Module number 3050




Database revision : gnsdb28.10
Date : Tue Feb 25 17:10:21 2003
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mCIN1:Protein involved in chromosome segregation, required for mic\nrotubule stability,tubulin folding cofactor D,Null mutant is\n viable, exhibits cold sensitivity for viability; defect in \nnuclear migration and nuclear fusion, supersensitivity to be\nnomyl and nocodozole\n mYPL201C:Unknown ,, Unknown\n mADY3:Protein involved in Accumulation of DYads,,forms largely asc\ni that contain 2 spores (dyads) when sporulated\n mGUT2:glycerol-3-phosphate dehydrogenase, mitochondrial,glycerol-3\n-phosphate dehydrogenase,Null mutant is viable, unable to ut\nilize glycerol as a carbon source\n mICL1:component of glyoxylate cycle,isocitrate lyase,Null mutant i\ns viable, fails to grow on ethanol as a carbon source\n mRAD61:Unknown ,, Unknown\n mYPR015C:Unknown ,, Unknown\n Cond698:gal3-gal\n mSPG1:Hypothetical ORF,,Null mutant is viable; SPG1 is required fo\nr long-term survival in YPD at 37 degrees C.\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n mFUN34:Highly homologous to Ycr010p and similar to Yarrowia lipolyt\nica glyoxylate pathway regulator GPR1 (see MIPS),transmembra\nne protein (putative),Null mutant is viable\n mYOL157C:Unknown ,, Unknown\n Cond697:gal2-gal\n mFIT1:Facilitator of Iron Transport,Cell wall protein involved in \niron uptake,Impaired siderophore-iron uptake, activation of \nthe major iron-dependent transcription factor AFT1.\n mGPX1:Glutathione peroxidase paralogue,,Null mutant is viable\n mFIT2:Facilitator of iron transport,Cell wall protein involved in \niron transport,impaired siderophore-iron uptake, activation \nof the major iron -dependent transcription factor, AFT1\n mYML072C:Unknown ,, Unknown\n mYBR259W:Unknown ,, Unknown\n mMPC54:Meiotic Plaque Component,,Null: viable. Other phenotypes: sp\norulation deficient.\n mYFL052W:Unknown ,, Unknown\n Cond702:gal7-gal\n Cond696:gal1-gal\n mLEE1:Product of gene unknown,,\n mYML050W:Unknown ,, Unknown\n mYJL216C:Unknown ,, Unknown\n mYER087W:Unknown ,, Unknown\n Cond701:gal6-gal\n mMEK1:Disp. for chr. pairing & chr. condensation seen by in situ h\nybrid. Required for full double strand breaks, normal length\n synaptonemal complexes, meiotic recomb. & spore viability. \nmek1 is rescued by spo13 & in early recomb. function,meiosis\n-specific serine/threonine protein kinase,Null mutant is via\nble, however diploids homozygous for a mek1 null mutation pr\noduce only low percentages of viable spores, reduced spore v\niability is rescued by spo13 mutations\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n mRDS2:Unknown ,, Unknown\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n mMIG1:Transcription factor involved in glucose repression,C2H2 zin\nc finger protein that resembles the mammalian Egr and Wilms \ntumour proteins,Null mutant is viable, exhibits partial dere\npression of numerous glucose regulated transcripts; MIG1 ove\nrexpression and deletion studies suggest that other represso\nrs such as MIG2 may act in a redundant fashion with MIG1\n Cond689:gal3+gal\n Cond693:gal7+gal\n mSTL1:sugar transporter-like protein,sugar transporter-like protei\nn,Null mutant is viable, no growth defects on galactose, man\nnose, maltose, or glycerol.