Module number 3111




Database revision : gnsdb28.10
Date : Tue Feb 25 17:08:07 2003
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Cond330:29C_+1M_sorbitol_to_33C_+_1M_sorbitol_-_15_minutes\n mHSP104:involved in thermal and ethanol tolerance, inheritance of [P\nSI+], and reactivation of mRNA splicing after heat shock,hea\nt shock protein 104,Null mutant is viable and defective in i\nnduced thermotolerance\n Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n Cond796:Ca5'\n Cond826:tlc1_Expt.1_Passage_7\n mYOL083W:Unknown ,, Unknown\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mTFS1:(putative) lipid binding protein; supressor of a cdc25 mutat\nion,lipid binding protein (putative) , supressor of a cdc25 \nmutation,Null mutant is viable.\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response.  Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond302:Heat_Shock_15_minutes_hs-1\n Cond418:YPD_1_d_ypd-2\n Cond675:MHY1_(dun1)_+_heat_20_min\n Cond362:dtt_000_min__dtt-2\n Cond981:F82G_pho4D_10_mM_1NaPP1\n mKAR2:Involved in translocation of nascent polypeptides across the\n ER membrane,HSP70 family , mammalian BiP (GPR78) homolog , \nHSP70 family , mammalian BiP (GPR78) homolog,null mutants ar\ne inviable; other mutants block karyogamy (nuclear fusion) d\nuring mating\n Cond400:Nitrogen_Depletion_12_h\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond834:tlc1_Expt.2_Passage_6\n Cond976:F82G_1_mM_1NaPP1\n Cond467:steady_state_21_dec_C_ct-2\n Cond674:DES459_(mec1)_+_heat_20_min\n Cond810:Na45'\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTSL1:123 kD regulatory subunit of trehalose-6-phosphate synthase/\nphosphatase complex; homologous to TPS3 gene product,similar\n to TPS3 gene product , trehalose-6-phosphate synthase/phosp\nhatase complex 123 kDa regulatory subunit,Null mutant is via\nble\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond373:1.5_mM_diamide_(40_min)\n mYDL222C:Unknown ,, Unknown\n Cond822:tlc1_Expt.1_Passage_3\n Cond454:YP_fructose_vs_reference_pool_car-2\n Cond445:Msn4_overexpression\n mGAD1:glutamate decarboxylase,glutamate decarboxylase,\n Cond802:CaFK30'\n Cond300:Heat_Shock_05_minutes_hs-1\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n mGPM2:Similar to GPM1 (phosphoglycerate mutase); converts 3-phosph\noglycerate to 2-phosphoglycerate in glycolysis,,Null mutant \nis viable, gpm2 gpm3 double deletion mutants exhibit no synt\nhetic phenotypes\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n Cond814:Na+FK45'\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles.  Science. 200\n0 Feb 4;287(5454):873-80\n mGND2:6-phosphogluconate dehydrogenase, decarboxylating; converts \n6-phosphogluconate + NADP to ribulose-5-phosphate + NADPH + \nCO2,6-phosphogluconate dehydrogenase,cannot grow on media co\nntaining D-glucono-delta-lactone as the sole carbon source\n Cond376:1.5_mM_diamide_(90_min)\n Cond318:37C_to_25C_shock_-_60_min\n Cond673:DES460_(wild_type)_+_heat_20_min\n mHOR7:hyperosmolarity-responsive gene,,\n mHCH1:high copy Hsp90 supressor,,Null mutant is viable; when overe\nxpressed, HCH1 is an allele-specific suppressor of hsp82 ts \nmutants\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond312:Heat_Shock_015_minutes_hs-2\n mYJL161W:Unknown ,, Unknown\n Cond306:Heat_Shock_60_minutes_hs-1\n mYOR052C:Unknown ,, Unknown\n Cond367:dtt_240_min_dtt-2\n tcl1.tcl1:The genome-wide expression response to telomerase deletion i\nn Saccharomyces cerevisiae.  Proc Natl Acad Sci U S A. 2002 \nJul 9;99(14):9316-21.\n Cond825:tlc1_Expt.1_Passage_6\n mYLR217W:Unknown ,, Unknown\n Cond313:Heat_Shock_030inutes__hs-2\n Cond760:Heat_15'\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYNL274C:Unknown ,, Unknown\n Cond378:1M_sorbitol_-_15_min\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mSTI1:Heat shock protein also induced by canavanine and entry into\n stationary phase,heat shock protein also induced by canavan\nine and entry into stationary phase,Null mutant is viable bu\nt shows slow growth at high or low temperatures; shows synth\netic interactions with hsp82, cpr7, kin28 and sba1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond443:DBYyap1_+_0.32_mM_H2O2_(20_min)\n Cond314:Heat_Shock_060_minutes__hs-2\n Y-Stre.Alkali:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond833:tlc1_Expt.2_Passage_5\n