Module number 2808




Database revision : gnsdb28.10
Date : Tue Feb 25 17:28:26 2003
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mHAP1:Activator of CYC1 and CYP3 transcription; positive regulator\n of cytochrome C genes CYC1 and CYC7,zinc finger transcripti\non factor of the Zn(2)-Cys(6) binuclear cluster domain type,\nEssential for anaerobic or heme deficient growth; Null mutan\nt is viable, deficient in expression of CYC1 and CYC7\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYNL047C:Unknown ,, Unknown\n mCEG1:mRNA guanylyltransferase (mRNA capping enzyme), alpha subuni\nt,mRNA capping enzyme alpha subunit , mRNA guanylyltransfera\nse,Null mutant is inviable\n mYPL009C:Unknown ,, Unknown\n mNOT5:member of the NOT complex, a global negative regulator of tr\nanscription,NOT complex member, a global negative regulator \nof transcription,Null mutant is viable, mutations in not4(mo\nt2) are synthetically lethal with mutations in not5, overexp\nression of NOT3 or NOT4(MOT2) suppresses not5 mutations\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n mYDR239C:Unknown ,, Unknown\n mNUP116:Involved in nucleocytoplasmic transport; may be required for\n biogenesis of tRNA,nuclear pore complex subunit,Null mutant\n grows slowly, accumulates unspliced pre-tRNAs, acumulates p\noly(A)+ RNA in the nucleus, and is temperature-sensitive; at\n nonpermissive temperature, null mutants show membrane seals\n covering cytoplasmic face of nuclear pore complexes; synthe\ntically lethal with nsp1, nup100, and nup145\n Cond892:S\n mRPB2:second largest subunit of RNA polymerase II,,Null mutant is \ninviable\n Cond883:5\n mSPC42:involved in SPB duplication, may facilitate attachment of th\ne SPB to the nuclear membrane,spindle pole body component,Nu\nll mutant is inviable; temperature sensitive mutations show \nSBP duplication\n mYOR131C:Unknown ,, Unknown\n Cond890:G1\n mCDC48:Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; fu\nll length homology to mammalian protein VCP; involved in sec\nretion, peroxisome formation and gene expression,,Null mutan\nt is inviable\n Cond889:4NQO_2\n mARC35:Arp complex subunit,,Null mutant is viable, but exhibits sev\nere growth defects\n mAPN1:major apurinic/apyrimidinic endonuclease/3'-repair diesteras\ne,major apurinic/apyrimidinic endonuclease/3'-repair diester\nase,hypersensitive to both oxidative and alkylating agents t\nhat damage DNA; higher rate of spontaneous mutation\n mHYS2:Putative role in DNA replication,DNA polymerase delta 55 kDa\n subunit,Null mutant is inviable\n Cond897:STATMMS\n mRAT1:RNA trafficking protein; transcription activator,5'-3' exori\nbonuclease,Null mutant is inviable.\n Cond888:MNNG_2\n Cond894:G2\n Cond900:(11i1)_S150-2B_YPGL_NormInt\n Cond893:SMMS\n mSPP1:YPL138C,,\n mNAB2:nuclear polyadenylated RNA binding protein,polyadenylated RN\nA binding protein,Null mutant is inviable\n mWHI2:Protein involved in growth regulation,,Null mutant is viable\n mENT2:epsin N-terminal homology-containing protein,,Null mutant is\n viable; synthetically lethal with ent1 (YDL161w). ent2/1 do\nuble mutants have endocytosis and actin cytoskeleton defects\n.\n Cond901:(11i2)_HBY4_YPGL_NormInt\n Cond895:G2MMS\n mSEC12:Required for recruitment of Sar1p and vessicle formation at \nthe endoplasmic reticulum.,guanine nucleotide exchange facto\nr for Sar1p,Null mutant is inviable. Defective in endoplasmi\nc reticulum to Golgi transport.\n mYOR088W:Unknown ,, Unknown\n mUFD2:Ubiquitin fusion degradation protein,,Null mutant is viable \nbut exhibits increased sensitivity to ethanol stress.\n mYLR199C:Unknown ,, Unknown\n mCUS1:cold sensitive U2 snRNA Suppressor,U2 snRNP protein,suppress\nes cold sensitivity of a U2 G53A cs mutant\n Cond877:MMS\n Cond875:60min\n mRTT106:Regulator of Ty1 Transposition - same phenotype as RTT101 - \nRTT105, disruption causes increase in Ty1 transposition. Iso\nlated from the same screen as the other named RTT genes.,,Nu\nll mutant is viable, but Ty1 retrotransposition is increased\n.