Module number 903




Database revision : gnsdb28.10
Date : Tue Feb 25 17:07:03 2003
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mPCM1:Phosphoacetylglucosamine Mutase,phosphoacetylglucosamine mut\nase,Null mutant is inviable; a Ty insertion mutant exhibits \nslow growth.\n mYMR316C-A:Unknown ,, Unknown\n mVTH1:vps ten homolog,potential membrane glycoprotein (putative) ,\n strong similarity to Vth2 and Pep1/Vps10,Null mutant is via\nble; overexpression partially suppresses the sorting defect \nof a pep1 null mutant.\n mVTH2:vps ten homolog,potential membrane glycoprotein , strong sim\nilarity to Vth1 and Pep1,Null mutant is viable; overexpressi\non of the nearly identical Vth1 partially suppresses the sor\nting defect of a pep1 null mutant strain.\n mYKL162C-A:Unknown ,, Unknown\n Cond221:yer083c\n mTFS1:(putative) lipid binding protein; supressor of a cdc25 mutat\nion,lipid binding protein (putative) , supressor of a cdc25 \nmutation,Null mutant is viable.\n mDIA1:may be involved in invasive growth, pseudohyphal growth,,Nul\nl mutant is viable and causes invasive growth in haploids an\nd pseudohyphal growth in diploids\n mYMR107W:Unknown ,, Unknown\n mYNL058C:Unknown ,, Unknown\n mSTR3:Sulfur TRansfer,cystathionine beta-lyase,Null mutant is viab\nle but unable to turn cysteine into homocysteine. No growth \nwhen supplied with cystathionine.\n mYJL171C:Unknown ,, Unknown\n mMCH5:Unknown ,, Unknown\n Cond121:qcr2(haploid)\n Cond362:dtt_000_min__dtt-2\n mYKL161C:Unknown ,, Unknown\n Cond363:dtt_015_min_dtt-2\n mYPL088W:Unknown ,, Unknown\n Cond513:GAL-STE11-4,3hrs.gallog10(intensity)\n mYHR209W:Unknown ,, Unknown\n Cond224:CMD1(tetpromoter)\n mRIM21:Unknown ,, Unknown\n Cond504:wtħ50nMaF,90minlog10(intensity)\n Cond280:FKS1(tetpromoter)\n Stress.HypoOsmot:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYET1:Yeast BAP31 homolog,yeast endoplasmic reticulum 25 kDa trans\nmembrane protein,Null mutant is viable\n Cond15:bim1(**15)\n mYPL052W:Unknown ,, Unknown\n mPST1:Protoplasts-secreted,the gene product has been detected amon\ng the proteins secreted by regenerating protoplasts,Viable\n Cond364:dtt_030_min__dtt-2\n mYBR005W:Unknown ,, Unknown\n mSUL1:Putative sulfate permease,,Null mutant is viable, unable to \ngrow on media containing less than 5 mM sulphate\n Cond384:Hypo-osmotic_shock_-_5_min\n Cond505:wtħ50nMaF,120minlog10(intensity)\n Cond53:erg2\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYJL107C:Unknown ,, Unknown\n mYLR194C:Unknown ,, Unknown\n mNCE103:involved in secretion of proteins that lack classical secret\nory signal sequences,,An uncharacterized allele exhibits def\nects in the export of the mammalian protein galectin-1.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mGFA1:catalyzes first step in hexosamine pathway required for bios\nynthesis of cell wall precursors,glucoseamine-6-phosphate sy\nnthase , glutamine_fructose-6-phosphate amidotransferase,Nul\nl mutant is viable, glucosamine auxotroph\n mAMS1:vacuolar alpha mannosidase,alpha mannosidase,null mutant is \nviable\n Cond530:GAL-BNI1D,3hrs.gallog10(intensity)\n Cond531:GAL-PKC1-R398A,3hrs.gallog10(intensity)\n mCRH1:congo red hypersensitive,cell wall protein,Null mutant is vi\nable and hypersensitive to Congo Red and Calcofluor White\n Cond532:GAL-RHO1-Q68H,3hrs.gallog10(intensity)\n mDFG5:Protein required for filamentous growth, cell polarity, and \ncellular elongation,,Null mutant is viable and defective in \nfilamentous growth\n mYMR315W:Unknown ,, Unknown\n