Module number 854




Database revision : gnsdb28.10
Date : Tue Feb 25 17:11:51 2003
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mYGR269W:Unknown ,, Unknown\n mYDL199C:Unknown ,, Unknown\n mYJL211C:Unknown ,, Unknown\n mYML058C-A:Unknown ,, Unknown\n mYJL131C:Unknown ,, Unknown\n mSET4:,,\n mSET6:Hypothetical ORF,,\n mPPM1:carboxy methyl transferase for protein phosphatase 2A cataly\ntic subunit,carboxy methyl transferase for protein phosphata\nse 2A catalytic subunit,Mutant is rapamycin resistant, benom\nyl supersensitive, and nocodazole sensitive.\n mSRT1:cis-prenyltransferase homologue,cis-prenyltransferase,Null m\nutant is viable, grows at all temperatures tested and is not\n hygromycin B sensitive; srt1 rer2 double disruption mutants\n are inviable; overexpression of SRT1 suppresses the tempera\nture sensitive and slow growth phenotypes of rer2 mutants\n mFYV2:Function required for Yeast Viability on toxin exposure,,K1 \nkiller toxin hypersensitivity\n mYHL021C:Unknown ,, Unknown\n mYDR282C:Unknown ,, Unknown\n mYEL048C:Unknown ,, Unknown\n mHNT3:Unknown ,, Unknown\n mYAL045C:Unknown ,, Unknown\n mYPR196W:Unknown ,, Unknown\n mYGL217C:Unknown ,, Unknown\n mYFL013W-A:Unknown ,, Unknown\n mSWF5:Unknown ,, Unknown\n mYPL150W:Unknown ,, Unknown\n mYMR057C:Unknown ,, Unknown\n mSFC1:succinate-fumarate carrier,succinate-fumarate transport prot\nein,\n mNCR1:Niemann-Pick Type C homologous gene,transmembrane protein (p\nutative),Null mutant is viable.\n mYPR153W:Unknown ,, Unknown\n mYPL216W:Unknown ,, Unknown\n Cond:\n mYPL136W:Unknown ,, Unknown\n mYNL338W:Unknown ,, Unknown\n mYBL010C:Unknown ,, Unknown\n mYJR149W:Unknown ,, Unknown\n mRFX1:DNA binding protein, homologous to a family of mammalian RFX\n1-4 proteins which have a novel highly conserved DNA binding\n domain,,\n mSDC25:homologous to cdc25,GDP/GTP exchange factor for Ras,null is \nviable; the C-terminal 584 amino acids (but not the entire p\nrotein) suppresses cdc25 mutations\n mRNP1:ribonucleoprotein 1,RNA binding protein (putative),Null muta\nnt is viable\n mYGL260W:Unknown ,, Unknown\n mYDR203W:Unknown ,, Unknown\n mSPL2:Suppressor of plc1-delta. Isolated as a dosage suppressor of\n the temperature-sensitive phenotype of a plc1 null mutant. \nAlso suppresses the hyperosmotic-sensitive phenotype of the \nplc1 null mutant.,,Null mutant is viable and shows no obviou\ns phenotype; spl2-delta plc1-delta double mutant fails to gr\now on SCD complete media, but grows on YPD at 25 degrees C\n mMAK10:Glucose-repressible protein,,Null mutant is viable, grows po\norly on nonfermentable carbons sources\n mMEK1:Disp. for chr. pairing & chr. condensation seen by in situ h\nybrid. Required for full double strand breaks, normal length\n synaptonemal complexes, meiotic recomb. & spore viability. \nmek1 is rescued by spo13 & in early recomb. function,meiosis\n-specific serine/threonine protein kinase,Null mutant is via\nble, however diploids homozygous for a mek1 null mutation pr\noduce only low percentages of viable spores, reduced spore v\niability is rescued by spo13 mutations\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n mYOR298W:Unknown ,, Unknown\n mYKL031W:Unknown ,, Unknown\n mYBR100W:Unknown ,, Unknown\n mFKS3:Protein with similarity to Gls1p and Gls2p (GB:Z49212),,\n mYCL076W:Unknown ,, Unknown\n mSLX4:Hypothetical ORF,,\n mYNL143C:Unknown ,, Unknown\n mYHR177W:Unknown ,, Unknown\n mYCL069W:Unknown ,, Unknown\n mYMR254C:Unknown ,, Unknown\n mYPR038W:Unknown ,, Unknown\n mYDR290W:Unknown ,, Unknown\n mYGR126W:Unknown ,, Unknown\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n mYLR137W:Unknown ,, Unknown\n mYAL018C:Unknown ,, Unknown\n mPTK1:Putative serine/threonine protein kinase,,Mutant shows decre\nase in total polyamine accumulation and resistance to polyam\nine analogs; ptk1 ptk2 double mutant shows virtually abolish\ned high-affinity spermidine transport\n mCOS10:Protein with strong similarity to subtelomerically-encoded p\nroteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, \nCos6p, Cos9p,,\n mCOS12:Protein with strong similarity to subtelomerically-encoded p\nroteins including Cos2p, Cos4p, Cos8p, YIR040c, Cos5p, Cos9p\n, and Cos6p,,\n mSEO1:Suppressor of Sulfoxyde Ethionine resistance,permease (putat\nive),\n mYNL122C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYLR334C:Unknown ,, Unknown\n mYOR314W:Unknown ,, Unknown\n mYNL311C:Unknown ,, Unknown\n mPPH3:protein phosphatase type 2A,protein phosphatase type 2A,Null\n mutant is viable, pph3 pph21 pph22 mutants are inviable\n mYBR174C:Unknown ,, Unknown\n mYPR039W:Unknown ,, Unknown\n mYFR032C:Unknown ,, Unknown\n mYBL012C:Unknown ,, Unknown\n mYMR320W:Unknown ,, Unknown\n mYSW1:Spore-specific protein,,\n mAPL3:clathrin Associated Protein complex Large subunit,clathrin a\nssociated protein complex large subunit,Null mutant is viabl\ne\n mYER119C:Unknown ,, Unknown\n mYGR287C:Unknown ,, Unknown\n mYOR300W:Unknown ,, Unknown\n mYFR054C:Unknown ,, Unknown\n mYOR024W:Unknown ,, Unknown\n mDUR3:Urea active transport protein,,Null mutant is viable; urea d\negradation deficient\n mLTE1:Gdp/GTP exchange factor required for growth at low temperatu\nres,,lethal at low temperature (8 degrees C)\n mYGL262W:Unknown ,, Unknown\n mELA1:similar to mammalian elongin A, interacts with elongin C,elo\nngin A transcription elongation factor,viable\n mESC8:Unknown ,, Unknown\n mYER140W:Unknown ,, Unknown\n mRCE1:Protease involved in ras and a-factor terminal proteolysis,p\nrotease,Null mutant is viable, has defects in Ras localizati\non and signaling, and suppresses the activated phenotype of \nthe RAS2val19 allele\n mGPH1:Releases glucose-1-phosphate from glycogen,glycogen phosphor\nylase,Null mutant is viable; haploid cells contain higher le\nvels of intracellular glycogen\n mYLR415C:Unknown ,, Unknown\n mYBR219C:Unknown ,, Unknown\n mYLR408C:Unknown ,, Unknown\n mYNL319W:Unknown ,, Unknown\n mSDL1:L-serine dehydratase,L-serine dehydratase,\n mYMR158W-A:Unknown ,, Unknown\n mYOR345C:Unknown ,, Unknown\n mYPR077C:Unknown ,, Unknown\n mYOL160W:Unknown ,, Unknown\n mYJL135W:Unknown ,, Unknown\n mMCM22:Required for maintenance of chromosomes and minichromosomes,\n,Null mutant is viable\n mYGR107W:Unknown ,, Unknown\n mYKL136W:Unknown ,, Unknown\n mYEL059W:Unknown ,, Unknown\n mYDR112W:Unknown ,, Unknown\n mYBR300C:Unknown ,, Unknown\n mSTD1:interacts with the SNF1 protein kinase and TBP in two-hybrid\n and in in vitro binding studies,MTH1 homolog,Null mutant is\n viable, no defects in mating or sporulation. Suppressor of \nTBP