Module number 955




Database revision : gnsdb28.10
Date : Tue Feb 25 17:15:35 2003
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mMAF1:Mod5 protein sorting,,Mislocalizes Mod5p to the nucleus\n mYBR280C:Unknown ,, Unknown\n mVPS70:Unknown ,, Unknown\n mVPS72:Unknown ,, Unknown\n mYBR287W:Unknown ,, Unknown\n mTOS5:Hypothetical ORF,,\n mPMC1:May be involved in depleting cytosol of Ca2+ ions,Ca2+ ATPas\ne (putative),Null mutant is viable but fails to grow in high\n Ca2+ medium; this death in high calcium is suppressed by mu\ntations in calcineurin (CNA1, CNA2, CNB1) and calmodulin (CM\nD1); pmc1 vcx1 double mutant is even more sensitive to Ca2+\n mGYP7:GTPase-activating protein,GTPase activating protein (GAP),Nu\nll mutant is viable\n mBUD2:GTPase-activating protein (GAP) for Rsr1p/Bud1p,GTPase activ\nating protein (GAP) for Rsr1p/Bud1p,Null mutant is viable, w\nith random bud site selection in all cell types\n mARK1:actin regulating kinase,serine/threonine kinase (putative),N\null mutant is viable and shows slight delocalisation of acti\nn cytoskeleton\n mYHL021C:Unknown ,, Unknown\n mUIP3:Unknown ,, Unknown\n mBUD6:actin interacting rotein,,Null mutant is viable; mutants exh\nibit severe disruption of the actin cytoskeleton; deletion s\ntrains have a depolarized cytoskeleton, mitotic delay, and p\nrobable cytokinesis defects\n mICT1:Increased Copper Tolerance; Similar to Ecm18p,,\n mYJL084C:Unknown ,, Unknown\n mCRZ1:calcineurin responsive zinc-finger,transcription factor (put\native),Null mutant is viable\n mYBR139W:Unknown ,, Unknown\n mCWH41:Glucosidase I, involved in assembly of cell wall beta 1,6 gl\nucan; an ER type II integral membrane N-glycoprotein,glucosi\ndase I,Null mutant is viable, associated with K1 killer toxi\nn-resistant phenotype and a 50% reduction in the cell wall b\neta 1,6-glucan level\n mYNL127W:Unknown ,, Unknown\n mYDL222C:Unknown ,, Unknown\n mGSH1:Glutathione biosynthesis,gamma-glutamylcysteine synthetase,N\null mutant is viable, exhibits alteration of glutathione con\ntent and reduction in growth rate\n mGPM2:Similar to GPM1 (phosphoglycerate mutase); converts 3-phosph\noglycerate to 2-phosphoglycerate in glycolysis,,Null mutant \nis viable, gpm2 gpm3 double deletion mutants exhibit no synt\nhetic phenotypes\n mYLR241W:Unknown ,, Unknown\n mYJL070C:Unknown ,, Unknown\n Cond805:Ca/Ca+FK30'\n mAMS1:vacuolar alpha mannosidase,alpha mannosidase,null mutant is \nviable\n mYHR097C:Unknown ,, Unknown\n mAMD1:putative alpha-mannosidase,alpha-mannosidase (putative),Null\n mutant is viable\n mSRY1:Serine Racemase homolog in Yeast,pyridoxal-5'phosphate-depen\ndent enzyme , similar to mouse glial serine racemase,Null mu\ntant is viable\n mPPR1:Positive regulator of URA1 and URA3,zinc finger transcriptio\nn factor of the Zn(2)-Cys(6) binuclear cluster domain type,N\null mutant is viable, deficient in pyrimidine biosynthetic p\nathway\n mSPL2:Suppressor of plc1-delta. Isolated as a dosage suppressor of\n the temperature-sensitive phenotype of a plc1 null mutant. \nAlso suppresses the hyperosmotic-sensitive phenotype of the \nplc1 null mutant.,,Null mutant is viable and shows no obviou\ns phenotype; spl2-delta plc1-delta double mutant fails to gr\now on SCD complete media, but grows on YPD at 25 degrees C\n mYJL016W:Unknown ,, Unknown\n mHOG1:osmoregulation,MAP kinase,Null mutant is viable and unable t\no grow in high osmolarity media\n mYPS1:Gpi-anchored aspartic protease (Yapsin 1),GPI-anchored aspar\ntic protease,Null mutant is viable, defective in expression \nof