Module number 2932




Database revision : gnsdb28.10
Date : Tue Feb 25 17:36:16 2003
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Cond899:RPN4_MMS__\n mSPC2:subunit of signal peptidase complex, homologous to mammalian\n protein SPC25,signal peptidase complex subunit , similar to\n mammalian protein SPC25,Null mutant is viable. spc1 spc2 do\nuble deletion mutants grow relatively well as compared to wi\nld-type. spc2 sec11 double deletion mutant is inviable. Spc2\np is important for cell viability and signal peptidase activ\nity at high temperatures (42 degrees celsius).\n Cond912:(99i1)_S150-2B_YPGL_NormInt\n mRBL2:binds to beta-tubulin and may participate in microtubule mor\nphogenesis,tubulin folding cofactor A,Overexpression rescues\n lethality caused by excess beta-tubulin\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYHR121W:Unknown ,, Unknown\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mYNR024W:Unknown ,, Unknown\n mRPB10:RNA polymerase II subunit,RNA polymerase II core subunit,Nul\nl mutant is inviable\n Cond711:t2+Vec\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond670:DES459_(mec1)_-_mock_irradiation_-_5_min\n mRPL25:Homology to E. coli L23 and rat L23a,ribosomal protein L25 (\nrpl6L) (YL25),\n mVMA21:Protein involved in vacuolar H-ATPase assembly or function,,\nNull mutant is viable but grows slowly and exhibits increase\nd calcium sensitivity. Null mutants also cannot grow on glyc\nerol or at pH 7.5\n mVMA22:Required for V-ATPase activity,,Null mutant is viable but is\n defective in vacuolar H(+)-ATPase activity, sensitive to ca\nlcium, cyclosporin A, and FK506, and requires calcineurin fo\nr viability\n mYOR305W:Unknown ,, Unknown\n Cond892:S\n Cond898:RPN4\n Cond463:29_deg_growth_ct-1\n mURM1:ubiquitin-like protein,ubiquitin-like protein,Null mutant is\n viable and has temperature-sensitive growth defect at 37 de\ngrees C\n Cond719:t4-SSD1\n mLSM2:Like Sm-D1 protein,snRNA-associated protein, Sm class,Null m\nutant is inviable\n mYOL146W:Unknown ,, Unknown\n Cond872:Zero1\n Cond940:6h\n mNOP16:Nucleolar protein 16,ribosome biogenesis,\n mLSM7:Like Sm-G protein,snRNP protein,Null mutant is viable but gr\nows slowly at 23deg and 30deg, and is required for growth at\n 37deg\n Cond713:t4+Vec\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYDR210W:Unknown ,, Unknown\n mFRQ1:Product of gene unknown,,\n mDTD1:Unknown ,, Unknown\n mDCP1:Decapping protein involved in mRNA degradation,,Null mutant \nis inviable in the FY1679 background, but viable, though gro\nws slowly, in the CEN.PK141 background.\n Cond722:t2+SSD1,H44\n mYCR082W:Unknown ,, Unknown\n Cond672:DES459_(mec1)_-_mock_irradiation_-_60_min\n mYDR152W:Unknown ,, Unknown\n mRDS3:Unknown ,, Unknown\n mTOM7:Involved in mitochondrial protein import,translocase of the \nouter mitochondrial membrane,Null mutant is viable\n Cond749: mSUI3:beta subunit of translation initiation factor eIF-2,translat\nion initiation factor eIF-2 beta subunit,suppression of init\niator codon mutations\n mLOC1:Localization of mRNA,,Mutant exhibits slow growth at 30C\n mCGR1:coiled-coil growth-regulated,coiled-coil protein,Null mutant\n is inviable; CGR1 expression is down-regulated in the postd\niauxic growth phase\n Cond717:t2-SSD1\n Cond720:t0+SSD1,H44\n mSRP14:Signal recognition particle subunit,,Null mutant is viable\n Cond278:CDC42(tetpromoter)\n Cond725:t4-SSD1,M31\n mRTT102:Regulator of Ty1 Transposition,,Null mutant is viable and ca\nuses increase in Ty1 transposition\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n mYER030W:Unknown ,, Unknown\n Cond906:(77i5)_S150-2B_YPD_NormInt\n mTRI1:Topoisomerase 1 and RAD52 epistasis group Interactions,,Null\n mutant is viable.