4, Xenopus L1, Drosophila L1,ribosomal prot\nein L4A (L2A) (rp2) (YL2),\n Cond401:Nitrogen_Depletion_1_d\n mRPL4B:Highly similar to ribosomal protein L4A,ribosomal protein L4\nB (L2B) (rp2) (YL2),\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n Cond453:YP_ethanol_vs_reference_pool_car-2\n Cond815:Na+FK60'\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond968:swi1,_YPD_(d)\n mRPL23A:Homology to E. coli L14 and rat L23,ribosomal protein L23A (\nL17aA) (YL32),\n mRPL23B:Homology to rat L23 and E. coli L14,ribosomal protein L23B (\nL17aB) (YL32),\n mRPP0:Homology to rat P0, human P0, and E. coli L10e,ribosomal pro\ntein P0 (A0) (L10E),Null mutant is inviable\n mRPL16A:Homology to rat L13a,ribosomal protein L16A (L21A) (rp22) (Y\nL15),\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mRPL16B:Homology to rat ribosomal protein L13a,ribosomal protein L16\nB (L21B) (rp23) (YL15),\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n mRPC19:subunit common to RNA polymerases I (A) and III (C),RNA poly\nmerases I (A) and III (C) subunit,Null mutant is inviable\n mRPS28A:Homology to mammalian S28,ribosomal protein S28A (S33A) (YS2\n7),\n mRPS28B:Homology to mammalian S28,ribosomal protein S28B (S33B) (YS2\n7),\n Cond304:Heat_Shock_30_minutes_hs-1\n Cond428:YPD_stationary_phase_3_d_ypd-1\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n Cond703:gal10-gal\n Cond958:t0.5_g/r_ratio\n mGAR1:small nucleolar RNP proteins,small nucleolar RNP protein,Nul\nl mutant is inviable\n mBUD28:Hypothetical ORF,,Diploid null mutants exhibit random buddin\ng\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mSSB2:stress-seventy subfamily B,SSB1 homolog , heat shock protein\n of HSP70 family,Null mutant is viable, ssb1 ssb2 double dis\nruption mutants exhibit poor growth at all temperatures, but\n particularly at low temperatures; as well as hypersensitivi\nty to certain protein synthesis inhibitors, including aminog\nlycosides such as hygromycin B\n mYPR044C:Unknown ,, Unknown\n mCIC1:Nop seven associated protein 3,ribosome biogenesis,\n Cond302:Heat_Shock_15_minutes_hs-1\n Cond418:YPD_1_d_ypd-2\n mRPS0A:Homology to rat Sa,ribosomal protein S0A,Null mutant is viab\nle; yst1 (rps0a) yst2 (rps0b) double deletion mutant is invi\nable; yst1 (rps0a) mutants are defective for filamentous gro\nwth\n mRPS0B:Homology to rat Sa; closely related to mammalian p40/laminin\n receptor precursors (LRPs); required for translation and co\nntributes to the assembly and/or stability of the 40S riboso\nmal subunit,ribosomal protein S0B,Null mutant is viable with\n significant reduction in growth rate and change in distribu\ntion and make up of ribosomes; yst1 (rps0a) yst2 (rps0b) dou\nble mutant is inviable\n mRPL31A:Homology to rat L31,ribosomal protein L31A (L34A) (YL28),\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mAAH1:adenine aminohydrolase (adenine deaminase),adenine aminohydr\nolase (adenine deaminase),Null mutant is viable\n mRPL24A:Homology to rat L24,ribosomal protein L24A (rp29) (YL21) (L3\n0A),Null mutant is viable.\n mRPL24B:Homology to rat L24,ribosomal protein L24B (rp29) (YL21) (L3\n0B),Null mutant is viable.