Module number 638




Database revision : gnsdb28.10
Date : Tue Feb 25 17:45:55 2003
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mSSM4:Protein involved in mRNA turnover,integral membrane protein,\nNull mutant is viable, suppresses temperature sensitive rna1\n4 mutations; ssm4 sls1 mutants are inviable\n mKRE25:Killer toxin REsistant,,Null mutant is K1 killer toxin resis\ntent\n mVTH2:vps ten homolog,potential membrane glycoprotein , strong sim\nilarity to Vth1 and Pep1,Null mutant is viable; overexpressi\non of the nearly identical Vth1 partially suppresses the sor\nting defect of a pep1 null mutant strain.\n Cond448:galactose_vs._reference_pool_car-1\n Cond301:Heat_Shock_10_minutes_hs-1\n mYBL111C:Unknown ,, Unknown\n mBUD3:cell cycle regulated protein required for axial bud formatio\nn; co-assembles with Bud4p at bud sites,,Null mutant is viab\nle; bipolar budding pattern in all cell types\n Cond751: mEGT2:cell-cycle regulation protein, may be involved in the correc\nt timing of cell separation after cytokinesis,,\n mPDR3:Zinc-finger transcription factor related to Pdr1p,,pleiotrop\nic drug resistance\n mPDR5:multidrug resistance transporter,multidrug resistance transp\norter,pleiotropic drug resistance\n mCLB2:Involved in mitotic induction,B-type cyclin,Null mutant is v\niable (lethal in combination with clb1 mutation)\n mUTR2:Product of gene unknown,,\n mNEW1:This gene encodes a protein with an Q/N-rich amino terminal \ndomain that acts as a prion, termed [NU]+.,,Null mutant is v\niable\n mDHH1:Putative RNA helicase of DEAD box family, required for Rap1p\n localization to telomeres,,Null mutant is viable, but grows\n poorly\n mYCL046W:Unknown ,, Unknown\n mYLR462W:Unknown ,, Unknown\n mRPA135:135 kDa subunit of RNA polymerase I,RNA polymerase I subunit\n,suppression of rpb1, cold sensitive\n mPET111:translational activator of cytochrome c oxidase subunit II,t\nranslational activator of cytochrome C oxidase subunit II,Nu\nll mutant is viable, petite, unable to grow on non-fermentab\nle carbon sources\n mNUP157:yeast nuclear pore complex component,nuclear pore complex su\nbunit,Null mutant is viable; synthetically lethal with nup17\n0 and nup188\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYGR190C:Unknown ,, Unknown\n mVAS1:mitochondrial and cytoplasmic valyl-tRNA synthetase,valine-t\nRNA ligase,Null mutant is inviable\n mCDC47:Essential for initiation of DNA replication,,Null mutant is \ninviable, at nonpermissive temperature cdc47(ts) mutants arr\nest with a large bud and a single nucleus\n mKIN2:Serine/threonine protein kinase,,\n mYBR238C:Unknown ,, Unknown\n mYGL239C:Unknown ,, Unknown\n mYNL087W:Unknown ,, Unknown\n mYLR463C:Unknown ,, Unknown\n Cond748: mATF2:Alcohol acetyltransferase,alcohol acetyltransferase,\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n Cond393:aa_starv_4_h\n mCSE1:Protein required for accurate mitotic chromosome segregation\n,,Null mutant is inviable\n mPEP1:vacuolar protein sorting receptor for carboxypeptidase Y and\n proteinase A; related to Sortilin,Type I integral membrane \nprotein 166aa cytoplasmic tail, 1300 aa lumenal domain,prote\ninase deficient\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mKAP95:protein involved in nuclear import; required for the docking\n of import substrate to the nuclear membrane/pore; identifie\nd as an rna1-1 synthetic lethal,karyopherin beta (importin 9\n0) homolog (95 kDa),essential, ts mutant shows nuclear impor\nt defect\n mSLA1:Involved in assembly of cortical actin cytoskeleton, contain\ns 3 SH3 domains, interacts with Bee1p,cytoskeletal protein b\ninding protein,Null mutant is viable, temperature sensitive.\n sla1 mutants are synthetically lethal in combination with a\nnc1 and abp1 mutants\n Cond753: mOPT1:Oligopeptide transporter; Opt1p transports tetra- and pentap\neptides, including the endogenous opioid pentapeptide leucin\ne enkephalin.,glutathione transporter , peptide transporter,\nNull mutant is viable, exhibits loss of plasma membrane glut\nathione transport\n mYBR074W:Unknown ,, Unknown\n mYOR1:multispecific organic anion transporter important for tolera\nnce against toxic environmental organic anions,ABC transport\ner,Null mutant is viable but exhibits a slight growth defect\n; null mutant is hypersensitive to reveromycin A and fumonis\nin B1. Overexpression increases resistance to fumonisin B, s\nphingosine, and reveromycin A.