Module number 2922




Database revision : gnsdb28.10
Date : Tue Feb 25 17:34:44 2003
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Cond717:t2-SSD1\n mNDC1:dispensable for mitotic spindle pole body duplication, but r\nequired for insertion of nascent spindle pole bodies into th\ne nuclear envelope. ndc1 parental spindle pole bodies form m\nonopolar spindles in mitosis. Required for meiosis II.,multi\nple transmembrane domains (putative) , nuclear envelope prot\nein,Null mutant is inviable. Conditional lethal mutants are \navailable that show asymmetric chromosomal segregation durin\ng mitosis and meiosis II due to a defect in spindle pole bod\ny duplication\n mYLR224W:Unknown ,, Unknown\n Cond716:t2+SSD1wt\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond725:t4-SSD1,M31\n Cond711:t2+Vec\n mMNN10:Required for mannan synthesis and for polarized growth and b\nud emergence,galactosyltransferase,Null mutant is viable, is\n larger than wild-type cells, is deficient in bud emergence,\n and depends upon an intact morphogenesis checkpoint control\n to survive\n mMNN11:member of a cis Golgi complex that is involved in mannan syn\nthesis, other complex members include Mnn10p, Hoc1p, Anp1p, \nMnn9p,mannosyltransferase complex component,Null mutant is v\niable, exhibits defects in mannan synthesis\n mPTM1:Putative membrane protein,membrane protein (putative),Null m\nutant is viable, no observable phenotype\n Cond712:t4+SSD1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYEL033W:Unknown ,, Unknown\n mSRM1:Gdp/GTP exchange factor for Gsp1p/Gsp2p,pheromone response p\nathway suppressor,\n mROT1:Reversal of tor2 lethality,membrane protein (putative),Null \nmutant is inviable; rot1 mutations can suppress tor2 mutatio\nns; synthetically lethal with rot2\n mPHO86:May collaborate with Pho87p and Pho84p in phosphate uptake,i\nnorganic phosphate transporter (putative),Null mutant is via\nble and expresses repressible acid phosphatase in high phosp\nhate medium; pho86 pho87 double mutant and pho86 pho88 doubl\ne mutant constituvely synthesize repressible acid phosphatas\ne and are arsenate-resistant; pho84 pho86 pho87 triple mutan\nt grows more slowly than pho84 mutant\n Cond714:t0+SSD1wt\n mARF2:ADP-ribosylation factor 2,ADP-ribosylation factor 2,Null mut\nant is viable\n mEMG1:Essential for Mitotic Growth,ribosome biogenesis,Lethal\n Cond713:t4+Vec\n mSEH1:Nuclear pore protein, homologous to sec13,,\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mNUP85:Protein in nuclear pore complex; may function in nuclear env\nelope integrity; may also be involved in tRNA biogenesis,,Nu\nll mutant is viable but is temperature-sensitive; at nonperm\nissive temperature, null mutant accumulates poly(A)+ RNA and\n has fragmented nucleolus; at permissive temperature, nuclea\nr envelope of null mutant detaches from nucleus\n mKTR3:Putative alpha-1,2-mannosyltransferase,alpha-1,2-mannosyltra\nnsferase (putative),\n mKTR4:Putative alpha-1,2-mannosyltransferase,alpha-1,2-mannosyltra\nnsferase (putative),\n mCKB1:beta (38kDa) subunit of casein kinase II (CKII),casein kinas\ne II beta subunit,Null mutant is viable, exhibits salt sensi\ntivity specific to NaCl and LiCl\n mRPS22B:Homology to rat S15a,ribosomal protein S22B (S24B) (rp50) (Y\nS22),\n Cond721:t0-SSD1,M31\n mHEM12:fifth enzyme in the heme biosynthetic pathway,uroporphyrinog\nen decarboxylase,Null mutant is viable; auxotroph for heme a\nnd methionine\n mMDL1:ATP-binding cassette (ABC) transporter family member,,Null m\nutant is viable\n Cond722:t2+SSD1,H44\n Cond938:2h\n mHRB1:an ORF of unknown function located in a centromeric region d\nuplicated between chromosomes III and XIV,hypothetical RNA-b\ninding protein,\n mNIP7:Nip7p is required for 60S ribosome subunit biogenesis,,Null \nmutant is inviable; in the temperature-sensitive mutant nip7\n-1, glycine 71 is replaced by aspartic acid\n mMAK32:Protein necessary for structural stability of L-A double-str\nanded RNA-containing particles,,\n Cond709:t0+Vec\n mRPO41:mitohcondrial RNA polymerase,mitochondrial RNA polymerase,Nu\nll mutant is viable\n mBMH1:Brain Modulosignalin Homolog,member of conserved eukaryotic \n14-3-3 gene family,Null mutant is viable; bmh1 bmh2 double m\nutant is inviable; (in strain Sigma-1278b, required for pseu\ndohyphal development but not for viability)\n mPPG1:Serine/threonine protein phosphatase involved in glycogen ac\ncumulation,,Null mutant is viable but accumulates less glyco\ngen\n mCCT3:Homolog of mammalian CCT family of chaperonin proteins; requ\nired for assembly of microtubules and actin in vivo,gamma ch\naperonin subunit,Defects in microtubule and actin assembly i\nn vivo, abberant chromosome segregation, supersensitivity to\n benomyl\n mCCT4:cytoplasmic chaperonin subunit required for actin cytoskelet\non assembly or function,,Null mutant is inviable; cct4 mutan\nt exhibit allele-specific non-complementing interactions wit\nh different act1 mutations; anc2-1 mutants contain abnormal \nand disorganized actin structures, are defective in cellular\n morphogenesis, and are hypersensitive to the microtubule in\nhibitor benomyl. Overexpression of wild-type Anc2p ameliorat\nes defects in actin organization and cell growth caused by a\nctin overproduction.\n mUBS1:General positive regulator of CDC34; Suppress some cdc34 mut\nations when over-expressed,,Null mutant is viable but exhibi\nts a synthetic phenotype with temperature-sensitive alleles \nof cdc34.\n mCCT5:Required for assembly of microtubules and actin in vivo,chap\neronin subunit epsilon subunit,\n mMNN10 mMNN11 mSEH1 mNUP85
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Computational Genomics Lab, Tel-Aviv uniresity