\n mRPL17A:Homology to rat L17, human L17, and E. coli L22,ribosomal pr\notein L17A (L20A) (YL17),\n mRPL17B:Homology to rat L17, human L17, and E. coli L22,ribosomal pr\notein L17B (L20B) (YL17),\n Cond467:steady_state_21_dec_C_ct-2\n Cond674:DES459_(mec1)_+_heat_20_min\n Cond425:YPD_stationary_phase_12_h_ypd-1\n mRPS29A:Homology to rat S29,ribosomal protein S29A (S36A) (YS29),\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRPS29B:Homology to rat S29,ribosomal protein S29B (S36B) (YS29),\n Cond364:dtt_030_min__dtt-2\n Cond373:1.5_mM_diamide_(40_min)\n Cond445:Msn4_overexpression\n Cond454:YP_fructose_vs_reference_pool_car-2\n mRPB8:16-kDa RNA polymerase subunit (common to polymerases I, II a\nnd III),16 kDa RNA polymerase subunit (common to polymerases\n I, II and III),Null mutant is inviable\n mDIM1:Dimethyladenosine transferase, (rRNA(adenine-N6,N6-)-dimethy\nltransferase),reponsible for m6[2]Am6[2]A dimethylation in 3\n'-terminal loop of 18S rRNA,dimethyladenosine transferase,Nu\nll mutant is inviable\n mRPS12:Homology to rat S12,ribosomal protein S12,\n mRPS13:Homology to rat S13,ribosomal protein S13 (S27a) (YS15),\n Cond391:aa_starv_1_h\n mNMD3:putative Upf1p-interacting protein,factor required for a lat\ne assembly step of the 60S subunit,Null mutant is inviable, \nat nonpermissive temperature, nmd3 ts mutants exhibit decrea\nsed levels of 60S subunits resulting in formation of half-me\nr polysomes; nmd3 xrn1(kem1) double mutants are inviable\n mRPS15:Homology to rat S15 and E. coli S19,ribosomal protein S15 (S\n21) (rp52) (RIG protein),\n mRPL6A:Homology to rat L6 and human L6,ribosomal protein L6A (L17A)\n (rp18) (YL16),\n Cond814:Na+FK45'\n mRPL6B:Homology to rat and human L6; involved initiation of protein\n synthesis,ribosomal protein L6B (L17B) (rp18) (YL16),Null m\nutant is viable, grows slower than wild-type. rpl6a rpl6b do\nuble mutants are inviable; rpl6 mutants are deficient in 60S\n ribosomal subunits relative to 40S subunits; 43S preinitiat\nion complexes accumulate in half-mer polyribosomes in the ab\nsence of sufficient 60S subunits.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Cond805:Ca/Ca+FK30'\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond900:(11i1)_S150-2B_YPGL_NormInt\n Cond894:G2\n mRPS1A:Homologous to rat S3A,ribosomal protein S1A (rp10A),\n mRPS1B:Homologous to rat ribosomal protein S3A,ribosomal protein S1\nB (rp10B),\n Cond704:gal80-gal\n Cond395:Nitrogen_Depletion_30_min.\n Cond279:ERG11(tetpromoter)\n Cond701:gal6-gal\n mNIP7:Nip7p is required for 60S ribosome subunit biogenesis,,Null \nmutant is inviable; in the temperature-sensitive mutant nip7\n-1, glycine 71 is replaced by aspartic acid\n Cond749: mRPL18A:Homology to rat ribosomal protein L18,ribosomal protein L18A\n (rp28A),\n mRPL18B:Homology to rat ribosomal protein L18,ribosomal protein L18B\n (rp28B),\n Cond479:WT+/-100mM3AT(SetD)(R491)\n Cond694:gal10+gal\n Cond306:Heat_Shock_60_minutes_hs-1\n mRPS20:Homology to rat S20, human S20, Xenopus S22, and E. coli S10\n,ribosomal protein S20,Null mutant is inviable\n Cond361:2.5mM_DTT_180_min_dtt-1\n Cond367:dtt_240_min_dtt-2\n mEFB1:Translation elongation factor EF-1beta, GDP/GTP exchange fac\ntor for Tef1p/Tef2p,translation elongation factor EF-1beta, \nGDP/GTP exchange factor for Tef1p/Tef2p,Null mutant is invia\nble\n mMES1:methionyl tRNA synthetase,methionine-tRNA ligase,no growth a\nt 36 degrees C\n mTIF11:Translation initiation factor eIF1A,translation initiation f\nactor eIF1A,Null mutant is inviable\n