Module number 848




Database revision : gnsdb28.10
Date : Tue Feb 25 17:10:10 2003
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mHIS3:imidazoleglycerol-phosphate dehydratase,imidazoleglycerol-ph\nosphate dehydratase,Null mutant is viable and requires histi\ndine\n Cond158:sir2\n mHIS4:histidinol dehydrogenase,histidinol dehydrogenase,Null mutan\nt is viable and requires histidine\n Cond277:AUR1(tetpromoter)\n mHIS5:responsive to control of general amino acid biosynthesis,his\ntidinol-phosphate aminotransferase,Null mutant is viable and\n requires histidine\n Cond476:GCN4C/GCN4(R4760/R6257)\n mHIS7:glutamine amidotransferase:cyclase, also called imidazole gl\nycerol phosphate synthase,glutamine amidotransferase:cyclase\n , imidazole glycerol phosphate synthase (synonym),Null muta\nnt is viable and requires histidine\n Cond221:yer083c\n Cond104:npr2\n mSIP4:Possibly involved in Snf1p regulated transcriptional activat\nion,,\n mMCH1:Unknown ,, Unknown\n Cond164:sst2(haploid)\n mMCH4:Unknown ,, Unknown\n Cond95:mac1\n Cond13:ase1(**12)\n mYOR203W:Unknown ,, Unknown\n Cond730:hda1\n mYGR110W:Unknown ,, Unknown\n Cond244:ymr010w\n mSUL1:Putative sulfate permease,,Null mutant is viable, unable to \ngrow on media containing less than 5 mM sulphate\n mCTF13:58 kd component (Cbf3c) of the multisubunit 'Cbf3' kinetocho\nre protein complex, which binds to the CDE III element of ce\nntromeres,,Null mutant is inviable\n mSUL2:Sulfate uptake,high affinity sulfate permease,\n Cond30:clb6\n Cond391:aa_starv_1_h\n mFRM2:Protein involved in the integration of lipid signaling pathw\nays with cellular homeostatis,,Null mutant is viable and sen\nsitive to arachidonic acid\n Cond517:sst2D/wtlog10(intensity)\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond245:ymr014w\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond184:ubr1\n mVID24:also involved in vacuolar protein targeting,peripheral vesic\nle membrane protein,Null mutant is viable, defective in fruc\ntose-1,6-bisphosphatase dergadation\n Cond123:rad57\n mYHR162W:Unknown ,, Unknown\n Cond279:ERG11(tetpromoter)\n Cond247:ymr029c\n mPEX21:Peroxin; Pex18p and Pex21p are partially functionally redund\nant.,peroxin,Null mutant is viable.\n Cond216:yer044c(haploid)\n Cond86:imp2'(**12)\n Cond479:WT+/-100mM3AT(SetD)(R491)\n mTEA1:Mutants are defective in Ty1 Enhancer-mediated Activation,,D\niminished Ty1 expression\n mICY2:Interacting with the cytoskeleton,,\n Cond57:erg6\n mLYS1:saccharopine dehydrogenase,,Lysine requiring\n Cond226:yhl029c\n Cond482:WT+/-100mM3AT(SetC)(KNY164)\n Cond194:yap1\n mLYS2:alpha aminoadipate reductase,alpha aminoadipate reductase,Nu\nll mutant is viable, lysine auxotroph\n mADH5:alcohol dehydrogenase isoenzyme V,alcohol dehydrogenase isoe\nnzyme V,\n mTRP2:anthranilate synthase Component I,anthranilate synthase comp\nonent I,tryptophan requiring\n mTRP3:anthranilate synthase Component II and indole-3-phosphate (m\nultifunctional enzyme),anthranilate synthase component II , \nindole-3-phosphate,Null mutant is viable, tryptophan auxotro\nph\n mTRP4:anthranilate phosphoribosyl transferase,anthranilate phospho\nribosyl transferase,tryptophan requiring\n Cond145:rts1\n mTRP5:tryptophan synthetase,tryptophan synthetase,Null mutant is v\niable and requires tryptophan\n mSNZ1:Snooze: stationary phase-induced gene family; may be involve\nd in cellular response to nutrient limitation and growth arr\nest,highly conserved 35 kDa protein that shows increased exp\nression after entry into stationary phase,Null mutant is via\nble, sensitive to 6-azauracil and methylene blue.