Module number 2895




Database revision : gnsdb28.10
Date : Tue Feb 25 17:41:45 2003
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mCPT1:Phospholipid biosynthesis,sn-1,2-diacylglycerol cholinephosp\nhotransferase,Null mutant is viable, cpt1 ept1 double deleti\non mutants are viable\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mTFB2:Transcription/repair factor TFIIH subunit,TFIIH subunit,Null\n mutant is inviable; a c-terminal deletion mutant is associa\nted with defects in nucleotide excision repair (as demonstra\nted by UV sensitivity\n mPIG1:Putative type 1 phosphatase regulatory subunit; interacts wi\nth Gsy2p,similar to Gac1p, a putative type 1 protein phospha\ntase targeting subunit,Null mutant is viable; gac1 pig1 doub\nle mutant has more severe glycogen-deficient phenotype than \ngac1 mutant\n mLEU1:leucine biosynthesis,isopropylmalate isomerase,Leucine requi\nring\n mHFM1:C4 zinc finger DNA-binding protein of low sequence specifici\nty in vitro; Probable 119 kD DNA/RNA helicase family member,\nC4 zinc finger DNA-binding protein of low sequence specifici\nty in vitro; Probable 119 kDa DNA/RNA helicase family member\n,Null mutant is viable\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n Cond963:t11.5_g/r_ratio\n mKAR3:kinesin-like nuclear fusion protein,kinesin-like nuclear fus\nion protein,Null mutant is viable, kar3 mutations prevent ka\nryogamy (nuclear fusion)\n mTUB2:beta subunit of tubulin monomer; involved in chromosome segr\negation and nuclear migration,beta-tubulin,null is inviable;\n conditional mutants show block of mitotic nuclear migration\n and chromosome segregation and defects in spindle and/or cy\ntoplasmic microtubules at non-permissive conditions; some mu\ntants are benomyl-hypersensitive\n mYNL116W:Unknown ,, Unknown\n mDBP1:putative ATP-dependent RNA helicase; Dead box protein,ATP de\npendent RNA helicase (putative) , dead box protein (putative\n),Null mutant is viable\n mDAL80:Negative regulator of multiple nitrogen catabolic genes,GATA\n family transcriptional repressor,Null mutant is viable, def\nicient in allantoin degradation\n mYOR365C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYNR048W:Unknown ,, Unknown\n mYIL024C:Unknown ,, Unknown\n mDOC1:Doc1p and Cdc26p are associated with the anaphase-promoting \ncomplex and are involved in the degradation of Clb2p,,Null m\nutant is viable, grows slowly and forms colonies in which mo\nst of the cells have large buds and cannot grow at 37 degree\ns C; doc1-1 is temperature sensitive and shows a Clb2p degra\ndation defect\n Cond959:t2_g/r_ratio\n Cond943:SK1_YPA\n mZIP2:Required for 'ZIPpering' up meiotic chromosomes during chrom\nosome synapsis,,Null mutant is viable but is defective in ch\nromosome synapsis, but not chromosome pairing, and causes me\niosis I non-disjunction and reduced homologous recombination\n mYNL080C:Unknown ,, Unknown\n mREC114:meiosis-specific recombination gene; dispensable for mitotic\n recombination and axial elements in meiosis but required fo\nr synaptonemal complexes, meiotic recombination, and spore v\niability; classified as an early recombination gene,early sp\norulation protein,reduced meiotic recombination, rec114 muta\nnts execute meiosis I early, are rescued by spo13 and are ep\nistatic to rad52 spo13\n Cond940:6h\n mECM37:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mKIP3:Kinesin-related protein,,defective in pre-anaphase nuclear m\nigration\n Cond965:ndt80_delete_mid_g/r_ratio_\n mRTS2:similar to mouse KIN7 protein,,\n mSPR28:Septin-related protein expressed during sporulation,,Null mu\ntant is viable\n Cond948:W303_ume6_YPA_\n Cond937:t=0\n Cond934:8h\n Cond960:t5_g/r_ratio\n mIME4:IME4 appears to activate IME1 in response to cell-type and n\nutritional signals and thereby regulate meiosis,methyltransf\nerase (putative),Homozygous mutant diploid cannot accumulate\n IME1 mRNA during early stages of meiosis and cannot sporula\nte\n Cond938:2h\n mULP2:Product of gene unknown,,Null mutant is viable but exhibits \ntemperature-sensitive growth, abnormal cell morphology, decr\neased plasmid and chromosome stability, and a severe sporula\ntion defect as well as hypersensitivity to DNA-damaging agen\nts, hydroxyurea, and benomyl. SMT4/ULP2 was also isolated as\n a high copy suppressor of a temperature sensitive mutation \nin MIF2, a putative centromere protein gene\n Cond961:t7_g/r_ratio\n mYLR445W:Unknown ,, Unknown\n mVPS30:Required for sorting and delivery of soluble hydrolases to t\nhe vacuole.,,Vacuolar hydrolases sorting receptor Vps10p is \nmislocalized in vps30 mutants.\n mYML053C:Unknown ,, Unknown\n Cond962:t9_g/r_ratio\n mMSH4:dispensable for DNA repair, required for full levels of reci\nprocal exchange and spore viability,meiosis specific protein\n, E.coli MutS protein, localizes to discrete sites on meioti\nc chromosomes,Null mutant is viable, has no apparent defect \nin mismatch repair, wild-type levels of gene conversion and \npostmeiotic segregation\n mAPG1:Required for autophagy,protein kinase,Defective in autophagy\n; loses viability more rapidly than wild type during nitroge\nn starvation; defective in vacuolar protein degradation duri\nng nitrogen starvation; defective in sporulation\n Cond939:4h\n Cond958:t0.5_g/r_ratio\n
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Computational Genomics Lab, Tel-Aviv uniresity