deletion; multicopy suppressor of SNF; std1-mth1 has def\nective glucose derepression and sporulation\n mYER185W:Unknown ,, Unknown\n mYDR149C:Unknown ,, Unknown\n mYGL235W:Unknown ,, Unknown\n mCCW14:Secretory Stress Response protein,cell wall mannoprotein,Nul\nl mutant is viable\n mCTF3:Unknown ,, Unknown\n mYMR279C:Unknown ,, Unknown\n mYKR103W:Unknown ,, Unknown\n mYLR431C:Unknown ,, Unknown\n mYMR306C-A:Unknown ,, Unknown\n mYPS5:Gpi-anchored aspartic protease (Yapsin 5),GPI-anchored aspar\ntic protease,\n mYOR055W:Unknown ,, Unknown\n mSYT1:Suppressor of Ypt3,,\n mYGL177W:Unknown ,, Unknown\n mOPI3:Second and third steps of methylation pathway for phosphatid\nylcholine biosynthesis,methylene-fatty-acyl-phospholipid syn\nthase (unsaturated phospholipid N-methyltransferase),Null mu\ntant is viable, temperature sensitive in the presence of mon\nomethylethanolamine, exhibits an inositol secretion phenotyp\ne\n mYNL335W:Unknown ,, Unknown\n mYNR062C:Unknown ,, Unknown\n mKSP1:Serine/threonine kinase similar to casein kinase II and othe\nr serine/threonine protein kinases,,Null mutant is viable\n Cond871:yhe710-ss\n Cond128:rgt1\n mDAK2:dihydroxyacetone kinase,dihydroxyacetone kinase,Null mutant \nis viable and show no growth defect in normal medium; mutant\n lacking both dak1 and dak2 is sensitive to dihydroxyacetone\n during saline growth\n mYPL025C:Unknown ,, Unknown\n mYCR076C:Unknown ,, Unknown\n mYKL050C:Unknown ,, Unknown\n mSGE1:multi-copy suppressor of gal11 null; member of drug-resistan\nce protein family,,Null mutant is viable; shows decreased ex\npression of galactose-inducible genes; shows increased sensi\ntivity to crystal violet\n mYOL046C:Unknown ,, Unknown\n mYDR048C:Unknown ,, Unknown\n mPSY2:Unknown ,, Unknown\n mYPR151C:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYBR235W:Unknown ,, Unknown\n mYOL075C:Unknown ,, Unknown\n mSNO2:SNZ2 proximal ORF, stationary phase induced gene,,Null mutan\nt is viable.\n mYNL089C:Unknown ,, Unknown\n mVTC1:Null mutant identified in different genetic screens both by \nits ability to reverse the Cdc42p suppression of a cdc24-4ts\n mutant and its ability to suppress the vacuolar ATPase null\n phenotype,S. pombe Nrf1p homolog (97% identical in predicte\nd amino acid sequence),Null mutant is viable, but exhibits b\noth reduced V-ATPase in the vacuolar membrane and reduced H(\n+)-ATPase(Pma1p) in the plasma membrane\n mYGL149W:Unknown ,, Unknown\n mVAM7:Regulator of vacuolar morphogenesis,heptad repeat motif , hy\ndrophilic protein,Null mutant is viable, exhibits prominent \nlarge vacuoles\n mLYP1:lysine permease,lysine permease,\n mMAL31:Part of the complex locus MAL3; functional in S288C; highly \nhomologous to MAL61 from S. cerevisiae, MAL61 from S. carlsb\nergenesis strains JM1901 and CB11, and MAL1T from strain 405\n9,maltose permease,Defective maltose fermentation\n mMAL32:Part of the complex locus MAL3; functional in S288C; highly \nhomologous to MAL62 from S. carlsbergenesis strain CB11,malt\nase,Defective maltose fermentation\n mPHO84:inorganic phosphate transporter, transmembrane protein,inorg\nanic phosphate transporter,Null mutant is viable\n mSPO13:Spo13 acts as a transcriptional activator in a one-hybrid as\nsay (see Henninger et al (1996) SPO13 and control of