\n mYFL064C:Unknown ,, Unknown\n mYER189W:Unknown ,, Unknown\n Cond752: mYJR026W:Unknown ,, Unknown\n Cond672:DES459_(mec1)_-_mock_irradiation_-_60_min\n mPHO5:Acid phosphatase, repressible,acid phosphatase,phosphatase d\neficient\n mNAM7:Involved in mRNA degradation,helicase (putative),Null mutant\n is viable, exhibits impairment in respiratory growth that i\ns exacerbated by low temperatures; exhibits stabilization of\n nonsense-containing mRNAs which leads to a nonsense suppres\nsion phenotype\n Cond466:steady_state_17_dec_C_ct-2\n mRAX2:Involved in the maintenance of bipolar pattern,,Null mutant \nis defective in bipolar pattern\n mJSN1:benomyl dependent tubulin mutant,,Overexpression suppresses \nsome tub2 alleles and confers greater benomyl sensitivity\n Cond749: Cond449:glucose_vs._reference_pool_car-1\n mRET1:second-largest subunit of RNA polymerase III,,Null mutant is\n inviable\n mYPR096C:Unknown ,, Unknown\n mFKS1:Required for viability of calcineurin mutants,1,3-beta-D-glu\ncan synthase,Null mutant is viable, demonstrates slow growth\n, hypersensitivity to FK506 and cyclosporin A, sensitivity t\no echinocandin and a reduction in 1,3-beta-D-glucan synthase\n activity in vitro; sensitivity to papulacandin B\n mGCN1:translational activator of GCN4 through activation of GCN2 i\nn response to starvation,translational activator of GCN4 thr\nough activation of GCN2 in response to starvation,Null mutan\nt is viable and sensitive to 3-aminotriazole\n Cond452:sucrose_vs._reference_pool_car-1\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n mRRP5:Ribosomal RNA Processing,required for processing of pre-rRNA\n,Overexpression of RRP5 facilitates mitochondrial import of \nhydrophobic proteins; overexpression of an RRP5 mutant compl\nements the rRNA processing defect of the null alllele, but d\noes not facilitate mitochondrial import\n mCDC54:essential for initiation of DNA replication; homolog of S. p\nombe CDC21,,Null mutant is inviable; at nonpermissive temper\nature cdc54(ts) mutants arrest with a large bud and a single\n nucleus and exhibit a high rate of recombination\n mYOR066W:Unknown ,, Unknown\n mYEL076C-A:Unknown ,, Unknown\n mRPG1:Exhibits significant sequence similarity with a subunit of t\nhe mammalian translation initiation factor 3,translation ini\ntiation factor eIF3 subunit,Null mutant is inviable; tempera\nture sensitive mutant arrests in G1 phase\n Cond450:mannose_vs._reference_pool__car-1\n Cond451:raffinose_vs._reference_pool_car-1\n mSPT5:transcription factor,transcription factor,Null mutant is inv\niable\n mPMA1:major regulator of cytoplasmic pH,plasma membrane H+-ATPase,\ninviable; pma1 mutants are resistant to Dio-9, ethidium brom\nide and guanidine derivatives\n mMET18:Involved in nucleotide excision repair and regulation of TFI\nIH,TFIIH regulator,Null mutant is viable but is temperature-\nsensitive, defective in ability to remove UV_induced dimers \nfrom nuclear DNA, and shows enhanced UV-induced mutations; e\nxtracts from mutant exhibit thermolabile defect in RNA Pol I\nI transcription; methionine auxotroph\n mYOL046C:Unknown ,, Unknown\n mYLR413W:Unknown ,, Unknown\n mYGR242W:Unknown ,, Unknown\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mVIP1:Homologous to S. pombe asp1+,,\n mYEL075C:Unknown ,, Unknown\n mNAN1:Net1-Associated Nucleolar protein 1,,Null mutant is inviable\n mNUP1:nuclear pore complex protein,nuclear pore complex subunit,Da\nvis and Fink (Cell 61:965-978) report that a NUP1 deletion i\ns inviable, whereas Schlaich and Hurt (Eur J Cell Biol 127:3\n19-332) report that NUP1 deletion is viable.