Module number 809




Database revision : gnsdb28.10
Date : Tue Feb 25 17:03:35 2003
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mSTN1:involved in telomere length regulation, function in telomere\n metabolism during late S phase,,Null mutant is inviable\n mCIN4:Protein involved in chromosome segregation and microtubule f\nunction; homologue of human Arl2,GTP-binding protein,Null m\nutant is viable; supersensitivity to benomyl and nocodozole\n mSIP2:Member of a family of proteins, including Sip1p and Gal83p, \nthat interact with Snf1p and Snf4p and are involved in the r\nesponse to glucose starvation,,Null mutant is viable\n mMCM16:Involved in a nonessential role that governs the kinetochore\n-microtubule mediated process of chromosome segregation,,Nul\nl mutant is viable, exhibits increased sensitivity to the an\nitmitotic drugs benomyl and thiabenzadole; exhibits a high r\nate of chromosome III loss without a significant increase in\n recombination frequency, may exhibit altered kinetochore as\nsembly\n mFIL1:Putative mitochondrial ribosome recycling factor,mitochondri\nal ribosome recycling factor (putative),Null mutant is viabl\ne but grows slowly; growth is further impaired by addition o\nf diepoxybutane or mitomycin C to medium. Null mutant also e\nxhibits decreased abundance of mitochondrial proteins.\n mLOT6:LOw Temperature responsive,,\n mYLR404W:Unknown ,, Unknown\n mYDR013W:Unknown ,, Unknown\n Cond711:t2+Vec\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n mDNM1:involved in receptor-mediated endocytosis and mitochondrial \norganization,similar to dynamin GTPase,Null mutant is viable\n, shows mating defects consistent with a delay in receptor-m\nediated endocytosis\n mHNT3:Unknown ,, Unknown\n Cond913:(99i3)_S150-2B_YPD_NormInt\n mNSE1:Unknown ,, Unknown\n mSPO7:dispensable for mitosis, but required for a normal mutation \nrate, required for premeiotic DNA synthesis, recombination, \nmeiosis I, meiosis II, glycogen degradation and spores,,Null\n mutant is viable, sporulation defective\n Cond719:t4-SSD1\n Cond724:t4+SSD1,H44\n mMCM21:Involved in minichromosome maintenance,,Null mutant is viabl\ne but exhibits defects in the stability of minichromosomes. \nMutants also exhibit elevated rates of chromosome loss (but \nnot those of recombination) and are hypersensitive to the an\nti-mitotic drug benomyl.\n mYML014W:Unknown ,, Unknown\n mYAL027W:Unknown ,, Unknown\n mARH1:adrenodoxin oxidoreductase homolog,adrenodoxin oxidoreductas\ne homolog,Null mutant is inviable\n mTAF10:TFIID subunit (TBP-associated factor) with predicted molecul\nar weight of 23 kD.,TFIID subunit,Null mutant is inviable\n Cond713:t4+Vec\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mESA1:contains amino-terminal chromodomains; Essential SAS family \nAcetyltransferase sharing homology with acetyltransferases f\nrom many different organisms,acetyltransferase in the SAS ge\nne family,Null mutant is inviable\n mYLR252W:Unknown ,, Unknown\n mCSE2:Protein required for accurate mitotic chromosome segregation\n,RNA polymerase II mediator subcomplex component,Null mutant\n is viable, accumulates large-budded cells, results in signi\nficant increase in chromosome missegregation, slower growth,\n and defective meiosis\n mPNT1:Involved in targeting of proteins to the mitochondrial inner\n membrane; Pentamidine resistance protein,,Null mutant is vi\nable and shows slightly increased susceptibility to pentamid\nine (an anti-Pneumocystis carinii drug) and related compound\ns; confers resistance to pentamidine when present in high co\npy number\n Cond718:t4+SSD1wt\n mYUH1:ubiquitin hydrolase,ubiquitin hydrolase,\n mYMR155W:Unknown ,, Unknown\n Cond709:t0+Vec\n mYLR456W:Unknown ,, Unknown\n mUBS1:General positive regulator of CDC34; Suppress some cdc34 mut\nations when over-expressed,,Null mutant is viable but exhibi\nts a synthetic phenotype with temperature-sensitive alleles \nof cdc34.