Module number 3264




Database revision : gnsdb28.10
Date : Tue Feb 25 17:21:34 2003
How to read this figure?


mRPE1:D-ribulose-5-Phosphate 3-epimerase,D-ribulose-5-Phosphate 3-\nepimerase,Null mutants are viable but show no ribulose-5-pho\nsphate epimerase activity, cannot grow on D-xylulose, and ar\ne sensitive to hydrogren peroxide\n mTOS1:Hypothetical ORF,,\n mSET3:,,\n mYPL208W:Unknown ,, Unknown\n mYKL037W:Unknown ,, Unknown\n mGYP1:Gtpase activating protein for Ypt1p,GTPase activating protei\nn (GAP),Null mutant is viable and shows no phenotype\n mCTP1:citrate transport protein,citrate tranporter,Null mutant is \nviable\n mARG3:Sixth step in arginine biosynthesis,ornithine carbamoyltrans\nferase,Arginine requiring\n mYDL072C:Unknown ,, Unknown\n mMSN2:multicopy suppressor of snf1 mutation,zinc finger protein,Nu\nll mutant is viable; msn2 msn4 double deletion mutants exhib\nit higher sensitivity to different stresses, including carbo\nn source starvation, heat shock, and severe osmotic and oxid\native stresses\n mYDR271C:Unknown ,, Unknown\n mYLR171W:Unknown ,, Unknown\n mYIH1:piecemeal microautophagy of the nucleus (PMN),,Null mutant i\ns viable and exhibits no growth defects; derepression of PMN\n in rich medium.\n mYNR042W:Unknown ,, Unknown\n mATX1:antioxidant protein and metal homeostasis factor, protects a\ngainst oxygen toxicity,copper binding homeostasis protein (p\nutative),hypersensitive toward paraquat (a generator of supe\nroxide anion)\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mMRPL33:essential for mitochondrial function,ribosomal protein (YmL3\n3) (E. coli L30),Null mutant is viable\n mYNL011C:Unknown ,, Unknown\n mCBP2:Protein required for splicing of COB aI5 intron,,Null mutant\n is viable\n mMDM38:Unknown ,, Unknown\n mCBP3:Protein required for assembly of ubiquinol cytochrome-c redu\nctase complex (cytochrome bc1 complex),,reduced levels of a \nsubset of subunit polypeptides of the coenzyme QH2-cytochrom\ne c reductase complex\n mYJL022W:Unknown ,, Unknown\n mFTR1:Plasma membrane iron permease,iron permease,Lacks high affin\nity iron uptake\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mYOL008W:Unknown ,, Unknown\n mCBT1:Subunit of complex involved in processing of the 3' end of c\nytochrome b pre-mRNA,,Null mutant is viable, shows results i\nn a respiratory deficiency\n mPET54:translational activator of cytochrome c oxidase subunit III;\n required for splicing of cytochrome c oxidase subunit I mRN\nA,translational activator of cytochrome C oxidase subunit II\nI; required for splicing of cytochrome c oxidase subunit I \nmRNA,petite; unable to grow on non-fermentable carbon source\ns\n mYET1:Yeast BAP31 homolog,yeast endoplasmic reticulum 25 kDa trans\nmembrane protein,Null mutant is viable\n mPET112:May serve important general function in mitochondrial gene e\nxpression, probably in translation; required for translation\n of COX2 mRNA,62 kDa protein,Null mutant is viable but shows\n destabilization of the mitochondrial genome, making cells r\nho- and unable to grow on non-fermentable carbon sources; pe\nt112-1 mutant is blocked in accumulation of cytochrome c oxi\ndase subunit II\n mSYS1:Multicopy suppressor of ypt6 null mutation,,Null mutant is v\niable. sys1 ypt6 double mutant displays enhanced defects in \nvacuolar sorting and cell growth\n mYDR431W:Unknown ,, Unknown\n mPET117:Required for assembly of active cytochrome c oxidase,,petite\n; unable to grow on non-fermentable carbon sources\n mSSN2:Required for stable association of Srb10p-Srb11p kinase with\n RNA polymerase holoenzyme,transcription factor,Null mutant \nis viable; ssn2 mutations can suppress CTD truncations or ph\nosphorylation mutants and snf1 mutations\n mYPL013C:Unknown ,, Unknown\n mSNF4:involved in release from glucose repression, invertase expre\nssion, and sporulation,associates with Snf1p,Null mutant is \nviable, sucrose nonfermenting; high copy MSI1 and PDE2 parti\nally suppress sporulation defect\n mSMI1:Protein involved in (1,3)-beta-glucan synthesis, possibly th\nrough regulation of cell wall glucan and chitin synthesis; c\nhromatin binding protein,57 kDa nuclear protein,Null mutant \nis viable, shows osmotic