Module number 2930




Database revision : gnsdb28.10
Date : Tue Feb 25 17:36:11 2003
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mYDL180W:Unknown ,, Unknown\n mHSP104:involved in thermal and ethanol tolerance, inheritance of [P\nSI+], and reactivation of mRNA splicing after heat shock,hea\nt shock protein 104,Null mutant is viable and defective in i\nnduced thermotolerance\n mYDR071C:Unknown ,, Unknown\n mVPS74:Unknown ,, Unknown\n mTOS5:Hypothetical ORF,,\n mYHR121W:Unknown ,, Unknown\n Cond136:rpl27a(**4)\n mSHS1:Interacts with Spa2p and plays a role in cytokinesis,,defici\nent for cytokinesis\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mPUF6:member of the PUF protein family,,\n mYDR282C:Unknown ,, Unknown\n mHNT2:Fhit homolog, member of the histidine triad superfamily of n\nucleotide binding-proteins,,\n mYDR492W:Unknown ,, Unknown\n mYKL063C:Unknown ,, Unknown\n Cond679:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison\n mKAR4:May assist Ste12p in pheromone-dependent expression of KAR3 \nand CIK1,involved in karyogamy , transcription factor,Defect\nive in pheromone-induced expression of KAR3 and CIK1; theref\nore, defective in nuclear fusion because of defect in microt\nubule-dependent movement of nuclei; also required for meiosi\ns\n mYBR052C:Unknown ,, Unknown\n mVMA22:Required for V-ATPase activity,,Null mutant is viable but is\n defective in vacuolar H(+)-ATPase activity, sensitive to ca\nlcium, cyclosporin A, and FK506, and requires calcineurin fo\nr viability\n mYPR1:homologous to the aldo-keto reductase protein family,,\n mSEC72:protein involved in membrane protein insertion into the ER,,\nNull mutant is viable, accumulates a subset of secretory pre\ncursors\n mRXT3:Unknown ,, Unknown\n mARO3:DAHP synthase; a.k.a. phospho-2-dehydro-3-deoxyheptonate ald\nolase, phenylalanine-inhibited; phospho-2-keto-3-deoxyhepton\nate aldolase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-\ndeoxy-D-arabine-heptulosonate-7-phosphate synthase,DAHP synt\nhase; a.k.a. phospho-2-dehydro-3-deoxyheptonate aldolase, ph\nenylalanine-inhibited; phospho-2-keto-3-deoxyheptonate aldol\nase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-deoxy-D-a\nrabine-heptulosonate-7-phosphate synthase,null mutant is via\nble\n mTPM2:Tropomyosin isoform 2,tropomyosin isoform II,Null mutant is \nviable, exhibits no detectable phenotype; tpm1 tpm2 double d\neletion mutants are inviable; TPM2 overexpression does not s\nuppress tpm1 mutant phenotypes\n Cond680:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison_,\n2\n mUBC5:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,vi\nable, ubc4/ubc5 double mutant is temperature sensitive\n mSSP120:secretory protein,,Null mutant is viable\n mRSM18:protein similar to bacterial ribosomal subunit S18,mitochond\nrial ribosome small subunit component,null is unable to grow\n on glycerol\n Cond940:6h\n mEND3:Required for endocytosis and organization of the cytoskeleto\nn,,Null mutant is viable and defective in endocytosis\n mSNF7:Involved in derepression of SUC2 in response to glucose limi\ntation,,Null mutant is viable. Similar to disruption SNF8, S\nNF7 disruption causes a fewfold decrease in invertase derepr\nession, a growth defect on raffinose, temperature-sensitive \ngrowth on glucose, and a sporulation defect in homozygous di\nploids. Genetic interactions suggest SNF7 is different from \nSNF2, SNF5 and SNF6, members of the SNF/SWI chromatin remode\nling complex\n mERO1:involved in protein disulfide bond formation in the ER,,Null\n mutant is inviable; in ero1-1(ts) mutants newly synthesized\n carboxypeptidase Y is retained in the ER and lacks disulfid\ne bonds; ero1 mutants are hypersensitive to to the reductant\n DTT, whereas overexpression of ERO1 confers resistance to D\nTT, the oxidant diamide can restore growth