mRPL7A:Homology to rat L7 and E. coli L30,ribosomal protein L7A (L6\nA) (rp11) (YL8),Null mutant is viable; grows more slowly tha\nn wild-type\n mYGL102C:Unknown ,, Unknown\n mRPL7B:Homolog of mammalian ribosomal protein L7 and E. coli L30,ri\nbosomal protein L7B (L6B) (rp11) (YL8),Null mutant is viable\n; disruption of both RPL7A and RPL7B is lethal\n mYLR413W:Unknown ,, Unknown\n Cond313:Heat_Shock_030inutes__hs-2\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond818:crz1/Na30'\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n Cond378:1M_sorbitol_-_15_min\n mIMD4:similar to IMP dehydrogenase,IMP dehydrogenase homolog,\n mRPL40A:Homology to rat L40,ribosomal protein L40A,Null mutant is vi\nable\n mRPL40B:Homology to rat L40,ribosomal protein L40B,Null mutant is vi\nable\n mRPC40:RNA polymerase III (C) subunit,RNA polymerase III subunit,Nu\nll mutant is inviable.\n mRPL33A:Homology to rat L35a,ribosomal protein L33A (L37A) (YL37) (r\np47),Null mutant is viable, severely impaired in growth. rpl\n33a rpl33b double deletion mutants are inviable\n mRPL33B:Homology to rat L35a,ribosomal protein L33B (L37B) (rp47) (Y\nL37),Null mutant is viable.\n Cond816:Na/Na+FK30'\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mRPL26A:Homology to rat L26,ribosomal protein L26A (L33A) (YL33),\n mRPL26B:Homology to rat L26,ribosomal protein L26B (L33B) (YL33),\n mRPL19A:Homology to rat L19,ribosomal protein L19A (L23A) (rpl5L) (Y\nL14),Null mutant is viable but grows slowly.\n mRPS2:Homology to rat S2 and E. coli S5,ribosomal protein S2 (S4) \n(rp12) (YS5),Omnipotent suppressor of nonsense mutations\n mRPL19B:Homology to rat L19,ribosomal protein L19B (YL14) (L23B) (rp\nl5L),Null mutant is viable but grows slowly.\n mRPS3:Homology to mammalian S3,ribosomal protein S3 (rp13) (YS3),N\null mutant is inviable\n mPRP43:Pre-mRNA processing factor involved in disassembly of splice\nosomes after the release of mature mRNA,RNA helicase,\n mRPS5:ribosomal small subunit protein homologous to mammalian S5 (\nhas approx. 70% identity with human, rat and hydrozoan S5). \nIt is the least basic of the non-acidic ribosomal proteins. \nIt is phosphorylated in yeast.,ribosomal protein S5 (S2) (rp\n14) (YS8),null is inviable; transcription of RPS5 is sensiti\nve to heat-shock and carbon source shift.\n mASC1:WD repeat protein (G-beta like protein) that interacts with \nthe translational machinery,G-beta like protein,Null mutant \nis viable. Null mutation suppresses the absence of growth of\n a cyp1- strain in anaerobiosis and also causes delayed grow\nth in aerobic or heme sufficient conditions; trp auxotrophs \nof the asc1 null allele are cold sensitive for growth; other\n mutants have increased cell size\n Cond374:1.5_mM_diamide_(50_min)\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond959:t2_g/r_ratio\n mRPS31:Homology to rat S27a,ribosomal protein S31 (S37) (YS24),Null\n mutant is viable\n Cond809:Na30'\n Cond965:ndt80_delete_mid_g/r_ratio_\n mRPL8A:Homolgous to human L7a, mouse L7a, and rat L7a,ribosomal pro\ntein L8A (rp6) (YL5) (L4A),Null mutant is viable, rpl4A rpl4\nB double mutant is inviable; deficient in maintenance of kil\nler\n Cond905:(77i4)_S150-2B_YPGL+G__NormInt\n mRPL8B:Homology to human L7a, mouse L7a, rat L7a,ribosomal protein \nL8B (L4B) (rp6) (YL5),Null mutant is viable. rpl8a rpl8b