Module number 818




Database revision : gnsdb28.10
Date : Tue Feb 25 17:04:50 2003
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mYER130C:Unknown ,, Unknown\n mHSP104:involved in thermal and ethanol tolerance, inheritance of [P\nSI+], and reactivation of mRNA splicing after heat shock,hea\nt shock protein 104,Null mutant is viable and defective in i\nnduced thermotolerance\n mYOL163W:Unknown ,, Unknown\n mSRT1:cis-prenyltransferase homologue,cis-prenyltransferase,Null m\nutant is viable, grows at all temperatures tested and is not\n hygromycin B sensitive; srt1 rer2 double disruption mutants\n are inviable; overexpression of SRT1 suppresses the tempera\nture sensitive and slow growth phenotypes of rer2 mutants\n mMSN4:multicopy suppressor of snf1 mutation,zinc finger protein,Nu\nll mutant is viable; msn2 msn4 double deletion mutants exhib\nit higher sensitivity to different stresses, including carbo\nn source starvation, heat shock and severe osmotic and oxida\ntive stresses\n mERR2:enolase-related subtelomeric sequence (ERR1 and ERR2 code fo\nr identical proteins),,\n mYHR125W:Unknown ,, Unknown\n mUBP11:Ubiquitin-specific protease,ubiquitin-specific protease,viab\nle\n mTIR4:Hypothetical ORF,cell wall mannoprotein,inviable under anaer\nobic conditions\n mYBR230C:Unknown ,, Unknown\n mFYV6:Function required for Yeast Viability on toxin exposure,,Nul\nl mutant is K1 killer toxin hypersensitive\n mPDC6:Third, minor isozyme of pyruvate decarboxylase,pyruvate deca\nrboxylase isozyme,Null mutant is viable and shows reduced py\nruvate decarboxylase activity only in cells grown in ethanol\n mFRE5:similar to FRE2,,\n mYDR340W:Unknown ,, Unknown\n mYOR029W:Unknown ,, Unknown\n mPST1:Protoplasts-secreted,the gene product has been detected amon\ng the proteins secreted by regenerating protoplasts,Viable\n mYJL037W:Unknown ,, Unknown\n mYLR041W:Unknown ,, Unknown\n mYDL222C:Unknown ,, Unknown\n mABM1:aberrant microtubules,,\n mSSP120:secretory protein,,Null mutant is viable\n mJIP3:Unknown ,, Unknown\n mYLR194C:Unknown ,, Unknown\n mYGR052W:Unknown ,, Unknown\n mKSS1:Recovery from alpha factor arrest,MAP kinase , involved in p\nheromone signal transduction,\n mYNR014W:Unknown ,, Unknown\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mYHR097C:Unknown ,, Unknown\n mHOR2:RHR2 (GPP1) encodes another DL-glycerol-3-phosphatase,DL-gly\ncerol-3-phosphatase,\n mRNP1:ribonucleoprotein 1,RNA binding protein (putative),Null muta\nnt is viable\n mSUT1:Involved in sterol uptake,,Null mutant is viable\n mHOR7:hyperosmolarity-responsive gene,,\n mDDR48:DNA damage inducible; implicated in the production or recove\nry of mutations,contains >35 repeats of the amino acid seque\nnce NNNDSYGS , flocculent specific protein,Null mutant is vi\nable, displays reduced spontaneous mutation rate\n mPAM1:multicopy suppressor of protein phosphatase 2A,,Multicopy PA\nM1 suppresses loss of protein phosphatase 2A (PP2A, encoded \nby PPH21, PPH21, and PPH3); overexpression of PAM1 inhibits \ngrowth and causes a filamentous phenotype\n mYKR041W:Unknown ,, Unknown\n mWSC2:cell wall integrity and stress response component 2,contains\n novel cysteine motif , integral membrane protein (putative)\n , similar to SLG1 (WSC1), WSC3 and WSC4,Null mutant is viab\nle and shows no phenotypes; slg1 (wsc1)-null wsc2-null doubl\ne mutant shows a lysis defect on YPD at room temperature and\n heat shock sensitivity; overexpression of WSC genes suppres\nses heat shock sensitivity of hyperactivated ras mutant; hea\nt shock sensitivity of wsc mutant strain is suppressed by de\nletion of ras2\n mSGA1:intracellular sporulation-specific glucoamylase involved in \nglycogen degradation. Induced during starvation of a/a late \nin sporulation, but dispensable for sporulation,glucoamylase\n,suppression of growth arrest of cdc25\n mYMR181C:Unknown ,, Unknown\n Cond65:fus3(haploid)\n mGAT2:Product of gene unknown,,\n mYMR007W:Unknown ,, Unknown\n mPMP2:May regulate plasma membrane H(+)-ATPase; nearly identical t\no PMP1,proteolipid associated with plasma membrane H(+)-ATPa\nse (Pma1p),Null mutant is viable; pmp1 pmp2 double mutant di\nsplays lower Vmax for the plasma membrane