sensitivity, sensitivity to cercosp\noramide, resistance to zymolase; temperature sensitive mutan\nt arrests at S phase with small buds\n mSNF7:Involved in derepression of SUC2 in response to glucose limi\ntation,,Null mutant is viable. Similar to disruption SNF8, S\nNF7 disruption causes a fewfold decrease in invertase derepr\nession, a growth defect on raffinose, temperature-sensitive \ngrowth on glucose, and a sporulation defect in homozygous di\nploids. Genetic interactions suggest SNF7 is different from \nSNF2, SNF5 and SNF6, members of the SNF/SWI chromatin remode\nling complex\n mYOR135C:Unknown ,, Unknown\n mYLR202C:Unknown ,, Unknown\n mYDR203W:Unknown ,, Unknown\n mNFU1:Nifu-like protein,,Null mutant is viable on YPD 30 degrees C\n, and is synthetically lethal with SSQ1\n mYDR493W:Unknown ,, Unknown\n mSAC2:May interact with actin as a component or controller of the \nassembly or stability of the actin cytoskeleton,,Null mutant\n is viable, cold-sensitive growth phenotype, suppressor of a\nctin mutation; aberrant organization of intracellular actin \nand deposition of chitin at the cell surface\n mPEP8:Plays a role in delivery of proteins to the vacuole,vacuolar\n protein similar to mouse gene H<beta>58,Null mutant is viab\nle but is defective in processing of soluble vacuole proteas\nes due to inability of soluble vacuolar hydrolase to reach t\nhe vacuole\n mYML090W:Unknown ,, Unknown\n mGAL2:Galactose transport, also able to transport hexoses,galactos\ne permease,Galactose non-utilizer\n mGAL3:Involved in galactose induction of GAL genes,,Galactose non-\nutilizer\n mGAL4:Positive regulator of GAL genes,zinc finger transcription fa\nctor of the Zn(2)-Cys(6) binuclear cluster domain type,Null \nmutant is viable, cannot utilize galactose as sole carbon so\nurce\n mCAT5:may encode a protein involved in one or more monoxygenase or\n hydroxylase steps of ubiquinone biosynthesis,may encode a p\nrotein involved in one or more monoxygenase or hydroxylase s\nteps of ubiquinone biosynthesis,Null mutant is viable, resul\nts in complete loss of glucose derepression affecting glucon\neogenic key enzymes. Respiration, but not mitochondrial cyto\nchrome c oxidase activity, are also affected; fails to synth\nesize ubiquinone\n mMBA1:involved in assembly of mitochondrial respiratory complexes,\n,Null mutant is viable, conditionally defective in the assem\nbly of mitochondrial respiratory complexes\n mCCC2:copper-transporting P-type ATPase with similarity to human M\nenkes and Wilsons genes,,Null mutant is viable, exhibits def\nects in respiration and iron uptake\n mYDR269C:Unknown ,, Unknown\n mGAL7:galactose-1-phosphate uridyl transferase,galactose-1-phospha\nte uridyl transferase,Null mutant is viable and cannot utili\nze galactose.\n mCYC3:cytochrome c heme lyase (CCHL),cytochrome c heme lyase (CCHL\n),Cytochrome c deficiency\n mVPS17:Peripheral membrane protein required for vacuolar protein so\nrting,,Null mutant is viable, exhibits defect in vacuolar mo\nrphology and protein sorting\n mYNL205C:Unknown ,, Unknown\n mYPL159C:Unknown ,, Unknown\n mOPI3:Second and third steps of methylation pathway for phosphatid\nylcholine biosynthesis,methylene-fatty-acyl-phospholipid syn\nthase (unsaturated phospholipid N-methyltransferase),Null mu\ntant is viable, temperature sensitive in the presence of mon\nomethylethanolamine, exhibits an inositol secretion phenotyp\ne\n mMET10:subunit of assimilatory sulfite reductase,assimilatory sulfi\nte reductase subunit,Null mutant is viable, and is a methion\nine auxotroph\n mECM40:ExtraCellular Mutant,acetylornithine acetyltransferase,A Tn3\n insertion into this gene causes hypersensitivity to the cel\nl surface polymer perturbing agent calcofluor white.