mut\nants are inviable. The rpl8b allele, krb1, can suppress some\n mak mutations and represents a chromosomal rearrangement in\nvolving chromosome XII\n Cond366:dtt_120_min_dtt-2\n mRLP7:Significant sequence similarity to RPL7B, but neither can fu\nnctionally replace the other. Does not correspond to any rib\nosomal component identified so far, based on its biochemical\n features,,Null mutant is inviable\n mYTM1:microtubule-associated protein,microtubule-associated protei\nn,\n mRPL34A:Homology to rat L34,ribosomal protein L34A,\n mRPL34B:Homology to rat L34,ribosomal protein L34B,\n mRPL27A:Homology to mammalian L27,ribosomal protein L27A,\n mRPL27B:Homology to mammalian L27,ribosomal protein L27B,\n Cond652:wt_plus_gamma_20_min\n Cond899:RPN4_MMS__\n mNOP1:nucleolar protein, homologous to mammalian fibrillarin,nucle\nolar protein , similar to mammalian fibrillarin,Null mutant \nis inviable. Temperature-sensitive alleles exhibit various d\nefects in rRNA processing.\n mNOP2:May participate in nucleolar function during the transition \nfrom stationary phase to rapid growth,90 kDa protein homolog\nous to a human proliferation-associated nucleolar protein, p\n120,Null mutant is inviable; overexpression leads to changes\n in nucleolar morphology\n mRPS10A:Homology to rat S10,ribosomal protein S10A,\n Cond305:Heat_Shock_40_minutes_hs-1\n Cond396:Nitrogen_Depletion_1_h\n mRPS10B:Homology to rat S10,ribosomal protein S10B,\n Cond658:DES460_(wt)_-_mock_irradiation_-_5_min\n mNOP7:Required for normal pre-rRNA processing,,Null: lethal.\n mSAM4:S-adenosylmethionine:homocysteine S-methyltransferase,,Slow \ngrowth on S-adenosylmethionine used as a sulfur source\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mRPL9A:Homology to rat L9,ribosomal protein L9A (L8A) (rp24) (YL11)\n,\n mRPL9B:Homology to rat L9,ribosomal protein L9B (L8B) (rp24) (YL11)\n,\n Cond363:dtt_015_min_dtt-2\n mRPS4A:Homology to rat S4 and human S4,ribosomal protein S4A (YS6) \n(rp5) (S7A),Null mutant is viable; rps4a rps4b double deleti\non is inviable\n mRPL42A:Homology to rat L36a and human L36a,ribosomal protein L42A (\nYL27) (L41A),\n mRPL42B:Homology to rat L36a and human L36a,ribosomal protein L42B (\nYL27) (L41B) (YP44),Deficient in maintenance of killer\n mRPS4B:Homology to rat S4 and human S4,ribosomal protein S4B (YS6) \n(rp5) (S7B),\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n mRPL35A:Homology to rat L35,ribosomal protein L35A,Null mutant is vi\nable.\n Cond892:S\n mRPL35B:Homology to rat L35,ribosomal protein L35B,\n Cond447:ethanol_vs._reference_pool_car-1\n Cond967:swi1,_YPD_(c)\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYNL174W:Unknown ,, Unknown\n Cond323:heat_shock_29_to_37,_20_minutes\n mRPF2:Hypothetical ORF,,\n Cond733: Cond940:6h\n mSNU13:RNA binding protein (putative), similar to Nhp2p,U4/U6.U5 sn\nRNP component,the null mutant is inviable\n mRPS11A:Homology to rat S11, human S11, and E. coli S17,ribosomal pr\notein S11A (S18A) (rp41A) (YS12),Null mutant is viable\n mRPS11B:Homology to rat S11, human S11, and E. coli S17,ribosomal pr\notein S11B (S18B) (rp41B) (YS12),Null mutant is viable\n Cond426:YPD_stationary_phase_1_d_ypd-1\n mYOR004W:Unknown ,, Unknown\n Cond531:GAL-PKC1-R398A,3hrs.gallog10(intensity)\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n Cond934:8h\n