Module number 2849




Database revision : gnsdb28.10
Date : Tue Feb 25 17:34:02 2003
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Cond664:mec1_plus_gamma_20_min\n mBNI1:Protein involved in cytoskeletal control and required for pr\noper bipolar budding pattern; interacts with Rho1p,formin, i\nnvolved in spindle orientation,Null mutant is viable, bni1 b\nnr1 double deletion mutants are temperature sensitive and ar\ne deficient in bud emergence, exhibit a random distribution \nof cortical actin patches and often become multinucleate at \nthe restrictive temperature; rho1 bni1 double mutants exhibi\nt synthetic lethality\n mMRPL4:essential for mitochondrial function and for proper cell gro\nwth under non-respiratory conditions,ribosomal protein 60S L\n4,Null mutant is viable, fails to grow on nonfermentable car\nbon sources, has growth defects on fermentable carbon source\ns\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond944:SK1_ume6_YPA\n Cond565:alpha98\n Cond278:CDC42(tetpromoter)\n mYOR081C:Unknown ,, Unknown\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mINP53:Synaptojanin-like protein,inositol polyphosphate 5-phosphata\nse,Null mutant is viable but has abnormal vacuoles\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond670:DES459_(mec1)_-_mock_irradiation_-_5_min\n Cond906:(77i5)_S150-2B_YPD_NormInt\n Cond256:ymr141c\n Cond666:mec1_plus_gamma_45_min\n mDIG1:Down-regulator of Invasive Growth, Regulator of Sterile Twel\nve, binds Fus3 and Ste12,MAP kinase-associated protein,Null \nmutant is viable, shows abnormal bud morphology; dig1 dig2 d\nouble mutants show constitutive mating defect and invasive g\nrowth; overexpression causes pheromone resistance\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mTRK2:membrane protein; low affinity potassium transport,low affin\nity potassium transport , membrane protein,Null mutant is vi\nable, requires added potassium; trk1 trk2 double mutants are\n viable\n Cond284:PMA1(tetpromoter)\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n mAHC1:Ada Histone acetyltransferase complex component ,Ada histone\n acetyltransferase complex component,Null mutant is viable\n Cond81:hog1(haploid)\n Cond283:KAR2(tetpromoter)\n mAFG3:ATPase family gene,ATP dependent metalloprotease,nuclear pet\nite phenotype; loss of repspiratory competence\n Cond940:6h\n mRPS15:Homology to rat S15 and E. coli S19,ribosomal protein S15 (S\n21) (rp52) (RIG protein),\n Cond942:SK1ume6_YPD\n Cond947:W303_YPA\n mCLN2:role in cell cycle START,G1 cyclin,Null mutant is viable, ex\nhibits G1 arrest; dominant mutation advances the G(sub)1- to\n S- phase transition and impairs ability of cells to arrest \nin G(sub)1 phase in response to external signals\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mTAH11:Product of gene unknown,,tah11-1 mutant is hypersensitive to\n hydroxyurea, camptothecin when overexpressing wild-type TOP\n1\n mSEC24:The Sec23p-Sec24p complex is one of three cytoplamic COPII f\nactors involved in ER to Golgi transport,vesicle coat compon\nent,Null mutant is inviable\n mLSB6:LAs17 Binding protein,,\n Cond937:t=0\n Cond920:3h\n mSWC1:Unknown ,, Unknown\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond938:2h\n Cond61:fks1(haploid)\n Cond521:fus3-K42Dą50nMaF,30minlog10(intensity)\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n Cond939:4h\n mGRH1:Yeast (GR)ASP65 (H)omologue,mammalian GRASP protein homolog,\nNull mutation is viable, exhibits defects in spindle checkpo\nint\n
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Computational Genomics Lab, Tel-Aviv uniresity