\n Cond71:gln3\n Cond88:isw1,isw2\n Cond481:WT+/-100mM3AT(SetB)(491)\n Cond54:erg3(haploid)\n Cond233:yhr039c\n mILV2:acetolactate synthase,acetolactate synthase,Isoleucine-plus-\nvaline requiring; Sulfometuron methyl resistance\n Cond68:gas1\n mILV3:catalyzes third step in common pathway leading to biosynthes\nis of branched-chain amino acids,dihydroxyacid dehydratase,N\null mutant is viable and requires isoleucine and valine\n Cond116:pex12\n Cond143:rrp6\n mBOP2:bypass of PAM1,,\n mYLR152C:Unknown ,, Unknown\n Cond512:GAL-STE5-CTM,3hrs.gallog10(intensity)\n Cond26:cka2\n mILV6:acetolactate synthase regulatory subunit,,\n Cond69:gcn4\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYJL213W:Unknown ,, Unknown\n Cond108:pac2\n mYNL129W:Unknown ,, Unknown\n Cond27:ckb2\n Cond731:hda1 \n Cond73:gyp1\n Cond162:spf1\n mECM17:ExtraCellular Mutant,sulfite reductase (putative),loss of fu\nnction mutants are methionine requiring and sensitive to the\n cell wall perturbing agent calcoflour white.\n Cond634:DES460_+_0.02%_MMS_-_15_min\n Cond475:0.5x/1xAA(MildLeu,HisStarvation)(R176)\n mRIB3:Riboflavin biosynthesis,3,4-dihydroxy-2-butanone 4-phosphate\n synthase,\n Cond25:cin5\n mRIB5:Riboflavin biosynthesis,,Null mutant is viable, exhibits rib\noflavin auxotrophy\n mYGL117W:Unknown ,, Unknown\n mIDP1:Mitochondrial form of NADP-specific isocitrate dehydrogenase\n,NADP-dependent isocitrate dehydrogenase,Null mutant is viab\nle\n mYMC1:putative mitochondrial carrier protein,carrier protein (puta\ntive),\n mBAT1:branched-chain amino acid transaminase, highly similar to ma\nmmalian ECA39, which is regulated by the oncogene myc,branch\ned-chain amino acid transaminase , highly similar to mammali\nan ECA39, which is regulated by the oncogene myc , branched-\nchain amino acid transaminase , highly similar to mammalian \nECA39, which is regulated by the oncogene myc,Null mutant is\n viable; ILV auxotrophy in bat1 bat2 double mutant\n mBAT2:Branched-Chain Amino Acid Transaminase,branched-chain amino \nacid transaminase,Null mutant is viable; ILV auxotrophy in b\nat1 bat2 double mutants\n Chromo.chromo:Genomewide studies of histone deacetylase function in yeast.\n Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13.\n mPOS5:involved in oxidative stress,,pos5 mutants are peroxide sens\nitive\n mVHT1:vitamin H transporter,H+-biotin symporter,reduced biotin upt\nake, reduced levels of protein biotinylation\n Cond39:dig1\n Cond160:sir4\n Cond135:rpl20a\n mCPA1:Carbamoyl phosphate synthetase, arginine specific,arginine s\npecific , carbamoyl phosphate synthetase,Null mutant is viab\nle\n mYJL200C:Unknown ,, Unknown\n mCPA2:carbamyl phosphate synthetase,carbamyl phosphate synthetase,\nNull mutant is viable\n mMTG1:Unknown ,, Unknown\n Cond477:GCN4/gcn4Din100mM3AT(KNY164/KNY124)\n mURA10:Fifth step in pyrimidine bio5,orotate phosphoribosyltransfer\nase 2,Null mutant is viable\n