Module number 2873




Database revision : gnsdb28.10
Date : Tue Feb 25 17:38:10 2003
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mBRR1:Protein involved in snRNP biogenesis,spliceosomal snRNP comp\nonent,in brr1 mutants, newly synthesized snRNAs are destabil\nized and 3'-end processing is slowed\n mNTG2:Endonuclease III-like glycosylase,endonuclease III DNA base \nexcision repair N-glycosylase,\n mVPS73:Unknown ,, Unknown\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYNL101W:Unknown ,, Unknown\n mSEC10:100 kD component of the Exocyst complex; required for exocyt\nosis. The Exocyst complex contains the gene products encoded\n by SEC3, SEC5, SEC6, SEC8, SEC10, SEC15 and EXO70.,exocyst \ncomplex 100 kDa component,Null is inviable\n Cond878:MNNG\n Cond879:MMC\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mYOR088W:Unknown ,, Unknown\n Cond887:t-BuOOH\n mSEC15:Protein involved in vesicle traffic between Golgi and plasma\n membrane. The Exocyst complex is required for exocytosis.,e\nxocyst complex 113kDa component,The sec15-1 allele exhibits \ntemperature-sensitive growth and defects in the secretory pa\nthway.\n Cond882:zero3\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond875:60min\n mRAD2:Incision step of nucleotide excision repair of DNA damaged b\ny UV light; co-purifies with transcription factor, TFIIH mRN\nA is cell cycle regulated & induced by DNA damage & by meios\nis,xeroderma pigmentosum group G (XPG) protein homolog,Null \nmutant is viable, radiation sensitive\n mQRI8:ubiquitin conjugating enzyme,ubiquitin-conjugating enzyme,Nu\nll mutant is viable\n mPTK2:Putative serine/threonine protein kinase that enhances sperm\nine uptake,,Mutant shows reduced spermine and putrescine upt\nake and is resistant to toxic polyamine analogs and Li+ and \nNa+ ions; ptk1 ptk2 double mutant shows virtaully abolished \nhigh-affinity spermidine transport\n mTPK1:putative catalytic subunit of cAMP-dependent protein kinase,\ncAMP-dependent protein kinase catalytic subunit (putative),m\nulticopy suppression of ras mutant\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mAPS2:Related to the sigma subunit of the mammalian plasma membran\ne clathrin-associated protein (AP-2) complex,clathrin associ\nated protein complex small subunit,null mutant is viable; sl\night effect on chc1-ts cell growth\n mCVT19:Cytoplasm to Vacuole Targeting; Mutant is defective in impor\nt of aminopeptidase I through the cytoplasm to vacuole targe\nting pathway,Receptor for biosynthetic cytoplasm to vacuole \ntargeting,Null: viable, unable to target vacuolar aminopepti\ndase I and to vacuoles, both under growing and nitrogen star\nvation conditions.\n mSYS1:Multicopy suppressor of ypt6 null mutation,,Null mutant is v\niable. sys1 ypt6 double mutant displays enhanced defects in \nvacuolar sorting and cell growth\n Cond892:S\n mHRT1:High level expression Reduces Ty3 Transposition,Skp1-Cullin-\nF-box ubiquitin protein ligase (SCF) subunit,Null mutant is \ninviable.\n mERG8:Involved in isoprene and ergosterol biosynthesis pathways,48\n kDa phosphomevalonate kinase,Null mutant is inviable\n mYNR036C:Unknown ,, Unknown\n Cond876:zero2\n Cond890:G1\n mYJL055W:Unknown ,, Unknown\n mVMA6:vacuolar ATPase V0 domain subunit d (36 kDa),vacuolar ATPase\n V0 domain subunit d (36 kDa) , vacuolar H(+) ATPase 36 kDa \nsubunit (D subunit of VO sector),Null mutant is viable, sens\nitive to media buffered at neutral pH or media containing 10\n0 mM Ca2+\n Cond885:20\n Cond873:10min\n mYGR033C:Unknown ,, Unknown\n mMDH3:malate dehydrogenase,malate dehydrogenase,Null mutant is via\nble, does not grow on oleate and grows slowly on acetate\n mYLR387C:Unknown ,, Unknown\n Cond881:4NQO\n Cond894:G2\n mRPN11:Suppressor of mutant (ts on glycerol) tRNA gene deficient in\n the processing of its 3'-end; homologous to S. pombe PAD1 g\nene - global positive regulator of nuclear transcription and\n is involved in maintenance of chromatin structure,,Null mut\nant is inviable\n mRNR4:ribonucleotide reductase, small subunit (alt),ribonucleotide\n reductase, small (R2) subunit,Null mutant is inviable in th\ne W303 strain background, but viable and sick in another (Wa\nng et al.[1997] Mol. Cell Biol.17:6114-6121). An rnr4 mutan\nt is resistant to 40 ug/ml benomyl, supersensitive to hydrox\nyurea (HU)[dead at 0.005M HU], and cold sensitive [cells arr\nest at 14 deg. C. with a large bud and short mitotic spindle\n].\n Cond910:(83i4)_S150-2B_YPGL+G_NormInt\n Cond935:10h\n mYJL178C:Unknown ,, Unknown\n mBDF1:Required for sporulation, possible component of chromatin; a\nffects synthesis of snRNA,two bromodomains,Null mutant is vi\nable; defect in sporulation and spore formation, reduced rat\ne of vegetative growth, sensitivity to a DNA-damaging agent,\n defective in snRNA production\n mDPP1:contains a novel phosphatase sequence motif found in a super\n family of phosphatases including mammalian PAP2,diacylglyce\nrol pyrophosphate phosphatase,Null mutant is viable, does no\nt exhibit any obvious growth defects\n mPRE2:proteasome subunit,proteasome subunit,Null mutant is inviabl\ne, pre2 mutants exhibit defects in chymotrypsin-like proteol\nysis, stress response and ubiquitin signaled protein degrada\ntion\n mSEC15 mSEC10
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Computational Genomics Lab, Tel-Aviv uniresity