Module number 828




Database revision : gnsdb28.10
Date : Tue Feb 25 17:05:49 2003
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mHST2:Homolog of SIR2,,\n mYCR049C:Unknown ,, Unknown\n mYPL251W:Unknown ,, Unknown\n mYLR339C:Unknown ,, Unknown\n mTFS1:(putative) lipid binding protein; supressor of a cdc25 mutat\nion,lipid binding protein (putative) , supressor of a cdc25 \nmutation,Null mutant is viable.\n Cond248:ymr030w\n mYLR179C:Unknown ,, Unknown\n mYER152C:Unknown ,, Unknown\n mFPR3:binds the immunosuppressant drugs, FK506 and rapamycin, and \nis localized to the nucleolus; binds to nuclear localization\n signal-containing peptides in vitro,peptidyl-prolyl cis-tra\nns isomerase (PPIase),Null mutant is viable; overexpression \ngives no phenotype except is growth inhibitory in fpr1 mutan\nt; both null mutant and over-expressor show wild-type sensit\nivity to FK506 and rapamycin; npi46 fpr1 fpr2 triple mutant \nis viable\n mYBL111C:Unknown ,, Unknown\n mLAS17:Homolog of human WASP, proline-rich protein,actin assembly f\nactor,Null mutant is viable, demonstrates impaired budding a\nnd cytokenesis and severely disrupted cortical actin; other \nmutants accumulate secretory vesicles in the bud\n mSEC31:involved in protein transport from endoplasmic reticulum to \nGolgi,COPII coat of secretory pathway vesicles component (p1\n50),Null mutant is inviable\n mPDC1:pyruvate decarboxylase,pyruvate decarboxylase,undetectable p\nyruvate decarboxylase activity in pdc1pdc5 double mutants\n mURA8:Last step in pyrimidine biosynthesis pathway,CTP synthase,Nu\nll mutant is viable. Double deletion of URA7, which also enc\nodes CTP synthetase, and URA8 is lethal\n mPDC5:pyruvate decarboxylase,pyruvate decarboxylase,undetectable p\nyruvate decarboxylase activity in pdc1pdc5 double mutants\n mPDC6:Third, minor isozyme of pyruvate decarboxylase,pyruvate deca\nrboxylase isozyme,Null mutant is viable and shows reduced py\nruvate decarboxylase activity only in cells grown in ethanol\n Cond185:ubr2\n mLAT1:Dihydrolipoamide acetyltransferase component (E2) of pyruvat\ne dehydrogenase complex,pyruvate dehydrogenase complex dihyd\nrolipoamide acetyltransferase component (E2),Null mutant is \nviable\n mWWM1:Unknown ,, Unknown\n mSCS2:Likely to be involved in regulating INO1 expression, suppres\nsor of a dominant nuclear mutation that is inositol-dependen\nt in the presence of choline,,Null mutant is viable but is a\nn inositol auxotroph above 34 deg.\n Cond105:nrf1\n mENO1:enolase I,enolase I,Null mutant is viable\n mENO2:enolase,enolase,Null mutant is inviable\n Cond81:hog1(haploid)\n mRRD1:Resistant to Rapamycin Deletion,,Null mutant is viable but s\nhows pleiotropic phenotypes (eg. caffeine and rapamycin resi\nstance, vanadate and calcium sensitivity, etc.); synthetic l\nethal with RRD2 (YPL152w)\n mCIS3:cik1 suppressor,similar to Hsp150p and Pir1p, Pir2p, and Pir\n3p,Null mutant is viable; CIS3 is a high copy suppressor of \ncik1 deletion mutants\n Cond200:yel001c\n mBPL1:Biotin:apoprotein ligase,biotin:apoprotein ligase,Null mutan\nt is inviable.