Cond397:Nitrogen_Depletion_2_h\n mARG1:arginosuccinate synthetase,arginosuccinate synthetase,Argini\nne requiring\n mHOM2:threonine and methionine pathway,aspartic beta semi-aldehyde\n dehydrogenase,Homoserine requiring\n mARG3:Sixth step in arginine biosynthesis,ornithine carbamoyltrans\nferase,Arginine requiring\n Cond396:Nitrogen_Depletion_1_h\n Cond225:yhl013c\n mHOM3:First step in common pathway for methionine and threonine bi\nosynthesis,aspartate kinase (L-aspartate 4-P-transferase) (E\nC 2.7.2.4),Homoserine requiring; Borrelidin resistance\n mARG4:argininosuccinate lyase,argininosuccinate lyase,Arginine req\nuiring\n mLYS20:homocitrate synthase, highly homologous to YDL131W,YDL131W (\nLYS21) homolog , homocitrate synthase,Null mutant is viable,\n is able to grow on minimal media, and exhibits reduced but \nsignificant homocitrate synthase activity\n Cond260:ymr237w\n mLYS21:homocitrate synthase, highly homologous to YDL182W,YDL182W (\nLYS20) homolog , homocitrate synthase,\n mSTR2:Sulfur TRansfer,cystathionine gamma-synthase,Null mutant is \nviable but unable to turn cysteine into homocysteine. Grows \nwhen supplied with cystathionine.\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mSTR3:Sulfur TRansfer,cystathionine beta-lyase,Null mutant is viab\nle but unable to turn cysteine into homocysteine. No growth \nwhen supplied with cystathionine.\n mARG8:Acetylornithine aminotransferase,acetylornithine aminotransf\nerase,Arginine requiring\n mSSU1:sensitive to sulfite,major facilitator superfamily,Null muta\nnt is viable; sulfite sensitive\n Cond29:clb2\n Cond89:isw2\n mARG5,6:N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutam\nate kinase,N-acetyl-gamma-glutamyl-phosphate reductase and a\ncetylglutamate kinase,Arginine requiring\n Cond224:CMD1(tetpromoter)\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mARO1:pentafunctional arom polypeptide (contains: 3-dehydroquinate\n synthase, 3-dehydroquinate dehydratase (3-dehydroquinase), \nshikimate 5-dehydrogenase, shikimate kinase, and epsp syntha\nse),3-dehydroquinate dehydratase (3-dehydroquinase) , 3-dehy\ndroquinate synthase , epsp synthase , pentafunctional arom p\nolypeptide , shikimate 5-dehydrogenase , shikimate kinase,ar\nomatic amino acid requiring; lack of premeiotic DNA synthesi\ns; blocked sporulation in homozygous mutant\n Cond190:vps8\n mARO3:DAHP synthase; a.k.a. phospho-2-dehydro-3-deoxyheptonate ald\nolase, phenylalanine-inhibited; phospho-2-keto-3-deoxyhepton\nate aldolase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-\ndeoxy-D-arabine-heptulosonate-7-phosphate synthase,DAHP synt\nhase; a.k.a. phospho-2-dehydro-3-deoxyheptonate aldolase, ph\nenylalanine-inhibited; phospho-2-keto-3-deoxyheptonate aldol\nase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-deoxy-D-a\nrabine-heptulosonate-7-phosphate synthase,null mutant is via\nble\n mARO4:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase \nisoenzyme,3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP)\n synthase isoenzyme,null mutant is viable\n mAQR2:Unknown ,, Unknown\n Cond729:sin3\n mARO8:aromatic amino acid aminotransferase,aromatic amino acid ami\nnotransferase,Null mutant is viable\n mSDT1:suppressor of deletion of TFIIS,,null mutant