Module number 3231




Database revision : gnsdb28.10
Date : Tue Feb 25 17:16:02 2003
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Cond498:wtħ500nMaF,30minlog10(intensity)\n mHST3:Homolog of SIR2,,hst3 hst4 double mutant has defects in telo\nmeric silencing, cell cycle progression, radiation resistanc\ne, and genomic stability\n mMCD1:Mitotic Chromosome Determinant; similar to S. pombe RAD21; m\nay function in chromosome morphogenesis from S phase through\n mitosis,,Null mutant is inviable; temperature sensitive mut\nants are defective in mitotic sister chromatid cohesion and \nmitotic chromosome condensation; multicopy suppressor of smc\n1-2 mutation\n mSWI5:transcriptional activator,transcriptional activator,homothal\nlic switching deficient\n Cond494:wtħ5nMaF,30minlog10(intensity)\n Cond565:alpha98\n Cond548:cln3-2\n Cond552:alpha7\n mBUD4:co-assembles with Bud3p at bud sites,,Null mutant is viable,\n haploids have dipolar budding, normally they have axial bud\nding, no effects on diploids\n mYER079W:Unknown ,, Unknown\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond533:fus3D+50nMaF/wt+50nMaF,30minlog10(intensity)\n mCLB2:Involved in mitotic induction,B-type cyclin,Null mutant is v\niable (lethal in combination with clb1 mutation)\n mHHO1:Histone H1,histone H1,Null mutant is viable; other phenotype\n: Increased basal expression of a CYC1-lacz reporter gene; n\nuclear localization of a Hho1-GFP fusion protein\n Cond504:wtħ50nMaF,90minlog10(intensity)\n mHPR5:Required for proper timing of committment to meiotic recombi\nnation and the transition from Meiosis I to Meiosis II,DNA h\nelicase,Null mutant is viable, radiation (ultraviolet or ion\nizing sensitive), loss of function results in RAD52-dependen\nt hyperrecombination suggesting recombination suppression oc\ncurs by antagonizing the Rad52 recombinational repair pathwa\ny; wild-type suppresses mitotic recombination; some mutant a\nlleles have lower spore viability which is not rescued by sp\no13, suggesting they affect a late recombination function; h\npr5 mutations are rad6 suppressors\n mCLB6:role in DNA replication during S phase,B-type cyclin,Null mu\ntant is viable\n mMNN1:Alpha-1,3-mannosyltransferase,alpha-1,3-mannosyltransferase,\nNull mutant is viable\n mYJL051W:Unknown ,, Unknown\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond586:cdc15_210\n mCDC5:CDC5 is dispensable for premeiotic DNA synthesis and recombi\nnation, but required for tripartite synaptonemal complexes, \nhaploidization, and spores,protein kinase,Null mutant is inv\niable. cdc5(ts) mutants form synaptonemal complexes lacking \ncentral elements and arrest either at meiosis I with broken \nspindles or at meiosis II with short spindles. Late shifts t\no a restrictive temperature result in reductional dyads; eac\nh spore contains an entire meiosis II short spindle with uns\neparated chromatids. In some strains at semi-permissive temp\nerature, chromosomes segregate reductionally or equationally\n depending upon the centromere.\n Cond505:wtħ50nMaF,120minlog10(intensity)\n mGAS1:Glycophospholipid-anchored surface protein,cell surface glyc\noprotein 115-120 kDa,Null mutant is slow growing and exhibit\ns cell wall defects.\n Cond53:erg2\n Cond507:bni1Dħ50nMaF,90minlog10(intensity)\n mNCE102:involved in secretion of proteins that lack classical secret\nory signal sequences,,An uncharacterized allele exhibits def\nects in the export of the mammalian protein galectin-1.\n Cond509:kss1Dħ50nMaF,30minlog10(intensity)\n Cond496:wtħ50nMaF,30minlog10(intensity)\n mCLN1:role in cell cycle START,G1 cyclin,Null mutant is viable, ex\nhibits G1 arrest\n mPPN1:Phosphate metabolism; transcription is regulated by PHO syst\nem,vacuolar polyphosphatase,Null mutant is viable and shows \naccumulation of long chain polyphosphate\n Cond805:Ca/Ca+FK30'\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mCIS3:cik1 suppressor,similar to Hsp150p and Pir1p, Pir2p, and Pir\n3p,Null mutant is viable; CIS3 is a high copy suppressor of \ncik1 deletion mutants\n mHTZ1:Histone-related protein that can suppress histone H4 point m\nutation,evolutionarily conserved member of the histone H2A F\n/Z family of histone variants,Null mutant is viable at 28C; \nhigh copy suppressor of histone H4 point mutant affecting nu\ncleosome structure\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n mYMR144W:Unknown ,, Unknown\n mYLR190W:Unknown ,, Unknown\n Cond566:alpha105\n mYPL267W:Unknown ,, Unknown\n Cond495:wtħ15.8nMaF,30minlog10(intensity)\n Cond279:ERG11(tetpromoter)\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond553:alpha14\n mPHO5:Acid phosphatase, repressible,acid phosphatase,phosphatase