\n Cond904:(77i3)_HBY4_YPGL+G_NormInt\n mCNB1:Type 2B protein phosphatase; regulatory B subunit of calcine\nurin,calcineurin regulatory B subunit , type 2B protein phos\nphatase , calcineurin regulatory B subunit , type 2B protein\n phosphatase,Null mutant is viable, Li+ and Na+ sensitive, c\nnb1 fks1 and cnb1 vma3 double mutants are inviable\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mVPS24:involved in secretion,,Null mutant missorts vacuolar hydrola\nses and accumulates a late endosomal compartment; Class E vp\ns mutant\n mYKR060W:Unknown ,, Unknown\n mOST4:May be subunit or accessory component of oligosaccharyltrans\nferase,3.6 kDa protein, probably membrane-located,Null mutan\nt is viable but is cold- and heat-sensitive; vanadate-resist\nant, hygromycin B-sensitive; defective in oligosaccharyltran\nsferase activity in vivo and in vitro\n mYOR252W:Unknown ,, Unknown\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYBR210W:Unknown ,, Unknown\n mDPB4:DNA Polymerase B (II), 4th subunit,DNA polymerase II (epsilo\nn) 4th subunit,Null mutant is viable\n Cond714:t0+SSD1wt\n Cond905:(77i4)_S150-2B_YPGL+G__NormInt\n mYKE2:Yeast nuclear gene encoding a protein showing homology to mo\nuse KE2 and containing a putative leucine-zipper motif,bovin\ne NABC complex component homolog , non-native actin binding \ncomplex polypeptide 6 , bovine NABC complex component homolo\ng , non-native actin binding complex polypeptide 6,Null muta\nnt is viable\n mGIM3:Prefoldin subunit 4; putative homolog of subunit 4 of bovine\n prefoldin, a chaperone comprised of six subunits,bovine pre\nfoldin subunit 4 homolog (putative),Null mutant is viable, s\nuper-sensitive towards the microtubule-depolymerizing drug b\nenomyl, synthetically lethal with tub4-1 mutations\n Cond721:t0-SSD1,M31\n mGIM4:Prefoldin subunit 2; putative homolog of subunit 2 of bovine\n prefoldin, a chaperone comprised of six subunits,bovine pre\nfoldin subunit 2 homolog (putative),Null mutant is viable, s\nensitive to anti-microtubule drugs benomyl and nocadazole; s\nynthetically lethal with tub4-1 mutations\n mRPA34:RNA polymerase I subunit, not shared (A34.5),,Null mutant is\n viable but its RNA polymerase I lacks subunit A49 (rpa49p);\n synthetically lethal with RPA14; shows synthetic interactio\nns with DNA topoisomerase I (TPO1)\n mGIM5:Prefoldin subunit 5; putative homolog of subunit 5 of bovine\n prefoldin, a chaperone comprised of six subunits,bovine pre\nfoldin subunit 5 homolog (putative),Null mutant is viable, c\nold sensitive, benomyl and nocadazole sensitive and fails to\n grow on YPD+1.2M KCl or YPD+1.8M sorbitol ; synthetically l\nethal with tub4-1 mutations\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPFD1:Prefoldin subunit 1; putative homolog of subunit 1 of bovine\n prefoldin, a chaperone comprised of six subunits,bovine pre\nfoldin subunit 1 homolog (putative),\n Cond938:2h\n mBUD21:protein possibly involved in protein synthesis,,Null mutant \nis viable; random budding in diploid null mutants; null has \nboth reduced growth and reduced protein synthesis rates\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n mYNL155W:Unknown ,, Unknown\n Cond660:DES460_(wt)_-_mock_irradiation_-_60_min\n Cond939:4h\n mLSM2 mLSM7 mDCP1 mFRQ1 mVMA22 mGIM4 mYKE2 mGIM5 mGIM3
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Computational Genomics Lab, Tel-Aviv uniresity