is viable, but \nis sensitive to 6-azauracil\n mARO9:aromatic amino acid aminotransferase II,aromatic amino acid \naminotransferase II,Null mutant is viable\n Cond90:jnm1\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond53:erg2\n mZTA1:Zeta-crystallin homolog, has similarity to E. coli quinone o\nxidoreductase and human zeta-crystallin which has quinone ox\nidoreductase activity,,\n mNCE103:involved in secretion of proteins that lack classical secret\nory signal sequences,,An uncharacterized allele exhibits def\nects in the export of the mammalian protein galectin-1.\n mYLR089C:Unknown ,, Unknown\n mYOL118C:Unknown ,, Unknown\n mAAT2:aspartate aminotransferase, cytosolic,aspartate aminotransfe\nrase,\n mYNR069C:Unknown ,, Unknown\n Cond6:anp1\n mSRY1:Serine Racemase homolog in Yeast,pyridoxal-5'phosphate-depen\ndent enzyme , similar to mouse glial serine racemase,Null mu\ntant is viable\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond298:Terbinafine\n mYBR147W:Unknown ,, Unknown\n Cond78:hir2\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond85:imp2\n mNIT1:nitrilase,nitrilase,\n Cond201:yel008w\n mYPL264C:Unknown ,, Unknown\n Cond229:yhr011w(**14)\n mSER1:phosphoserine transaminase,phosphoserine transaminase,Null m\nutant is viable, serine-requiring\n mYHR029C:Unknown ,, Unknown\n mMET10:subunit of assimilatory sulfite reductase,assimilatory sulfi\nte reductase subunit,Null mutant is viable, and is a methion\nine auxotroph\n mSER3:catalyzes the first step in serine biosynthesis; isozyme of \nSER33,3-phosphoglycerate dehydrogenase,enzyme activity of 3P\n-glycerate dehydrogenase is decreased in null mutant compare\nd to wildtype and abolished in ser3 ser33 double deletion mu\ntant\n Cond176:swi5\n mAPG1:Required for autophagy,protein kinase,Defective in autophagy\n; loses viability more rapidly than wild type during nitroge\nn starvation; defective in vacuolar protein degradation duri\nng nitrogen starvation; defective in sporulation\n mECM40:ExtraCellular Mutant,acetylornithine acetyltransferase,A Tn3\n insertion into this gene causes hypersensitivity to the cel\nl surface polymer perturbing agent calcofluor white.\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond287:2-deoxy-D-glucose\n mMET13:putative methylenetetrahydrofolate reductase (mthfr),methyle\nnetetrahydrofolate reductase (mthfr) (putative),Null mutant \nis viable and shows methionine auxotrophy; double disruption\n of MET12 and MET13 (the two putative mthfr genes) also conf\ners methionine auxotrophy, but has no other known phenotype \nat this time.\n mATR1:aminotriazole resistance,very hydrophobic, has many membrane\n-spanning regions, several potential glycosylation sites, po\ntential ATP-binding site,Null mutant is viable, but is sensi\ntive to very low (5 mM) levels of aminotriazole and to 4-nit\nroquinoline-N-oxide (4-NQO); multiple copies of ATR1 confer \nhyper-resistance to 4-NQO; multiple copies of ATR1 in gcn4 b\nackground confer resistance to high (80mM) levels of aminotr\niazole\n Cond48:ecm29\n mMET16:3'phosphoadenylylsulfate reductase,3'phosphoadenylylsulfate \nreductase,Null mutant is viable, and is a methionine auxotro\nph\n Cond478:WT+/-10mM3AT(R491)\n Cond128:rgt1\n