Module number 970




Database revision : gnsdb28.10
Date : Tue Feb 25 17:18:40 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n mHST3:Homolog of SIR2,,hst3 hst4 double mutant has defects in telo\nmeric silencing, cell cycle progression, radiation resistanc\ne, and genomic stability\n Cond221:yer083c\n Cond494:wtħ5nMaF,30minlog10(intensity)\n Cond798:Ca30'\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n Cond418:YPD_1_d_ypd-2\n mBUD4:co-assembles with Bud3p at bud sites,,Null mutant is viable,\n haploids have dipolar budding, normally they have axial bud\nding, no effects on diploids\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond362:dtt_000_min__dtt-2\n mCLB1:Involved in mitotic induction,B-type cyclin,Null mutant is v\niable (lethal in combination with clb2 mutation)\n mCLB2:Involved in mitotic induction,B-type cyclin,Null mutant is v\niable (lethal in combination with clb1 mutation)\n mYML119W:Unknown ,, Unknown\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond579:cdc15_140\n mYJL051W:Unknown ,, Unknown\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mCDC5:CDC5 is dispensable for premeiotic DNA synthesis and recombi\nnation, but required for tripartite synaptonemal complexes, \nhaploidization, and spores,protein kinase,Null mutant is inv\niable. cdc5(ts) mutants form synaptonemal complexes lacking \ncentral elements and arrest either at meiosis I with broken \nspindles or at meiosis II with short spindles. Late shifts t\no a restrictive temperature result in reductional dyads; eac\nh spore contains an entire meiosis II short spindle with uns\neparated chromatids. In some strains at semi-permissive temp\nerature, chromosomes segregate reductionally or equationally\n depending upon the centromere.\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond505:wtħ50nMaF,120minlog10(intensity)\n mGAS3:Unknown ,, Unknown\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond769:Acid_80'\n Cond805:Ca/Ca+FK30'\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Cond568:alpha119\n Cond279:ERG11(tetpromoter)\n mPHO3:Acid phosphatase, constitutive,acid phosphatase,phosphatase \ndeficient\n Cond553:alpha14\n Cond404:Nitrogen_Depletion_5_d\n mPHO5:Acid phosphatase, repressible,acid phosphatase,phosphatase d\neficient\n Cond508:bni1Dħ50nMaF,120minlog10(intensity)\n mWSC4:cell wall integrity and stress response component 4,contains\n novel cysteine motif , integral membrane protein (putative)\n , similar to SLG1 (WSC1), WSC2 and WSC3,\n Cond580:cdc15_150\n Cond804:Ca/Ca+FK15'\n Cond797:Ca15'\n mPMA1:major regulator of cytoplasmic pH,plasma membrane H+-ATPase,\ninviable; pma1 mutants are resistant to Dio-9, ethidium brom\nide and guanidine derivatives\n Cond581:cdc15_160\n Cond54:erg3(haploid)\n Cond558:alpha49\n Cond512:GAL-STE5-CTM,3hrs.gallog10(intensity)\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond653:wt_plus_gamma_30_min\n Cond571:cdc15_50\n mCHA1:catabolism of hydroxy amino acids,catabolic serine (threonin\ne) dehydratase,Null mutant is viable and cannot grow on medi\na with L-serine or L-threonine as sole nitrogen source\n mHEK2:Unknown ,, Unknown\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Calcin.Ca/Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond555:alpha28\n Cond493:wtħ1.5nMaF,30minlog10(intensity)\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond570:cdc15_30\n Cond639:DES460_+_0.02%_MMS_-_120_min\n mACE2:involved in transcriptional regulation of CUP1,zinc finger t\nranscription factor,Null mutant is viable, exhibits decrease\nd CUP1 mRNA expression\n Cond584:cdc15_190\n Cond503:wtħ50nMaF,60minlog10(intensity)\n Cond511:GAL-STE4,3hrs.gallog10(intensity)\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n mMYO1:myosin class II,class II myosin,Null mutant is viable, exhib\nts abnormal chitin distribution and cell wall organization a\nt the mother-bud neck in a high proportion of dividing cells\n; exhibits abberant nuclear migration and cytokinesis; bem2 \nmyo1 double mutants are inviable\n Cond567:alpha112\n mYOR315W:Unknown ,, Unknown\n Cond652:wt_plus_gamma_20_min\n Cond281:HMG2(tetpromoter)\n mSWI5:transcriptional activator,transcriptional