Module number 2795




Database revision : gnsdb28.10
Date : Tue Feb 25 17:37:06 2003
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mPEP12:integral membrane protein; c-terminal TMD; located in endoso\nme,c-terminal TMD , integral membrane protein , c-terminal T\nMD , integral membrane protein , c-terminal TMD , integral m\nembrane protein,proteinase deficient\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond944:SK1_ume6_YPA\n mCEG1:mRNA guanylyltransferase (mRNA capping enzyme), alpha subuni\nt,mRNA capping enzyme alpha subunit , mRNA guanylyltransfera\nse,Null mutant is inviable\n Cond798:Ca30'\n mPPM1:carboxy methyl transferase for protein phosphatase 2A cataly\ntic subunit,carboxy methyl transferase for protein phosphata\nse 2A catalytic subunit,Mutant is rapamycin resistant, benom\nyl supersensitive, and nocodazole sensitive.\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mYOL048C:Unknown ,, Unknown\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mHNT2:Fhit homolog, member of the histidine triad superfamily of n\nucleotide binding-proteins,,\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mCVT19:Cytoplasm to Vacuole Targeting; Mutant is defective in impor\nt of aminopeptidase I through the cytoplasm to vacuole targe\nting pathway,Receptor for biosynthetic cytoplasm to vacuole \ntargeting,Null: viable, unable to target vacuolar aminopepti\ndase I and to vacuoles, both under growing and nitrogen star\nvation conditions.\n mYOR131C:Unknown ,, Unknown\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond373:1.5_mM_diamide_(40_min)\n mUBC5:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,vi\nable, ubc4/ubc5 double mutant is temperature sensitive\n mSSP120:secretory protein,,Null mutant is viable\n Cond802:CaFK30'\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSCL1:Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7),pro\nteasome subunit YC7alpha/Y8 (protease yscE subunit 7),Null m\nutant is inviable, SCL1 is a dominant suppressor of the ts l\nethality of crl3\n mYKL206C:Unknown ,, Unknown\n mPEP4:vacuolar proteinase A,vacuolar proteinase A,Null mutant is v\niable, proteinase deficient, phosphatase deficient; pep4 mut\nants exhibit a 60-70% reduction in total protein degradation\n during sporulation\n mYOR059C:Unknown ,, Unknown\n mRPN11:Suppressor of mutant (ts on glycerol) tRNA gene deficient in\n the processing of its 3'-end; homologous to S. pombe PAD1 g\nene - global positive regulator of nuclear transcription and\n is involved in maintenance of chromatin structure,,Null mut\nant is inviable\n Cond894:G2\n mRPN12:Part of 26S proteasome complex that may activate Cdc28p,32-3\n4 kDa protein,Null mutant is inviable; nin1-1 mutant is temp\nerature-sensitive mutant that shows i) higher rates of recom\nbination and chromosome and plasmid loss; ii) greater sensit\nivity to UV irradiation; iii) at restrictive temperature, ar\nrest in G2, failure to activate histone H1 kinase, and accum\nulation of polyubiquinated proteins\n mRPN13:Proteasome subunit,,Null mutant is viable but defective in d\negradation of ubiquitinated substrates.\n mYIM1:Mitochondrial inner membrane protease, similar to E. coli le\nader peptidase,protease , similar to E. coli leader peptidas\ne,\n mYDR196C:Unknown ,, Unknown\n mYGR111W:Unknown ,, Unknown\n mRET3:vesicle coat component,vesicle coat component,ret3-1 mutant \nis thermosensitive and shows defects in retrieval of dilysin\ne-tagged proteins from the Golgi back to the ER\n mGLR1:converts oxidized glutathine and NADPH into two glutathiones\n and NADP+,glutathione oxidoreductase,Null mutant is viable\n Cond879:MMC\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n mYGR207C:Unknown ,, Unknown\n mYPR148C:Unknown ,, Unknown\n mAPS1:Involved in a subset of clathrin functions at the Golgi,clat\nhrin associated protein complex small subunit,Null mutant is\n viable; aps1 mutants demonstrate synthetic effects with chc\n1 alleles\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPUP2:Proteasome subunit,proteasome subunit,Null mutant is inviabl\ne\n mYFR003C:Unknown ,, Unknown\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n mNPL4:Nuclear pore or nuclear pore-associated protein required for\n nuclear membrane integrity and nuclear transport,,Temperatu\nre-sensitive mutants accumulate nuclear-targeted proteins in\n the cytoplasm and poly(A)+RNA