Module number 2902




Database revision : gnsdb28.10
Date : Tue Feb 25 17:31:58 2003
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Cond330:29C_+1M_sorbitol_to_33C_+_1M_sorbitol_-_15_minutes\n Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond399:Nitrogen_Depletion_8_h\n mTKL1:Transketolase 1,transketolase 1,Null mutant is viable; growt\nh on fermentable carbon sources, but not gluconeogenic carbo\nn sources, is reduced; tkl1 tkl2 mutants are auxotrophic for\n aromatic amino acids\n Cond432:YPD_stationary_phase_22_d_ypd-1\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond418:YPD_1_d_ypd-2\n Cond675:MHY1_(dun1)_+_heat_20_min\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n Cond913:(99i3)_S150-2B_YPD_NormInt\n Cond400:Nitrogen_Depletion_12_h\n mTUF1:Translation elongation factor Tu, mitochondrial,translation \nelongation factor Tu, mitochondrial,Null mutant is viable, b\nlocks mitochondrial translation and destabilizes mitochondri\nal genome.\n Cond416:YPD_10_h__ypd-2\n Cond425:YPD_stationary_phase_12_h_ypd-1\n mRPS29B:Homology to rat S29,ribosomal protein S29B (S36B) (YS29),\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond364:dtt_030_min__dtt-2\n mDYS1:Deoxyhypusine synthase carries out the first step in hypusin\ne biosynthesis, converting lysine and spermidine into deoxyh\nypusine.,deoxyhypusine synthase,Null mutant is inviable\n mRPB8:16-kDa RNA polymerase subunit (common to polymerases I, II a\nnd III),16 kDa RNA polymerase subunit (common to polymerases\n I, II and III),Null mutant is inviable\n Cond454:YP_fructose_vs_reference_pool_car-2\n Cond445:Msn4_overexpression\n Cond890:G1\n Cond:\n mAUR1:involved in phospolipid metabolism,,Null mutant is inviable;\n mutant exhibits dominant resistance to aureobasidin A. Wild\n type (sensitive) is recessive.\n Cond391:aa_starv_1_h\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n Cond814:Na+FK45'\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n mRPP2A:Homology to rat P2, human P2, and E.coli L12eIB,60S acidic r\nibosomal protein P2A (L44) (A2) (YP2alpha),Null mutant is vi\nable\n mRPA12:A12.2 subunit of RNA polymerase I,RNA polymerase I A12.2 sub\nunit,Null mutant is viable but is temperature sensitive; syn\nthetically lethal with RPA14\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond318:37C_to_25C_shock_-_60_min\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond894:G2\n Cond395:Nitrogen_Depletion_30_min.\n Cond279:ERG11(tetpromoter)\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond404:Nitrogen_Depletion_5_d\n mSSZ1:DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a \nribosome-associated complex (RAC) that is bound to the ribos\nome via the Zuo1p subunit,HSP70 family,Null mutant is viable\n, cold sensitive; SSZ1 overexpression causes increased expre\nssion of some PDR genes\n Cond479:WT+/-100mM3AT(SetD)(R491)\n Cond849:120_min\n Cond306:Heat_Shock_60_minutes_hs-1\n Cond430:YPD_stationary_phase_7_d_ypd-1\n Cond848:90_min\n Cond879:MMC\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond422:YPD_stationary_phase_2_h_ypd-1\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mCBR1:cytochrome b reductase,cytochrome b reductase,\n mRPC40:RNA polymerase III (C) subunit,RNA polymerase III subunit,Nu\nll mutant is inviable.\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mRPS2:Homology to rat S2 and E. coli S5,ribosomal protein S2 (S4) \n(rp12) (YS5),Omnipotent suppressor of nonsense mutations\n Cond433:YPD_stationary_phase_28_d_ypd-1\n mARF1:implicated in signal transduction and intracellular protein \ntransport to or within the Golgi apparatus,ADP-ribosylation \nfactor,Null mutant is viable and shows slow growth, cold sen\nsitivity and sensitivity to normally sublethal concentration\ns of fluoride ion in the medium.\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond942:SK1ume6_YPD\n Cond965:ndt80_delete_mid_g/r_ratio_\n Cond891:G1MMS\n Cond881:4NQO\n Cond813:Na+FK30'\n Cond303:Heat_Shock_20_minutes_hs-1\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n mTIF2:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mTIF6:similar to human translation initiation factor 6 (eIF6); how\never, TIF6 does not act as a true translation initiation fac\ntor.The protein may be involved in the biogenesis and or sta\nbility of the 60S ribosomal subunits,,Null mutant is inviabl\ne; cells are depleted of 60S ribosomal subunits, translation\n initiation is inhibited, and cells arrest in G1\n mGUA1:GMP synthase,GMP synthase,Null mutant is viable but is a gua\nnine auxotroph\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n mRLI1:Strong protein homology (68% identical) to human RNase L Inh\nibitor (RLI),ATP-binding cassette (ABC) superfamily nontrans\nporter group (putative),Null mutant is inviable; overexpress\nion of RLI1 from a galactose-inducible promoter has a modera\nte inhibitory effect on growth.