\n Cond886:g-ray\n mYKL195W:Unknown ,, Unknown\n mVPS21:Rab5-like GTPase involved in vacuolar protein sorting and en\ndocytosis post vesicle internalization; geranylgeranylated; \ngeranylgeranylation required for membrane association,small \nGTP-binding protein,Null mutant is viable, temperature-sensi\ntive, missorts multiple vacuolar proteins, accumulate 40-50 \nnm vesicles, and contain a large vacuole\n mADE2:phosphoribosylamino-imidazole-carboxylase,phosphoribosylamin\no-imidazole-carboxylase,Null mutant is viable and requires a\ndenine. ade2 mutants are blocked at a stage in the adenine b\niosynthetic pathway that causes an intermediate to accumulat\ne in the vacuole; the intermediate gives the cell a red colo\nr.\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mUBP2:Ubiquitin-specific protease,ubiquitin-specific protease,Null\n mutant is viable. Null yuh1 ubp1 ubp2 ubp3 quadruple mutant\ns are viable and retain the ability to deubiquitinate ubiqui\ntin fusions.\n mVPS24:involved in secretion,,Null mutant missorts vacuolar hydrola\nses and accumulates a late endosomal compartment; Class E vp\ns mutant\n mDOP1:homolog of Emericella nidulans developmental regulatory gene\n, dopey (dopA).,,essential gene\n mUBP6:deubiquitinating enzyme (putative),,\n mHIR3:Involved in cell-cycle regulation of histone transcription,,\nHTA1-HTB1 transcription is derepressed and is no longer cell\n-cycle regulated\n mTAF6:TATA-binding protein-associated-factor,TATA-binding protein-\nassociated-factor,Null mutant is inviable\n mEAF3:Esa1p-Associated Factor,,\n mNGL2:DNase/RNase (putative); CCR4 C-terminal homolog; displays ho\nmology to drosophila Angelgene; homolog to ngl1 and ngl3 ,DN\nase (putative) , RNase (putative),Null mutant is viable.\n Cond885:20\n Cond891:G1MMS\n mRSC8:Rsc8 is the eighth largest subunit of RSC, a fifteen-protein\n chromatin remodeling complex and related to the Swi/snf Com\nplex.,,Null mutant is inviable\n mSWP1:oligosaccharyl transferase glycoprotein complex, delta subun\nit,oligosaccharyl transferase glycoprotein complex, delta su\nbunit,lethal\n Cond881:4NQO\n mDID4:Hypothetical ORF,class E vacuolar-protein sorting and endocy\ntosis factor,secretion of vacuolar proteins; canavanine-hype\nrsensitive; temperature-sensitive; suppresses defects associ\nated with loss of Doa4\n mMTR2:mRNA transport regulator,mRNA transport regulator,Null mutan\nt is inviable; mtr2 mutants exhibit nuclear mRNA accumulatio\nn and nucleolar fragmentation\n mCSN12:Unknown ,, Unknown\n mMVP1:Protein required for sorting proteins to the vacuole,,MVP1 w\nas identified as a multicopy suppressor of dominant-negative\n vps1 mutations, as well as an extragenic suppressor of a te\nmperature-sensitive pma1 mutation (sop gene)\n mGAL11:Regulates transcription of a diverse array of genes. Require\nd for mating and sporulation.,RNA polymerase II holoenzyme c\nomplex component , positive and negative transcriptional reg\nulator of genes involved in mating-type specialization , RNA\n polymerase II holoenzyme complex component , positive and n\negative transcriptional regulator of genes involved in matin\ng-type specialization , RNA polymerase II holoenzyme complex\n component , positive and negative transcriptional regulator\n of genes involved in mating-type specialization,Null mutant\n is viable, exhibits reduced expression of Gal4 regulated ge\nnes\n mSMD1:Homolog of human core snRNP protein D1, involved in snRNA ma\nturation,,Null mutant is inviable\n mYOL036W:Unknown ,, Unknown\n Cond884:10\n mCDC48 mUFD2
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Computational Genomics Lab, Tel-Aviv uniresity