in the nucleus and show defec\nts in nuclear membrane integrity at the nonpermissive temper\nature\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond891:G1MMS\n mYGL117W:Unknown ,, Unknown\n mTFG2:transcription initiation factor TFIIF middle subunit,transcr\niption initiation factor TFIIF middle subunit,Null mutant is\n inviable\n Cond881:4NQO\n mYOR220W:Unknown ,, Unknown\n Cond636:DES460_+_0.2%_MMS_-_45_min\n mNBP35:NBP35 encodes an essential evolutionary conserved protein wi\nth homology to bacterial partitioning ATPases,35 kDa nucleot\nide binding protein,Null mutant is inviable\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond564:alpha91\n Cond347:1_mM_Menadione_(30_min)_redo\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n mRPT3:probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable; yta2 is an \nextragenic suppressor of yme1 mutations\n mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n mHSP82:82 kDa heat shock protein; homolog of mammalian Hsp90,heat s\nhock protein 90 , mammalian Hsp90 homolog , heat shock prote\nin 90 , mammalian Hsp90 homolog,Null mutant is viable at 25 \ndegrees C; ability to grow at higher temperatures varies wit\nh gene copy number\n mRPT5:Probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable\n mRPT6:member of the 26 S proteasome,ATPase,Null mutant is inviable\n mTOS5:Hypothetical ORF,,\n mYAP1:jun-like transcription factor,jun-like transcription factor,\npleiotropic drug resistance\n Cond896:STAT\n mIKS1:ira1* kinase suppressor,serine/threonine kinase (putative),N\null mutant is heat shock sensitive\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n mLAP4:vacuolar aminopeptidase ysc1,vacuolar aminopeptidase ysc1,Le\nucine aminopeptidase deficient\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mYPR1:homologous to the aldo-keto reductase protein family,,\n mYET1:Yeast BAP31 homolog,yeast endoplasmic reticulum 25 kDa trans\nmembrane protein,Null mutant is viable\n mHRT1:High level expression Reduces Ty3 Transposition,Skp1-Cullin-\nF-box ubiquitin protein ligase (SCF) subunit,Null mutant is \ninviable.\n mDCS1:Unknown ,, Unknown\n Cond898:RPN4\n mYNL181W:Unknown ,, Unknown\n Cond371:1.5_mM_diamide_(20_min)\n mVPS45:Protein of the Sec1p family essential for vacuolar protein s\norting,,Null mutant is viable, defective in the segregation \nof vacuolar material into the developing daughter cell, has \nlarge central vacuoles\n Cond375:1.5_mM_diamide_(60_min)\n Cond940:6h\n mEND3:Required for endocytosis and organization of the cytoskeleto\nn,,Null mutant is viable and defective in endocytosis\n mTSA1:antioxidant enzyme that provides protection against oxidatio\nn systems capable of generating reactive oxygen and sulfur s\npecies,thioredoxin-peroxidase (TPx); reduces H2O2 and alkyl \nhydroperoxides with the use of hydrogens provided by thiored\noxin, thioredoxin reductase, and NADPH,Null mutant is viable\n, grows slower than wild-type under aerobic conditions\n mCAP1:capping - addition of actin subunits,capping protein,Null mu\ntant is viable; severe deficit of actin cables and increased\n number of actin spots in the mother; round, relatively larg\ne cells\n Cond638:DES460_+_0.02%_MMS_-_90_min\n mYLR387C:Unknown ,, Unknown\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mPRE10:proteasome component YC1 (protease yscE subunit 1),proteasom\ne component YC1 (protease yscE subunit 1),Null mutant is inv\niable\n mRPN5:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit p55,proteasome regulatory particle subunit,Null\n mutant is inviable\n mRPN8:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S12/p40,proteasome regulatory particle subunit,\n Cond893:SMMS\n mRPN9:Regulatory Particle Non-ATPase,proteasome regulatory particl\ne subunit,Null mutant is viable, temperature sensitive; rpn9\n rpn10 double deletion mutants are viable\n Cond379:1M_sorbitol_-_30_min\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mPRE1:Required for mitotic division and sporulation,22.6 kDa prote\nasome subunit,Null mutant is inviable, pre1 mutants accumula\nte ubiquitin-protein conjugates\n mNMA2:Unknown ,, Unknown\n mPRE3:Proteasome subunit necessary for hydrolysis of peptidylgluta\nmyl-peptide,20S proteasome subunit,Null mutant is inviable\n mPRE4:B-type subunit of proteasome, euk. & archae. multicatalytic \nproteinase complex likelyinvolved in