Module number 945




Database revision : gnsdb28.10
Date : Tue Feb 25 17:13:52 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n Cond158:sir2\n Cond277:AUR1(tetpromoter)\n Cond698:gal3-gal\n Cond476:GCN4C/GCN4(R4760/R6257)\n Cond221:yer083c\n Cond104:npr2\n mMCH1:Unknown ,, Unknown\n Cond13:ase1(**12)\n mPRO2:gamma-glutamyl phosphate reductase,gamma-glutamyl phosphate \nreductase,Proline requiring and unable to grow on YPD (yeast\n extract-peptone-glucose); synthetic lethality with ctk1\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond730:hda1\n mYPR059C:Unknown ,, Unknown\n Cond244:ymr010w\n Cond445:Msn4_overexpression\n Cond702:gal7-gal\n Cond391:aa_starv_1_h\n mFRM2:Protein involved in the integration of lipid signaling pathw\nays with cellular homeostatis,,Null mutant is viable and sen\nsitive to arachidonic acid\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond245:ymr014w\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond184:ubr1\n Cond123:rad57\n Cond279:ERG11(tetpromoter)\n Cond216:yer044c(haploid)\n Cond86:imp2'(**12)\n Cond479:WT+/-100mM3AT(SetD)(R491)\n mLYS1:saccharopine dehydrogenase,,Lysine requiring\n Cond226:yhl029c\n Cond482:WT+/-100mM3AT(SetC)(KNY164)\n Cond194:yap1\n mLYS4:homoaconitase,homoaconitase,Lysine requiring\n mTRP2:anthranilate synthase Component I,anthranilate synthase comp\nonent I,tryptophan requiring\n mTRP3:anthranilate synthase Component II and indole-3-phosphate (m\nultifunctional enzyme),anthranilate synthase component II , \nindole-3-phosphate,Null mutant is viable, tryptophan auxotro\nph\n mTRP4:anthranilate phosphoribosyl transferase,anthranilate phospho\nribosyl transferase,tryptophan requiring\n Cond145:rts1\n mLYS9:Seventh step in lysine biosynthesis pathway,,lysine auxotrop\nh\n mTRP5:tryptophan synthetase,tryptophan synthetase,Null mutant is v\niable and requires tryptophan\n Cond71:gln3\n Cond481:WT+/-100mM3AT(SetB)(491)\n Cond54:erg3(haploid)\n Cond233:yhr039c\n mILV1:threonine deaminase,threonine deaminase,Isoleucine-plus-vali\nne requiring\n Cond68:gas1\n Cond26:cka2\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond69:gcn4\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond27:ckb2\n Cond731:hda1 \n Cond73:gyp1\n Cond162:spf1\n Cond634:DES460_+_0.02%_MMS_-_15_min\n Cond475:0.5x/1xAA(MildLeu,HisStarvation)(R176)\n mRIB3:Riboflavin biosynthesis,3,4-dihydroxy-2-butanone 4-phosphate\n synthase,\n Cond25:cin5\n mLYS12:homo-isocitrate dehydrogenase, an NAD-linked mitochondrial e\nnzyme required for the fourth step in the biosynthesis of ly\nsine, in which homo-isocitrate is oxidatively decarboxylated\n to alpha-ketoadipate.,homo-isocitrate dehydrogenase,Null mu\ntant is viable but shows decreased growth in the absence of \nlysine\n mLYS14:Transcriptional activator of lysine pathway genes with 2-ami\nnoadipate semialdehyde as co-inducer; saccharopine reductase\n synthesis,,Lysine requiring\n mIDP1:Mitochondrial form of NADP-specific isocitrate dehydrogenase\n,NADP-dependent isocitrate dehydrogenase,Null mutant is viab\nle\n Chromo.chromo:Genomewide studies of histone deacetylase function in yeast.\n Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13.\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n Cond160:sir4\n Cond135:rpl20a\n mYJL200C:Unknown ,, Unknown\n mMTG1:Unknown ,, Unknown\n Cond477:GCN4/gcn4Din100mM3AT(KNY164/KNY124)\n Cond397:Nitrogen_Depletion_2_h\n mHOM2:threonine and methionine pathway,aspartic beta semi-aldehyde\n dehydrogenase,Homoserine requiring\n mARG2:First step in ornithine biosynthesis pathway,acetylglutamate\n synthase,\n mHOM3:First step in common pathway for methionine and threonine bi\nosynthesis,aspartate kinase (L-aspartate 4-P-transferase) (E\nC 2.7.2.4),Homoserine requiring; Borrelidin resistance\n mLYS20:homocitrate synthase, highly homologous to YDL131W,YDL131W (\nLYS21) homolog , homocitrate synthase,Null mutant is viable,\n is able to grow on minimal media, and exhibits reduced but \nsignificant homocitrate synthase activity\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mSTR2:Sulfur TRansfer,cystathionine gamma-synthase,Null mutant is \nviable but unable to turn cysteine into homocysteine. Grows \nwhen supplied with cystathionine.