Module number 2768




Database revision : gnsdb28.10
Date : Tue Feb 25 17:32:29 2003
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mSRP1:karyopherin alpha homolog of 60 kDa,karyopherin alpha,supres\nsor of rpb1, cold-sensitive\n mATP4:ATP synthase F0 sector subunit 4; analogous to the bovine b \nsubunit,F(1)F(0)-ATPase complex subunit b,Null mutant is via\nble but is oxidative phosphorylation deficient, is unable to\n grow on glycerol, shows an F1 loosely bound to mitochondria\nl membrane, lacks subunit 6 in F0, has a five times lower cy\ntochrome oxidase activity, produces a high percentage of spo\nnteneous rho- mutants, and is oligomycin-insensitive\n Cond423:YPD_stationary_phase_4_h_ypd-1\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mERG12:mevalonate catabolism,mevalonate kinase,Null mutant is invia\nble and unable to grow vegetatively or germinate spores; mut\nants exhibit increased mitotic stability of plasmids with we\nak ARS elements.\n mTIM18:mitochondrial inner membrane translocase,translocase,Null mu\ntant is viable\n Cond879:MMC\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mARG8:Acetylornithine aminotransferase,acetylornithine aminotransf\nerase,Arginine requiring\n mPOP2:Putative transcription factor,transcription factor (putative\n),Mutant is resistant to glucose derepression, temperature-s\nensitive, and unable to sporulate and contains reduced amoun\nts of reserve carbohydrates\n Cond887:t-BuOOH\n mGNT1:Unknown ,, Unknown\n mAPM4:Clathrin associated protein, medium subunit,clathrin associa\nted protein complex medium subunit,\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYIL041W:Unknown ,, Unknown\n mYOR286W:Unknown ,, Unknown\n Cond875:60min\n mQRI8:ubiquitin conjugating enzyme,ubiquitin-conjugating enzyme,Nu\nll mutant is viable\n Cond886:g-ray\n mYOL008W:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond892:S\n Cond874:30min\n mOST1:Oligosaccharyltransferase catalyzes the transfer of oligosac\ncharide from dolichol-oligosaccharide donor to consensus gly\ncosylation acceptor sites (asparagines) in newly synthesized\n proteins in ER lumen,64 kDa, alpha subunit of oligosacchary\nltransferase complex; homologous to mammalian ribophorin I,N\null mutant is inviable; temperature-sensitive mutants show p\nleiotropic underglycosylation of soluble and membrane-bound \nglycoproteins\n mOST3:Catalyzes the transfer of oligosaccharide from dolichol-olig\nosaccharide donor to consensus glycosylation acceptor sites \n(asparagines) in newly synth. proteins - ER lumen; may enhan\nce oligosacch. transfer to subset of acceptor substrates,oli\ngosaccharyl transferase glycoprotein complex 34 kDa gamma su\nbunit,Null mutant is viable but shows underglycosylation of \nsoluble and membrane-bound glycoproteins and contains less o\nligosaccharyltransferase activity in vitro\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mOST6:Putative new 37kDa subunit of N-oligosaccharyltransferase co\nmplex,N-oligosaccharyltransferase complex 37kDa subunit (put\native),\n Cond890:G1\n Cond880:BCNU\n mVMA4:vacuolar ATPase V1 domain subunit E (27 kDa),E subunit of V1\n sector , vacuolar ATPase V1 domain subunit E (27 kDa) , vac\nuolar H(+) ATPase 27 kDa subunit,Null mutant is viable, slow\n growing, cold-sensitive, thermo-sensitive, and exhibits poo\nr growth on glycerol; fails to grow on media supplemented wi\nth 100 mM CaCl2 or ZnCl2\n mITR2:member of sugar transporter superfamily,myo-inositol transpo\nrter,Null mutant is viable\n Cond:\n mYGL198W:Unknown ,, Unknown\n Cond889:4NQO_2\n mYNR021W:Unknown ,, Unknown\n Cond942:SK1ume6_YPD\n mMRP2:14 kDa mitochondrial ribosomal protein; homologous to E. col\ni S14 protein,14 kDa mitochondrial ribosomal protein , simil\nar to E. coli S14 protein,defective mitochondrial protein sy\nnthesis; absence of a and b type cytochromes; reduced levels\n of mitochondrial 15 S rRNA; defective processing of apocyto\nchrome b intron; convert to rho- and rho0 at high frequency\n Cond947:W303_YPA\n Cond891:G1MMS\n mSNL1:Suppressor of nup116-C lethal,18.3 kDa integral membrane pro\ntein,Null mutant is viable; SNL1 is a high copy suppressor o\nf nup116, gle2 and nic96 alleles\n mSEC22:Synaptobrevin (v-SNARE) homolog present on ER to Golgi vesic\nles,,null mutant is cold and heat sensitive. Defective in ER\n to Golgi transport.\n mYOR155C:Unknown ,, Unknown\n mRSC9:Remodels the Structure of Chromatin,,Null: Lethal.\n mYPR063C:Unknown ,, Unknown\n mYOR164C:Unknown ,, Unknown\n Cond948:W303_ume6_YPA_\n mSWP1:oligosaccharyl transferase glycoprotein complex, delta subun\nit,oligosaccharyl transferase glycoprotein complex, delta su\nbunit,lethal\n Cond881:4NQO\n Cond888:MNNG_2\n mHEM12:fifth enzyme in the heme biosynthetic pathway,uroporphyrinog\nen decarboxylase,Null mutant is viable; auxotroph for heme a\nnd methionine\n mANT1:adenine nucleotide transporter,,Null: growth defect on mediu\nm-chain length fatty acids.\n mYAH1:Yeast Adrenodoxin Homologue 1; This protein is targeted to t\nhe mitochondrial matrix as shown by using a specific polyclo\nnal antibody,iron-sulfur protein similar to human adrenodoxi\nn,Null mutant is inviable\n mVMA13:vacuolar ATPase V1 domain subunit H (54 kDa),vacuolar ATPase\n V1 domain subunit H (54 kDa) , vacuolar H(+) ATPase V1 sect\nor 54 kDa subunit,Null mutant is viable, V-ATPase complex fr\nom null mutants is less stable than from wild-type strains\n mERV25:COPII coat component of certain ER-derived vesicles,vesicle \ncoat component,Null mutant is viable, displays a selective d\nefect in transport of secretory proteins from the ER to Golg\ni complex.\n mARP2:Involved in endocytosis and membrane growth and polarity,act\nin related protein,Null mutant is inviable\n mPHO91:Low-affinity phosphate transporter,,\n mHSP60:60 kDa heat shock protein,chaperonin , groEL homolog , chape\nronin , groEL homolog,Null mutant is inviable\n mTOM40:Translocase of Outer Mitochondrial membrane,forms the outer \nmembrane import channel , mitochondrial outer membrane prote\nin , forms the outer membrane import channel , mitochondrial\n outer membrane protein,Null mutant is inviable; cells accum\nulate uncleaved mitochondrial precursor proteins\n mYPR004C:Unknown ,, Unknown\n Cond939:4h\n mARP2 mSRP1
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Computational Genomics Lab, Tel-Aviv uniresity