d\neficient\n Cond508:bni1Dħ50nMaF,120minlog10(intensity)\n mYHP1:Hypothetical ORF,,\n mALK1:,leucine zipper (putative) , membrane protein (putative),\n Cond550:clb2-1\n mHHT1:Histone H3 (HHT1 and HHT2 code for identical proteins),histo\nne H3 (HHT1 and HHT2 code for identical proteins),Null mutan\nt is viable\n Cond557:alpha42\n Cond506:bni1Dħ50nMaF,60minlog10(intensity)\n Cond804:Ca/Ca+FK15'\n mYKL097C:Unknown ,, Unknown\n mCHS2:chitin synthase 2,chitin synthase 2,disruption results in lo\nss of well-defined septa and in growth arrest\n mYPL141C:Unknown ,, Unknown\n Cond502:wtħ50nMaF,45minlog10(intensity)\n Cond54:erg3(haploid)\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond563:alpha84\n Cond558:alpha49\n mELO1:elongation enzyme 1, required for the elongation of the satu\nrated fatty acid tetradecanoic acid (14:0) to that of hexade\ncanoic acid (16:0),,Null mutant is viable, but shows no grow\nth on media supplemented with less than 16-C saturated fatty\n acid in a fatty acid synthase minus background\n mFIR1:Factor Interacting with REF2, interacts strongly with REF2 p\nrotein in 2-hybrid screen,participant in 3' mRNA processing \n(putative),Null mutant is viable, shows slow growth in all m\nedia\n Cond512:GAL-STE5-CTM,3hrs.gallog10(intensity)\n Cond175:swi4\n mMRH1:Membrane protein related to Hsp30p; Localized by immunofluor\nescence to membranes, mainly the plasma membr. punctuate imm\nunofluorescence pattern observed in buds. The nuclear envelo\npe, but not vacuole or mitochondrial membranes also stained,\n,Null mutant is viable\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYEL017W:Unknown ,, Unknown\n Cond501:wt+/-50nMaF,30minlog10(intensity)\n Cond250:ymr031w-a\n mHTA2:Histone H2A (HTA1 and HTA2 code for nearly identical protein\ns),histone H2A (HTA1 and HTA2 code for nearly identical prot\neins),Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2\n) locus has no reported observable phenotypes, presumably be\ncause HTA1-HTB1 (TRT1) expression is upregulated and can com\npensate in the absence of TRT2. Overexpression of TRT2 can s\nuppress Ty insertion mutations\n Cond554:alpha21\n mSPC29:Nuclear import protein,spindle pole body associated protein,\nNull mutant is inviable\n mHEK2:Unknown ,, Unknown\n mCHA1:catabolism of hydroxy amino acids,catabolic serine (threonin\ne) dehydratase,Null mutant is viable and cannot grow on medi\na with L-serine or L-threonine as sole nitrogen source\n mYIL158W:Unknown ,, Unknown\n Cond294:Itraconazole\n Calcin.Ca/Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mTOS11:Hypothetical ORF,,\n mEXG1:Exo-1,3-beta-glucanase,exo-1,3-beta-glucanase,Null mutant is\n viable, displays modest increase in killer toxin sensitivit\ny and beta 1,6-glucan levels\n mEXG2:Exo-1,3-b-glucanase,exo-1,3-beta-glucanase,Null mutant is vi\nable\n Cond497:wtħ158nMaF,30minlog10(intensity)\n Cond576:cdc15_110\n Cond493:wtħ1.5nMaF,30minlog10(intensity)\n mYNR009W:Unknown ,, Unknown\n mYOR246C:Unknown ,, Unknown\n mSTU2:May play a role in attachment, organization, and/or dynamics\n of microtubule ends at the spindle pole body,,Null mutant i\ns inviable; stu2 mutations can suppress cold-sensitivity of \ntub2-423 mutants\n mSVS1:involved in vanadate resistance,,Null mutant is viable, show\ns increased sensitivity to vanadate, but not other metallic \nions or drugs\n mACE2:involved in transcriptional regulation of CUP1,zinc finger t\nranscription factor,Null mutant is viable, exhibits decrease\nd CUP1 mRNA expression\n Cond503:wtħ50nMaF,60minlog10(intensity)\n Cond511:GAL-STE4,3hrs.gallog10(intensity)\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond559:alpha56\n mYRO2:Homolog to HSP30 heat shock protein Yro1p,,\n mSRL1:Suppressor of rad53 lethality,,\n mSWE1:protein kinase homolog,protein kinase homolog,Null mutant is\n viable\n Cond514:GAL-STE12,3hrs.gallog10(intensity)\n Cond567:alpha112\n mYOR315W:Unknown ,, Unknown\n mHTB1:Histone H2B (HTB1 and HTB2 code for nearly identical protein\ns),histone H2B (HTB1 and HTB2 code for nearly identical prot\neins),Null mutant is viable\n Cond551:alpha0\n Cond549:clb2-2\n mHTB2:Histone H2B (HTB1 and HTB2 code for nearly identical protein\ns),histone H2B (HTB1 and HTB2 code for nearly identical prot\neins),Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2\n) locus has no reported observable phenotypes, presumably be\ncause HTA1-HTB1 (TRT1) expression is upregulated and can com\npensate in the absence of TRT2\n mYOX1:Homeodomain protein that binds leu-tRNA gene,homeobox-domain\n containing protein,Null mutant is viable\n mMCD1 mCDC5 mSWE1 mCLB2
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Computational Genomics Lab, Tel-Aviv uniresity