\n Cond245:ymr014w\n mRPA14:14 kDa subunit of RNA polymerase I,RNA polymerase I subunit,\nNull mutant is viable but is temperature sensitive\n mYBL112C:Unknown ,, Unknown\n mCRH1:congo red hypersensitive,cell wall protein,Null mutant is vi\nable and hypersensitive to Congo Red and Calcofluor White\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n mDPH5:diphthamide biosynthesis,,Null mutant is viable\n mYCR050C:Unknown ,, Unknown\n mYHR199C:Unknown ,, Unknown\n mYPL246C:Unknown ,, Unknown\n Cond61:fks1(haploid)\n mHSP60:60 kDa heat shock protein,chaperonin , groEL homolog , chape\nronin , groEL homolog,Null mutant is inviable\n mRMD7:Unknown ,, Unknown\n mCYC3:cytochrome c heme lyase (CCHL),cytochrome c heme lyase (CCHL\n),Cytochrome c deficiency\n mRET2:coatomer (COPI) complex delta subunit,,ret2-1 mutant is ther\nmosensitive and shows defects in retrieval of dilysine-tagge\nd proteins from the Golgi back to the ER and, at the non-per\nmissive temperature, in forward ER-to-Golgi transport\n mADH2:alcohol dehydrogenase II,alcohol dehydrogenase II,Null mutan\nt is viable\n mCAF120:Hypothetical ORF,,Null mutant is viable\n mGRH1:Yeast (GR)ASP65 (H)omologue,mammalian GRASP protein homolog,\nNull mutation is viable, exhibits defects in spindle checkpo\nint\n mPTC2:Protein phosphatase type 2C,protein phosphatase type 2C,\n mYHR177W:Unknown ,, Unknown\n mYBL083C:Unknown ,, Unknown\n mCYC8:General repressor of transcription (with Tup1p); mediates gl\nucose repression,,Null mutant is viable; high level constitu\ntivity for invertase, clumpiness, temperature-sensitive grow\nth, alpha-specific mating defects and failure of homozygous \ndiploids to sporulate\n mGAT2:Product of gene unknown,,\n mADE5,7:glycinamide ribotide synthetase and aminoimidazole ribotide \nsynthetase,aminoimidazole ribotide synthetase , glycinamide \nribotide synthetase,Adenine requiring\n mCAM1:Calcium and phospholipid binding protein homologous to trans\nlation elongation factor 1-gamma (EF-1gamma),calcium and pho\nspholipid binding protein homologous to translation elongati\non factor 1-gamma (EF-1gamma),Null mutant is viable under no\nrmal growth conditions\n Cond145:rts1\n mTRP5:tryptophan synthetase,tryptophan synthetase,Null mutant is v\niable and requires tryptophan\n mSPT8:transcription factor, probable member of histone acetyltrans\nferase SAGA complex,probable member of histone acetyltransfe\nrase SAGA complex , transcription factor,Null mutant is viab\nle, no growth defects, exhibits suppression of Ty insertion \nmutations, defects in Ty transcription\n mSRV2:70-kDa adenylyl cyclase-associated protein,70 kDa adenylyl c\nyclase-associated protein,Null mutant is inviable.\n mPTK2:Putative serine/threonine protein kinase that enhances sperm\nine uptake,,Mutant shows reduced spermine and putrescine upt\nake and is resistant to toxic polyamine analogs and Li+ and \nNa+ ions; ptk1 ptk2 double mutant shows virtaully abolished \nhigh-affinity spermidine transport\n mRNQ1:Rich in asparagine (N) and glutamine (Q),transferable epigen\netic modifier,\n Cond58:erp2\n mGLK1:Glucose phosphorylation,glucokinase,Null mutant is viable wi\nth no discernible difference from wild-type; hxk1, hxk2, glk\n1 triple null mutants are unable to grow on any sugar except\n galactose and fail to sporulate\n Cond52:erd1\n Cond26:cka2\n mDIG1:Down-regulator of Invasive Growth, Regulator of Sterile Twel\nve, binds Fus3 and Ste12,MAP kinase-associated protein,Null \nmutant is viable, shows abnormal bud morphology; dig1 dig2 d\nouble mutants show constitutive mating defect and invasive g\nrowth; overexpression causes pheromone resistance\n mILV6:acetolactate synthase regulatory subunit,,\n mIMP2':Protein involved in nucleo-mitochondrial control of maltose,\n galactose and raffinose utilization,transcription factor,Nu\nll mutant is viable, Inability to grow on maltose, galactose\n