Module number 904




Database revision : gnsdb28.10
Date : Tue Feb 25 17:07:06 2003
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mADY2:Accumulation of DYads,,Null mutant is viable; forms predomin\nantly asci containing 2 spores (dyads) whensporulated; requi\nred for long-term growth on YPD at 37 degrees C.\n mARE2:Acyl-CoA cholesterol acyltransferase (sterol-ester synthetas\ne),acyl-CoA cholesterol acyltransferase (sterol-ester synthe\ntase),Null mutant is viable; greatly reduces in vivo and in \nvitro ergosterol esterification (to 15 - 35 % of wild-type).\n Deletion of both ARE1 and ARE2 completely eliminates in viv\no and in vitro ergosterol esterification\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond936:12h\n mCRR1:CRH-Related,,\n Cond871:yhe710-ss\n Cond451:raffinose_vs._reference_pool_car-1\n mFLO10:Protein with similarity to flocculation protein Flo1p,,\n mHFM1:C4 zinc finger DNA-binding protein of low sequence specifici\nty in vitro; Probable 119 kD DNA/RNA helicase family member,\nC4 zinc finger DNA-binding protein of low sequence specifici\nty in vitro; Probable 119 kDa DNA/RNA helicase family member\n,Null mutant is viable\n Cond88:isw1,isw2\n mAMA1:Required for sporulation, highly induced during sporulation;\n activator of meiotic anaphase promoting complex,,Null mutan\nt is viable; homozygous null mutant does not sporulate but d\noes not exhibit any vegetative phenotype.\n mUGA4:GABA-specific transport protein,GABA-specific transport prot\nein,Null mutant is viable.\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond183:ubp8\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPAU4:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n Cond422:YPD_stationary_phase_2_h_ypd-1\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n mYGL081W:Unknown ,, Unknown\n Cond963:t11.5_g/r_ratio\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n mYER085C:Unknown ,, Unknown\n mCLB5:role in DNA replication during S phase; additional functiona\nl role in formation of mitotic spindles along with Clb3 and \nClb4,B-type cyclin,Null mutant is viable, but has an extende\nd S phase\n mCDA1:Required for proper formation of the ascospore wall,chitin d\neacetylase,Null mutant is viable, mutants spores disrupted f\nor both cda1 and cda2 fail to emit natural fluorescence and \nare sensitive to hydrolyrtic enzymes, ether, and heat shock\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mDMC1:Disp. for double strand breaks, synaptonemal complexes & gen\ne conversion in return to growth assay. Required for full pa\niring by in situ hybrid. assay, wt time of appearance of syn\naptonemal complexes & reciprocal Rec in growth assay,meiosis\n-specific protein related to RecA and Rad51p. Dmc1p colocali\nzes with Rad51p to discrete subnuclear sites in nuclear spre\nads during mid prophase, briefly colocalizes with Zip1p, and\n then disappears by pachytene,Null mutant is viable. dmc1 ac\ncumulates synaptonemal complex-related dense body, has proce\nssed double strand breaks with longer 3' ends, and either de\nlays prophase or arrests in prophase at the mononucleate sta\nge with duplicated spindle pole bodies and no spindles (depe\nndent upon MEC1-, RAD17-, RAD24, and independent of RAD9). s\npo13 partially suppresses dmc1 meiotic lethality. spo11 and \nrad50 are epistatic to dmc1, suggesting a mid/late recombina\ntion function. mRNA is induced early in meiosis\n Cond319:37C_to_25C_shock_-_90_min\n mFRE7:similar to FRE2,,\n Cond14:ate1\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRIM4:Regulator of IMe2 expression,RNA-binding protein of the RRM \nclass (putative),Null mutant is viable. Homozygous null dipl\noid fails to sporulate, does not form meiosis I or II spindl\nes, and exhibits reduced expression of early and middle spor\nulation-specific genes. Null mutant is suppressed by hyperac\ntive Ime2p derivative, but not by overexpression IME1\n mYJL037W:Unknown ,, Unknown\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYOL162W:Unknown ,, Unknown\n mSPO16:Early meiotic protein required for efficient spore formation\n,,sporulation defective\n Cond959:t2_g/r_ratio\n mSSP1:Involved in the control of meiotic nuclear divisions & spore\n formation; dispensable for mitosis, premeiotic DNA synthesi\ns, recombination, meiosis I, meiosis II, & initiation of pro\nspore walls; required for spore wall elongation,,Null mutant\n is viable; spo3-1 at a semi-permissive temperature produces\n asci with one or two randomly packaged haploid spores; at a\n restrictive temperature, prospore walls grow and close prio\nr to the completion of meiosis II, resulting in immature ane\nuploid and/or anucleate spores. Multinucleate cells completi\nng meiosis II, but blocked in spore development, bud and res\nume division in return to growth assay.\n Cond940:6h\n Cond228:yhl045w\n Cond:\n mFRM2:Protein involved in the integration of lipid signaling pathw\nays with cellular homeostatis,,Null mutant is viable and sen\nsitive to arachidonic acid\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond965:ndt80_delete_mid_g/r_ratio_\n mHOP1:Meiosis-specific protein involved in homologous chromosome s\nynapsis and chiasmata formation,DNA binding protein,decrease\nd levels of meiotic crossing over and intragenic recombinati\non between markers on homologous chromosomes\n mYJL038C:Unknown ,, Unknown\n Cond948:W303_ume6_YPA_\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond934:8h\n Cond960:t5_g/r_ratio\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n mMEK1:Disp. for chr. pairing & chr. condensation seen by in situ h\nybrid. Required for full double strand breaks, normal length\n synaptonemal complexes, meiotic recomb. & spore viability. \nmek1 is rescued by spo13 & in early recomb. function,meiosis\n-specific serine/threonine protein kinase,Null mutant is via\nble, however diploids homozygous for a mek1 null mutation pr\noduce only low percentages of viable spores, reduced spore v\niability is rescued by spo13 mutations\n Cond35:cup5\n Cond938:2h\n Cond961:t7_g/r_ratio\n Cond964:ndt80_delete_early_g/r_ratio\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond935:10h\n Cond449:glucose_vs._reference_pool_car-1\n Cond962:t9_g/r_ratio\n mYFL040W:Unknown ,, Unknown\n mECM23:ExtraCellular Mutant; similar to SRD1,,A Tn3 insertion into \nthis gene causes hypersensitivity to the cell surface polyme\nr perturbing agent calcofluor white.\n
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Computational Genomics Lab, Tel-Aviv uniresity