H(+)-ATPase (Pma1p\n)\n mSTP3:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n mSTP4:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n mYLR413W:Unknown ,, Unknown\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n mYBL054W:Unknown ,, Unknown\n mMNN10:Required for mannan synthesis and for polarized growth and b\nud emergence,galactosyltransferase,Null mutant is viable, is\n larger than wild-type cells, is deficient in bud emergence,\n and depends upon an intact morphogenesis checkpoint control\n to survive\n mYCR022C:Unknown ,, Unknown\n mYOL166C:Unknown ,, Unknown\n mYGR250C:Unknown ,, Unknown\n mYPL014W:Unknown ,, Unknown\n mYOL101C:Unknown ,, Unknown\n mSKT5:protoplast regeneration and killer toxin resistance gene, ma\ny be a post-translational regulator of chitin synthase III a\nctivity, interacts with Chs3p,,Null mutant is viable, resist\nant to Calcofluor white, exhibits a reduction in cell wall c\nhitin and chitin synthase III activity\n mAFR1:coordinates regulation of alpha-factor receptor signalling a\nnd induction of morphogenesis during conjugation,cytoskeleta\nl protein , similar to arrestins,defect in alpha-factor-stim\nulated morphogenesis\n mPRB1:dispensable for haploidization and sporulation, but needed f\nor full protein degradation during sporulation, and proper s\npore morphology,vacuolar protease B,Null mutant is viable, p\nrotease B deficient, has smaller spores than wild-type embed\nded in a thick matrix\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mDMC1:Disp. for double strand breaks, synaptonemal complexes & gen\ne conversion in return to growth assay. Required for full pa\niring by in situ hybrid. assay, wt time of appearance of syn\naptonemal complexes & reciprocal Rec in growth assay,meiosis\n-specific protein related to RecA and Rad51p. Dmc1p colocali\nzes with Rad51p to discrete subnuclear sites in nuclear spre\nads during mid prophase, briefly colocalizes with Zip1p, and\n then disappears by pachytene,Null mutant is viable. dmc1 ac\ncumulates synaptonemal complex-related dense body, has proce\nssed double strand breaks with longer 3' ends, and either de\nlays prophase or arrests in prophase at the mononucleate sta\nge with duplicated spindle pole bodies and no spindles (depe\nndent upon MEC1-, RAD17-, RAD24, and independent of RAD9). s\npo13 partially suppresses dmc1 meiotic lethality. spo11 and \nrad50 are epistatic to dmc1, suggesting a mid/late recombina\ntion function. mRNA is induced early in meiosis\n mTPO2:Unknown ,, Unknown\n mTPO3:Unknown ,, Unknown\n mNTH1:hydrolyzes trehalose; may be inolved in growth transition fr\nom glucose to glycerol; shows significant sequence similarit\ny to Nth2p,neutral trehalase,Null mutant is viable\n mYLR297W:Unknown ,, Unknown\n mPRY2:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n mYER066C-A:Unknown ,, Unknown\n Cond177:swi6(haploid)\n mYAR064W:Unknown ,, Unknown\n mHRK1:Unknown ,, Unknown\n mKTR2:May be involved in extracellular matrix assembly; involved i\nn N-linked glycosylation of cell wall mannoproteins,mannosyl\ntransferase (putative) , type 2 membrane protein,Null mutant\n is viable, with partial resistance to killer toxin\n mYMR103C:Unknown ,, Unknown\n mMSB1:Protein that may play a role in polarity establishment and b\nud formation,,multicopy suppressor of cdc24 and cdc42 ts mut\nations\n mYDR539W:Unknown ,, Unknown\n mACT1:Involved in cell polarization, endocytosis and other cytoske\nletal functions,actin,Null mutant is inviable; ts mutants sh\now osmosensitivity and defects in actin organization at non-\npermissive temp.; overproduction is lethal\n mYDR249C:Unknown ,, Unknown\n mYGL262W:Unknown ,, Unknown\n mNDJ1:Involved in meiotic chromosome segregation; may stabilize ho\nmologus DNA interactions at telomeres and is required for a \ntelomere activity in distributive segregation; is associated\n with telomeres,,Null allele exhibits errors in meiotic chro\nmosome segregation about 10-fold higher than the wild-type e\nrror rate. Spore viability of homozygous diploids with the n\null allele is approximately 50% of wild-type. Mutant also sh\nows delayed meiotic chromosome synapsis, disrupted crossover\n interference