and raffinose in respiratory-deficient conditions or in the\n presence of ethidium bromide and erythromycin; leaky phenot\nype on oxidizable carbon sources: sensitivity to heat shock \nand sporulation deficiency\n mSTI1:Heat shock protein also induced by canavanine and entry into\n stationary phase,heat shock protein also induced by canavan\nine and entry into stationary phase,Null mutant is viable bu\nt shows slow growth at high or low temperatures; shows synth\netic interactions with hsp82, cpr7, kin28 and sba1\n mPRB1:dispensable for haploidization and sporulation, but needed f\nor full protein degradation during sporulation, and proper s\npore morphology,vacuolar protease B,Null mutant is viable, p\nrotease B deficient, has smaller spores than wild-type embed\nded in a thick matrix\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSCP160:May be required during cell division for faithful partitioni\nng of the ER-nuclear envelope membranes, involved in control\n of mitotic chromsome transmission,,Null mutant is viable, b\nut exhibits decreased viability, abnormal morphology, and in\ncreased DNA content.\n mYPL247C:Unknown ,, Unknown\n mSDS24:Similar to S. pombe SDS23, suppresses DIS2, localized to the\n nucleus,,Null mutant is viable\n mPAN1:Involved in actin organization and endocytosis,,Null mutant \nis inviable; conditional mutants show arrest of translation \ninitiation, alterations in mRNA poly(A) tail lengths, and al\ntered cellular location of Mod5p\n Cond205:yel033w\n mCYS3:cystathionine gamma-lyase,cystathionine gamma-lyase,Null mut\nant is viable, cysteine auxotroph\n mPUP1:putative proteasome subunit,proteasome subunit (putative),\n Cond91:kim4\n mYBR261C:Unknown ,, Unknown\n mFAS2:Trifunctional enzyme,fatty acid synthase alpha subunit,Fatty\n acid synthetase deficient\n mPRY1:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n mTIM44:48.8 kDa protein involved in mitochondrial protein import,48\n.8 kDa protein involved in mitochondrial protein import,Null\n mutant is inviable\n mRSC6:a subunit of RSC, a fifteen-protein chromatin remodeling com\nplex and related to the swi/snf complex.,,Null mutant is inv\niable\n mMET3:ATP sulfurylase,ATP sulfurylase,Null mutant is viable, and i\ns a methionine auxotroph\n mLGE1:Unknown ,, Unknown\n mYER119C:Unknown ,, Unknown\n mTUP1:general repressor of transcription (with Cyc8p); mediates gl\nucose repression,glucose repression regulatory protein, exhi\nbits similarity to beta subunits of G proteins,Null mutant i\ns viable; exhibits flocculent colony morphology\n mYCR051W:Unknown ,, Unknown\n mSTP22:Ste pseudorevertant; required for vacuolar targeting of temp\nerature-sensitive plasma membrane proteins; homologous to th\ne mouse and human Tsg101 tumor susceptibility gene; mutants \nexhibit a Class E Vps phenotype.,,\n mEHT1:alcohol acyl transferase,alcohol acyl transferase,Null mutan\nt is viable, temperature sensitive, and contains higher amou\nnts of phosphatidylinositol, phosphatidic acid, and ergoster\nyl esters\n mSVS1:involved in vanadate resistance,,Null mutant is viable, show\ns increased sensitivity to vanadate, but not other metallic \nions or drugs\n mSEC61:membrane component of ER protein translocation apparatus,,Nu\nll mutant is inviable. Conditional alleles are defective for\n protein translocation and the export of misfolded proteins \nfrom the endoplasmic reticulum at the restrictive temperatur\ne.