Cond6:anp1\n mSRY1:Serine Racemase homolog in Yeast,pyridoxal-5'phosphate-depen\ndent enzyme , similar to mouse glial serine racemase,Null mu\ntant is viable\n Cond155:she4\n Cond279:ERG11(tetpromoter)\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYSN1:Unknown ,, Unknown\n mSLT2:Suppressor of lyt2,,Null mutant is viable but temperature se\nnsitive. At elevated temperatures or in the presence of caff\neine, mull mutants exhibit cell wall defects that result in \ncell lysis. Lysis is prevented by addition of 1M sorbitol.\n mYPS1:Gpi-anchored aspartic protease (Yapsin 1),GPI-anchored aspar\ntic protease,Null mutant is viable, defective in expression \nof somatostatin-28; yps1 mkc7 double disruptants are tempera\nture sensitive; yps1 mkc7 kex2 mutants are profoundly temper\nature sensitive and are cold sensitive\n mYNL208W:Unknown ,, Unknown\n mYIL023C:Unknown ,, Unknown\n Cond61:fks1(haploid)\n mYPS3:Gpi-anchored aspartic protease (Yapsin 3),GPI-anchored aspar\ntic protease,Null mutant is viable\n mYPR078C:Unknown ,, Unknown\n mYPS5:Gpi-anchored aspartic protease (Yapsin 5),GPI-anchored aspar\ntic protease,\n Cond216:yer044c(haploid)\n mYPS6:Gpi-anchored aspartic protease (Yapsin 6),GPI-anchored aspar\ntic protease,\n mMET10:subunit of assimilatory sulfite reductase,assimilatory sulfi\nte reductase subunit,Null mutant is viable, and is a methion\nine auxotroph\n mYJL161W:Unknown ,, Unknown\n Cond287:2-deoxy-D-glucose\n mMET16:3'phosphoadenylylsulfate reductase,3'phosphoadenylylsulfate \nreductase,Null mutant is viable, and is a methionine auxotro\nph\n Cond367:dtt_240_min_dtt-2\n mSTP2:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n mYAL053W:Unknown ,, Unknown\n mCHS1:disrupts mating and sporulation efficiently,chitin synthase \n1,Null mutant is viable\n mSNZ1:Snooze: stationary phase-induced gene family; may be involve\nd in cellular response to nutrient limitation and growth arr\nest,highly conserved 35 kDa protein that shows increased exp\nression after entry into stationary phase,Null mutant is via\nble, sensitive to 6-azauracil and methylene blue.\n Cond278:CDC42(tetpromoter)\n Cond197:yar014c\n mPRM10:pheromone-regulated membrane protein,,\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mYKR046C:Unknown ,, Unknown\n mYGR043C:Unknown ,, Unknown\n Cond818:crz1/Na30'\n mPRM5:pheromone-regulated membrane protein,,\n mBOP1:bypass of PAM1,,\n mSNO1:SNZ1 proximal ORF, stationary phase induced gene,,Null mutan\nt is viable, sensitive to 6-azauracil and methylene blue.\n mPDE1:3',5'-Cyclic-nucleotide phosphodiesterase, low affinity,3',5\n'-cyclic-nucleotide phosphodiesterase, low affinity,Null mut\nant is viable\n Cond68:gas1\n mBOP2:bypass of PAM1,,\n Cond512:GAL-STE5-CTM,3hrs.gallog10(intensity)\n mGPG1:Unknown ,, Unknown\n mAFR1:coordinates regulation of alpha-factor receptor signalling a\nnd induction of morphogenesis during conjugation,cytoskeleta\nl protein , similar to arrestins,defect in alpha-factor-stim\nulated morphogenesis\n mPRB1:dispensable for haploidization and sporulation, but needed f\nor full protein degradation during sporulation, and proper s\npore morphology,vacuolar protease B,Null mutant is viable, p\nrotease B deficient, has smaller spores than wild-type embed\nded in a thick matrix\n mYLR414C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond819:crz1/Na45'_\n mUBP5:Putative Ubiquitin-specific protease,ubiquitin-specific prot\nease (putative),Null mutant is viable\n mKRE11:Involved in biosynthetic pathway for cell wall beta-glucans,\n,Null mutant is viable; killer toxin resistant; reduced leve\nls of 1,6-beta-glucan in cell wall\n mSED1:putative cell surface glycoprotein,cell surface glycoprotein\n (putative),Null mutant is viable; during stationary phase, \nnull mutants exhibit increased sensitivity to Zymolyase.