activator,homothal\nlic switching deficient\n mYNL058C:Unknown ,, Unknown\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond552:alpha7\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond504:wtħ50nMaF,90minlog10(intensity)\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mHOF1:SH3 domain containing-protein required for cytokinesis,,Null\n mutant is defective in cytokinesis\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond586:cdc15_210\n Cond375:1.5_mM_diamide_(60_min)\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond53:erg2\n Y-Stre.Acid:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond507:bni1Dħ50nMaF,90minlog10(intensity)\n Cond940:6h\n mNCE102:involved in secretion of proteins that lack classical secret\nory signal sequences,,An uncharacterized allele exhibits def\nects in the export of the mammalian protein galectin-1.\n Cond638:DES460_+_0.02%_MMS_-_90_min\n mYLR190W:Unknown ,, Unknown\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond566:alpha105\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond340:constant_0.32_mM_H2O2_(60_min)_redo\n Cond379:1M_sorbitol_-_30_min\n mALK1:,leucine zipper (putative) , membrane protein (putative),\n Cond550:clb2-1\n Cond557:alpha42\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond506:bni1Dħ50nMaF,60minlog10(intensity)\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond478:WT+/-10mM3AT(R491)\n mCHS2:chitin synthase 2,chitin synthase 2,disruption results in lo\nss of well-defined septa and in growth arrest\n mYPL141C:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond502:wtħ50nMaF,45minlog10(intensity)\n Cond563:alpha84\n mCDC20:Required for onset of anaphase,anaphase promoting complex (A\nPC) subunit,Null mutant is inviable; conditional alleles sho\nw cell cycle arrest in G2\n mMRH1:Membrane protein related to Hsp30p; Localized by immunofluor\nescence to membranes, mainly the plasma membr. punctuate imm\nunofluorescence pattern observed in buds. The nuclear envelo\npe, but not vacuole or mitochondrial membranes also stained,\n,Null mutant is viable\n Cond175:swi4\n Cond403:Nitrogen_Depletion_3_d\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mHTA1:Histone H2A (HTA1 and HTA2 code for nearly identical protein\ns),histone H2A (HTA1 and HTA2 code for nearly identical prot\neins),Null mutant is viable\n Cond250:ymr031w-a\n Cond501:wt+/-50nMaF,30minlog10(intensity)\n mHTA2:Histone H2A (HTA1 and HTA2 code for nearly identical protein\ns),histone H2A (HTA1 and HTA2 code for nearly identical prot\neins),Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2\n) locus has no reported observable phenotypes, presumably be\ncause HTA1-HTB1 (TRT1) expression is upregulated and can com\npensate in the absence of TRT2. Overexpression of TRT2 can s\nuppress Ty insertion mutations\n Cond402:Nitrogen_Depletion_2_d\n Cond554:alpha21\n mHHF1:Histone H4 (HHF1 and HHF2 code for identical proteins),histo\nne H4 (HHF1 and HHF2 code for identical proteins),\n Cond575:cdc15_100\n mHHF2:Histone H4 (HHF1 and HHF2 code for identical proteins),histo\nne H4 (HHF1 and HHF2 code for identical proteins),\n Cond283:KAR2(tetpromoter)\n Cond294:Itraconazole\n mYIL158W:Unknown ,, Unknown\n Cond574:cdc15_90\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPHO12:acid phosphotase, nearly identical to Pho11p,acid phosphatas\ne,\n Cond560:alpha63\n Cond576:cdc15_110\n Cond299:Tunicamycin\n mSUR7:Multicopy suppressor of rvs167 mutation,integral membrane pr\notein (putative),Null mutant is viable, exhibits no growth d\nefects on non-fermentable carbon sources or sensitivites to \n3-AT or high salt\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond559:alpha56\n Cond551:alpha0\n Cond549:clb2-2\n mHTB2:Histone H2B (HTB1 and HTB2 code for nearly identical protein\ns),histone H2B (HTB1 and HTB2 code for nearly identical prot\neins),Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2\n) locus has no reported observable phenotypes, presumably be\ncause HTA1-HTB1 (TRT1) expression is upregulated and can com\npensate in the absence of TRT2\n mHHF1 mHTA1
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Computational Genomics Lab, Tel-Aviv uniresity