\n mSLC1:fatty acyltransferase homologous to E. coli plsC gene; funct\nionally complements plsC mutants,1-acyl-sn-gylcerol-3-phosph\nate acyl transferase (putative),slc1-1 mutant suppresses sph\ningolipid long chain biosynthetic defect; the mutant also ma\nkes novel phosphatidylinositol derivatives and lacks sphingo\nlipids\n mPIN3:[PSI+] induction,,Other phenotypes: overexpression of PIN3 a\nllows for the induction of the [PSI+] prion in strains cured\n of [PIN+].\n mZWF1:Glucose-6-phosphate dehydrogenase,glucose-6-phosphate dehydr\nogenase,sensitive to oxidizing agents; methionine requiring\n mYFL066C:Unknown ,, Unknown\n mLCB1:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Null mutant is viabl\ne; auxotrophic for long-chain component of sphingolipids; ho\nmozygous lcb1 diploids fail to sporulate\n mMYO3:myosin I,myosin I,Null mutant is viable, myo3 myo5 double de\nletion mutants exhibit severe defects in growth and actin cy\ntoskeletal organization\n mMYO5:contains proline-rich tail homology 2 (TH2) and SH3 domains,\nmyosin I,Null mutant is viable; myo3 myo5 double deletion mu\ntants exhibit loss of actin polarity, growth arrest at 37 de\ngrees or high osmotic strength, accumulation of intracellula\nr membranes, and loss of polarized cell surface growth; myo3\n myo5 double mutants have longer doubling times and thicker \ncell walls\n mRPE1:D-ribulose-5-Phosphate 3-epimerase,D-ribulose-5-Phosphate 3-\nepimerase,Null mutants are viable but show no ribulose-5-pho\nsphate epimerase activity, cannot grow on D-xylulose, and ar\ne sensitive to hydrogren peroxide\n mKRE23:Killer toxin REsistant,,Null mutant is K1 killer toxin resis\ntent\n mFAT2:Fatty acid transporter, very similar to FAT1,,\n mNOP1:nucleolar protein, homologous to mammalian fibrillarin,nucle\nolar protein , similar to mammalian fibrillarin,Null mutant \nis inviable. Temperature-sensitive alleles exhibit various d\nefects in rRNA processing.\n Cond292:Glucosamine\n Cond102:mrt4\n mSAM1:S-adenosylmethionine synthetase,,Null mutant is viable.\n mABP1:Actin binding protein,actin binding protein,Null mutant is v\niable\n mSAM3:S-adenosylMethionine Permease,high affinity S-adenosylmethio\nnine permease,Null mutant is viable but has inability to use\n S-adenosylmethionine as a sulfur source\n mHCR1:High Copy suppressor of RPG1,,viable\n Cond130:rml2(**13)\n mESS1:Mitotic regulator; structurally and functionally homologous \nto human PIN1,peptidyl-prolyl cis-trans isomerase (PPIase),N\null mutant is inviable; arrest phenotype of mitotic arrest a\nnd nuclear fragmentation\n mYER156C:Unknown ,, Unknown\n mSMP2:involved in plasmid maintenance,,Null mutant is viable, resp\niration deficient and show increased stability of heterologo\nus plasmids\n mSLS1:Does not appear to be involved in mitochondrial DNA replicat\nion, transcription, or in RNA splicing maturation or stabili\nty,73 kDa mitochondrial integral membrane protein,Null mutan\nt is viable on glucose and inviable on non-fermentable carbo\nn sources; sls1-1 has a pet phenotype and is synthetically l\nethal an ssm4 null mutation\n Cond280:FKS1(tetpromoter)\n mYBR241C:Unknown ,, Unknown\n Cond140:rps24a(**9)\n mTRK2:membrane protein; low affinity potassium transport,low affin\nity potassium transport , membrane protein,Null mutant is vi\nable, requires added potassium; trk1 trk2 double mutants are\n viable\n Cond28:cla4(haploid)\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n mRNH35:RNase H(35), a 35 kDa ribonuclease H,,Null mutant is viable \nbut shows 