Module number 737




Database revision : gnsdb28.10
Date : Tue Feb 25 17:03:41 2003
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Cond547:cln3-1\n Cond498:wtħ500nMaF,30minlog10(intensity)\n mPOL2:DNA polymerase II,DNA polymerase II,\n Cond494:wtħ5nMaF,30minlog10(intensity)\n mHLR1:LRE1 homolog,,Null mutant is viable.\n mPXA1:Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-b\ninding cassette transporter necessary for transport of long-\nchain fatty acids into peroxisomes,ABC transporter of long-c\nhain fatty acids,Null mutant is viable but cannot grow on me\ndia with oleic acid as sole carbon source\n Cond578:cdc15_130\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mECI1:enoyl-CoA isomerase,d3,d2-Enoyl-CoA Isomerase,Null mutant is\n viable but fails to metabolize unsaturated fatty acids\n Cond500:wtħ50nMaF,15minlog10(intensity)\n mHO:Homothallic switching,homothallic switching endonuclease,Nul\nl mutant is viable and cannot undergo mating type switching\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond504:wtħ50nMaF,90minlog10(intensity)\n mCLB5:role in DNA replication during S phase; additional functiona\nl role in formation of mitotic spindles along with Clb3 and \nClb4,B-type cyclin,Null mutant is viable, but has an extende\nd S phase\n Cond579:cdc15_140\n mRFA1:Required for DNA-damage repair, full levels of gene conversi\non and sporulation,heterotrimeric RPA (RF-A) single-stranded\n DNA binding protein 69 kDa subunit; binds URS1 and CAR1,Nul\nl mutant is inviable; cells lacking RFA1 accumulate as multi\nply budded cells with a single nucleus suggesting a defect i\nn DNA replication; rfa1 repair defects are suppressed by hig\nh copy RAD52\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mYDL211C:Unknown ,, Unknown\n Cond586:cdc15_210\n Cond463:29_deg_growth_ct-1\n mMF(ALPHA)2:alpha mating factor,alpha mating factor,Null mutant is viabl\ne.\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n Cond702:gal7-gal\n Cond509:kss1Dħ50nMaF,30minlog10(intensity)\n Cond562:alpha77\n Cond496:wtħ50nMaF,30minlog10(intensity)\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mPMS1:Required for mismatch repair in mitosis and meiosis, low lev\nels of postmeiotic segregation, and high spore viability, di\nspensable for homeologous recombination,mutL homolog , simil\nar to Mlh1p, associates with Mlh1p, possibly forming a heter\nodimer, Pms1p and Msh1p act in concert to bind to a Msh2p-he\nteroduplex complex containing a G-T mismatch,Null mutant is \nviable; postmeiotic segregation increased\n Cond934:8h\n Cond495:wtħ15.8nMaF,30minlog10(intensity)\n Cond553:alpha14\n mMSH2:Functions with Pms1p and Pms2/Mlh1p in a complex that intera\ncts with Pms3p/Msh6p to repair single-base and insertion-del\netion mispairs, or Msh3p to repair insertion-deletion mispai\nrs.,mutS homolog,Null mutant is viable. Haploid mutants disp\nlay an 85-fold increased rate of spontaneous mutation to can\navanine resistance. Mutants are defective for gene conversio\nn polarity gradients and high spore viability.\n mMSH6:Required for mismatch repair in mitosis & meiosis, low level\ns of postmeiotic segregation & high spore viability; forms c\nomplex with Msh2p to repair both single-base & insertion-del\netion mispairs; redundant with Msh3p in repair of in-dels,hu\nman GTBP protein homolog,Null mutant is viable, msh3 msh6 do\nuble deletion mutants exhibit microsatellite instability and\n mutability similar to that in a msh2 mutant\n Cond580:cdc15_150\n Cond506:bni1Dħ50nMaF,60minlog10(intensity)\n Cond581:cdc15_160\n Cond502:wtħ50nMaF,45minlog10(intensity)\n Cond558:alpha49\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond692:gal6+gal\n mSEC16:multidomain vesicle coat protein that interacts with Sec23p,\nvesicle coat component,Null mutant is inviable; temperature-\nsensitive mutants accumulate Kar2 (BiP) and PDI at the nonpe\nrmissive temperature.\n Cond734: gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mCDA2:Required for proper formation of the ascospore wall,chitin d\neacetylase,Null mutant is viable, mutant spores disrupted fo\nr both cda1 and cda2 fail to emit natural fluorescence and a\nre sensitive to hydrolyrtic enzymes, ether, and heat shock\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond501:wt+/-50nMaF,30minlog10(intensity)\n Cond582:cdc15_170\n Cond686:wt+gal\n Cond554:alpha21\n Cond706:gal2gal80-gal\n Cond575:cdc15_100\n Cond571:cdc15_50\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPHO89:Probable Na+/Pi symporter,Na+/Pi symporter (putative),Null m\nutant is viable\n mDUN1:DNA damage response,protein kinase,Null mutant is viable, de\nfective in DNA damage repair and in DNA damage-resposive ind\nuction of RNR genes, and sensitive to DNA damaging agents\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRIF1:RAP1-interacting factor, involved in establishment of repres\nsed chromatin,RAP1-interacting factor,defective in telomeric\n silencing and telomere length regulation\n Cond497:wtħ158nMaF,30minlog10(intensity)\n mHSL1:Negative regulator of swe1 kinase (which regulates cdc28),pr\notein kinase (putative) , similar to S. pombe cdr1/nim1,Nul\nl mutant is viable; synthetically lethal with histone H3 mut\nations; G2 delay\n Cond576:cdc15_110\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond511:GAL-STE4,3hrs.gallog10(intensity)\n Cond503:wtħ50nMaF,60minlog10(intensity)\n mRNR3:Ribonucleotide reductase (ribonucleoside-diphosphate reducta\nse) large subunit,ribonucleotide reductase, large (R1) subun\nit,Null mutant is viable\n Cond559:alpha56\n mESC8:Unknown ,, Unknown\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond567:alpha112\n mMSH6 mPMS1 mMSH2
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Computational Genomics Lab, Tel-Aviv uniresity