mMET17:O-Acetylhomoserine-O-Acetylserine Sulfhydralase,O-acetylhomo\nserine (thiol)-lyase,Null mutant is viable, methionine auxot\nroph, becomes darkly pigmented in the presence of Pb2+ ions;\n resistant to methylmercury and exhibits increased levels of\n H2S\n Cond144:rtg1\n Cond150:sbh2\n Cond47:ecm18(**7)\n mUGA3:Transcriptional activator necessary for gamma-aminobutyrate \n(GABA)-dependent induction of GABA genes (such as UGA1, UGA2\n, UGA4),zinc finger transcription factor of the Zn(2)-Cys(6)\n binuclear cluster domain type,Null mutant is viable but exh\nibits defects in activation of UGA1 and UGA4.\n mLEU4:leucine biosynthesis,alpha-isopropylmalate synthase (2-isopr\nopylmalate synthase),Null mutant is viable, Leu+\n Cond43:dot4\n mYIL165C:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond24:cem1\n mYDR426C:Unknown ,, Unknown\n Cond132:rnr1(haploid**9)\n mALD5:Utilizes NADP+ as the preferred coenzyme. Activated by K+.,a\nldehyde dehydrogenase,\n mPRM5:pheromone-regulated membrane protein,,\n mSNO1:SNZ1 proximal ORF, stationary phase induced gene,,Null mutan\nt is viable, sensitive to 6-azauracil and methylene blue.\n Cond171:ste24(haploid)\n mYHM1:high copy suppressor of abf2 lacking the HMG1-like mitochond\nrial HM protein; putative mitochondrial carrier protein,,Nul\nl mutant is viable; shm1 abf2 double deletion cannot grow on\n glycerol\n mASN1:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n Cond175:swi4\n mYJR111C:Unknown ,, Unknown\n Cond250:ymr031w-a\n mPDX3:pyridoxine (pyridoxiamine) phosphate oxidase,pyridoxine (pyr\nidoxiamine) phosphate oxidase,\n mTMT1:Trans-aconitate Methyltransferase 1,,\n Cond284:PMA1(tetpromoter)\n mYIL056W:Unknown ,, Unknown\n Cond153:sgs1\n mBIO3:biotin biosynthesis,7,8-diamino-pelargonic acid aminotransfe\nrase (DAPA) aminotransferase,\n mYJR154W:Unknown ,, Unknown\n mBIO5:transmembrane regulator of KAPA/DAPA transport,transmembrane\n regulator of KAPA/DAPA transport,\n mPHO89:Probable Na+/Pi symporter,Na+/Pi symporter (putative),Null m\nutant is viable\n mMET22:Putative phosphatase gene involved in salt tolerance and met\nhionine biogenesis; halotolerance,3'(2')5'-bisphosphate nucl\neotidase,Methionine requiring; lacks 3'-phosphoadenylylsulfa\nte (PAPS) reductase activity; unable to grow on sulfate as s\nole sulfur source\n mPCL5:PHO85 cyclin,,Null mutant is viable.\n mISU1:Iron-sulfur cluster nifU-like protein,,Null mutant is viable\n on YPD at 30 degrees C, and is synthetically lethal with is\nu2 null.\n Cond294:Itraconazole\n mYPL033C:Unknown ,, Unknown\n Cond159:sir3\n Cond295:Lovastatin\n mYBR047W:Unknown ,, Unknown\n mBNA1:biosynthesis of nicotinic acid,3-hydroxyanthranilic acid dio\nxygenase,Null mutant is viable, nicotinic acid auxotroph\n Cond299:Tunicamycin\n Cond274:yor080w(**3)\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond938:2h\n Cond392:aa_starv_2_h\n mORT1:Mitochondrial integral membrane protein, ornithine transport\ner,,Null mutant is viable, arginine bradytroph\n mHIS1:involved in the first step of histidine biosynthesis,ATP pho\nsphoribosyltransferase,Null mutant is viable and requires hi\nstidine\n mTRP2 mTRP3 mCPA2 mCPA1 mSNO1 mSNZ1
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Computational Genomics Lab, Tel-Aviv uniresity