and secretion in \nero1 mutants\n mYFR041C:Unknown ,, Unknown\n mTAF10:TFIID subunit (TBP-associated factor) with predicted molecul\nar weight of 23 kD.,TFIID subunit,Null mutant is inviable\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSCL1:Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7),pro\nteasome subunit YC7alpha/Y8 (protease yscE subunit 7),Null m\nutant is inviable, SCL1 is a dominant suppressor of the ts l\nethality of crl3\n mNYV1:Synaptobrevin (v-SNARE) homolog involved in vacuolar vesicle\n fusion,vacuolar v-SNARE,Null mutant is viable\n mYDR370C:Unknown ,, Unknown\n mPEP3:vacuolar membrane protein,vacuolar membrane protein,Null mut\nant is viable, exhibits growth defects at 37 degrees celsius\n, exhibits vacuolar protein sorting and processing and defec\nts, exhibits decreased levels of protease A, protease B, and\n carboxylpeptidase Y antigens; decreased repressible alkalin\ne phosphatase activity; null mutants contain very few normal\n vacuolelike organelles; homozygous null mutants are sporula\ntion defective\n Cond677:DES459_(mec1)_-_log_phase_(IR_time_=_0_sample)\n mMGT1:6-O-methylguanine-DNA methylase,6-O-methylguanine-DNA methyl\nase,Null mutant is viable, sensitive to alkylation induced k\nilling and mutation\n mYLR387C:Unknown ,, Unknown\n mYDR279W:Unknown ,, Unknown\n mSWR1:Sick With Rat8 ts,RNA helicase (putative) , deah box protein\n,Null mutant is viable and shows no growth defects; swr1 rat\n8-2 double mutant has a slow growth phenotype; SWR1 is a par\ntial High copy suppressor of pse1-1 kap123\n mRMS1:Transcription regulator,,null mutant is viable with no appar\nent defects\n mRPN13:Proteasome subunit,,Null mutant is viable but defective in d\negradation of ubiquitinated substrates.\n mRPN5:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit p55,proteasome regulatory particle subunit,Null\n mutant is inviable\n mYDR330W:Unknown ,, Unknown\n mRPN6:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S9/p44.5.,proteasome regulatory particle subuni\nt,Null mutant is inviable\n mYKR023W:Unknown ,, Unknown\n mYJR088C:Unknown ,, Unknown\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mYDR458C:Unknown ,, Unknown\n Cond678:DES459_(mec1)_-_log_phase_(MMS_time_=_0_sample)\n mRTN2:Unknown ,, Unknown\n mYDR229W:Unknown ,, Unknown\n mYDR117C:Unknown ,, Unknown\n mDOS2:Product of gene unknown,,\n mIST1:Similar to Nuf1p (spindle pole body component),,\n mNHP10:Non-Histone Protein 10,HMG1-box containing protein,null muta\nnt is viable and has normal growth rate\n mSPT3:Transcription factor,histone acetyltransferase SAGA complex \nmember , transcription factor,Null mutant is viable, exhibit\ns defects in mating and sporulation, Ty transcription, and s\nuppression of certain Ty insertion mutations\n mYBR101C:Unknown ,, Unknown\n mENT5:Unknown ,, Unknown\n mYGL004C:Unknown ,, Unknown\n mSRP14:Signal recognition particle subunit,,Null mutant is viable\n mYDR066C:Unknown ,, Unknown\n mGCV1:Required for metabolizing glycine as a nitrogen source,glyci\nne decarboxylase complex T subunit,Null mutant is viable but\n cannot use glycine as sole nitrogen source\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n mRTT103:Regulator of Ty1 Transposition,,Gene disruption causes Ty1 h\nypertransposition phenotype\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n mYDL099W:Unknown ,, Unknown\n mYER030W:Unknown ,, Unknown\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mMAP2:methionine aminopeptidase 2,methionine aminopeptidase 2,Null\n mutant is viable, map1 map2 double null mutant is inviable\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n mVPS20:vaculolar protein sorting (putative),,Null mutant is viable \nbut is a class E vps mutant (missorts vacuolar hydrolases an\nd accumulates late endosomal compartment).