and increased frequency of nonexchange chromos\nomes leading to meiosis I nondisjunction and disruption of d\nistributive disjunction\n mARN2:Siderophore transporter for triacetylfusarinine C,triacetylf\nusarinine C transporter,YHL047c disrupted cells are unable t\no take up and utilize iron from triacetylfusarinine C und fu\nsigen\n mYGR069W:Unknown ,, Unknown\n mYGL118C:Unknown ,, Unknown\n mYLR415C:Unknown ,, Unknown\n mYDR220C:Unknown ,, Unknown\n mRGA1:putative GTPase-activating protein for the polarity-establis\nhment protein Cdc42p or Rho1p; activates the pheromone-respo\nnse pathway,rho GTPase activating protein (GAP),Null mutant \nis viable but shows increased signaling in the pheromone pat\nhway; haploid null mutants bud predominantly in a bipolar, r\nather than the normal axial, manner\n mYIR035C:Unknown ,, Unknown\n mYNL319W:Unknown ,, Unknown\n mYPL277C:Unknown ,, Unknown\n mTOS3:Hypothetical ORF,,\n mSKN1:Involved in (1->6)-beta-glucan biosynthesis,highly homologou\ns to Kre6p , type II membrane protein (putative),Null mutant\n is viable; exhibits no alterations in killer sensitivity, g\nrowth, or (1->6)-beta-glucan levels; skn1 kre6 double deleti\non mutants show a dramatic reduction in both (1-->6)-beta-gl\nucan levels and growth rate compared with either single disr\nuptant\n mTYE7:may be involved in glycolytic gene expression,33 kDa , serin\ne-rich protein, is a potential member of the bHLH/leucine-zi\npper protein family,Null mutant is viable; expression of eno\nlase genes is reduced three-fivefold in null mutant; gcr1 ty\ne7 double deletion mutants exhibit additive defects in enola\nse expression. TYE7 was isolated as a dominant suppressor of\n gcr1 mutations\n mYDR533C:Unknown ,, Unknown\n mADR1:Positive transcriptional regulator of ADH2 and peroxisomal p\nrotein genes,positive transcriptional regulator,abolished de\nrepression of ADH2\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n mYPL088W:Unknown ,, Unknown\n mPES4:Suppressor of DNA polymerase epsilon mutation,poly(A) bindin\ng protein , similar to YHR015W,\n mYMR322C:Unknown ,, Unknown\n mYFL030W:Unknown ,, Unknown\n mFIT1:Facilitator of Iron Transport,Cell wall protein involved in \niron uptake,Impaired siderophore-iron uptake, activation of \nthe major iron-dependent transcription factor AFT1.\n mFIT3:Facilitator of Iron Transport,Cell wall protein involved in \niron transport,impaired siderophore iron uptake, activation \nof the major iron-dependent transcription factor, AFT1\n Cond2:ade2(haploid)\n mPGU1:Endo-polygalacturonase,endo-polygalacturonase,Null mutant is\n viable; exhibits clear halo around colonies on polygalactur\nonate medium\n mYBL064C:Unknown ,, Unknown\n mAST1:Protein involved in targeting of plasma membrane [H+]ATPase,\n,multicopy AST1 suppresses pma1 alleles defective for target\ning\n mYDR250C:Unknown ,, Unknown\n mYPL278C:Unknown ,, Unknown\n mYOR338W:Unknown ,, Unknown\n mYER135C:Unknown ,, Unknown\n mYPR157W:Unknown ,, Unknown\n mLSB3:LAs17 Binding protein,,\n mTHI11:thiamine regulated gene, homologous to S. pombe NMT1A. Propo\nsed biosynthetic enzyme involved in pyrimidine biosynth. pat\nhway above the hydroxymethyl-pyrimidine precursor leading to\n the thiamine moiety. Three copies THI5, THI11 & THI12,thiam\nine biosynthetic enzyme,\n mTHI12:thiamine regulated gene, homologous to nmt1a in Schizosaccha\nromyces pombe; putatively involved in pyrimidine biosynthesi\ns,,\n mYGL046W:Unknown ,, Unknown\n mTHI13:Product of gene unknown,,\n mYLR445W:Unknown ,, Unknown\n mYPS1:Gpi-anchored aspartic protease (Yapsin 1),GPI-anchored aspar\ntic protease,Null mutant is viable, defective in expression \nof somatostatin-28; yps1 mkc7 double disruptants are tempera\nture sensitive; yps1 mkc7 kex2 mutants are profoundly temper\nature sensitive and are cold sensitive\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n mYPS3:Gpi-anchored aspartic protease (Yapsin 3),GPI-anchored aspar\ntic protease,Null mutant is viable\n mRHO3:ras homolog--GTP binding protein,GTP-binding protein , ras h\nomolog,severe growth delay and decrease in cell viability\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n mYBR285W:Unknown ,, Unknown\n mKNH1:46% identical at amino acid level to Kre9p; located extracel\nlularly,KRE9 homolog,Null mutant is viable; overexpression s\nuppresses kre9 mutation; knh1 kre9 double mutant is inviable\n mTIP1:cold- and heat-shock induced protein of the Srp1p/Tip1p fami\nly of serine-alanine-rich proteins,cell wall mannoprotein,Nu\nll mutant is viable; exhibits increased sensitivity to calco\nflour white and congo red\n mNDE1:Unknown ,, Unknown\n mYOR186W:Unknown ,, Unknown\n mSPI1:Stationary Phase Induced; strongly expressed during stationa\nry phase, and trancription is dependent on MSN2/MSN4.,,\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mMATALPHA1:transcription factor involved in the regulation of alpha-spe\ncific genes,involved in the regulation of alpha-specific gen\nes , transcription factor , involved in the regulation of al\npha-specific genes , transcription factor,\n mSFH5:Unknown ,, Unknown\n mSTE3:The a factor receptor encoded by the STE3 gene allows yeast \ncells of the Alpha mating type to recognize cells of the a m\nating type,a-factor receptor,The null mutant is viable. Alph\na cells lacking STE3 are sterile, but a cells lacking STE3 c\nan mate.\n mPRM5:pheromone-regulated membrane protein,,\n mPRM7:pheromone-regulated membrane protein,,\n mYDR222W:Unknown ,, Unknown\n mYER158C:Unknown ,, Unknown\n mYMR192W:Unknown ,, Unknown\n mRSN1:overexpression Rescues sro7/sop1 in NaCl,,viable in both hig\nh and low salinity\n mYLR366W:Unknown ,, Unknown\n mYNL190W:Unknown ,, Unknown\n mYHR087W:Unknown ,, Unknown\n mYOL162W:Unknown ,, Unknown\n mRGS2:Regulator of G-protein Signalling for gpa2; belongs to the R\nGS protein family and acts on Gpa2,GTPase activating protein\n (GAP),Null mutant is viable but exhibits high PKA phenotype\ns (low trehalose and glycogen levels, heat sensitivity, low \nexpression of HSP12). Overexpression results in low PKA phen\notypes and suppresses the glucose induced cAMP signal.\n mNCA3:With NCA2, regulates proper expression of subunits 6 (Atp6p)\n and 8 (Atp8p ) of the Fo-F1 ATP synthase,,Null mutant is vi\nable\n mSPO19:sporulation-defective; SPO19 was found as a weak high-copy s\nuppressor of the spo1-1 ts mutation. The gene is specificall\ny induced late in meiosis (Primig et al. (2000) Nat Genet 26\n:415-423),meiosis-specific GPI-protein,Null mutant is viable\n; unable to form spores\n mMEP3:ammonia permease of high capacity and low affinity; shows se\nquence similarity to Mep1p and Mep2p,NH4+ transporter,Null m\nutant is viable. mep1 mep2 mep3 triple mutants cannot grow o\nn media containing less than 5mM NH4+ as the sole nitrogen s\nource\n mPUT1:proline oxidase,proline oxidase,inability to use proline as \na nitrogen source\n mTOS11:Hypothetical ORF,,\n mSIP18:Salt-Induced Protein,,Null mutant is viable.\n mYLR040C:Unknown ,, Unknown\n mYOL047C:Unknown ,, Unknown\n Cond538:fus3D/wtlog10(intensity)\n mPNC1:pyrazinamidase and nicotinamidase,nicotinamidase , pyrazinam\nidase,Null mutant is viable\n mBNA1:biosynthesis of nicotinic acid,3-hydroxyanthranilic acid dio\nxygenase,Null mutant is viable, nicotinic acid auxotroph\n mBNA2:Unknown ,, Unknown\n mYAR068W:Unknown ,, Unknown\n mHXT5:Member of superfamily of monosaccharide transporters,hexose \ntransporter,Null mutant is viable\n mSTF2:ATPase stabilizing factor,ATPase stabilizing factor,\n mYOR296W:Unknown ,, Unknown\n mPHM8:involved in phosphate metabolism,,\n mYGR290W:Unknown ,, Unknown\n mHXT15:High-affinity hexose transporter,hexose transporter,\n mYRO2:Homolog to HSP30 heat shock protein Yro1p,,\n mSRL1:Suppressor of rad53 lethality,,\n mGSC2:Highly similar to FKS1 (GSC1). GSC2 and FKS1 encode redundan\nt catalytic components of 1,3-beta-glucan synthase. Deletion\n of both is lethal,1,3-beta-D-glucan synthase catalytic comp\nonent,Null mutant is viable and shows partially reduced 1,3-\nbeta-glucan synthase activity\n mYKR032W:Unknown ,, Unknown\n mYDR521W:Unknown ,, Unknown\n mPIR3:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) pi\nr3 triple mutant is slow-growing on agar slab and sensitive \nto heat shock\n
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Computational Genomics Lab, Tel-Aviv uniresity