\n mADH3:alcohol dehydrogenase isoenzyme III,alcohol dehydrogenase is\noenzyme III,Null mutant is viable\n mYBR187W:Unknown ,, Unknown\n mCOX10:Required for an essential posttranslational stage in assembl\ny of cytochrome oxidase,farnesyl transferase (putative),muta\nnt lacks cytochrome oxidase activity and cytochromes a and a\n3 and is respiratory-defective\n mIRS4:Increased rDNA silencing,,Null mutant is viable and shows in\ncreased rDNA silencing\n mRIP1:oxidizes ubiquinol at center P in the protonmotive Q cycle m\nechanism, transferring one electron to cytochrome c1 and gen\nerating a low-potential ubisemiquinone anion which reduces t\nhe low-potential cytochrome b-566 heme group,Rieske iron-sul\nfur protein of the mitochondrial cytochrome bc1 complex,Null\n mutant is viable, unable to grow on nonfermentable carbon s\nources\n mMET14:adenylylsulfate kinase,adenylylsulfate kinase,Null mutant is\n viable, and is a methionine auxotroph\n mYNL077W:Unknown ,, Unknown\n mYDR290W:Unknown ,, Unknown\n mCOX15:cytochrome oxidase assembly factor,cytochrome oxidase assemb\nly factor,fail to synthesize cytochrome oxidase\n mCCZ1:calcium caffeine zinc sensitivity,,Null mutant is viable, bu\nt is sensitive to caffeine, calcium and zinc; no sporulation\n in homozygous null diploids\n mSRC1:Spliced mRNA and Cell cycle regulated gene,,Null mutant is v\niable and shows normal growth in standard media; expression \nis induced at G2/M transition.\n mCOX17:Involved in copper metabolism and assembly of cytochrome oxi\ndase,cysteine-rich protein,Null mutant is viable, respirato\nry defective, rescued by addition of copper to growth media \nand/or high copy expression of SCO1 and SCO2 genes\n mSPT8:transcription factor, probable member of histone acetyltrans\nferase SAGA complex,probable member of histone acetyltransfe\nrase SAGA complex , transcription factor,Null mutant is viab\nle, no growth defects, exhibits suppression of Ty insertion \nmutations, defects in Ty transcription\n mYGL250W:Unknown ,, Unknown\n mYHR116W:Unknown ,, Unknown\n mBAS1:Transcription factor regulating basal and induced activity o\nf histidine and adenine biosynthesis genes,transcription fac\ntor,\n mYDR426C:Unknown ,, Unknown\n mRTT103:Regulator of Ty1 Transposition,,Gene disruption causes Ty1 h\nypertransposition phenotype\n mRTG1:Transcription factor (bHLH) involved in interorganelle commu\nnication between mitochondria, peroxisomes, and nucleus,tran\nscription factor,Null mutant is viable but cannot grow on ac\netate as the sole carbon source, is a glutamate and aspartat\ne auxotroph, and shows decreased citrate synthase, acetyl-Co\nA synthetase, NAD isocitrate dehydrogenase, and pyruvate car\nboxylase activities\n mKEL2:protein containing kelch repeats, similar to YHR158c and YPL\n263c,,The null mutant is viable.\n mPET494:translational activator of cytochrome c oxidase,translationa\nl activator of cytochrome C oxidase,petite; unable to grow o\nn non-fermentable carbon sources\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCOX5A:One of two genes (COX5A and COX5B, both nuclear-encoded) cod\ning for subunit V of cytochrome c oxidase; COX5A gene produc\nt is the predominantform of subunit V found in holocytochrom\ne c oxidase under normal growth conditions,cytochrome c oxid\nase chain Va,Null mutant is viable, respires at 10-15% of th\ne wild-type rate due to the presence of COX5B; cox5a cox5b d\nouble deletion mutants are completely non-respiratory\n mBRO1:BCK1-like resistance to osmotic shock,,Temperature-sensitive\n growth defect, sensitive to caffeine and respond abnormally\n to nutrient limitation at the permissive temperature\n mYNL056W:Unknown ,, Unknown\n mCYS3:cystathionine gamma-lyase,cystathionine gamma-lyase,Null mut\nant is viable, cysteine auxotroph\n mCYS4:Cystathionine beta-synthase,cystathionine beta-synthase,Null\n mutant is viable, exhibits vacuolar acidification defects; \ncys2 and cys4 mutations are linked together and co-operative\nly confer cysteine dependence\n mIDH2:NAD+-dependent isocitrate dehydrogenase,NAD-dependent isocit\nrate dehydrogenase,Null mutant is viable\n mECM17:ExtraCellular Mutant,sulfite reductase (putative),loss of fu\nnction mutants are methionine requiring and sensitive to the\n cell wall perturbing agent calcoflour white.\n mYNL224C:Unknown ,, Unknown\n mYJL007C:Unknown ,, Unknown\n mNGL2:DNase/RNase (putative); CCR4 C-terminal homolog; displays ho\nmology to drosophila Angelgene; homolog to ngl1 and ngl3 ,DN\nase (putative) , RNase (putative),Null mutant is viable.