Module number 2918




Database revision : gnsdb28.10
Date : Tue Feb 25 17:33:15 2003
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mPDR10:Putative ABC transporter highly similar to Pdr5p,ABC transpo\nrter (putative) , highly similar to Pdr5p,\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mTIP20:transport protein that interacts with Sec20p; required for p\nrotein transport from the endoplasmic reticulum to the golgi\n apparatus,transport protein that interacts with Sec20p; req\nuired for protein transport from the endoplasmic reticulum t\no the golgi apparatus,\n mMCM16:Involved in a nonessential role that governs the kinetochore\n-microtubule mediated process of chromosome segregation,,Nul\nl mutant is viable, exhibits increased sensitivity to the an\nitmitotic drugs benomyl and thiabenzadole; exhibits a high r\nate of chromosome III loss without a significant increase in\n recombination frequency, may exhibit altered kinetochore as\nsembly\n mSDH3:succinate dehydrogenase cytochrome b,succinate dehydrogenase\n cytochrome b,Null mutant is viable, has impaired mitochondr\nial function, fails to grow on non-fermentable carbon source\ns\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mUFD2:Ubiquitin fusion degradation protein,,Null mutant is viable \nbut exhibits increased sensitivity to ethanol stress.\n Y-Stre.NaCl:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n mYGL250W:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSOL3:weak multicopy suppressor of los1-1,,Null mutant is viable\n Cond67:gal83\n mPHO80:Negative regulator of PHO81 and PHO5,Pho80p cyclin,The null \nmutant is viable but constitutively derepresses PHO5 (acid p\nhosphatase) transcription and is postive for deoxythymidine \nmonophosphate uptake. The null mutant is supersensitive to a\nminoglycoside.\n mGRE1:Induced by osmotic stress,,Null mutant is viable and shows n\no phenotype in osmotic, ionic or oxidative stress\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPET54:translational activator of cytochrome c oxidase subunit III;\n required for splicing of cytochrome c oxidase subunit I mRN\nA,translational activator of cytochrome C oxidase subunit II\nI; required for splicing of cytochrome c oxidase subunit I \nmRNA,petite; unable to grow on non-fermentable carbon source\ns\n mMSS18:Protein involved in splicing intron a15beta of COX1,,blocked\n in splicing of cox1 pre-mRNA\n mTWF1:Twinfilin A is a member of a conserved family of actin monom\ner sequestering proteins. TWF1 is comprised almost entirely \nof two tandem repeats, each having sequence homology with co\nfilin (COF1).,twinfilin A, an actin monomer sequestering pro\ntein,Null mutant is viable, twf1 null cof1-22 mutants exhibi\nt synthetic lethality\n mYTA12:Mitochondrial ATPase (similar to E. coli FtsH protein) that \nresides in the innner mitochondrial membrane,ATPase , CDC48/\nPAS1/SEC18 (AAA) family,Null mutant is viable, petite grossl\ny deficient in mitochondrial respiratory and ATPase complexe\ns, yet synthesizes all proteins encoded by mitochondrial DNA\n mDSN1:Unknown ,, Unknown\n Cond212:yer030w\n mSSP2:Sporulation Specific,,Null mutant is viable, fails to sporul\nate\n Cond942:SK1ume6_YPD\n mMEC3:Involved in checkpoint control and DNA repair,,Null mutant i\ns viable\n Cond787:NaCl_45'\n mYFR043C:Unknown ,, Unknown\n mKTR5:Putative mannosyltransferase of the KRE2 family,mannosyltran\nsferase (putative),Null mutant is viable\n mYMR295C:Unknown ,, Unknown\n Cond786:NaCl_30'\n Cond937:t=0\n mIME1:Transcriptional activator of meiotic gene expression.,,The n\null mutant is viable. Diploids homozygous for the null mutat\nion lack premeiotic DNA synthesis and do not sporulate; thes\ne phenotypes are recessive.\n mYCR023C:Unknown ,, Unknown\n mYGR117C:Unknown ,, Unknown\n mYGL262W:Unknown ,, Unknown\n mCSI1:Unknown ,, Unknown\n mGUP1:Involved in active glycerol uptake,glycerol transporter (put\native),\n mSPP2:Required for final stages of splicesome maturation; promotes\n step 1 of splicing,,Null mutant is inviable. Depletion of S\npp2p from yeast cells results in accumulation of unspliced p\nre-mRNAs. A temperature-sensitive spp2-1 mutant accumulates \npre-mRNAs in vivo and is unable to undergo the first splicin\ng reaction in vitro.\n mRHO2:Gtp-binding protein of the rho subfamily of ras-like protein\ns,GTP-binding protein , rho subfamily,null is viable\n mPEX3:48-kDa peroxisomal integral membrane protein,48 kDa peroxiso\nmal integral membrane protein,Mutant lacks peroxisomes and s\nhows cytosolic mislocalization of peroxisomal matrix enzymes\n mVPS36:Defective in vacuolar protein sorting,,\n Cond211:yer024w\n
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Computational Genomics Lab, Tel-Aviv uniresity