\n mCNB1:Type 2B protein phosphatase; regulatory B subunit of calcine\nurin,calcineurin regulatory B subunit , type 2B protein phos\nphatase , calcineurin regulatory B subunit , type 2B protein\n phosphatase,Null mutant is viable, Li+ and Na+ sensitive, c\nnb1 fks1 and cnb1 vma3 double mutants are inviable\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSUP35:altered form creates [PSI] prion,translation termination fac\ntor eRF3,accumulation of large budded cells and substantial \narrest of DNA synthesis at the nonpermissive temperature (ar\nrests at G(sub)1/S transition); omnipotent suppressor of non\nsense mutations\n mSLF1:Associates with translating ribosomes; may function in cytop\nlasm to modulate mRNA translation; regulates the copper-depe\nndent mineralization of copper sulfide complexes on cell sur\nface in cells cultured in medium containing copper salts,,Nu\nll mutant is viable, copper sensitive, has lost ability to d\neplete Cu, but not Cd ions from surrounding medium; SLF1 ove\nrexpression confers copper superresistance and enhances Ca d\nepletion ability\n mSDC1:YDR469W,,\n mSFA1:Long-chain alcohol dehydrogenase (glutathione-dependent form\naldehyde dehydrogenase),glutathione-dependent formaldehyde d\nehydrogenase , long-chain alcohol dehydrogenase,Null mutant \nis viable; sensitive to formaldehyde\n mUBP6:deubiquitinating enzyme (putative),,\n mGLO2:Cytoplasmic glyoxylase-II,glyoxylase-II,Null mutant is viabl\ne but shows increased sensitivity to methylglyoxal\n mYDR132C:Unknown ,, Unknown\n mPPH3:protein phosphatase type 2A,protein phosphatase type 2A,Null\n mutant is viable, pph3 pph21 pph22 mutants are inviable\n mPLP1:Phosducin-Like Protein,,Null mutant is viable\n mARF2:ADP-ribosylation factor 2,ADP-ribosylation factor 2,Null mut\nant is viable\n mHSP78:Similar to E. coli ClpB protein; involved in folding of some\n mitochondrial proteins,heat shock protein 78,Null mutant is\n viable but in ssc1 mutant background gives rho- phenotype\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n mYDR209C:Unknown ,, Unknown\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYDR067C:Unknown ,, Unknown\n mMSS116:Mitochondrial RNA helicase of the DEAD box family,RNA helica\nse DEAD box,mss116 mutations affect the splicing of several \nintrons of the cytochrome B and cytochrome C oxidase subunit\n I primary transcripts\n mRAV2:Regulator of (H+)-ATPase in Vacuolar membrane,,\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n mPRP11:snRNA-associated protein,snRNA-associated protein,RNA proces\nsing defective\n mPPH21:serine-threonine protein phosphatase 2A,,Null mutant is viab\nle, pph21 pph22 mutants produce very small spores in some st\nrain backgrounds and are inviable in others, pph21 pph22 pph\n3 mutants are inviable\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n mERV29:ER Vesicle protein of 29 kDa (apparent MW),ER-Golgi transpor\nt vesicle protein,Null mutant is viable.\n mNBP2:interacts with Nap1, which is involved in histone assembly,,\n mCCT4:cytoplasmic chaperonin subunit required for actin cytoskelet\non assembly or function,,Null mutant is inviable; cct4 mutan\nt exhibit allele-specific non-complementing interactions wit\nh different act1 mutations; anc2-1 mutants contain abnormal \nand disorganized actin structures, are defective in cellular\n morphogenesis, and are hypersensitive to the microtubule in\nhibitor benomyl. Overexpression of wild-type Anc2p ameliorat\nes defects in actin organization and cell growth caused by a\nctin overproduction.\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n mYFR011C:Unknown ,, Unknown\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mRPT2 mRPN5 mYGL004C mRPN6 mRPT1 mRPN13 mTAF10 mSPT3 mSUP35 mHSP104 mSDC1 mVMA22
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Computational Genomics Lab, Tel-Aviv uniresity