Module number 650




Database revision : gnsdb28.10
Date : Tue Feb 25 17:02:24 2003
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mHST4:Homolog of SIR2,,hst3 hst4 double mutant has defects in telo\nmeric silencing, cell cycle progression, radiation resistanc\ne, and genomic stability\n mYLR012C:Unknown ,, Unknown\n mHAT1:histone acetyltransferase,histone acetyltransferase,Null mut\nant is viable\n mYDR438W:Unknown ,, Unknown\n mYDR031W:Unknown ,, Unknown\n mALD4:Glucose repressed. Utilizes NADP+ or NAD+ as a coenzyme equa\nlly well. (sold by SIGMA under the catalogue number A5550, a\nccording to A. Blomberg).,aldehyde dehydrogenase,\n Cond679:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison\n mARO3:DAHP synthase; a.k.a. phospho-2-dehydro-3-deoxyheptonate ald\nolase, phenylalanine-inhibited; phospho-2-keto-3-deoxyhepton\nate aldolase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-\ndeoxy-D-arabine-heptulosonate-7-phosphate synthase,DAHP synt\nhase; a.k.a. phospho-2-dehydro-3-deoxyheptonate aldolase, ph\nenylalanine-inhibited; phospho-2-keto-3-deoxyheptonate aldol\nase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-deoxy-D-a\nrabine-heptulosonate-7-phosphate synthase,null mutant is via\nble\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mACH1:Mannose-containing glycoprotein which binds concanavalin A,a\ncetyl CoA hydrolase,\n mSPO11:Dispensable for mitosis, premeiotic DNA synthesis, spindle p\nole body duplication, meiosis I, meiosis II & spores. Requir\ned for chromosome pairing seen by in situ hybridization, dou\nble strand breaks, synaptonemal complexes.,early meiosis-spe\ncific recombination protein,Null mutant is viable, sporulati\non defective; spo11 executes meiosis I early, is rescued by \nspo13 and is epistatic to rad52 spo13; and is classified as \nan early recombination function. It fails to form any recomb\nination intermediates and is partially suppressed by X-irrad\niation (by induced double strand breaks), in meiosis. The sp\no11-1 temperature sensitive mutant is double strand break-, \nrecombination-, and exhibits tripartite synaptonemal complex\n structures at a restrictive temperature, suggesting synapto\nnemal complex formation may be partially independent of doub\nle strand breaks and recombination. mRNA is induced early in\n meiosis; meiosis-specific regulation is dependent on a URS1\n element within the coding region.\n Cond729:sin3\n mSPO13:Spo13 acts as a transcriptional activator in a one-hybrid as\nsay (see Henninger et al (1996) SPO13 and control of meiotic\n chromosome segregation in Saccharomyces cerevisiae),,Null m\nutant is viable, defective for sporulation; loss of function\n results in a single division during meiosis (with some chro\nmosomes segregating reductionally or aberrantly depending on\n strain background), occurring slightly earlier or at the ti\nme of wild type meiosis I, and dyad asci containing two dipl\noid spores. spo13 rescues the meiotic lethality of early Rec\n- mutants and Rec+ haploids. Gain of function causes a CDC28\n-dependent arrest at M-phase in mitosis and a delay in MI nu\ncleardivision.\n mARO9:aromatic amino acid aminotransferase II,aromatic amino acid \naminotransferase II,Null mutant is viable\n Cond731:hda1 \n mYDR018C:Unknown ,, Unknown\n mZIP1:Synaptonemal complex protein, component of the central eleme\nnt,,Null mutant is viable and shows defects in meiosis\n mDPB2:DNA polymerase epsilon, subunit B,DNA polymerase epsilon sub\nunit B,Null mutant is inviable; conditional mutant shows def\nects in DNA replication\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYLR161W:Unknown ,, Unknown\n mYMR289W:Unknown ,, Unknown\n mHOP1:Meiosis-specific protein involved in homologous chromosome s\nynapsis and chiasmata formation,DNA binding protein,decrease\nd levels of meiotic crossing over and intragenic recombinati\non between markers on homologous chromosomes\n Cond727:rpd3\n mYGK3:Unknown ,, Unknown\n mYDL157C:Unknown ,, Unknown\n Chromo.chromo:Genomewide studies of histone deacetylase function in yeast.\n Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13.\n mTID3:Product of gene unknown,,Null mutant is inviable\n mYDL110C:Unknown ,, Unknown\n mYDL124W:Unknown ,, Unknown\n mYDR111C:Unknown ,, Unknown\n mCAF40:Hypothetical ORF,,Null mutant is viable\n mASM4:Suppressor of thermosensitive mutations in the DNA polymeras\ne delta gene,nuclear pore complex subunit,Null mutant is via\nble in some strain backgrounds (including CEN.PK2); however,\n in the FY1679 genetic background, it is inviable.\n mYMR191W:Unknown ,, Unknown\n mYDR008C:Unknown ,, Unknown\n mDSK2:Required with RAD23 for duplication of the spindle pole body\n,ubiquitin-like protein,Null mutant is viable\n mYDR521W:Unknown ,, Unknown\n mADH3:alcohol dehydrogenase isoenzyme III,alcohol dehydrogenase is\noenzyme III,Null mutant is viable\n
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Computational Genomics Lab, Tel-Aviv uniresity