\n mRPL1A:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1B (Ssm2p),ribosomal protein L\n1A, forms part of the 60S ribosomal subunit,Null mutant is v\niable; shows double mutant lethality with rpl1b (ssm2b) null\n mutants\n mRPL1B:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1A (Ssm1p),ribosomal protein L\n1B,\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond899:RPN4_MMS__\n Cond423:YPD_stationary_phase_4_h_ypd-1\n Cond397:Nitrogen_Depletion_2_h\n Cond390:aa_starv_0.5_h\n mERG10:acetoacetyl CoA thiolase,acetoacetyl CoA thiolase,Nul mutant\n is inviable; other mutants are ergosterol biosynthesis defe\nctive or nystatin resistant\n Cond320:heat_shock_17_to_37,_20_minutes\n Cond316:37C_to_25C_shock_-_30_min\n Cond396:Nitrogen_Depletion_1_h\n Cond305:Heat_Shock_40_minutes_hs-1\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond887:t-BuOOH\n mTIF34:p39 subunit of translation initiation factor eIF3,translatio\nn initiation factor eIF3 p39 subunit,Null mutant is inviable\n Cond363:dtt_015_min_dtt-2\n Cond941:SK1_YPD\n mECM1:putative transmembrane domain protein involved in cell wall \nbiogenesis,,A Tn3 insertion into ECM1 causes hypersensitivit\ny to the cell surface polymer perturbing agent calcofluor wh\nite.\n mYVH1:nitrogen starvation-induced protein phosphatase,protein tyro\nsine phosphatase induced by nitrogen starvation,\n mYKL056C:Unknown ,, Unknown\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n Cond892:S\n Cond898:RPN4\n mPRS5:Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyr\nophosphokinase),phosphoribosylpyrophosphate synthetase (ribo\nse-phosphate pyrophosphokinase),Null mutant is viable but re\nduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate s\nynthetase activity by 84%. prs5 mutations are synthetically \nlethal with mutations in prs1 or prs3.\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond323:heat_shock_29_to_37,_20_minutes\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond872:Zero1\n Cond940:6h\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond889:4NQO_2\n Cond426:YPD_stationary_phase_1_d_ypd-1\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n mMIR1:Product of gene unknown,,Null mutant is viable on glucose co\nntaining media, but is unable to grow on a non-fermentable c\narbon source, shows reduced levels of mitochondrial proteins\n mGSP1:maintenance of nuclear organization; homologous to mammalian\n Ran, a small nuclear GTPase of the ras superfamily,GTP-bind\ning protein,Null mutant is inviable\n Cond934:8h\n Cond322:heat_shock_25_to_37,_20_minutes\n Cond459:YP_sucrose_vs_reference_pool_car-2\n Cond420:YPD_3_d_ypd-2\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond857:pm38-gtoe\n Cond893:SMMS\n mTOM22:Translocase of Outer Mitochondrial membrane,mitochondrial im\nport receptor protein,Null mutant is inviable\n Cond379:1M_sorbitol_-_30_min\n mSUI2:Translation initiation factor eIF-2 alpha subunit,,suppressi\non of initiator codon mutations\n mHXK2:Glucose phosphorylation,hexokinase II (PII) (also called hex\nokinase B),Null mutant is viable and can ferment fructose, b\nut fails to show glucose repression at SUC2, CYC1, GAL10. hx\nk1, hxk2 double null mutant cannot ferment fructose\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n RapamycinDip.dip_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond419:YPD_2_d_ypd-2\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond431:YPD_stationary_phase_13_d_ypd-1\n mARX1:Unknown ,, Unknown\n Cond783:Peroxide_60'\n Cond878:MNNG\n Cond895:G2MMS\n mSEC14:Required for vesicle budding from the Golgi,phosphatidylinos\nitol transfer protein,Null mutant is inviable; other mutatio\nns are temperature sensitive\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond882:zero3\n Cond877:MMS\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n Cond875:60min\n Cond417:YPD_12_h_ypd-2\n Cond886:g-ray\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond403:Nitrogen_Depletion_3_d\n Cond415:YPD_8_h_ypd-2\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n Cond319:37C_to_25C_shock_-_90_min\n Cond402:Nitrogen_Depletion_2_d\n Cond876:zero2\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond401:Nitrogen_Depletion_1_d\n Cond294:Itraconazole\n Cond885:20\n mPFK1:phosphofructokinase alpha subunit,phosphofructokinase alpha \nsubunit,Null mutant is viable, accumulates fructose-6-phosph\nate, glucose-6-phosphate, and sedoheptulose-7-phosphate, exh\nibits decreased levels of fructose-1,6-bisphosphate; pfk1 pf\nk2 double deletion mutants fail to grow on 2% glucose\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n Cond815:Na+FK60'\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mFRS2:Phenylalanyl-tRNA synthetase, beta subunit, cytoplasmic,phen\nylalanine-tRNA ligase subunit,\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n mRPP0:Homology to rat P0, human P0, and E. coli L10e,ribosomal pro\ntein P0 (A0) (L10E),Null mutant is inviable\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond421:YPD_5_d_ypd-2\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n mCDC33:Required for START A of cell cycle and sporulation,mRNA cap \nbinding protein eIF-4E,Null mutant is inviable. cdc33 mutant\ns arrest at G(sub)1. cdc33 has normal cAMP pools and is not \nsuppressed by cAPK mutants, suggesting sporulation is indepe\nndent of the cAMP pathway\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Cond304:Heat_Shock_30_minutes_hs-1\n Cond939:4h\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n Cond884:10\n Cond958:t0.5_g/r_ratio\n mARF1 mRPC40 mTIF2 mSUI2 mCDC33 mRPP0 mTIF6
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Computational Genomics Lab, Tel-Aviv uniresity