\n mMNE1:similar to Lucilia illustris mitochondria cytochrome oxidase\n,,\n mGCS1:Zn-finger-containing protein that functions as ADP-ribosylat\nion factor GTPase-activating protein and is involved in regu\nlating vesicle transport,ADP-ribosylation factor GTPase-acti\nvating protein (ARF GAP),Null mutant is cold-sensitive for r\neentry into mitotic cell cycle from stationary phase and sho\nws inefficient secretion of invertase\n mMET1:Methionine metabolism,,Null mutant is viable, and is a methi\nonine auxotroph\n mIMP2:Inner membrane protease (mitochondrial protein),protease,\n mMET3:ATP sulfurylase,ATP sulfurylase,Null mutant is viable, and i\ns a methionine auxotroph\n mEMI2:Unknown ,, Unknown\n mMIP1:catalytic subunit of mitochondrial DNA polymerase,mitochondr\nial DNA polymerase catalytic subunit,Null mutant is viable, \nassociated with total loss of mitochondrial DNA and mitochon\ndrial DNA polymerase activity\n mSPS18:sporulation-specific protein,transcription factor,suppressio\nn of X-ray sensitivity of rad55\n mMRPL23:mitochondrial ribosomal protein of the large subunit,ribosom\nal protein large subunit,\n mYOL138C:Unknown ,, Unknown\n mMET8:Protein involved in the expression of PAPS reductase and sul\nfite reductase,,Null mutant is viable, and is a methionine a\nuxotroph\n mMCK1:Disp. for mitosis, required for chr. segregation, benomyl re\nsist., basal IME1 transcript. in mitosis, IME1 induction in \nmeiosis & ascus mat. independ. of IME1; maybe in mitotic chr\n. segregation specific to CDEIII,43.1 kDa serine/threonine/t\nyrosine protein kinase,Null mutant is viable, cold sensitive\n, temperature sensitive, and benomyl sensitive; associated w\nith delays and decreased levels of sporulation. High copy MC\nK1 acclerates early gene expression.\n mVPS5:vacuolar Protein Sorting Defective; Golgi retention and vacu\nolar protein sorting,simialr to sorting nexin I,Null mutant \nis viable, missort and secrete soluble vacuolar proteins, co\nntain fragmented vacuoles and mislocalize carboxypepsidase a\nnd Vps10p.\n mYOR068C:Unknown ,, Unknown\n mDID4:Hypothetical ORF,class E vacuolar-protein sorting and endocy\ntosis factor,secretion of vacuolar proteins; canavanine-hype\nrsensitive; temperature-sensitive; suppresses defects associ\nated with loss of Doa4\n mVPS8:involved in vacuolar protein sorting; required for localizat\nion and trafficking of the CPY sorting receptor,membrane-ass\nociated hydrophilic protein which contains a C-terminal cyst\neine-rich region that conforms to the H2 variant of the RING\n finger Zn2+ binding motif,Null mutant is viable, missorts a\nnd secretes vacuolar hydrolases, overexpression of VPS21 par\ntially suppresses vps8 null\n mYGR058W:Unknown ,, Unknown\n mGEF1:Integral membrane protein highly homologous to voltage-gated\n chloride channels from humans, mice and fish,transport prot\nein involved in intracellular iron metabolism (putative),Nul\nl mutant is viable; cells grow slowly on rich media containi\nng carbon sources utilized by respiration; fail to grow on g\nlucose when iron concentrations are low in the media\n mRAV1:Regulator of (H+)-ATPase in vacuolar membrane,,\n mCBS2:Translational activator of COB mRNA; soluble protein,cytochr\nome b translational activator,Null mutant is viable, exhibit\ns a mitochondrial apocytochrome b mRNA translational defect\n mORT1:Mitochondrial integral membrane protein, ornithine transport\ner,,Null mutant is viable, arginine bradytroph\n mGAL10:UDP-glucose 4-epimerase,UDP-glucose 4-epimerase,Null mutant \nis viable and cannot utilize galactose.\n mCPA1:Carbamoyl phosphate synthetase, arginine specific,arginine s\npecific , carbamoyl phosphate synthetase,Null mutant is viab\nle\n mCPA2:carbamyl phosphate synthetase,carbamyl phosphate synthetase,\nNull mutant is viable\n mNBP2:interacts with Nap1, which is involved in histone assembly,,\n mYIL039W:Unknown ,, Unknown\n mYCR045C:Unknown ,, Unknown\n mCYT2:links heme covalently to apocytochrome c1,cytochrome c1 heme\n lyase,\n mVPS35:Protein involved in vacuolar sorting,retromer complex compon\nent,Null mutant is viable, exhibits defects in sorting of va\ncuolar carboxypeptidase Y, proteinase A, proteinase B, and a\nlkaline phosphatase\n mCCC2 mATX1 mSMI1 mBAS1 mPEP8 mVPS35 mVPS5 mVPS17 mCPA2 mCPA1
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity