Module number 3245




Database revision : gnsdb28.10
Date : Tue Feb 25 17:18:16 2003
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mYNL134C:Unknown ,, Unknown\n Cond464:37_deg_growth_ct-1\n mYOL083W:Unknown ,, Unknown\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mTRR1:Thioredoxin reductase,thioredoxin reductase,Null mutant is v\niable but grow slowly; trr1 mutations are sensitive to hydro\ngen peroxide and activate Mlu1 cell cycle box (MCB)- and Swi\n4/Swi6 cell cycle box (SCB)-dependent reporter genes in swi6\n null mutants.\n Cond338:constant_0.32_mM_H2O2_(40_min)_rescan\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n Cond369:1.5_mM_diamide_(5_min)\n mMCH4:Unknown ,, Unknown\n mAAD3:high degree of similarity with the AAD of P. chrysosporium,a\nryl-alcohol dehydrogenase (putative),\n Cond780:Peroxide_10'\n mYDR533C:Unknown ,, Unknown\n mAAD6:high degree of similarity with the AAD of P. chrysosporium,a\nryl-alcohol dehydrogenase (putative),Responds to oxidative s\ntress induced by diamide and di-ethyl maleic acid ester in Y\nAP1 dependant manner\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n mLAP4:vacuolar aminopeptidase ysc1,vacuolar aminopeptidase ysc1,Le\nucine aminopeptidase deficient\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond782:Peroxide_40'\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mECM4:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n Cond352:1_mM_Menadione_(120_min)redo\n mCAF17:CCR4 associated factor,CCR4 transcriptional complex componen\nt,Null mutant is viable, shows petite phenotype\n mGPX2:Glutathione peroxidase paralogue,,Null mutant is viable\n Cond353:1_mM_Menadione_(160_min)_redo\n mYOR225W:Unknown ,, Unknown\n mYBL064C:Unknown ,, Unknown\n mGTT2:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive in stationary phase\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond375:1.5_mM_diamide_(60_min)\n Cond373:1.5_mM_diamide_(40_min)\n Cond371:1.5_mM_diamide_(20_min)\n Cond880:BCNU\n mGSH1:Glutathione biosynthesis,gamma-glutamylcysteine synthetase,N\null mutant is viable, exhibits alteration of glutathione con\ntent and reduction in growth rate\n Stress.DTT1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mGAD1:glutamate decarboxylase,glutamate decarboxylase,\n mYOL150C:Unknown ,, Unknown\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n mTSA1:antioxidant enzyme that provides protection against oxidatio\nn systems capable of generating reactive oxygen and sulfur s\npecies,thioredoxin-peroxidase (TPx); reduces H2O2 and alkyl \nhydroperoxides with the use of hydrogens provided by thiored\noxin, thioredoxin reductase, and NADPH,Null mutant is viable\n, grows slower than wild-type under aerobic conditions\n mTSA2:Unknown ,, Unknown\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond344:constant_0.32_mM_H2O2_(160_min)_redo\n Cond346:1_mM_Menadione_(20_min)_redo\n Cond376:1.5_mM_diamide_(90_min)\n Cond638:DES460_+_0.02%_MMS_-_90_min\n mOYE2:NAPDH dehydrogenase (old yellow enzyme), isoform 2,NAPDH deh\nydrogenase (old yellow enzyme), isoform 2,Null mutant is via\nble\n Cond335:constant_0.32_mM_H2O2_(10_min)_redo\n mYMR315W:Unknown ,, Unknown\n mYLR108C:Unknown ,, Unknown\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mDDR48:DNA damage inducible; implicated in the production or recove\nry of mutations,contains >35 repeats of the amino acid seque\nnce NNNDSYGS , flocculent specific protein,Null mutant is vi\nable, displays reduced spontaneous mutation rate\n mYDL124W:Unknown ,, Unknown\n Cond341:constant_0.32_mM_H2O2_(80_min)_redo\n mYFL057C:Unknown ,, Unknown\n Cond672:DES459_(mec1)_-_mock_irradiation_-_60_min\n Cond683:MHY1_(crt1)_vs._CRY1_(wild_type)_-_log_phase\n Cond340:constant_0.32_mM_H2O2_(60_min)_redo\n Cond357:2.5mM_DTT_045_min_dtt-1\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mSOD1:Cu, Zn superoxide dismutase,Cu, Zn superoxide dismutase,Null\n mutant is viable; dioxygen and paraquat sensitive; fails to\n grow on lactate as a carbon source; exhibits increased copp\ner sensitivity; exhibits slower proliferation time due to in\ncreased length of G1; methionine auxotroph and oxygen sensit\nive; SOD1 is required for sporulation\n mNMA2:Unknown ,, Unknown\n Cond194:yap1\n mYLR460C:Unknown ,, Unknown\n Cond350:1_mM_Menadione_(80_min)_redo\n mATR1:aminotriazole resistance,very hydrophobic, has many membrane\n-spanning regions, several potential glycosylation sites, po\ntential ATP-binding site,Null mutant is viable, but is sensi\ntive to very low (5 mM) levels of aminotriazole and to 4-nit\nroquinoline-N-oxide (4-NQO); multiple copies of ATR1 confer \nhyper-resistance to 4-NQO; multiple copies of ATR1 in gcn4 b\nackground confer resistance to high (80mM) levels of aminotr\niazole\n mADH6:Unknown ,, Unknown\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYMR173W-A:Unknown ,, Unknown\n mAAD14:aryl-alcohol dehydrogenase located on chromosome 14,aryl-alc\nohol dehydrogenase (putative),\n mYKL071W:Unknown ,, Unknown\n mAAD15:high degree of similarity with the AAD of P. chrysosporium,a\nryl-alcohol dehydrogenase (putative),\n Cond783:Peroxide_60'\n mYML131W:Unknown ,, Unknown\n mTTR1:Glutaredoxin (thioltransferase) (glutathione reductase),glut\naredoxin , thioltransferase/glutathione reductase,\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond882:zero3\n mYCR102C:Unknown ,, Unknown\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond877:MMS\n mMRS4:mitochondrial carrier protein, highly homologous to Mrs3p,ca\nrrier protein , highly homologous to Mrs3p,Null mutant is vi\nable, has no defects in mitochondrial function. Mrs4p overex\npression causes a temperature sensitive petite phenotype in \na wild-type background and can suppress the mitochondrial RN\nA splicing defects ofmit- intron mutants\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mYMR090W:Unknown ,, Unknown\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond342:constant_0.32_mM_H2O2_(100_min)_redo\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mAHP1:alkyl hydroperoxide reductase,alkyl hydroperoxide reductase,\nhypersensitive to tert-butyl hydroperoxide\n mGRE2:induced by osmotic stress; similar to dihydroflavonol 4-redu\nctase from plants,,\n mGRE3:Induced by osmotic stress; similar to xylose reductase from \nother fungi,,\n mYDR132C:Unknown ,, Unknown\n Cond349:1_mM_Menadione_(50_min)redo\n Cond781:Peroxide_20'\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n Cond372:1.5_mM_diamide_(30_min)\n Cond876:zero2\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond634:DES460_+_0.02%_MMS_-_15_min\n Cond336:constant_0.32_mM_H2O2_(20_min)_redo\n mISU2:Iron-sulfur cluster nifU-like protein,,Null mutant is viable\n on YPD at 30 degrees C, and is synthetically lethal with is\nu1 null.\n Cond446:YAP1_overexpression\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mEMI1:Unknown ,, Unknown\n Cond348:1mM_Menadione_(40_min)_redo\n Cond351:1_mM_Menadione_(105_min)_redo\n mCCP1:Cytochrome-c peroxidase,cytochrome c peroxidase,\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n Cond343:constant_0.32_mM_H2O2_(120_min)_redo\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Cond35:cup5\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond347:1_mM_Menadione_(30_min)_redo\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n mYGR011W:Unknown ,, Unknown\n mFLR1:Fluconazole Resistance 1,major facilitator transporter,Null \nmutant is viable; overexpression confers resistance to fluco\nnazole, cycloheximide, 4-nitroquinoline N-oxide\n
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Computational Genomics Lab, Tel-Aviv uniresity