Module number 2899




Database revision : gnsdb28.10
Date : Tue Feb 25 17:42:21 2003
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mYDL180W:Unknown ,, Unknown\n mHAP5:Regulates respiratory functions; subunit of a heterotrimeric\n complex required for CCAAT binding,CCAAT-binding transcript\nion factor component (along with Hap2p and Hap3p),Null mutan\nt is viable\n mMRPS18:Unknown ,, Unknown\n mYNL275W:Unknown ,, Unknown\n mYBL009W:Unknown ,, Unknown\n mMEU1:Protein that regulates ADH2 gene expression,,Null mutant is \nviable, displays reduced ADH2 expression\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mCKA2:may have a role in regulation and/or execution of the eukary\notic cell cycle,casein kinase II alpha' subunit,Null mutant \nis viable, cka1 cka2 double deletion mutants are inviable; C\nells in which casein kinase II activity is depleted increase\n substantially in size prior to growth arrest, and a signifi\ncant fraction of the arrested cells exhibit a pseudomycelial\n morphology. Disruption of the activity also results in floc\nculation. Yeast strains lacking both endogenous catalytic su\nbunit genes can be rescued by expression of the alpha and be\nta subunits of Drosophila casein kinase II or by expression \nof the Drosophila alpha subunit alone\n Cond711:t2+Vec\n mDNM1:involved in receptor-mediated endocytosis and mitochondrial \norganization,similar to dynamin GTPase,Null mutant is viable\n, shows mating defects consistent with a delay in receptor-m\nediated endocytosis\n mMRPL35:Mitochondrial ribosomal protein MRPL35 (YmL35),ribosomal pro\ntein (YmL35),\n mYLR077W:Unknown ,, Unknown\n mXPT1:Xanthine Phosphoribosyl Transferase,xanthine phosphoribosyl \ntransferase,Cannot utilize xanthine as a source of GMP\n mYEL015W:Unknown ,, Unknown\n mYGR012W:Unknown ,, Unknown\n mMNN5:mannan synthesis,golgi alpha-1,2-mannosyltransferase (putati\nve),Null mutant is viable but defective in addition of the a\nlpha-1,3-linked mannose branch to the mannan structure found\n on N-linked glycans.\n mHIT1:Protein required for growth at high temperature,,no growth a\nt high temperature; confers pet phenotype\n Cond724:t4+SSD1,H44\n mGSH2:Glutathione Synthetase,glutathione synthetase,Null mutant is\n viable, growth was poor under aerobic conditions in minimum\n medium\n Cond713:t4+Vec\n mNNT1:Unknown ,, Unknown\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSMM1:Suppressor of Mitochondrial Mutation in the tRNAasp gene; Di\nhydrouridine synthase 2,tRNA dihydrouridine synthase,Overexp\nression weakly suppresses a mutation affecting the maturatio\nn of mitochondrial tRNA-Asp.\n mNDT80:Meiosis-specific gene; mRNA is sporulation specific; require\nd for exit from pachytene and for full meiotic recombination\n,DNA binding transcription factor that activates middle spor\nulation genes,Null mutant is viable, arrests in pachytene st\nage of meiosis at the mononucleate stage with duplicated spi\nndle pole bodies and no spindles, is not rescued by spo11 or\n rad50; no mitotic phenotype detected, dispensable for doubl\ne-stranded breaks\n mCKB1:beta (38kDa) subunit of casein kinase II (CKII),casein kinas\ne II beta subunit,Null mutant is viable, exhibits salt sensi\ntivity specific to NaCl and LiCl\n mCKB2:Casein kinase II, beta' subunit,Casein kinase II beta' subun\nit,Null mutant is viable\n Cond718:t4+SSD1wt\n mYGL082W:Unknown ,, Unknown\n mYME1:Mitochondrial protein of the CDC48/PAS1/SEC18 family of ATPa\nses,,Null mutant is viable, exhibits an elevation in the rat\ne at which copies of TRP1 and ARS1, integrated into the mito\nchondrial genome, escape to the nucleus; a heat-sensitive re\nspiratory-growth defect; a cold-sensitive growth defect on r\nich glucose medium; and synthetic lethality in rho- (cytopla\nsmic petite) cells; yme1 (osd1) mutants fail to degrade newl\ny synthesized subunits of cytochrome c\n mMRPS9:Probable mitochondrial ribosomal protein S9,ribosomal protei\nn S9 (putative),Null mutant is viable, respiration deficient\n, exhibits defects in mitochondrial protein synthesis as ind\nicated by a loss of cytochrome c oxidase activity\n Cond722:t2+SSD1,H44\n mYIM1:Mitochondrial inner membrane protease, similar to E. coli le\nader peptidase,protease , similar to E. coli leader peptidas\ne,\n mPRP4:associated with the U4/U6 snRNP,associates with the U4/U6 sn\nRNP,Null mutant is inviable; other alleles are defective in \nRNA synthesis and unable to grow at 36 degrees C.