Module number 3069




Database revision : gnsdb28.10
Date : Tue Feb 25 17:13:10 2003
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Cond158:sir2\n mHIS4:histidinol dehydrogenase,histidinol dehydrogenase,Null mutan\nt is viable and requires histidine\n Cond277:AUR1(tetpromoter)\n mHIS5:responsive to control of general amino acid biosynthesis,his\ntidinol-phosphate aminotransferase,Null mutant is viable and\n requires histidine\n Cond476:GCN4C/GCN4(R4760/R6257)\n Cond698:gal3-gal\n mHIS7:glutamine amidotransferase:cyclase, also called imidazole gl\nycerol phosphate synthase,glutamine amidotransferase:cyclase\n , imidazole glycerol phosphate synthase (synonym),Null muta\nnt is viable and requires histidine\n Cond221:yer083c\n Cond164:sst2(haploid)\n Cond95:mac1\n Cond13:ase1(**12)\n mYOR203W:Unknown ,, Unknown\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond730:hda1\n Cond697:gal2-gal\n mMTD1:NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase,N\nAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase,Nu\nll mutant is viable, associated with loss of NAD-dependent 5\n,10-methylene-THF dehydrogenase activity and a purine requir\nement in some genetic backgrounds\n Cond352:1_mM_Menadione_(120_min)redo\n Stress.HypoOsmot:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond315:37C_to_25C_shock_-_15_min\n Cond244:ymr010w\n Cond702:gal7-gal\n Cond696:gal1-gal\n Cond391:aa_starv_1_h\n Cond517:sst2D/wtlog10(intensity)\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond393:aa_starv_4_h\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond245:ymr014w\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond184:ubr1\n Cond123:rad57\n Cond395:Nitrogen_Depletion_30_min.\n Cond704:gal80-gal\n Cond279:ERG11(tetpromoter)\n Cond701:gal6-gal\n Cond689:gal3+gal\n Cond216:yer044c(haploid)\n Cond86:imp2'(**12)\n mSHM2:serine hydroxymethyltransferase,,Null mutant is viable\n Cond479:WT+/-100mM3AT(SetD)(R491)\n Cond693:gal7+gal\n mLYS1:saccharopine dehydrogenase,,Lysine requiring\n Cond482:WT+/-100mM3AT(SetC)(KNY164)\n Cond226:yhl029c\n Cond694:gal10+gal\n mADE5,7:glycinamide ribotide synthetase and aminoimidazole ribotide \nsynthetase,aminoimidazole ribotide synthetase , glycinamide \nribotide synthetase,Adenine requiring\n mTRP3:anthranilate synthase Component II and indole-3-phosphate (m\nultifunctional enzyme),anthranilate synthase component II , \nindole-3-phosphate,Null mutant is viable, tryptophan auxotro\nph\n Cond700:gal5-gal\n Cond145:rts1\n Cond71:gln3\n Cond688:gal2+gal\n Cond481:WT+/-100mM3AT(SetB)(491)\n Cond54:erg3(haploid)\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n mGCV2:Glycine CleaVage system,glycine cleavage system P subunit , \nglycine decarboxylase complex P subunit , glycine synthase P\n subunit,Inability to convert glycine to serine (ser1 backgr\nound); Inability to utilize glycine as a nitogen source.\n Cond116:pex12\n Cond512:GAL-STE5-CTM,3hrs.gallog10(intensity)\n Cond26:cka2\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond69:gcn4\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond205:yel033w\n Y-Stre.Alkali:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond687:gal1+gal\n Cond27:ckb2\n Cond731:hda1 \n Cond394:aa_starv_6_h\n Cond73:gyp1\n Cond691:gal5+gal\n Cond162:spf1\n mYER091C-A:Unknown ,, Unknown\n Cond475:0.5x/1xAA(MildLeu,HisStarvation)(R176)\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond25:cin5\n mMET6:vitamin B12-(cobalamin)-independent isozyme of methionine sy\nnthase (also called N5-methyltetrahydrofolate homocysteine m\nethyltransferase or 5-methyltetrahydropteroyl triglutamate h\nomocysteine methyltransferase),vitamin B12-(cobalamin)-indep\nendent isozyme of methionine synthase (also called N5-methyl\ntetrahydrofolate homocysteine methyltransferase or 5-methylt\netrahydropteroyl triglutamate homocysteine methyltransferase\n),Null mutant is viable, and is a methionine auxotroph\n Cond690:gal4+gal\n Chromo.chromo:Genomewide studies of histone deacetylase function in yeast.\n Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13.