Module number 768




Database revision : gnsdb28.10
Date : Tue Feb 25 17:07:52 2003
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mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n mUFO1:F-box protein,F-box protein,Null mutant is viable and UV sen\nsitive\n mARE2:Acyl-CoA cholesterol acyltransferase (sterol-ester synthetas\ne),acyl-CoA cholesterol acyltransferase (sterol-ester synthe\ntase),Null mutant is viable; greatly reduces in vivo and in \nvitro ergosterol esterification (to 15 - 35 % of wild-type).\n Deletion of both ARE1 and ARE2 completely eliminates in viv\no and in vitro ergosterol esterification\n mSMY1:not believed to act as a kinesin, colocalizes with Myo2p,kin\nesin heavy chain homolog,high copy suppressor of myosin\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYAP1:jun-like transcription factor,jun-like transcription factor,\npleiotropic drug resistance\n Cond878:MNNG\n Cond895:G2MMS\n Cond879:MMC\n mUFD4:Ubiquitin Fusion Degradation,,Null is viable; defective in p\nroteolysis of fusion proteins containing a 'nonremovable' N-\nterminal ubiquitin moiety\n Cond877:MMS\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond875:60min\n Cond886:g-ray\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond892:S\n Cond883:5\n mCTK2:cyclin-related subunit of the kinase complex that phosphoryl\nates the RPO21 CTD (carboxy-terminal domain); also called CT\nDK-I beta subunit,RNA polymerase II C-terminal domain kinase\n beta subunit, similar to cyclin,Null mutant is viable, disp\nlays slow growth and cold sensitive phenotypes in combinatio\nn with ctk1 and ctk3 null mutants\n mNUP159:Located on cytoplasmic side of nuclear pore complex; may be \ninvolved in nuclear import or mRNA export; binds to karyophe\nrin beta and a nuclear transport substrate in vitro,contains\n coiled-coil domain and repeated motifs typical of nucleopor\nins , nuclear pore complex subunit , nucleoporin 159 kDa , c\nontains coiled-coil domain and repeated motifs typical of nu\ncleoporins , nuclear pore complex subunit , nucleoporin 159 \nkDa,Null mutant is inviable; at nonpermissive temperature, a\n temperature-sensitive mutant shows cessation of mRNA export\n without cytoplasmic accumulation of NLS-containing reporter\n protein, while at permissive temperature, the nuclear pore \ncomplexes are clustered; temperature-sensitive allele is syn\nthetically lethal with nup120 and is suppressed by high copy\n GLE1\n mPHO85:involved in phosphate and glycogen metabolism and cell cycle\n progression,cyclin-dependent protein kinase,\n mPAP1:poly(A) polymerase,poly(A) polymerase,lethal\n Cond876:zero2\n Cond890:G1\n mYPL070W:Unknown ,, Unknown\n mCDC46:Member of complex that acts at ARS's to initiate replication\n,,Null mutant is inviable; at nonpermissive temperature cdc4\n6(ts) mutants arrest with a large bud and a single nucleus a\nnd exhibit a high rate of recombination\n Cond872:Zero1\n mYNL158W:Unknown ,, Unknown\n Cond885:20\n Cond715:t0-SSD1\n mPCP1:Unknown ,, Unknown\n Cond891:G1MMS\n mYMR115W:Unknown ,, Unknown\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCOG8:Unknown ,, Unknown\n mNUP85:Protein in nuclear pore complex; may function in nuclear env\nelope integrity; may also be involved in tRNA biogenesis,,Nu\nll mutant is viable but is temperature-sensitive; at nonperm\nissive temperature, null mutant accumulates poly(A)+ RNA and\n has fragmented nucleolus; at permissive temperature, nuclea\nr envelope of null mutant detaches from nucleus\n mYKL215C:Unknown ,, Unknown\n Cond881:4NQO\n Cond897:STATMMS\n mCST6:Chromosome STability; contains an ATF/CREB-like bZIP domain;\n transcriptional activator,basic leucine zipper (bZIP) trans\ncription factor,Overexpression of CSTs induces chromosome lo\nss\n mRPN1:Subunit of 26S Proteasome (PA700 subunit),26S proteasome PA7\n00 subunit,Null mutant is inviable; hrd2-1 mutation slows de\ngradation of Hmg2p. hrd2-1 strains are sensitive to canavani\nne and show a global accumulation of ubiquitin-conjugated pr\noteins, but are not temperature-sensitive\n Cond894:G2\n Cond903:(77i2)_S150-2B_YPGL_NormInt\n mYPR097W:Unknown ,, Unknown\n mVID27:Vacuole import and degradation,,Null mutant is viable but ex\nhibits vacuole degradation of cytosolic proteins\n mPRP4:associated with the U4/U6 snRNP,associates with the U4/U6 sn\nRNP,Null mutant is inviable; other alleles are defective in \nRNA synthesis and unable to grow at 36 degrees C.\n mUGT51:Udp-glycosyltransferase,UDP-glucose:sterol glucosyltransfera\nse,Null mutant is viable and unable to synthesize sterol glu\ncoside\n Cond893:SMMS\n mHUL5:ubiquitin-protein ligase (E3),ubiquitin ligase (E3),Null mut\nant is viable\n mMUD2:Involved in early pre-mRNA splicing,,Null mutant is viable\n mMON1:Product of gene unknown,,null mutant is sensitive to monensi\nn and brefeldin A\n Cond902:(77i1)_HBY4_YPGL_NormInt\n mEBS1:EST1-like bcy1 Suppressor,,\n mPRE2:proteasome subunit,proteasome subunit,Null mutant is inviabl\ne, pre2 mutants exhibit defects in chymotrypsin-like proteol\nysis, stress response and ubiquitin signaled protein degrada\ntion\n Cond884:10\n
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Computational Genomics Lab, Tel-Aviv uniresity