mYLR327C:Unknown ,, Unknown\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n Cond634:DES460_+_0.02%_MMS_-_15_min\n mNTH1:hydrolyzes trehalose; may be inolved in growth transition fr\nom glucose to glycerol; shows significant sequence similarit\ny to Nth2p,neutral trehalase,Null mutant is viable\n Cond778:msn2/4_acid_10'\n Cond325:29C_to_33C_-_5_minutes\n Cond809:Na30'\n mHSP78:Similar to E. coli ClpB protein; involved in folding of some\n mitochondrial proteins,heat shock protein 78,Null mutant is\n viable but in ssc1 mutant background gives rho- phenotype\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSIS1:sit4 suppressor, dnaJ homolog,,Null mutant is inviable; stra\nins limited for SIS1 accumulate cells that appear blocked fo\nr migration from the nucleus from the mother cell into the d\naughter cell, may of the cells become very large and contain\n a large vacuole\n mSSE1:HSP70 family member, highly homologous to Ssa1p and Sse2p,HS\nP70 family , SSA1 SSE2 homolog , HSP70 family , SSA1 SSE2 ho\nmolog,Null mutant is viable, slow growing, shows no additive\n effects with sse2 null mutation; temperature sensitive in s\nome strain backgrounds\n mSSE2:HSP70 family member, highly homologous to Sse1p,HSP70 family\n , SSE1 homolog,Null mutant is viable\n Cond461:21_deg_growth_ct-1\n Cond828:tlc1_Expt.1_Passage_9\n Cond303:Heat_Shock_20_minutes_hs-1\n Cond813:Na+FK30'\n Cond636:DES460_+_0.2%_MMS_-_45_min\n mYKL091C:Unknown ,, Unknown\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n mPIN3:[PSI+] induction,,Other phenotypes: overexpression of PIN3 a\nllows for the induction of the [PSI+] prion in strains cured\n of [PIN+].\n mHSC82:constitutively expressed heat shock protein,chaperonin,Null \nmutant is viable at 25 degrees C; ability to grow at higher \ntemperatures varies with gene copy number\n Cond160:sir4\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n Cond837:tlc1_Expt.2_Passage_9__\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond801:CaFK15'\n Cond332:29C_+1M_sorbitol_to_33C_+_*NO_sorbitol_-_5_minutes\n mHSP82:82 kDa heat shock protein; homolog of mammalian Hsp90,heat s\nhock protein 90 , mammalian Hsp90 homolog , heat shock prote\nin 90 , mammalian Hsp90 homolog,Null mutant is viable at 25 \ndegrees C; ability to grow at higher temperatures varies wit\nh gene copy number\n Cond320:heat_shock_17_to_37,_20_minutes\n Cond836:tlc1_Expt.2_Passage_8\n Cond316:37C_to_25C_shock_-_30_min\n Cond305:Heat_Shock_40_minutes_hs-1\n Cond462:25_deg_growth_ct-1\n Cond301:Heat_Shock_10_minutes_hs-1\n Cond982:pho85D_10_mM_1NaPP1_\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond369:1.5_mM_diamide_(5_min)\n Cond824:tlc1_Expt.1_Passage_5\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n Cond363:dtt_015_min_dtt-2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n mLAP4:vacuolar aminopeptidase ysc1,vacuolar aminopeptidase ysc1,Le\nucine aminopeptidase deficient\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n Cond800:CaFK5'\n Y-Stre.msn2/4acid:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n Cond331:29C_+1M_sorbitol_to_33C_+_1M_sorbitol_-_30_minutes\n Cond375:1.5_mM_diamide_(60_min)\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond371:1.5_mM_diamide_(20_min)\n Cond377:1M_sorbitol_-_5_min\n Cond323:heat_shock_29_to_37,_20_minutes\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond832:tlc1_Expt.2_Passage_4\n Cond326:29C_to_33C_-_15_minutes\n Cond855:pm38-30\n mTSA2:Unknown ,, Unknown\n Cond426:YPD_stationary_phase_1_d_ypd-1\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n mMDJ1:involved in protection against heat-induced protein aggregat\nion but not necessary for protein import into the mitochondr\nion,DnaJ homolog , involved in mitochondrial biogenesis and \nprotein folding,Null mutant is viable, displays a petite phe\nnotype, loss of mitochondrial DNA, and inviability at 37 deg\nrees C\n Stress.WeakHeat:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond322:heat_shock_25_to_37,_20_minutes\n Cond827:tlc1_Expt.1_Passage_8\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n Cond379:1M_sorbitol_-_30_min\n Cond758:Heat_0'_(A)\n mYBR285W:Unknown ,, Unknown\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mCPR6:a cyclophilin related to the mammalian CyP-40; physically in\nteracts with RPD3 gene