Module number 2761




Database revision : gnsdb28.10
Date : Tue Feb 25 17:32:06 2003
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mHSE1:Unknown ,, Unknown\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mSAP30:Hypothetical ORF,,\n mSET5:,,\n mYNL047C:Unknown ,, Unknown\n mPSH1:Unknown ,, Unknown\n mGYP7:GTPase-activating protein,GTPase activating protein (GAP),Nu\nll mutant is viable\n mYNR068C:Unknown ,, Unknown\n mQRI5:Product of gene unknown,,\n mYJR083C:Unknown ,, Unknown\n mYDR239C:Unknown ,, Unknown\n mVTA1:Unknown ,, Unknown\n mRLF2:Chromatin Assembly Complex, subunit 1: largest (p90) subunit\n of three-subunit protein complex (yeast CAF-I) involved in \nDNA-replication-linked nucleosome assembly. Homol. to p150 s\nubunit human Chromatin Assembly Factor-I (CAF-I),chromatin a\nssembly factor-I (CAF-I) p90 subunit,Null mutant is viable, \nsensitive to UV radiation. Rap1 localization is disrupted an\nd silencing of genes adjacent to telomeric DNA is decreased \nin rfl2 mutants.\n Cond892:S\n Cond883:5\n Cond898:RPN4\n mYPL070W:Unknown ,, Unknown\n mHSF1:heat shock transcription factor,heat shock transcription fac\ntor,Null mutant is inviable\n mYNR029C:Unknown ,, Unknown\n mRNH70:RNase H(70), a 70 kDa ribonuclease H,ribonuclease H,Null mut\nant is viable.\n Cond872:Zero1\n mOCA1:Unknown ,, Unknown\n mEND3:Required for endocytosis and organization of the cytoskeleto\nn,,Null mutant is viable and defective in endocytosis\n Cond889:4NQO_2\n mYPK1:76.5 kDa Serine/threonine protein kinase with similarity to \nprotein kinase C, is 90% identical to Ypk2p,76.5 kDa serine/\nthreonine protein kinase , similarity to protein kinase C, i\ns 90% identical to Ypk2p,Null mutant is viable, slow growing\n, ypk1 ypk2 double deletion mutants are defective for vegeta\ntive growth\n mYFR016C:Unknown ,, Unknown\n mNMD4:putative Upf1p-interacting protein,,\n mMSO1:multicopy suppressor of sec1; small hydrophilic protein, enr\niched in microsomal membrane fraction, interacts with Sec1p,\n,Null mutant is viable, exhibits accumulation of secretory v\nesicles in the bud; mso1 null mutants exhibit double mutant \ninviability in combinaiton with sec1, sec2, and sec4 mutants\n mRTF1:Directly or indirectly regulates the DNA-binding properties \nof Spt15p, the TATA box-binding protein, and the relative ac\ntivities of different TATA elements,nuclear protein,Null mut\nant is viable and can suppress TATA box-binding protein muta\nnts (SPT15) in an allele-specific fashion\n Cond897:STATMMS\n Cond888:MNNG_2\n Cond894:G2\n mIES1:Hypothetical ORF,,Null mutant is viable\n Cond893:SMMS\n mYHR029C:Unknown ,, Unknown\n mNMA2:Unknown ,, Unknown\n mYDR229W:Unknown ,, Unknown\n mYKR089C:Unknown ,, Unknown\n mSIN3:DNA binding protein involved in transcriptional regulation,D\nNA binding protein , involved in transcriptional regulation \n, DNA binding protein , involved in transcriptional regulati\non , DNA binding protein , involved in transcriptional regul\nation , DNA binding protein , involved in transcriptional re\ngulation , DNA binding protein , involved in transcriptional\n regulation , DNA binding protein , involved in transcriptio\nnal regulation,inviable, reduced potassium dependency\n mSMY1:not believed to act as a kinesin, colocalizes with Myo2p,kin\nesin heavy chain homolog,high copy suppressor of myosin\n mSIN4:involved in positive and negative regualtion of transcriptio\nn, possibly via changes in chromatin structure,RNA polymeras\ne II holoenzyme/mediator subunit,Null mutant is viable, temp\nerature sensitive, displays defects in both positive and neg\native regulation of transcription, suppresses Ty insertion m\nutations (Spt-), exhibits decreased superhelical density of \ncircular DNA molecules, exhibits expression from promoters l\nacking UAS elements; associated with a defect in RME1-depend\nent repression and a methionine or cysteine requirement, exh\nibits flocculant/lacy colony morphology, suppressor of snf/s\nwi mutations\n