75% reduction of RNase H activity in cell extracts\n mSNF2:involved in the coordinate regulation of phospholipid synthe\nsis,transcriptional regulator,sucrose nonfermenting\n mDPS1:Aspartyl-tRNA synthetase, cytosolic,aspartyl-tRNA synthetase\n,\n mHEM1:First enzyme in heme biosynthetic pathway,5-aminolevulinate \nsynthase,Null mutant is viable; auxotroph for heme and methi\nonine\n mTHR1:homoserine kinase,homoserine kinase,Null mutant is viable, t\nhreonine auxotroph\n mCLN2:role in cell cycle START,G1 cyclin,Null mutant is viable, ex\nhibits G1 arrest; dominant mutation advances the G(sub)1- to\n S- phase transition and impairs ability of cells to arrest \nin G(sub)1 phase in response to external signals\n mAAT2:aspartate aminotransferase, cytosolic,aspartate aminotransfe\nrase,\n mCCW12:Hypothetical ORF,cell wall mannoprotein,Null mutant is viabl\ne and shows decrease in mating efficiency and defect in aggl\nutination\n mYFL067W:Unknown ,, Unknown\n mOYE2:NAPDH dehydrogenase (old yellow enzyme), isoform 2,NAPDH deh\nydrogenase (old yellow enzyme), isoform 2,Null mutant is via\nble\n mYNR018W:Unknown ,, Unknown\n mGSP1:maintenance of nuclear organization; homologous to mammalian\n Ran, a small nuclear GTPase of the ras superfamily,GTP-bind\ning protein,Null mutant is inviable\n mGSP2:maintenance of nuclear organization; homologous to mammalian\n Ran, a small nuclear GTPase of the ras superfamily,GTP-bind\ning protein , Gsp1p homolog,Null mutant is viable\n Cond285:RHO1(tetpromoter)\n mIMG1:Required for respiration and maintenance of mitochondrial ge\nnome,mitochondrial ribosomal protein,Null mutant is viable; \nrespiration deficient\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYPR114W:Unknown ,, Unknown\n mERV46:ER vesicle protein of 46 kDa,ER-Golgi transport vesicle prot\nein,Null mutant is viable but cold sensitive.\n mYOR041C:Unknown ,, Unknown\n mYCL044C:Unknown ,, Unknown\n mARP7:involved in transcriptional regulation,actin related protein\n , chromatin remodeling Snf/Swi complex subunit,Null mutant \nis viable, exhibits typical swi/snf phenotypes, including gr\nowth defects on media containing galactose, glycerol, or suc\nrose as sole carbon sources. ARP7 is required for expression\n of an HO-lacZ fusion gene and for full transcriptional enha\nncement by the GAL4 activator\n mDSK2:Required with RAD23 for duplication of the spindle pole body\n,ubiquitin-like protein,Null mutant is viable\n mMET10:subunit of assimilatory sulfite reductase,assimilatory sulfi\nte reductase subunit,Null mutant is viable, and is a methion\nine auxotroph\n mCDC19:Required for START A in the cell cycle and sporulation,pyruv\nate kinase,Null mutant is inviable. cdc19 mutants are pyruva\nte kinase deficient and show cell division cycle blocked at \n36 degrees C\n mSOD2:Manganese-containing superoxide dismutase,Mn-containing supe\nroxide dismutase,Null mutant is viable; growth is impaired b\ny oxygen; SOD2 is required for sporulation\n mMAS6:23 kDa mitochondrial inner membrane protein,23 kDa mitochond\nrial inner membrane protein,Null mutant is inviable; conditi\nonal mutants accumulate mitochondrial precursor proteins at \nrestrictive temperature\n Cond273:yor078w\n Cond287:2-deoxy-D-glucose\n mYDR411C:Unknown ,, Unknown\n mAUT10:Needed for pre-Meiotic Replication,,Null mutant is viable; a\nrrests with 2C DNA content after shift to sporulation medium\n.