meiotic\n chromosome segregation in Saccharomyces cerevisiae),,Null m\nutant is viable, defective for sporulation; loss of function\n results in a single division during meiosis (with some chro\nmosomes segregating reductionally or aberrantly depending on\n strain background), occurring slightly earlier or at the ti\nme of wild type meiosis I, and dyad asci containing two dipl\noid spores. spo13 rescues the meiotic lethality of early Rec\n- mutants and Rec+ haploids. Gain of function causes a CDC28\n-dependent arrest at M-phase in mitosis and a delay in MI nu\ncleardivision.\n mYPR195C:Unknown ,, Unknown\n mYOR325W:Unknown ,, Unknown\n mYJR154W:Unknown ,, Unknown\n mAUA1:Involved in ammonia regulation of GAP1 activity,,Null mutant\n is viable\n mYPR064W:Unknown ,, Unknown\n mAPG10:Involved in autophagy; protein-conjugating enzyme involved i\nn the Apg12p-Apg5p conjugation pathway,protein-conjugating e\nnzyme,Defective autophagy, apg10-1 allele shows reduced viab\nlility under starvation conditions\n mYDL162C:Unknown ,, Unknown\n mYGR022C:Unknown ,, Unknown\n mCOG7:Unknown ,, Unknown\n mYNL285W:Unknown ,, Unknown\n mSHR5:Involved in RAS localization and palmitoylation,,Null mutant\n is viable; exhibits normal palmityltransferase activity in \nvitro and attenuates Ras function in cells with mutant Ras2 \nproteins that are not farnesylated or palmitoylated; shr5 mu\ntation originally isolated as suppressor of Ras function\n mYJR119C:Unknown ,, Unknown\n mHOP2:HOmologous Pairing,meiosis-specific gene required for the pa\niring of similar chromosomes,Null mutant is viable; homozygo\nus hop2 null diploids arrest in meiotic prophase prior to th\ne first meiotic division\n mAPG16:autophagy,,Null mutant is viable, defective in autophagy\n mHXT2:hexose transporter,high affinity hexose transporter-2,Null m\nutant is viable\n mLRG1:Expressed most highly in sporulating cells; may also play a \nrole during mating,similar to LIM-domain proteins and to rho\n/rac GTPase-activating family of proteins,Null mutant is via\nble\n mYDR274C:Unknown ,, Unknown\n mYBL073W:Unknown ,, Unknown\n mYHR212C:Unknown ,, Unknown\n mHXT12:High-affinity hexose transporter,hexose permease,\n mMEI4:Functions in early recombination,88 bp intron at 5' end spli\nced independently of MER1 , meiosis-specific protein,Loss of\n full chromosome pairing, heteroduplex DNA, synaptonemal com\nplexes, meiotic intra- and interchromosomal gene conversion,\n reciprocal recombination and viable spores. mei4 executes b\noth divisions with a delay in meiosis II, is rescued by spo1\n3 and is epiststic to rad52\n mPFS1:Prospore Formation at Selected spindle poles,,Null mutant is\n viable; homozygous null diploid accumulates nonsister-spore\n dyads, normal meiotic spindles\n mYNR063W:Unknown ,, Unknown\n mYOR289W:Unknown ,, Unknown\n mSNA2:Unknown ,, Unknown\n mHXT15:High-affinity hexose transporter,hexose transporter,\n mHXT17:Hexose transporter,hexose transporter,\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n mARR2:Required for arsenate but not for arsenite resistance,,Null \nmutant is viable but sensitive to arsenate (but not arsenite\n).\n mPPH3 mPSY2 mKSP1 mSTD1 mGDS1 mSPO13 mPFS1

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Computational Genomics Lab, Tel-Aviv uniresity