product,cyclophilin 40 , peptidyl-pro\nlyl cis-trans isomerase (PPIase),Null mutant is viable, has \nnormal growth rate\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Y-Stre.Heat:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond625:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y12-121\n Cond333:29C_+1M_sorbitol_to_33C_+_*NO_sorbitol_-_15_minutes\n Cond329:29C_+1M_sorbitol_to_33C_+_1M_sorbitol_-_5_minutes\n mSPI1:Stationary Phase Induced; strongly expressed during stationa\nry phase, and trancription is dependent on MSN2/MSN4.,,\n Cond835:tlc1_Expt.2_Passage_7\n mYPR158W:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mALD4:Glucose repressed. Utilizes NADP+ or NAD+ as a coenzyme equa\nlly well. (sold by SIGMA under the catalogue number A5550, a\nccording to A. Blomberg).,aldehyde dehydrogenase,\n mYGR043C:Unknown ,, Unknown\n mSOL4:similar to SOL3,,\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n Cond417:YPD_12_h_ypd-2\n Cond779:msn2/4_acid_20'\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond823:tlc1_Expt.1_Passage_4\n Cond775:Alkali_80'\n mGRE3:Induced by osmotic stress; similar to xylose reductase from \nother fungi,,\n mAHA1:Unknown ,, Unknown\n Cond319:37C_to_25C_shock_-_90_min\n Cond811:Na60'\n Cond372:1.5_mM_diamide_(30_min)\n Cond876:zero2\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond283:KAR2(tetpromoter)\n Cond336:constant_0.32_mM_H2O2_(20_min)_redo\n Cond401:Nitrogen_Depletion_1_d\n Cond324:heat_shock_33_to_37,_20_minutes\n Cond327:29C_to_33C_-_30_minutes\n mGSY2:Highly similar to GSY1. GSY2 is the predominantly expressed \nglycogen synthase. Activity is probably regulated by cAMP-de\npendent and SNF1 protein kinases and type 1 phosphatase,glyc\nogen synthase (UDP-glucose-starch glucosyltransferase),Null \nmutant is viable. Mutant lacking both GSY1 and GSY2 is viabl\ne but lacks glycogen synthase activity and glycogen depositi\non\n mSSA3:heat-inducible cytosolic member of the 70 kDa heat shock pro\ntein family,heat shock protein of HSP70 family,Null mutant i\ns viable; an intact copy of SSA3 regulated by the constituti\nve SSA2 promoter is capable of rescuing the inviability of a\nn ssa1 ssa2 ssa4 strain; an intact copy of SSA3 regulated by\n the constitutive SSA2 promoter is capable of rescuing the i\nnviability of an ssa1 ssa2 ssa4 strain\n Cond380:1M_sorbitol_-_45_min_\n mSSA4:member of 70 kDa heat shock protein family,HSP70 family,Null\n mutant is viable; ssa1 ssa2 ssa4 strains are inviable; an i\nntact copy of SSA3 regulated by the constitutive SSA2 promot\ner is capable of rescuing the inviability of an ssa1 ssa2 ss\na4 strain\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond543:rst1Drst2Dtec1D/wtlog10(intensity)\n Cond831:tlc1_Expt.2_Passage_3\n mUBI4:involved in stress response system,ubiquitin,Null mutant is \nviable, grows at wild-type rates and contains wild-type leve\nls of free ubiquitin under exponential growth conditions, hy\npersensitive to high temperatures, starvation and amino acid\n analogs; although ubi4/UBI4 diploids form initially viable \nspores, the two ubi4 spores lose viability extremely rapidly\n; homozygous ubi4/ubi4 diploids are sporulation defective\n mPNC1:pyrazinamidase and nicotinamidase,nicotinamidase , pyrazinam\nidase,Null mutant is viable\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond815:Na+FK60'\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast.  Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPHM8:involved in phosphate metabolism,,\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n mHSP42:Similar to HSP26; expression is regulated by stress conditio\nns,,Null mutant is viable; hsp42 hsp26 double deletion mutan\nts are viable; hsp42 null mutants subjected to moderate ther\nmal stress reorganize the actin cytoskeleton more slowly tha\nn wild-type\n Cond980:F82G_10_mM_1NaPP1\n Cond307:Heat_Shock_80_minutes_hs-1\n Cond304:Heat_Shock_30_minutes_hs-1\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mBTN2:Gene/protein whose expression is elevated in a btn1 minus/Bt\nn1p lacking yeast strain.,,Null mutant is viable; expression\n of BTN2 is elevated in yeast lacking BTN1\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mCPR6 mHSP82 mSTI1

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Computational Genomics Lab, Tel-Aviv uniresity