\n Cond914:(99i2)_S150-2B_YPGL+G_NormInt\n mFTH1:FTS3 Homolog 1,,none observed\n mMNS1:specific alpha-mannosidase,alpha-mannosidase,Null mutant is \nviable\n mYFR045W:Unknown ,, Unknown\n Cond717:t2-SSD1\n mYGR042W:Unknown ,, Unknown\n mSSU72:functionally related to TFIIB, affects start site selection \nin vivo,,Null mutant is inviable\n mBSD2:metal homeostasis protein; putative membrane protein,,Null m\nutant is viable; suppressor of oxygen toxicity in sod1 mutan\nts, increased sensitivity to copper and cadmium toxicity, el\nevation in copper ion accumulation\n mYFL046W:Unknown ,, Unknown\n mSNZ2:Snooze: stationary phase-induced gene family,,hypersporulati\non\n Cond725:t4-SSD1,M31\n Cond708:t0+SSD1\n mMRPL16:Mitochondrial ribosomal protein MRPL16,ribosomal protein,\n mCUS2:cold sensitive U2 snRNA Supressor,,Null mutant is viable, en\nhances U2 mutations; mutations in this gene suppress the col\nd sensitive phenotype of U2 RNA mutation G53A\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond712:t4+SSD1\n mYLR021W:Unknown ,, Unknown\n mMTF1:Mitochondrial RNA polymerase specificity factor,mitochondria\nl RNA polymerase specificity factor,Null mutant is viable, d\nefective in respiration, and lacks mtDNA.\n mYOL053W:Unknown ,, Unknown\n mYHR192W:Unknown ,, Unknown\n mGLO2:Cytoplasmic glyoxylase-II,glyoxylase-II,Null mutant is viabl\ne but shows increased sensitivity to methylglyoxal\n mYKL123W:Unknown ,, Unknown\n Cond723:t2-SSD1,M31\n mNGL1:DNase/RNase (putative); CCR4 C-terminal homolog, homology to\n drosophila Angel gene,DNase (putative) , RNase (putative),N\null mutant is viable.\n mDPB3:C and C' subunits of DNA polymerase II,DNA polymerase II C a\nnd C' subunits,Null mutant is viable, shows increased sponta\nneous mutation rate\n mSNT309:Synergistic to prp19 (NineTeen) mutation. Essential for mRNA\n splicing.,protein complex component associated with the spl\nicing factor Prp19p,Null mutant is viable, temperature sensi\ntive, exhibits defects in splicing at elevated temperature; \nsnt309 prp19 mutants are synthetically lethal\n Cond714:t0+SSD1wt\n mYMR040W:Unknown ,, Unknown\n Cond715:t0-SSD1\n mRAD57:Required for X-ray damage repair, meiotic recombination, wil\nd-type levels of sporulation and viable spores,RecA homolog \n, interacts with Rad 55p by two-hybrid analysis , similar to\n DMC1, RAD51, and RAD55,Null mutant is viable, radiation sen\nsitive\n mMAI1:Unknown ,, Unknown\n mHSH49:Human SAP Homolog 49. A yeast homolog of a human spliceosome\n associated protein (SAP) called SAP 49.,mammalian splicing \nfactor/U2 snRNP protein homolog,\n mMET1:Methionine metabolism,,Null mutant is viable, and is a methi\nonine auxotroph\n mUFE1:t-SNARE that resides on the endoplasmic reticulum and mediat\nes retrograde traffic from the Golgi complex,t-SNARE (ER),Nu\nll mutant is inviable\n mYJR013W:Unknown ,, Unknown\n mPET100:cytochrome c oxidase-specific assembly factor,cytochrome c o\nxidase-specific assembly factor,Respiration deficient\n Cond710:t2+SSD1\n
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Computational Genomics Lab, Tel-Aviv uniresity