\n mOXA1:Mediates the export of proteins from the mitchondrial matrix\n to the intermembrane space. ,,Null mutant is viable but is \nrespiratory-deficient and lacks cytochrome oxidase activity;\n oxa1 mutant can be complemented by human OXA1; multicopy OX\nA1 suppresses afg3 and rca1 mutants\n mPAB1:Poly(A) binding protein, cytoplasmic and nuclear,poly(A) bin\nding protein,Null mutant is inviable.\n mYOR084W:Unknown ,, Unknown\n mREX2:RNA exonuclease,RNA exonuclease,Null mutant is viable and sh\nows cold-sensitive respiratory defect\n mUGP1:Uridinephosphoglucose pyrophosphorylase,uridinephosphoglucos\ne pyrophosphorylase,Null mutant is inviable, probably due to\n inability to properly form the cell wall\n mMSL5:branchpoint bridging protein -- component of the splicing co\nmmitment complex,,\n mWHI4:whi (Wee) mutants give small cell size,RNA binding protein (\nputative) , WHI3 homolog,Null mutant increases severity of t\nhe Whi phenotype of whi3.\n mYGR210C:Unknown ,, Unknown\n Cond139:rpl8a\n Cond278:CDC42(tetpromoter)\n mVRP1:Involved in cytoskeletal organization and cellular growth,pr\noline-rich protein verprolin,Null mutant is viable but is bo\nth temperature and pH sensitive and cannot grow on minimal m\nedium. Null mutant also exhibits depolarization of the actin\n cytoskeleton.\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPMT2:Transfers mannosyl residues from dolichyl phosphate-D-mannos\ne to seryl and threonyl residues in proteins; acts in comple\nx with Pmt1p,dolichyl phosphate-D-mannose:protein O-D-mannos\nyltransferase,Null mutants are viable but show diminished in\n vitro and in vivo O-mannosylation activity; pmt1 pmt2 doubl\ne mutant shows severe growth defect but has residual O-manno\nsylation activity; pmt2 pmt3 pmt4 triple mutant is inviable\n mYIL041W:Unknown ,, Unknown\n mSOL2:multicopy suppressor of los1-1,,Null mutant is viable\n mPMI40:catalyzes the interconversion of fructose-6-P and mannose-6-\nP,mannose-6-phosphate isomerase,Null mutant requires D-manno\nse for growth; temperature-sensitive mutant, in the absence \nof exogenous D-mannose, is unable to synthesize GDP-mannose \nand dolichol-phosphate-mannose and is unable to secrete some\n cell wall-associated proteins at the restrictive temperatur\ne\n Cond134:rpl12a\n Cond256:ymr141c\n mGDH1:NADP-specific glutamate dehydrogenase,NADP-specific glutamat\ne dehydrogenase,Null mutant is viable\n mYHR218W:Unknown ,, Unknown\n Cond62:fpr1\n mDPM1:dolichol phosphate mannose synthase,dolichol phosphate manno\nse synthase,Null mutant is inviable\n mADE3:Required for the biosynthesis of purines, thymidylate, methi\nonine, histidine, pantothenic acid and formylmethionyl-tRNA,\nC1-tetrahydrofolate synthase,Null mutant is viable, adenine \nauxotroph, histidine auxotroph\n mAHP1:alkyl hydroperoxide reductase,alkyl hydroperoxide reductase,\nhypersensitive to tert-butyl hydroperoxide\n mACH1:Mannose-containing glycoprotein which binds concanavalin A,a\ncetyl CoA hydrolase,\n mPDI1:protein disulfide isomerase,protein disulfide isomerase,Null\n mutant is inviable\n mPIB2:Phosphatidylinositol 3-phosphate binding,,\n mNCP1:NADP-cytochrome P450 reductase,NADP-cytochrome P450 reductas\ne,Null mutant is viable\n mSED1:putative cell surface glycoprotein,cell surface glycoprotein\n (putative),Null mutant is viable; during stationary phase, \nnull mutants exhibit increased sensitivity to Zymolyase.