Module number 923




Database revision : gnsdb28.10
Date : Tue Feb 25 17:11:33 2003
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Cond217:yer050c\n Cond292:Glucosamine\n Cond464:37_deg_growth_ct-1\n Cond3:aep2\n mMRPS18:Unknown ,, Unknown\n mFIL1:Putative mitochondrial ribosome recycling factor,mitochondri\nal ribosome recycling factor (putative),Null mutant is viabl\ne but grows slowly; growth is further impaired by addition o\nf diepoxybutane or mitomycin C to medium. Null mutant also e\nxhibits decreased abundance of mitochondrial proteins.\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond711:t2+Vec\n Cond130:rml2(**13)\n mQRI5:Product of gene unknown,,\n mMRPL32:Mitochondrial ribosomal protein MRPL32 (YmL32),ribosomal pro\ntein (YmL32),\n mMRPL33:essential for mitochondrial function,ribosomal protein (YmL3\n3) (E. coli L30),Null mutant is viable\n mYOR286W:Unknown ,, Unknown\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n mMRPL35:Mitochondrial ribosomal protein MRPL35 (YmL35),ribosomal pro\ntein (YmL35),\n mSCO2:Originally identified as a multicopy suppressor of a respira\ntory defective mutant; homolog of Sco1p,,\n mMRPL36:Mitochondrial ribosomal protein MRPL36 (YmL36),ribosomal pro\ntein (YmL36),\n mYDR115W:Unknown ,, Unknown\n mATP20:Protein associated with mitochondrial ATP Synthase; essentia\nl for dimeric state of ATP synthase,ATP synthase subunit g h\nomolog,Null mutant is viable but exhibits a reduced growth r\nate on respiratory substrates\n mMRPL37:Probable mitochondrial protein L37,ribosomal protein L37 (pu\ntative),\n mMRPL38:mitochondrial ribosomal protein L14,ribosomal protein L14,\n mXPT1:Xanthine Phosphoribosyl Transferase,xanthine phosphoribosyl \ntransferase,Cannot utilize xanthine as a source of GMP\n mCAF17:CCR4 associated factor,CCR4 transcriptional complex componen\nt,Null mutant is viable, shows petite phenotype\n Y-Stre.msn2/4acid:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTUF1:Translation elongation factor Tu, mitochondrial,translation \nelongation factor Tu, mitochondrial,Null mutant is viable, b\nlocks mitochondrial translation and destabilizes mitochondri\nal genome.\n mRSM10:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,\n mYMR158W:Unknown ,, Unknown\n mPET117:Required for assembly of active cytochrome c oxidase,,petite\n; unable to grow on non-fermentable carbon sources\n mYDR116C:Unknown ,, Unknown\n Cond719:t4-SSD1\n Cond943:SK1_YPA\n Cond724:t4+SSD1,H44\n Cond713:t4+Vec\n mMRPS28:Mitochondrial ribosomal protein MRPS28 (E. coli S15),ribosom\nal protein (E. coli S15),Null mutant is viable, unable to re\nspire, spontaneously loses portions of its mitochondrial gen\nomes at a high frequencY\n mPET191:Required for assembly of active cytochrome c oxidase,,petite\n; unable to grow on non-fermentable carbon sources\n mYML050W:Unknown ,, Unknown\n mMRP13:35 kDa mitochondrial ribosomal small subunit protein,35 kDa \nmitochondrial ribosomal small subunit protein,Null mutant is\n viable, no impairment in ribosome synthesis or function\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mACN9:Hypothetical ORF,,\n mMRPL40:Mitochondrial ribosomal protein MRPL40 (YmL40),ribosomal pro\ntein (YmL40),\n mMRP51:Mitochondrial Ribosomal Protein,mitochondrial ribosome small\n subunit component,Null mutant is viable, exhibits completel\ny blocked mitochondrial gene expression; missense mutations \nsuppress 5'-UTL mutations in at least 2 mitochondrial mRNAs\n Cond718:t4+SSD1wt\n mMRPS5:Probable mitochondrial ribosomal protein S5,ribosomal protei\nn S5 (putative),\n Cond937:t=0\n mMRPL44:Mitochondrial ribosomal protein MRPL44 (YmL44),ribosomal pro\ntein (YmL44),\n mYDR493W:Unknown ,, Unknown\n mYGR165W:Unknown ,, Unknown\n mMRPS9:Probable mitochondrial ribosomal protein S9,ribosomal protei\nn S9 (putative),Null mutant is viable, respiration deficient\n, exhibits defects in mitochondrial protein synthesis as ind\nicated by a loss of cytochrome c oxidase activity\n Cond701:gal6-gal\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYGL068W:Unknown ,, Unknown\n mMRPL49:mitochondrial ribosomal protein of the large subunit,ribosom\nal protein large subunit,\n Cond683:MHY1_(crt1)_vs._CRY1_(wild_type)_-_log_phase\n Cond672:DES459_(mec1)_-_mock_irradiation_-_60_min\n Cond709:t0+Vec\n Cond689:gal3+gal\n Cond902:(77i1)_HBY4_YPGL_NormInt\n mYDR316W:Unknown ,, Unknown\n mPET123:May be component of mitochondrial translation appartus and m\nay interact with small subunit of mitochondrial ribosomes or\n with Pet122p to promote translational initiation of cytochr\nome c oxidase subunit III mRNA,mitochondrial ribosomal prote\nin of small subunit,Null mutant is viable but is rho- (with \nlarge deletions in mtDNA); pet123 mutations can suppress pet\n122 mutations; some pet123 alleles show synthetic phenotypes\n with mrp1 mutations\n Cond693:gal7+gal\n Cond287:2-deoxy-D-glucose\n mCOX11:Mitochondrial membrane protein required for insertion of Cu(\nB) and magnesium during assembly of cytochrome c oxidase,,de\nficient in cytochrome oxidase\n mRSM25:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,Null mutant is viable, but\n unable to respire.