an ATP/ubiquitin-depend\nent nonlysosomal proteolytic pathway. eukary: the proteasome\n is composed of ~24 subunits forming a ring-shaped structure\n,necessary for peptidyl glutamyl peptide hydrolyzing activit\ny , proteasome subunit,Null mutant is inviable\n mTLG2:member of the syntaxin family of t-SNAREs,tSNARE that affect\ns a late Golgi compartment,Null mutant is viable in SEY6210,\n exhibits endocytosis defect and loss of Kex2p\n mYHR138C:Unknown ,, Unknown\n Cond434:DBY7286_37degree_heat_-_20_min\n mATR1:aminotriazole resistance,very hydrophobic, has many membrane\n-spanning regions, several potential glycosylation sites, po\ntential ATP-binding site,Null mutant is viable, but is sensi\ntive to very low (5 mM) levels of aminotriazole and to 4-nit\nroquinoline-N-oxide (4-NQO); multiple copies of ATR1 confer \nhyper-resistance to 4-NQO; multiple copies of ATR1 in gcn4 b\nackground confer resistance to high (80mM) levels of aminotr\niazole\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mIST1:Similar to Nuf1p (spindle pole body component),,\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mDAK1:putative dihydroxyacetone kinase,dihydroxyacetone kinase (pu\ntative),Null mutant is viable and shows no growth defect in \nnormal medium; mutant lacking both dak1 and dak2 is sensitiv\ne to dihydroxyacetone during saline growth\n mPRE9:proteasome component Y13,proteasome component Y13,\n Cond783:Peroxide_60'\n Cond895:G2MMS\n mUFD1:Ubiquitin fusion degradation protein,,Homozygous ufd1-1 muta\nnt diploids exhibit sporulation defects.\n mYPR158W:Unknown ,, Unknown\n Cond882:zero3\n Cond877:MMS\n Cond875:60min\n mYMR090W:Unknown ,, Unknown\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mTPK1:putative catalytic subunit of cAMP-dependent protein kinase,\ncAMP-dependent protein kinase catalytic subunit (putative),m\nulticopy suppression of ras mutant\n Cond886:g-ray\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mGRE2:induced by osmotic stress; similar to dihydroflavonol 4-redu\nctase from plants,,\n mGRE3:Induced by osmotic stress; similar to xylose reductase from \nother fungi,,\n mDOA1:Required for normal intracellular ubiquitin metabolism and f\nor normal rates of proteolysis of ubiquitin-dependent proteo\nlytic substrates in vivo,,Null mutant is viable and defectiv\ne in degradation of ubiquitinated proteins; homozygous null \ndiploid shows sporulation defect\n mUBP6:deubiquitinating enzyme (putative),,\n mVPS60:vacuolar protein sorting (putative),,Null mutant is viable b\nut a class E vps mutant (missorts vacuolar hydrolases and ac\ncumulates late endosomal compartment).\n Cond372:1.5_mM_diamide_(30_min)\n Cond876:zero2\n mYFL061W:Unknown ,, Unknown\n Cond885:20\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mARC18:Arp2/3 complex subunit,,\n Cond348:1mM_Menadione_(40_min)_redo\n mYJR096W:Unknown ,, Unknown\n mPNC1:pyrazinamidase and nicotinamidase,nicotinamidase , pyrazinam\nidase,Null mutant is viable\n mMRP8:mitochondrial ribosomal protein,ribosomal protein,\n mYKT6:Synaptobrevin (v-SNARE) homolog with similarity to Sec22p, S\nnc1p, and Snc2p, essential for endoplasmic reticulum-Golgi t\nransport,v-SNARE,Null mutant is inviable. Depletion of Ykt6p\n results in the accumulation of the p1 precursor (endoplasmi\nc reticulum form) of the vacuolar enzyme carboxypeptidase Y \nand morphological abnormalities consistent with a defect in \nsecretion.\n mYMR041C:Unknown ,, Unknown\n mYPT52:rab5-like GTPase involved in vacuolar protein sorting and en\ndocytosis,,Null mutant is viable; ypt51 ypt52 double deletio\nn exacerbates the temperature sensitivity and vacuolar prote\nin sorting defects of ypt51 deletion\n mFYV10:Function required for Yeast Viability on toxin exposure,,Nul\nl mutant is viable but exhibits K1 killer toxin hypersensiti\nvity.\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n mYNL155W:Unknown ,, Unknown\n Cond884:10\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mBET4:catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II),\ngeranylgeranyltransferase type II alpha subunit (PGGTase-II,\n alpha subunit),\n mNPL4 mUFD1 mRPT2 mRPN5 mRPT3 mRPN9 mRPN12 mRPT1 mRPN8 mRPN11 mRPT5 mRPT4 mRPT6 mHRT1 mPRE1 mSCL1 mPRE9 mPUP2 mPRE3 mYKL206C mPRE10 mVPS45 mTLG2 mPEP12 mLAP4 mCVT19
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Computational Genomics Lab, Tel-Aviv uniresity