somatostatin-28; yps1 mkc7 double disruptants are tempera\nture sensitive; yps1 mkc7 kex2 mutants are profoundly temper\nature sensitive and are cold sensitive\n mSSK1:Two-component signal transducer that with Sln1p regulates os\nmosensing MAP kinase cascade(suppressor of sensor kinase),tw\no-component signal transducer that with Sln1p regulates osmo\nsensing MAP kinase cascade(suppressor of sensor kinase),Null\n mutant is viable; suppresses the lethality of sln1 or ypd1 \ndisruption mutants\n Cond489:PHO81c_vs_WT_exp1\n mYDL233W:Unknown ,, Unknown\n mYKR100C:Unknown ,, Unknown\n mYOR055W:Unknown ,, Unknown\n mIRS4:Increased rDNA silencing,,Null mutant is viable and shows in\ncreased rDNA silencing\n mMLF3:Protein of unknown function,,Null mutant is viable and hyper\nsensitive to leflunomide\n mRCK2:Serine/threonine protein kinase,,Null mutant is viable\n mYAL053W:Unknown ,, Unknown\n mSGE1:multi-copy suppressor of gal11 null; member of drug-resistan\nce protein family,,Null mutant is viable; shows decreased ex\npression of galactose-inducible genes; shows increased sensi\ntivity to crystal violet\n mYMR258C:Unknown ,, Unknown\n mYMR102C:Unknown ,, Unknown\n mYBR071W:Unknown ,, Unknown\n mALD2:Expression induced in response to high osmotic stress. NAD+ \nis preferred coenzyme.,aldeyhde dehydrogenase,ald2 ald3 doub\nle mutants show reduced growth rate with ethanol as the sole\n carbon source.\n mYPL166W:Unknown ,, Unknown\n mTIS11:Zinc finger containing homolog of mammalian TIS11, glucose r\nepressible gene,,Null mutant is viable but alters metabolism\n that is reflected by a pH change on YPD plates.\n mPTK1:Putative serine/threonine protein kinase,,Mutant shows decre\nase in total polyamine accumulation and resistance to polyam\nine analogs; ptk1 ptk2 double mutant shows virtually abolish\ned high-affinity spermidine transport\n Cond818:crz1/Na30'\n mVIP1:Homologous to S. pombe asp1+,,\n mYNL194C:Unknown ,, Unknown\n mBOP2:bypass of PAM1,,\n mVTC1:Null mutant identified in different genetic screens both by \nits ability to reverse the Cdc42p suppression of a cdc24-4ts\n mutant and its ability to suppress the vacuolar ATPase null\n phenotype,S. pombe Nrf1p homolog (97% identical in predicte\nd amino acid sequence),Null mutant is viable, but exhibits b\noth reduced V-ATPase in the vacuolar membrane and reduced H(\n+)-ATPase(Pma1p) in the plasma membrane\n mPRB1:dispensable for haploidization and sporulation, but needed f\nor full protein degradation during sporulation, and proper s\npore morphology,vacuolar protease B,Null mutant is viable, p\nrotease B deficient, has smaller spores than wild-type embed\nded in a thick matrix\n mVTC2:Phosphate metabolism; transcription is regulated by PHO syst\nem,polyphosphate synthetase (putative),Null nutant is viable\n; no polyphosphate accumulation in a vtc2(phm1)/vtc3(phm2) d\nouble disruptant\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYLR414C:Unknown ,, Unknown\n mVTC3:Phosphate metabolism; transcription is regulated by PHO syst\nem,polyphosphate synthetase (putative),Null nutant is viable\n; no polyphosphate accumulation in a vtc2(phm1)/vtc3(phm2) d\nouble disruptant\n Cond819:crz1/Na45'_\n mGRE3:Induced by osmotic stress; similar to xylose reductase from \nother fungi,,\n mVTC4:Phosphate metabolism; transcription is regulated by PHO syst\nem,polyphosphate synthetase (putative),Null mutant has been \nshown to be either inviable, or viable while exhibiting no p\nolyphosphate accumulation\n mMAL31:Part of the complex locus MAL3; functional in S288C; highly \nhomologous to MAL61 from S. cerevisiae, MAL61 from S. carlsb\nergenesis strains JM1901 and CB11, and MAL1T from strain 405\n9,maltose permease,Defective maltose fermentation\n mUBP5:Putative Ubiquitin-specific protease,ubiquitin-specific prot\nease (putative),Null mutant is viable\n mPHO84:inorganic phosphate transporter, transmembrane protein,inorg\nanic phosphate transporter,Null mutant is viable\n mYJR024C:Unknown ,, Unknown\n mSED1:putative cell surface glycoprotein,cell surface glycoprotein\n (putative),Null mutant is viable; during stationary phase, \nnull mutants exhibit increased sensitivity to Zymolyase.\n mUBP9:similar to Ubp13p,ubiquitin carboxyl-terminal hydrolase,\n mYLR247C:Unknown ,, Unknown\n Calcin.crz1Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mPHO89:Probable Na+/Pi symporter,Na+/Pi symporter (putative),Null m\nutant is viable\n pho.Pho:New components of a system for phosphate accumulation and po\nlyphosphate metabolism in Saccharomyces cerevisiae revealed \nby genomic expression analysis. Mol Biol Cell. 2000 Dec;11(\n12):4309-21.\n mYAR028W:Unknown ,, Unknown\n Calcin.Ca/Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mSBE22:functionally redundant and similar in structure to SBE2,,syn\nthetic lethal with sbe2 mutation\n mMNT4:MaNnosylTransferase,mannosyltransferase (putative),\n mBAP2:contains 12 predicted transmembrane domains,amino acid perme\nase for leucine, valine, and isoleucine (putative),reduced u\nptake of leucine, isoleucine, and valine\n mAPG13:autophagy,,Defective in autophagy\n mCUP2:Upregulates metallothionein (CUP1) expression in response to\n Cu2+,transcriptional activator,Null mutant is sensitive to \nCu2+\n mKRE2:N-glycosylation,alpha-1,2-mannosyltransferase,have altered N\n-linked glycosylation of proteins and grow slowly at 30 degr\nees; unable to grow at 37 degrees\n mSUR1:Involved in maintenance of phospholipid levels,integral memb\nrane protein , similar to YBR161w, Hoc1p, and Och1p , integr\nal membrane protein , similar to YBR161w, Hoc1p, and Och1p ,\n integral membrane protein , similar to YBR161w, Hoc1p, and \nOch1p,Null mutant is viable, calcium sensitive at 37 degrees\n C on YPD but calcium tolerant at 26 degrees C, accumulates \ngreatly reduced levels of several mannosylated sphingolipids\n; sur1 mutations have been isolated based on their ability t\no suppress certain phenotype of rvs161 mutants including red\nuced viability upon starvation and sensitivies to unrelated \ndrugs; SUR1 is a high copy suppressor of the calcium sensiti\nvity of csg2 mutants\n Cond485:Low-Pi_vs_High-Pi_in_WT_(DBY7286)\n mYPT53:Involved in vacuolar protein sorting and endocytosis,GTP-bin\nding protein , rab family,Null mutant is viable\n mPHM7:Hypothetical ORF,,transcription is regulated by PHO system\n mYOR289W:Unknown ,, Unknown\n mNRG2:homologue of NRG1,NRG1 homolog,Null mutant is viable with no\n detected phenotypes\n mHAL5:Protein kinase homolog, mutant is salt and pH sensitive,,\n mYPL110C:Unknown ,, Unknown\n mRAD26:May be involved in transcription-coupled DNA repair,DNA depe\nndent ATPase , human Cockayne syndrome B gene ERCC6 homolog,\nNull mutant is viable, defective in transcription-coupled re\npair, and hypermutable following exposure to UV light and sh\nows delayed recovered of growth after UV exposure; rad7 rad2\n6 and rad16 rad26 double mutants show enhanced sensitivity t\no UV light\n mYBR139W mYBR280C mPRB1 mCUP2 mTOS5 mHOG1 mRCK2
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Computational Genomics Lab, Tel-Aviv uniresity