\n Cond130:rml2(**13)\n Cond29:clb2\n Cond89:isw2\n mARG5,6:N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutam\nate kinase,N-acetyl-gamma-glutamyl-phosphate reductase and a\ncetylglutamate kinase,Arginine requiring\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mARO1:pentafunctional arom polypeptide (contains: 3-dehydroquinate\n synthase, 3-dehydroquinate dehydratase (3-dehydroquinase), \nshikimate 5-dehydrogenase, shikimate kinase, and epsp syntha\nse),3-dehydroquinate dehydratase (3-dehydroquinase) , 3-dehy\ndroquinate synthase , epsp synthase , pentafunctional arom p\nolypeptide , shikimate 5-dehydrogenase , shikimate kinase,ar\nomatic amino acid requiring; lack of premeiotic DNA synthesi\ns; blocked sporulation in homozygous mutant\n Cond190:vps8\n mARO2:Chorismate synthase,chorismate synthase,aromatic amino acid \nrequiring; lack of premeiotic DNA synthesis; blocked sporula\ntion in homozygous mutant\n mARO3:DAHP synthase; a.k.a. phospho-2-dehydro-3-deoxyheptonate ald\nolase, phenylalanine-inhibited; phospho-2-keto-3-deoxyhepton\nate aldolase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-\ndeoxy-D-arabine-heptulosonate-7-phosphate synthase,DAHP synt\nhase; a.k.a. phospho-2-dehydro-3-deoxyheptonate aldolase, ph\nenylalanine-inhibited; phospho-2-keto-3-deoxyheptonate aldol\nase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-deoxy-D-a\nrabine-heptulosonate-7-phosphate synthase,null mutant is via\nble\n mARO4:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase \nisoenzyme,3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP)\n synthase isoenzyme,null mutant is viable\n Cond90:jnm1\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond53:erg2\n mAAT2:aspartate aminotransferase, cytosolic,aspartate aminotransfe\nrase,\n mTHR4:threonine synthase,threonine synthase,threonine requiring\n Cond6:anp1\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond298:Terbinafine\n Cond78:hir2\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond201:yel008w\n mNIT1:nitrilase,nitrilase,\n Cond229:yhr011w(**14)\n mSER1:phosphoserine transaminase,phosphoserine transaminase,Null m\nutant is viable, serine-requiring\n mECM40:ExtraCellular Mutant,acetylornithine acetyltransferase,A Tn3\n insertion into this gene causes hypersensitivity to the cel\nl surface polymer perturbing agent calcofluor white.\n Cond176:swi5\n mSER3:catalyzes the first step in serine biosynthesis; isozyme of \nSER33,3-phosphoglycerate dehydrogenase,enzyme activity of 3P\n-glycerate dehydrogenase is decreased in null mutant compare\nd to wildtype and abolished in ser3 ser33 double deletion mu\ntant\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mMET13:putative methylenetetrahydrofolate reductase (mthfr),methyle\nnetetrahydrofolate reductase (mthfr) (putative),Null mutant \nis viable and shows methionine auxotrophy; double disruption\n of MET12 and MET13 (the two putative mthfr genes) also conf\ners methionine auxotrophy, but has no other known phenotype \nat this time.\n Cond287:2-deoxy-D-glucose\n mMET17:O-Acetylhomoserine-O-Acetylserine Sulfhydralase,O-acetylhomo\nserine (thiol)-lyase,Null mutant is viable, methionine auxot\nroph, becomes darkly pigmented in the presence of Pb2+ ions;\n resistant to methylmercury and exhibits increased levels of\n H2S\n Cond128:rgt1\n Cond478:WT+/-10mM3AT(R491)\n Cond144:rtg1\n Cond43:dot4\n mYIL165C:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond171:ste24(haploid)\n Cond175:swi4\n mADE3:Required for the biosynthesis of purines, thymidylate, methi\nonine, histidine, pantothenic acid and formylmethionyl-tRNA,\nC1-tetrahydrofolate synthase,Null mutant is viable, adenine \nauxotroph, histidine auxotroph\n mYJR111C:Unknown ,, Unknown\n Cond250:ymr031w-a\n mPDX3:pyridoxine (pyridoxiamine) phosphate oxidase,pyridoxine (pyr\nidoxiamine) phosphate oxidase,\n mSER33:catalyzes the first step in serine biosynthesis; isozyme of \nSER3,3-phosphoglycerate dehydrogenase,enzyme activity of 3P-\nglycerate dehydrogenase is decreased in null mutant compared\n to wildtype and abolished in ser3 ser33 double deletion mut\nant\n Cond153:sgs1\n mADE8:glycinamide ribotide transformylase,glycinamide ribotide tra\nnsformylase,Adenine requiring\n Cond398:Nitrogen_Depletion_4_h\n mMET22:Putative phosphatase gene involved in salt tolerance and met\nhionine biogenesis; halotolerance,3'(2')5'-bisphosphate nucl\neotidase,Methionine requiring; lacks 3'-phosphoadenylylsulfa\nte (PAPS) reductase activity; unable to grow on sulfate as s\nole sulfur source\n mPHO89:Probable Na+/Pi symporter,Na+/Pi symporter (putative),Null m\nutant is viable\n Cond294:Itraconazole\n Cond159:sir3\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond295:Lovastatin\n Cond299:Tunicamycin\n mADE12:adenylosuccinate synthetase,adenylosuccinate synthetase,Aden\nine requiring\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond938:2h\n Cond392:aa_starv_2_h\n mORT1:Mitochondrial integral membrane protein, ornithine transport\ner,,Null mutant is viable, arginine bradytroph\n mSER3 mSER33 mTRP2 mTRP3
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Computational Genomics Lab, Tel-Aviv uniresity