Cond322:heat_shock_25_to_37,_20_minutes\n Cond961:t7_g/r_ratio\n Cond420:YPD_3_d_ypd-2\n Cond893:SMMS\n mRPL43A:Homology to human L37a,ribosomal protein L43A,\n Cond379:1M_sorbitol_-_30_min\n mRPL36A:Homology to rat L36,ribosomal protein L36A (L39) (YL39),\n Cond354:2.5mM_DTT_005_min_dtt-1\n mRRP5:Ribosomal RNA Processing,required for processing of pre-rRNA\n,Overexpression of RRP5 facilitates mitochondrial import of \nhydrophobic proteins; overexpression of an RRP5 mutant compl\nements the rRNA processing defect of the null alllele, but d\noes not facilitate mitochondrial import\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond321:heat_shock_21_to_37,_20_minutes\n mARX1:Unknown ,, Unknown\n Cond783:Peroxide_60'\n mNOC2:NucleOlar Complex 2; involved in nuclear export of pre-ribos\nomes,,\n Cond878:MNNG\n SwiSnf.swisnf:Whole-genome expression analysis of snf/swi mutants of Sacch\naromyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Mar 28;\n97(7):3364-9.\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n mTRM82:Unknown ,, Unknown\n Cond906:(77i5)_S150-2B_YPD_NormInt\n Cond417:YPD_12_h_ypd-2\n Cond946:W303ume6_YPD\n mHPT1:enzyme involved in de novo purine biosynthesis,hypoxanthine \nguanine phosphoribosyltransferase,Null mutant is viable; mut\nants show resistance to 8-azaguanine\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond415:YPD_8_h_ypd-2\n mRPS6A:Homology to rat, mouse, and human S6,ribosomal protein S6A (\nS10A) (rp9) (YS4),\n Cond319:37C_to_25C_shock_-_90_min\n mRPS6B:Homology to rat, human, and mouse S6,ribosomal gene product \nS6B (S10B) (rp9) (YS4),\n Cond685:wt-gal\n Cond402:Nitrogen_Depletion_2_d\n mRPL37A:Homology to rat L37,ribosomal protein L37A (L43) (YL35),\n mRPL37B:Homology to rat L37,ribosomal protein L37B (L43) (YL35),\n mRRB1:RiboSome Assembly 2,,Null mutant is inviable; a temperature-\nsensitive mutant has decreased free 60s ribosomal subunit.\n Cond876:zero2\n Calcin.crz1Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond732:fkh1,2_alpha_factor_000_min_y12n57\n Cond360:2.5mM_DTT_120_min_dtt-1\n Cond885:20\n mHAS1:Helicase Associated with SET1,RNA-dependent helicase (putati\nve),Null mutant is inviable\n mYLL044W:Unknown ,, Unknown\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mERB1:conserved eukaryotic protein involved in ribosome biogenesis\n,,Null mutant is inviable.\n mYPL142C:Unknown ,, Unknown\n mYAR075W:Unknown ,, Unknown\n mSUR4:Required for conversion of 24-carbon fatty acids to 26-carbo\nn species,,Null mutants is viable, not sensitive to UV or ga\nmma radiation. sur4 mutants suppress rad3, rvs161 delta, and\n rvs167 mutations. sur4 fen1 mutants and sur4 elo2 mutants a\nre inviable.\n Cond699:gal4-gal\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n mFYV13:Function required for Yeast Viability on toxin exposure,,Nul\nl mutant is viable but exhibits K1 killer toxin hypersensiti\nvity.\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond421:YPD_5_d_ypd-2\n mYNL119W:Unknown ,, Unknown\n Cond858:pm71-30\n mRPS7A:Homology to human S7 and Xenopus S8,ribosomal protein S7A (r\np30),Null mutant is viable\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRPS7B:Homology to human S7 and Xenopus S8,ribosomal protein S7B (r\np30),\n
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Computational Genomics Lab, Tel-Aviv uniresity