\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mMRPL6:Mitochondrial ribosomal protein MRPL6 (YmL6),ribosomal prote\nin (YmL6),\n mRSM27:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,\n mYFR045W:Unknown ,, Unknown\n Cond717:t2-SSD1\n mMRPL7:Mitochondrial ribosomal protein MRPL7 (YmL7),ribosomal prote\nin (YmL7),\n mRSM28:Unknown ,, Unknown\n mCOX17:Involved in copper metabolism and assembly of cytochrome oxi\ndase,cysteine-rich protein,Null mutant is viable, respirato\nry defective, rescued by addition of copper to growth media \nand/or high copy expression of SCO1 and SCO2 genes\n mYER182W:Unknown ,, Unknown\n mMRP21:Mitochondrial Ribosomal Protein,mitochondrial ribosome small\n subunit component,Null mutant is viable, exhibits completel\ny blocked mitochondrial gene expression; missense mutations \nsuppress 5'-UTL mutations in at least 2 mitochondrial mRNAs\n mYKL137W:Unknown ,, Unknown\n Cond716:t2+SSD1wt\n mMRPL11:Mitochondrial ribosomal protein MRPL11 (YmL11),ribosomal pro\ntein (YmL11),Null mutant is viable, respiratory deficient ac\ncompanied by a loss of mitochondrial DNA\n mYHR116W:Unknown ,, Unknown\n Cond708:t0+SSD1\n mYPR100W:Unknown ,, Unknown\n mMHR1:Involved in mitochondrial homologous DNA recombination,,Temp\nerature sensitive in the maintenance of mitochondrial DNA\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mMRPL16:Mitochondrial ribosomal protein MRPL16,ribosomal protein,\n mYMR090W:Unknown ,, Unknown\n mMSE1:Mitochondrial glutamyl-tRNA synthetase,glutamine-tRNA ligase\n,An uncharacterized allele is respiratory deficient.\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mYKL195W:Unknown ,, Unknown\n Cond945:W303_YPD\n Cond779:msn2/4_acid_20'\n Cond413:YPD_4_h_ypd-2\n Cond712:t4+SSD1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYOL053W:Unknown ,, Unknown\n mYGR021W:Unknown ,, Unknown\n mMCR1:NADH-cytochrome b5 reductase,NADH-cytochrome b5 reductase,\n Cond691:gal5+gal\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond682:MHY1_(crt1)_vs_CRY1_(wild_type)\n mYML030W:Unknown ,, Unknown\n mYNL100W:Unknown ,, Unknown\n Cond282:IDI1(tetpromoter)\n mMRP1:shows allele-specific genetic interactions with pet122 and p\net123,37 kDa mitochondrial ribosomal protein,defective mitoc\nhondrial protein synthesis; absence of a and b type cytochro\nmes; reduced levels of mitochondrial 15 S rRNA; defective pr\nocessing of apocytochrome b intron; convert to rho- and rho0\n at high frequency\n mMRP2:14 kDa mitochondrial ribosomal protein; homologous to E. col\ni S14 protein,14 kDa mitochondrial ribosomal protein , simil\nar to E. coli S14 protein,defective mitochondrial protein sy\nnthesis; absence of a and b type cytochromes; reduced levels\n of mitochondrial 15 S rRNA; defective processing of apocyto\nchrome b intron; convert to rho- and rho0 at high frequency\n Cond103:msu1\n Cond265:ymr293c\n mEMI5:Unknown ,, Unknown\n mMRPL23:mitochondrial ribosomal protein of the large subunit,ribosom\nal protein large subunit,\n mMRPL24:Mitochondrial ribosomal protein MRPL24 (YmL24),ribosomal pro\ntein (YmL24),\n mMRPL25:Mitochondrial ribosomal protein MRPL25 (YmL25),ribosomal pro\ntein (YmL25),Null mutant is viable, cells become Pet-\n mPPA2:mitochondrial inorganic pyrophosphatase,inorganic pyrophosph\natase,Null mutant is viable but is unable to grow on respira\ntory carbon sources and lacks mitochondrial DNA\n Cond903:(77i2)_S150-2B_YPGL_NormInt\n mMRPL27:essential for mitochondrial function,ribosomal protein (YmL2\n7),Null mutant is viable, fails to grow on nonfermentable ca\nrbon sources\n mYDC1:Yeast dihydro-ceramidase,alkaline dihydroceramidase with min\nor reverse activity,Null mutant is viable.\n mATP11:essential for assembly of a functional F1-ATPase; binds the \nbeta subunit of F1-ATPase.,,greatly reduced ATPase activity;\n alpha and beta subunits of F1-ATPase accumulate in mitochon\ndria as inactive aggregates\n mMRPL28:Mitochondrial ribosomal protein MRPL28 (YmL28),ribosomal pro\ntein (YmL28),\n mATP12:essential for assembly of a functional F1-ATPase; binds the \nalpha subunit of F1-ATPase.,,greatly reduced ATPase activity\n; alpha and beta subunits of F1-ATPase accumulate in mitocho\nndria as inactive aggregates\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPET100:cytochrome c oxidase-specific assembly factor,cytochrome c o\nxidase-specific assembly factor,Respiration deficient\n Cond710:t2+SSD1\n mYFR007W:Unknown ,, Unknown\n mMSY1:Tyrosyl-tRNA synthetase,tyrosine-tRNA ligase,\n
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Computational Genomics Lab, Tel-Aviv uniresity