\n Cond709:t0+Vec\n mCYC2:Involved in import of cytochrome c into mitochondria,cytochr\nome c mitochondrial import factor,Null mutant is viable. Del\netion of CYC2 leads to accumulation of apocytochrome c in th\ne cytoplasm; strains with deletions of CYC2 still import low\n levels of cytochrome c into mitochondria\n mCDC50:cell division cycle mutant,,Null mutant is cold-sensitive an\nd sensitive to MMS and HU\n mYLR031W:Unknown ,, Unknown\n mGAA1:ER protein essential for attaching GPI (glycosylphosphatidyl\ninositol) to protein,GPI:protein transamidase component (put\native),Null mutant is inviable; temperature-sensitive mutant\n, after shifting to restrictive temperature, does not attach\n GPI to protein; also defective in endocytosis and pheromone\n response\n mYGR031W:Unknown ,, Unknown\n mFKS3:Protein with similarity to Gls1p and Gls2p (GB:Z49212),,\n mRRP6:Ribosomal RNA Processing,,Null mutant is viable, heat sensit\nive; other mutants show a 5.8S rRNA 3' end formation defect\n mYOR091W:Unknown ,, Unknown\n mFTH1:FTS3 Homolog 1,,none observed\n mPTC3:protein phosphatase type 2C,protein phosphatase type 2C,\n Cond717:t2-SSD1\n mMRPL7:Mitochondrial ribosomal protein MRPL7 (YmL7),ribosomal prote\nin (YmL7),\n mCPR8:Shows similarity to the secretory pathway cyclophilin Cpr4,c\nyclophilin , peptidyl-prolyl cis-trans isomerase (PPIase),Nu\nll mutant is viable\n mRSM28:Unknown ,, Unknown\n Cond716:t2+SSD1wt\n mCHS5:Involved in chitin synthase III activity, also required for \nhomozygosis in the first stages of mating,,Null mutant is vi\nable, cells exhibit a strong mating defect; sensitive to Cal\ncofluor, reduced amount of chitin in the cell wall\n mCTR3:integral membrane protein that functions in high affinity co\npper transport,copper transporter,Null mutant is viable, gro\nws slower than w.t. under conditons of copper limitation on \nnon-fermentable carbon source; strains with a deletion of bo\nth CTR1 and CTR3 are unable to grow on nonfermentable carbon\n sources\n mYHR116W:Unknown ,, Unknown\n Cond725:t4-SSD1,M31\n Cond708:t0+SSD1\n mYPR100W:Unknown ,, Unknown\n mMNN11:member of a cis Golgi complex that is involved in mannan syn\nthesis, other complex members include Mnn10p, Hoc1p, Anp1p, \nMnn9p,mannosyltransferase complex component,Null mutant is v\niable, exhibits defects in mannan synthesis\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond712:t4+SSD1\n mFOL1:folic acid synthesis,dihydro-6-hydroxymethylpterin pyrophosp\nhokinase , dihydroneopterin aldolase , dihydropteroate synth\netase,essential, induces pseudohyphal growth\n mFOL3:FOLinic acid requiring,dihydrofolate synthetase,Null mutant \nis viable; requires folinic acid for growth\n mYTP1:Yeast putative Transmembrane Protein,,Null mutant is viable\n mPHO86:May collaborate with Pho87p and Pho84p in phosphate uptake,i\nnorganic phosphate transporter (putative),Null mutant is via\nble and expresses repressible acid phosphatase in high phosp\nhate medium; pho86 pho87 double mutant and pho86 pho88 doubl\ne mutant constituvely synthesize repressible acid phosphatas\ne and are arsenate-resistant; pho84 pho86 pho87 triple mutan\nt grows more slowly than pho84 mutant\n Cond723:t2-SSD1,M31\n mVPS29:vacuolar protein sorting,,Defective for sorting of soluble h\nydrolases to the vacuole. Mislocalisation of the vacuolar hy\ndrolase sorting receptor Vps10p.\n mYPL170W:Unknown ,, Unknown\n Cond715:t0-SSD1\n mMET1:Methionine metabolism,,Null mutant is viable, and is a methi\nonine auxotroph\n mYLR243W:Unknown ,, Unknown\n mKTR3:Putative alpha-1,2-mannosyltransferase,alpha-1,2-mannosyltra\nnsferase (putative),\n mYOR013W:Unknown ,, Unknown\n mOSM1:osmotic growth protein,osmotic growth protein,Null mutant is\n viable, sensitive to hypertonic medium\n mKTR4:Putative alpha-1,2-mannosyltransferase,alpha-1,2-mannosyltra\nnsferase (putative),\n mDST1:Meiotic DNA recombination factor,RNA polymerase II elongatio\nn factor , transcription elongation factor,Null mutant is vi\nable; reduced induction of DNA strand transfer; sensitivity \nto 6-azauracil\n mYLR407W:Unknown ,, Unknown\n mMGM101:Involved in mitochondrial genome maintenance,,Null mutant is\n viable\n mAOS1:along with Uba2p forms a heterodimeric activating enzyme for\n Smt3p,,Null mutant is inviable\n Cond938:2h\n Cond710:t2+SSD1\n mRPO41:mitohcondrial RNA polymerase,mitochondrial RNA polymerase,Nu\nll mutant is viable\n mYFR007W:Unknown ,, Unknown\n mCCT5:Required for assembly of microtubules and actin in vivo,chap\neronin subunit epsilon subunit,\n mTHI7:Thiamine Metabolism,thiamine transporter,Null mutant is viab\nle, thi7 mutants are pyrithiamine resistant and cordycepin r\nesistant\n mYBR178W:Unknown ,, Unknown\n mCKB1 mCKB2 mCKA2
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Computational Genomics Lab, Tel-Aviv uniresity