\n mYBR285W:Unknown ,, Unknown\n mCSM4:Protein required for meiotic chromosome segregation,,missegr\negates chromosomes in meiosis\n mMGM1:involved in the propagation of functional mitochondria yeast\n,GTP-binding domain protein related to dynamin,Null mutant i\ns viable, has a reduced number of copies of the mitochondria\nl chromosome per cell at each cell division, grows slowly on\n rich media, fails to grow on non-fermentable carbon sources\n Cond694:gal10+gal\n mYLR282C:Unknown ,, Unknown\n mYNL077W:Unknown ,, Unknown\n Cond871:yhe710-ss\n Cond700:gal5-gal\n mYOR193W:Unknown ,, Unknown\n mYIL172C:Unknown ,, Unknown\n mYMR018W:Unknown ,, Unknown\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mACS1:one of 2 acetyl-coA synthetases in yeast,acetyl CoA syntheta\nse,Null mutant is viable and grows on ethanol or glucose (bu\nt not acetate) as sole carbon source (but with long lag-phas\ne); acs1 acs2 double null mutant is inviable\n mPRM4:pheromone-regulated membrane protein,,\n mYFL054C:Unknown ,, Unknown\n mGIP1:Glc7-interacting protein.,,sporulation defective\n mPET494:translational activator of cytochrome c oxidase,translationa\nl activator of cytochrome C oxidase,petite; unable to grow o\nn non-fermentable carbon sources\n mYJL220W:Unknown ,, Unknown\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mREB1:DNA binding protein which binds sites found in genes transcr\nibed by both RNA polymerase I and RNA polymerase II. Reb1p i\ns required for termination of RNA polymerase I transcription\n.,RNA polymerase I enhancer binding protein,Null mutant is i\nnviable\n mZDS2:multicopy suppressor of a sin4 defect,,Null mutant is viable\n; zds1 zds2 double deletion causes slow growth and defects i\nn bud morphology and cell cycle progression\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond685:wt-gal\n Cond686:wt+gal\n mGIT1:permease involved in the uptake of glycerophosphoinositol (G\nroPIns),permease involved in the uptake of glycerophosphoino\nsitol (GroPIns),Null mutant is viable, exhibits decreased Gr\noPIns transport\n mYLR327C:Unknown ,, Unknown\n mNCA2:Regulates proper expression of subunits 6 (Atp6p) and 8 (Atp\n8p) of the Fo-F1 ATP synthase,,Null mutant is viable\n mBIO5:transmembrane regulator of KAPA/DAPA transport,transmembrane\n regulator of KAPA/DAPA transport,\n mMMS4:Product of gene unknown,,null is synthetically lethal with s\ngs1 null\n mYDR070C:Unknown ,, Unknown\n mBOI1:Involved in bud growth,,Null mutant is viable.\n Cond984:pho85D_DMSO_24_hrs._vs._F82G_10_mM_1-Na_PP1_24_hrs._\n mHBT1:Unknown ,, Unknown\n mYJR020W:Unknown ,, Unknown\n mIDP2:concerts isocitrate and NADP+ to 2-oxoglutarate, CO2, and NA\nDPH,NADP-dependent isocitrate dehydrogenase,Null mutant is v\niable\n mYFR054C:Unknown ,, Unknown\n mHXT4:hexose transporter,high affinity glucose transporter,Null mu\ntant is viable\n Cond690:gal4+gal\n mYPL185W:Unknown ,, Unknown\n mYPT53:Involved in vacuolar protein sorting and endocytosis,GTP-bin\nding protein , rab family,Null mutant is viable\n mYMR114C:Unknown ,, Unknown\n Cond699:gal4-gal\n mAGP2:General amino acid permease with broad substrate specificity\n,amino acid permease,Null mutant is viable; loss of growth o\nn some amino acids as nitrogen source (leu, thr) in a strain\n which has no Gap1p or Agp1p function\n mPFK26:6-Phosphofructose-2-kinase,6-phosphofructose-2-kinase,Null m\nutant is viable; on pyrvuate medium, no fructose 2,6-P2 is d\netectable in mutant\n mYPL222W:Unknown ,, Unknown\n Cond703:gal10-gal\n
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Computational Genomics Lab, Tel-Aviv uniresity