mYDR306C:Unknown ,, Unknown\n mYGL185C:Unknown ,, Unknown\n Cond895:G2MMS\n mCHS5:Involved in chitin synthase III activity, also required for \nhomozygosis in the first stages of mating,,Null mutant is vi\nable, cells exhibit a strong mating defect; sensitive to Cal\ncofluor, reduced amount of chitin in the cell wall\n mCUS1:cold sensitive U2 snRNA Suppressor,U2 snRNP protein,suppress\nes cold sensitivity of a U2 G53A cs mutant\n mYLR199C:Unknown ,, Unknown\n Cond877:MMS\n Cond886:g-ray\n mYPR148C:Unknown ,, Unknown\n mSAS5:Involved in silencing at telomeres, HML and HMR,,Null mutant\n is viable\n mALG11:Specifies addition of the terminal alpha 1,2-Man to the Man5\nGlcNAc2-PP-dolichol N-Glycosylation intermediate,,Null mutan\nt displays poor growth and temperature-sensitive lethality\n mVPS21:Rab5-like GTPase involved in vacuolar protein sorting and en\ndocytosis post vesicle internalization; geranylgeranylated; \ngeranylgeranylation required for membrane association,small \nGTP-binding protein,Null mutant is viable, temperature-sensi\ntive, missorts multiple vacuolar proteins, accumulate 40-50 \nnm vesicles, and contain a large vacuole\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPDX1:Plays a structural role in pyruvate dehydrogenase complex,py\nruvate dehydrogenase complex protein X component,Null mutant\n is viable\n mYJR111C:Unknown ,, Unknown\n mVPS24:involved in secretion,,Null mutant missorts vacuolar hydrola\nses and accumulates a late endosomal compartment; Class E vp\ns mutant\n mCAF4:CCR4 associated factor,CCR4 transcriptional complex componen\nt,Null mutant is viable\n mTAF1:TAFII complex component required for activated transcription\n,,Null mutant is inviable, taf145 (ts) mutants arrest as sma\nll unbudded cells with a G0 like morphology at the nonpermis\nsive temperature\n mRFC1:RFC is a DNA binding protein and ATPase that acts as a proce\nssivity factor for DNA polymerases delta and epsilon and loa\nds proliferating cell nuclear antigen (PCNA) on DNA,replicat\nion factor C subunit 1 , similar to human RFC 140 kDa subuni\nt,Null mutant is inviable, rfc1 conditional mutants arrest b\nefore mitosis\n mVPS27:hydrophilic protein; has cysteine rich putative zinc finger \nesential for function,cysteine rich putative zinc finger ess\nential for function , hydrophilic protein , cysteine rich pu\ntative zinc finger essential for function , hydrophilic prot\nein , cysteine rich putative zinc finger essential for funct\nion , hydrophilic protein , cysteine rich putative zinc fing\ner essential for function , hydrophilic protein , cysteine r\nich putative zinc finger essential for function , hydrophili\nc protein , cysteine rich putative zinc finger essential for\n function , hydrophilic protein,required for membrane traffi\nc to the vacuole\n mFAD1:Flavin adenine dinucleotide (FAD) synthetase, which performs\n second step in synthesis of FAD from riboflavin,FAD synthet\nase,Null mutant is inviable\n Cond885:20\n mSCJ1:dnaJ homolog,DnaJ homolog,Null mutant is viable but exhibits\n defects in protein sorting and sensitivity to tunicamycin.\n Cond891:G1MMS\n mVPS4:Defective in vacuolar protein sorting; homologous to mouse S\nKD1 and to human hVPS4,AAA ATPase,Null mutant is viable, exh\nibits protein sorting and morphological defects\n mRAV2:Regulator of (H+)-ATPase in Vacuolar membrane,,\n mIOC3:Iswi One Complex,,\n mPNG1:de-N-glycosylation enzyme,peptide:N-glycanase,Null mutant is\n viable and shows no growth or viability defect under experi\nmental conditions\n mNKP1:Unknown ,, Unknown\n mUGT51:Udp-glycosyltransferase,UDP-glucose:sterol glucosyltransfera\nse,Null mutant is viable and unable to synthesize sterol glu\ncoside\n mVPS30:Required for sorting and delivery of soluble hydrolases to t\nhe vacuole.,,Vacuolar hydrolases sorting receptor Vps10p is \nmislocalized in vps30 mutants.\n Cond884:10\n mHSE1 mVPS27
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Computational Genomics Lab, Tel-Aviv uniresity