Module number 927




Database revision : gnsdb28.10
Date : Tue Feb 25 17:11:55 2003
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PEX.Pex:Transcriptome profiling to identify genes involved in peroxi\nsome assembly and function. J Cell Biol. 2002 Jul 22;158(2)\n:259-71.\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mARG1:arginosuccinate synthetase,arginosuccinate synthetase,Argini\nne requiring\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mSSU1:sensitive to sulfite,major facilitator superfamily,Null muta\nnt is viable; sulfite sensitive\n Cond654:wt_plus_gamma_45_min\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mYNL200C:Unknown ,, Unknown\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n Cond657:wt_plus_gamma_120_min\n mYBR070C:Unknown ,, Unknown\n mRFA1:Required for DNA-damage repair, full levels of gene conversi\non and sporulation,heterotrimeric RPA (RF-A) single-stranded\n DNA binding protein 69 kDa subunit; binds URS1 and CAR1,Nul\nl mutant is inviable; cells lacking RFA1 accumulate as multi\nply budded cells with a single nucleus suggesting a defect i\nn DNA replication; rfa1 repair defects are suppressed by hig\nh copy RAD52\n mRFA2:Involved in nucleotide excision repair,29% identical to the \nhuman p34 subunit of RF-A , replication factor RF-A subunit \n2,Null mutant is inviable; arrests as budded and multiply bu\ndded cells; rfa2 (ts) cells have a mutator and a hyper-recom\nbination phenotype and are more sensitive to hydroxyurea and\n methyl-methane-sulfonate than wild-type cells\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond656:wt_plus_gamma_90_min\n Cond733: Cond651:wt_plus_gamma_10_min\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond231:yhr031c\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond568:alpha119\n Cond635:DES460_+_0.02%_MMS_-_30_min\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond553:alpha14\n Cond340:constant_0.32_mM_H2O2_(60_min)_redo\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mYNL335W:Unknown ,, Unknown\n mSMF3:Putative metal transporter, Nramp homolog, homolog of SMF1 a\nnd SMF2,Nramp homolog , SMF1 and SMF2 homolog , metal transp\norter (putative),Viable\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mDIN7:DNA-damage inducible gene,,\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond293:HU\n Cond877:MMS\n mYNL274C:Unknown ,, Unknown\n mGLK1:Glucose phosphorylation,glucokinase,Null mutant is viable wi\nth no discernible difference from wild-type; hxk1, hxk2, glk\n1 triple null mutants are unable to grow on any sugar except\n galactose and fail to sporulate\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n Cond838:expt1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond746: Cond653:wt_plus_gamma_30_min\n Cond98:mbp1\n Cond554:alpha21\n mRAD51:Involved in processing ds breaks, synaptonemal complex forma\ntion, meiotic gene conversion and reciprocal recombination.,\nRad51p colocalizes to ~ 65 spots with Dmc1p prior to synapsi\ns (independently of ZIP1 and DMC1), and interacts with Rad52\np and Rad55p; human Rad51p homolog interacts with Brca2 prot\nein which has been implicated in causing breast cancer , Rec\nA homolog,Null mutant is viable; accumulates meiosis-specifi\nc double strand breaks at a recombination hotspot and reduce\ns the formation of physical recombinants and processed doubl\ne strand breaks with long heterogeneous tails; rad51 mutants\n are also defective for X-ray damage repair and gene convers\nions; rad51 rad27 mutants are inviable.\n mPOL30:Accessory factor for DNA polymerase delta, mRNA increases in\n G1, peaks in S in mitosis, & increases prior to DNA synthes\nis in meiosis; required for DNA replication & repair, requir\ned for viability in cdc44, rad50, rad52 or rad57 backgrounds\n,,Null mutant is inviable\n Cond876:zero2\n Cond634:DES460_+_0.02%_MMS_-_15_min\n mYFL061W:Unknown ,, Unknown\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n mDUN1:DNA damage response,protein kinase,Null mutant is viable, de\nfective in DNA damage repair and in DNA damage-resposive ind\nuction of RNR genes, and sensitive to DNA damaging agents\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond737: mMRP8:mitochondrial ribosomal protein,ribosomal protein,\n mYEL047C:Unknown ,, Unknown\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n Cond636:DES460_+_0.2%_MMS_-_45_min\n mRNR1:ribonucleotide reductase,ribonucleotide reductase, large (R1\n) subunit,Null mutant is inviable\n Cond639:DES460_+_0.02%_MMS_-_120_min\n mRNR2:small subunit of ribonucleotide reductase,ribonucleotide red\nuctase subunit , ribonucleotide reductase, small (R2) subuni\nt,Null mutant is inviable\n mRNR4:ribonucleotide reductase, small subunit (alt),ribonucleotide\n reductase, small (R2) subunit,Null mutant is inviable in th\ne W303 strain background, but viable and sick in another (Wa\nng et al.[1997] Mol. Cell Biol.17:6114-6121). An rnr4 mutan\nt is resistant to 40 ug/ml benomyl, supersensitive to hydrox\nyurea (HU)[dead at 0.005M HU], and cold sensitive [cells arr\nest at 14 deg. C. with a large bud and short mitotic spindle\n].\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n mPLM2:Plasmid Maintenance,,Null mutant is viable and shows 2mu-m p\nlasmid instability\n Cond652:wt_plus_gamma_20_min\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n mRFA1 mRPT2 mRFA2 mRNR4 mRNR2
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Computational Genomics Lab, Tel-Aviv uniresity