\n mFSH2:Unknown ,, Unknown\n Cond283:KAR2(tetpromoter)\n mTPS1:Probable regulator of glucose influx into the cell & into gl\nycolytic pathway, indirectly regulating glucose-induced sign\nalling (activation & inactivation) & initial step(s) of gluc\nose metabolism. Homologue of E. coli otsA protein,trehalose-\n6-phosphate synthase/phosphatase complex 56 kDa synthase sub\nunit,null is viable, but does not grow on glucose and/or fru\nctose,and shows lack of trehalose\n mRVS167:Involved in endocytosis,cytoskeletal protein (putative),Null\n mutant is viable but exhibits reduced viability upon starva\ntion\n mGDA1:converts nucleoside diphosphates to nucleoside monophosphate\ns to recycle nucleosides and promote transport of additional\n nucleotide sugars into golgi,guanosine diphosphatase of Gol\ngi membrane,Null mutant is viable and has partial block in m\nannosylation of proteins and sphingolipids\n mCSR1:chs5 spa2 rescue; isolated as a multicopy suppressor of the \nlethality of chs5 spa2 double mutant at 37 degrees.,,Null mu\ntant is viable\n mKRE1:cell wall beta-glucan assembly,,Null mutant is viable, exhib\nits reduction in cell wall (1--6)-beta-glucan\n mPAC10:Polypeptide 3 of a Yeast Non-native Actin Binding Complex, h\nomolog of a component of the bovine NABC complex,bovine NABC\n complex component homolog , non-native actin binding comple\nx polypeptide 3 , bovine NABC complex component homolog , no\nn-native actin binding complex polypeptide 3 , bovine NABC c\nomplex component homolog , non-native actin binding complex \npolypeptide 3,Null mutant is viable, benomyl sensitive, cold\n sensitive, microtubules disassemble at 14 degrees celsius, \npac10 mutants exhibit synthetic lethality with tub4-1, cin8,\n cin1, pac2 and rbl2 mutants\n Cond103:msu1\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mWTM1:WD repeat containing transcriptional modulator 1,transcripti\nonal modulator,Null mutant is viable\n mMAM3:Product of gene unknown,,\n mCAR2:ornithine aminotransferase,ornithine aminotransferase,Catabo\nlism of arginine defective\n mGPD1:glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehy\ndrogenase,lethal under conditions of osmotic stress, unable \nto grow on glycerol\n mYRF1-4:Y'-helicase protein 1,Y'-helicase protein 1,\n mRPP0:Homology to rat P0, human P0, and E. coli L10e,ribosomal pro\ntein P0 (A0) (L10E),Null mutant is inviable\n mCUE5:Unknown ,, Unknown\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYRF1-7:Y'-helicase protein 1,Y'-helicase protein 1,\n mDAT1:datin, an oligo(dA).oligo(dT)-binding protein,datin , oligo(\ndA).oligo(dT)-binding protein,Null mutant is viable, but phe\nnotypically distinguishable\n mDEP1:Regulator of phospholipid metabolism,,Null mutant is viable\n mPTA1:pre-tRNA processing,,Null mutant is inviable; temperature-se\nnsitive mutant shows defects in pre-tRNA processing\n mARC1:associated with tRNA and amino acyl-tRNA synthetases; has af\nfinity for quadruplex nucleic acids,,Null mutant is viable, \nleads to slow growth and reduced MetRS activity; arc1- mutan\nts are synthetic lethals and are complemented by the genes f\nor methionyl-tRNA and glutamyl-tRNA synthetase.\n mYOX1:Homeodomain protein that binds leu-tRNA gene,homeobox-domain\n containing protein,Null mutant is viable\n mPIR3:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) pi\nr3 triple mutant is slow-growing on agar slab and sensitive \nto heat shock\n mCYC8 mTUP1 mABP1 mRVS167 mYHR199C mSRV2 mPMI40 mTRP5 mLAS17 mVRP1 mTIM44 mMAS6 mESS1 mCAR2 mAHP1 mRPP0 mGSP1 mGSP2
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Computational Genomics Lab, Tel-Aviv uniresity