\n Cond691:gal5+gal\n Calcin.crz1Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mYKL102C:Unknown ,, Unknown\n mPHO89:Probable Na+/Pi symporter,Na+/Pi symporter (putative),Null m\nutant is viable\n Cond283:KAR2(tetpromoter)\n mNTH1:hydrolyzes trehalose; may be inolved in growth transition fr\nom glucose to glycerol; shows significant sequence similarit\ny to Nth2p,neutral trehalase,Null mutant is viable\n mYDR070C:Unknown ,, Unknown\n Cond294:Itraconazole\n mYCL049C:Unknown ,, Unknown\n mPCA1:Putative P-type Cu(2+)-transporting ATPase,P-type ATPase Cu(\n2+)-transporting (putative),Null mutant is viable but ceases\n growth earlier when grown in minimal medium with high coppe\nr concentration; overexpression of PCA1 causes poor growth; \nmulticopy PCA1 results in slower growth on synthetic medium \nwith 0.3 mM CuSO4\n Cond129:rip1\n Cond107:ost3\n mKTR2:May be involved in extracellular matrix assembly; involved i\nn N-linked glycosylation of cell wall mannoproteins,mannosyl\ntransferase (putative) , type 2 membrane protein,Null mutant\n is viable, with partial resistance to killer toxin\n mAUT7:Forms a protein complex with Aut2p to mediate attachment of \nautophagosomes to microtubules. Defective in maturation of t\nhe vacuolar protein, aminopeptidase I,similar to LC3, a micr\notubule-associated protein from rat,Null mutant is viable bu\nt lacks autophagocytosis and is unable to sporulate. AUT7 is\n a suppressor of mutant phenotypes of aut2-1 cells. Uptake o\nf precursor Aminopeptidase I into the vacuole depends on Aut\n2p and Aut7p.\n mMSB3:Multicopy Suppressor of Bud Emergence,GTPase activating prot\nein (GAP) for Ypt6,Null mutant is viable. msb3/msb4 double \nmutant exhibits slow growth and disorganized actin cytoskele\nton\n Cond299:Tunicamycin\n mSVS1:involved in vanadate resistance,,Null mutant is viable, show\ns increased sensitivity to vanadate, but not other metallic \nions or drugs\n Cond511:GAL-STE4,3hrs.gallog10(intensity)\n mYCR099C:Unknown ,, Unknown\n mYIL108W:Unknown ,, Unknown\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYMR294W-A:Unknown ,, Unknown\n mGSC2:Highly similar to FKS1 (GSC1). GSC2 and FKS1 encode redundan\nt catalytic components of 1,3-beta-glucan synthase. Deletion\n of both is lethal,1,3-beta-D-glucan synthase catalytic comp\nonent,Null mutant is viable and shows partially reduced 1,3-\nbeta-glucan synthase activity\n mSRL3:Suppressor of rad53 lethality,,\n mYLL012W:Unknown ,, Unknown\n mPTP2:protein tyrosine phosphatase,tyrosine phosphatase,Null mutan\nt is viable, grows slowly, is hypersensitive to heat; ptp2 p\ntc1 mutants exhibit synthetic lethality\n mCPA2:carbamyl phosphate synthetase,carbamyl phosphate synthetase,\nNull mutant is viable\n mYNL057W:Unknown ,, Unknown\n mPFK26:6-Phosphofructose-2-kinase,6-phosphofructose-2-kinase,Null m\nutant is viable; on pyrvuate medium, no fructose 2,6-P2 is d\netectable in mutant\n mYPL110C:Unknown ,, Unknown\n mPIR3:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) pi\nr3 triple mutant is slow-growing on agar slab and sensitive \nto heat shock\n mGFA1 mYKL161C mSNO1 mSNZ1
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Computational Genomics Lab, Tel-Aviv uniresity