\n Cond39:dig1\n Cond135:rpl20a\n mCPA2:carbamyl phosphate synthetase,carbamyl phosphate synthetase,\nNull mutant is viable\n Cond477:GCN4/gcn4Din100mM3AT(KNY164/KNY124)\n Cond397:Nitrogen_Depletion_2_h\n mARG1:arginosuccinate synthetase,arginosuccinate synthetase,Argini\nne requiring\n mHOM2:threonine and methionine pathway,aspartic beta semi-aldehyde\n dehydrogenase,Homoserine requiring\n Cond225:yhl013c\n mHOM3:First step in common pathway for methionine and threonine bi\nosynthesis,aspartate kinase (L-aspartate 4-P-transferase) (E\nC 2.7.2.4),Homoserine requiring; Borrelidin resistance\n Cond396:Nitrogen_Depletion_1_h\n mARG3:Sixth step in arginine biosynthesis,ornithine carbamoyltrans\nferase,Arginine requiring\n mARG4:argininosuccinate lyase,argininosuccinate lyase,Arginine req\nuiring\n mLYS20:homocitrate synthase, highly homologous to YDL131W,YDL131W (\nLYS21) homolog , homocitrate synthase,Null mutant is viable,\n is able to grow on minimal media, and exhibits reduced but \nsignificant homocitrate synthase activity\n Cond130:rml2(**13)\n Cond29:clb2\n mARG5,6:N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutam\nate kinase,N-acetyl-gamma-glutamyl-phosphate reductase and a\ncetylglutamate kinase,Arginine requiring\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n Cond190:vps8\n Cond2:ade2(haploid)\n Cond90:jnm1\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond384:Hypo-osmotic_shock_-_5_min\n Cond53:erg2\n Cond772:Alkali_20'\n Cond6:anp1\n Cond298:Terbinafine\n Cond705:gal1gal10+gal\n Cond78:hir2\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond201:yel008w\n mSER1:phosphoserine transaminase,phosphoserine transaminase,Null m\nutant is viable, serine-requiring\n mSER2:phosphoserine phosphatase,phosphoserine phosphatase,serine-r\nequiring\n Cond176:swi5\n mSER3:catalyzes the first step in serine biosynthesis; isozyme of \nSER33,3-phosphoglycerate dehydrogenase,enzyme activity of 3P\n-glycerate dehydrogenase is decreased in null mutant compare\nd to wildtype and abolished in ser3 ser33 double deletion mu\ntant\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond287:2-deoxy-D-glucose\n mMET16:3'phosphoadenylylsulfate reductase,3'phosphoadenylylsulfate \nreductase,Null mutant is viable, and is a methionine auxotro\nph\n Cond128:rgt1\n Cond478:WT+/-10mM3AT(R491)\n Cond150:sbh2\n Cond144:rtg1\n Cond47:ecm18(**7)\n mUGA3:Transcriptional activator necessary for gamma-aminobutyrate \n(GABA)-dependent induction of GABA genes (such as UGA1, UGA2\n, UGA4),zinc finger transcription factor of the Zn(2)-Cys(6)\n binuclear cluster domain type,Null mutant is viable but exh\nibits defects in activation of UGA1 and UGA4.\n Cond43:dot4\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mCEM1:homology with beta-keto-acyl synthases,beta-keto-acyl syntha\nse homolog,Null mutant is viable; exhibits respiratory-defic\nient growth\n Cond171:ste24(haploid)\n Cond83:hpt1\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mASN1:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n mADE2:phosphoribosylamino-imidazole-carboxylase,phosphoribosylamin\no-imidazole-carboxylase,Null mutant is viable and requires a\ndenine. ade2 mutants are blocked at a stage in the adenine b\niosynthetic pathway that causes an intermediate to accumulat\ne in the vacuole; the intermediate gives the cell a red colo\nr.\n Cond175:swi4\n mADE3:Required for the biosynthesis of purines, thymidylate, methi\nonine, histidine, pantothenic acid and formylmethionyl-tRNA,\nC1-tetrahydrofolate synthase,Null mutant is viable, adenine \nauxotroph, histidine auxotroph\n mADE4:phosphoribosylpyrophosphate amidotransferase,phosphoribosylp\nyrophosphate amidotransferase,Adenine requiring\n Cond250:ymr031w-a\n mADE6:5'-phosphoribosylformyl glycinamidine synthetase,5'-phosphor\nibosylformyl glycinamidine synthetase,Adenine requiring\n Cond685:wt-gal\n mADE8:glycinamide ribotide transformylase,glycinamide ribotide tra\nnsformylase,Adenine requiring\n Cond398:Nitrogen_Depletion_4_h\n mMET22:Putative phosphatase gene involved in salt tolerance and met\nhionine biogenesis; halotolerance,3'(2')5'-bisphosphate nucl\neotidase,Methionine requiring; lacks 3'-phosphoadenylylsulfa\nte (PAPS) reductase activity; unable to grow on sulfate as s\nole sulfur source\n Cond707:gal4gal80-gal\n Cond294:Itraconazole\n Cond159:sir3\n Cond295:Lovastatin\n Cond299:Tunicamycin\n Cond699:gal4-gal\n mADE13:Adenylosuccinate Lyase,adenylosuccinate lyase,Unable to grow\n on complete media with glucose or fructose as a carbon sour\nce, but can grow with glycerol or ethanol\n Cond771:Alkali_10'\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond392:aa_starv_2_h\n Cond703:gal10-gal\n mHIS1:involved in the first step of histidine biosynthesis,ATP pho\nsphoribosyltransferase,Null mutant is viable and requires hi\nstidine\n
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Computational Genomics Lab, Tel-Aviv uniresity