\n mSTE6:ABC transporter, glycoprotein, component of a-factor secreto\nry pathway,ABC transporter , glycoprotein,sterility of MATa \ncells, failure to export a-factor\n mYPR089W:Unknown ,, Unknown\n mYHR218W:Unknown ,, Unknown\n mYPR202W:Unknown ,, Unknown\n mYDL096C:Unknown ,, Unknown\n mUTP10:Unknown ,, Unknown\n mKAP104:Karyopherin of 103,613 Da. Similar to yeast karyopherin beta\n (Kap95p; YLR347c),karyopherin beta 2,Null mutant is viable \nat 23 degrees C, but fails to germinate and dies at 30 C, sh\nows severe nuclear envelope defects\n mPHO81:Positive regulatory protein of phosphate pathway,,phosphatas\ne deficient\n mUBA1:ubiquitin activating enzyme, similar to Uba2p,ubiquitin acti\nvating enzyme, similar to Uba2p,Null mutant is inviable\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCRM1:Involved in nuclear export,chromosome region maintenance pro\ntein,Null mutant is inviable; a temperature sensitive crm1 a\nllele shows defects in nuclear protein export\n Cond746: mSMC4:Stable Maintenance of Chromosomes,SMC chromosomal ATPase fam\nily member,Null mutant is inviable\n mADE6:5'-phosphoribosylformyl glycinamidine synthetase,5'-phosphor\nibosylformyl glycinamidine synthetase,Adenine requiring\n mYLR464W:Unknown ,, Unknown\n mAAP1':arginine/alanine aminopeptidase,arginine/alanine aminopeptid\nase,null mutant is viable, decrease in glycogen accumulation\n mTAF2:TATA binding protein-associated factor (TAF),TATA binding pr\notein-associated factor,Null mutant is inviable\n mCDC60:cytosolic leucyl tRNA synthetase,leucine--tRNA ligase,arrest\n at START point of cell cycle upon shift to restrictive temp\nerature\n mLOS1:Nuclear pore protein involved in pre-tRNA splicing,,Null mut\nant is viable but is defective in pre-tRNA splicing at 37 de\ngrees\n Cond682:MHY1_(crt1)_vs_CRY1_(wild_type)\n mYHL049C:Unknown ,, Unknown\n mNUP100:Participates in nucleocytoplasmic transport; member of GLFG-\ncontaining family of nucleoporins,nuclear pore complex subun\nit,Null mutant is viable with no obvious phenotypes; synthet\nically lethal with nup116 and gle2 mutants\n mYLR465C:Unknown ,, Unknown\n mYBL012C:Unknown ,, Unknown\n mPHO11:Acid phosphatase, secreted,acid phosphatase,phosphatase defi\ncient\n mSEC21:non-clathrin coat protein involved in transport between ER a\nnd Golgi,PEST sequence-containing protein , non-clathrin coa\nt protein,Null mutant is inviable\n mPHO12:acid phosphotase, nearly identical to Pho11p,acid phosphatas\ne,\n mYMR259C:Unknown ,, Unknown\n mSEC23:cytoplasmic GTPase-activating protein,GTPase activating prot\nein (GAP),Defective for ER to Golgi transport\n mYBT1:Yeast bile transporter, similar to mammalian bile transporte\nr,,Null mutant is viable\n mDIS3:Possible component of RCC1-Ran pathway,3'-5' exoribonuclease\n complex subunit,Null mutant is inviable\n mHMG1:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is\nozyme,3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduct\nase isozyme,Null mutant is viable, sensitive to compactin, a\n competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 doubl\ne deletion mutants are inviable\n mYPR097W:Unknown ,, Unknown\n mYOR296W:Unknown ,, Unknown\n mRNR1:ribonucleotide reductase,ribonucleotide reductase, large (R1\n) subunit,Null mutant is inviable\n mYEL076C:Unknown ,, Unknown\n mFYV15:Function required for Yeast Viability on toxin exposure,,Nul\nl mutant is viable but a hHeterozygous diploid mutant exhibi\nt haploinsufficiency K1 killer toxin hypersensitivity.\n mPOM152:May be involved in duplication of nuclear pores and nuclear \npore complexes during S-phase,membrane glycoprotein , nuclea\nr pore complex subunit,Null mutant is viable; overproduction\n inhibits cell growth; synthetically lethal with NUP170 and \nNUP188\n mYGR265W:Unknown ,, Unknown\n mPHO90:Low-affinity phosphate transporter,,\n Cond671:DES459_(mec1)_-_mock_irradiation_-_30_min\n mYJL200C:Unknown ,, Unknown\n mUTP22:Unknown ,, Unknown\n mRPO41:mitohcondrial RNA polymerase,mitochondrial RNA polymerase,Nu\nll mutant is viable\n mYJR028W:Unknown ,, Unknown\n mMON2:Product of gene unknown,,null mutant is sensitive to monensi\nn and brefeldin A\n mYOL098C:Unknown ,, Unknown\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mKRE21:Killer toxin REsistant,,Null mutant is K1 killer toxin resis\ntent\n mKAP104 mNUP100 mKAP95 mNUP1 mUBA1 mKIN2
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Computational Genomics Lab, Tel-Aviv uniresity