Module number 2747




Database revision : gnsdb28.10
Date : Tue Feb 25 17:30:08 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n mYNL010W:Unknown ,, Unknown\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond399:Nitrogen_Depletion_8_h\n mTKL1:Transketolase 1,transketolase 1,Null mutant is viable; growt\nh on fermentable carbon sources, but not gluconeogenic carbo\nn sources, is reduced; tkl1 tkl2 mutants are auxotrophic for\n aromatic amino acids\n mSSB2:stress-seventy subfamily B,SSB1 homolog , heat shock protein\n of HSP70 family,Null mutant is viable, ssb1 ssb2 double dis\nruption mutants exhibit poor growth at all temperatures, but\n particularly at low temperatures; as well as hypersensitivi\nty to certain protein synthesis inhibitors, including aminog\nlycosides such as hygromycin B\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mRPP1A:Homology to rat P1, human P1, and E.coli L12eIIA,acidic ribo\nsomal protein P1A (YP1alpha) (A1),\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond418:YPD_1_d_ypd-2\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n Cond675:MHY1_(dun1)_+_heat_20_min\n mTIR3:TIP1-related,cell wall mannoprotein,inviable under unaerobic\n conditions\n Cond362:dtt_000_min__dtt-2\n Cond400:Nitrogen_Depletion_12_h\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond467:steady_state_21_dec_C_ct-2\n Cond416:YPD_10_h__ypd-2\n mRPS29A:Homology to rat S29,ribosomal protein S29A (S36A) (YS29),\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Cond674:DES459_(mec1)_+_heat_20_min\n Cond810:Na45'\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSCS7:Required for the hydroxylation of the very long chain fatty \nacid (VLCFA), located in the endoplasmic reticulum,desaturas\ne , hydroxylase,Null mutant is viable, suppresses the Ca2+-s\nensitive phenotype of csg2 delta mutants\n Cond364:dtt_030_min__dtt-2\n mDYS1:Deoxyhypusine synthase carries out the first step in hypusin\ne biosynthesis, converting lysine and spermidine into deoxyh\nypusine.,deoxyhypusine synthase,Null mutant is inviable\n Cond373:1.5_mM_diamide_(40_min)\n mRPB8:16-kDa RNA polymerase subunit (common to polymerases I, II a\nnd III),16 kDa RNA polymerase subunit (common to polymerases\n I, II and III),Null mutant is inviable\n Cond454:YP_fructose_vs_reference_pool_car-2\n Cond445:Msn4_overexpression\n Cond890:G1\n Cond391:aa_starv_1_h\n mRPL6A:Homology to rat L6 and human L6,ribosomal protein L6A (L17A)\n (rp18) (YL16),\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n Cond814:Na+FK45'\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n mRPA12:A12.2 subunit of RNA polymerase I,RNA polymerase I A12.2 sub\nunit,Null mutant is viable but is temperature sensitive; syn\nthetically lethal with RPA14\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond318:37C_to_25C_shock_-_60_min\n mRPS22A:Homology to rat S15a,ribosomal protein S22A (S24A) (rp50) (Y\nS22),\n Cond897:STATMMS\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond894:G2\n Cond395:Nitrogen_Depletion_30_min.\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond312:Heat_Shock_015_minutes_hs-2\n Cond479:WT+/-100mM3AT(SetD)(R491)\n Cond849:120_min\n mLOC1:Localization of mRNA,,Mutant exhibits slow growth at 30C\n Cond306:Heat_Shock_60_minutes_hs-1\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mRPS20:Homology to rat S20, human S20, Xenopus S22, and E. coli S10\n,ribosomal protein S20,Null mutant is inviable\n Cond367:dtt_240_min_dtt-2\n Cond879:MMC\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mEMP24:type I transmembrane protein, component of COPII-coated, ER-\nderived transport vesicles,type I transmembrane protein,Null\n mutant is viable\n mPAU7:similar to Pau3, member of Pau1 family,,\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n mIMD4:similar to IMP dehydrogenase,IMP dehydrogenase homolog,\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mRPL33A:Homology to rat L35a,ribosomal protein L33A (L37A) (YL37) (r\np47),Null mutant is viable, severely impaired in growth. rpl\n33a rpl33b double deletion mutants are inviable\n mRPL33B:Homology to rat L35a,ribosomal protein L33B (L37B) (rp47) (Y\nL37),Null mutant is viable.\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mRPL26B:Homology to rat L26,ribosomal protein L26B (L33B) (YL33),\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond809:Na30'\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond942:SK1ume6_YPD\n Cond965:ndt80_delete_mid_g/r_ratio_\n Cond891:G1MMS\n Cond881:4NQO\n Cond813:Na+FK30'\n Cond303:Heat_Shock_20_minutes_hs-1\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n mTIF1:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mRPS17B:Homology to rat ribosomal protein S17,ribosomal protein S17B\n (rp51B),Null mutant is viable, rp51a (rps17a) rp51b (rps17b\n) deletion mutants are inviable\n mTIF2:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mTIF6:similar to human translation initiation factor 6 (eIF6); how\never, TIF6 does not act as a true translation initiation fac\ntor.The protein may be involved in the biogenesis and or sta\nbility of the 60S ribosomal subunits,,Null mutant is inviabl\ne; cells are depleted of 60S ribosomal subunits, translation\n initiation is inhibited, and cells arrest in G1\n mAPT1:Adenine phosphoribosyltransferase,adenine phosphoribosyltran\nsferase,\n mGUA1:GMP synthase,GMP synthase,Null mutant is viable but is a gua\nnine auxotroph\n mLCB2:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Auxotrophic for long\n-chain component of sphingolipids; some mutations can suppre\nss the Ca2+-sensitive mutant csg2\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n mRPL1A:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1B (Ssm2p),ribosomal protein L\n1A, forms part of the 60S ribosomal subunit,Null mutant is v\niable; shows double mutant lethality with rpl1b (ssm2b) null\n mutants\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond899:RPN4_MMS__\n Cond390:aa_starv_0.5_h\n Cond320:heat_shock_17_to_37,_20_minutes\n mERG13:involved in mevalonate synthesis,3-hydroxy-3-methylglutaryl \ncoenzyme A synthase,\n Cond316:37C_to_25C_shock_-_30_min\n Cond305:Heat_Shock_40_minutes_hs-1\n Cond396:Nitrogen_Depletion_1_h\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mRPB10:RNA polymerase II subunit,RNA polymerase II core subunit,Nul\nl mutant is inviable\n mTIF34:p39 subunit of translation initiation factor eIF3,translatio\nn initiation factor eIF3 p39 subunit,Null mutant is inviable\n mRAS1:ras proto-oncogene homolog,ras homolog,\n mRPL13B:Homology to rat L13,ribosomal protein L13B,\n Cond363:dtt_015_min_dtt-2\n Cond941:SK1_YPD\n mYVH1:nitrogen starvation-induced protein phosphatase,protein tyro\nsine phosphatase induced by nitrogen starvation,\n mECM1:putative transmembrane domain protein involved in cell wall \nbiogenesis,,A Tn3 insertion into ECM1 causes hypersensitivit\ny to the cell surface polymer perturbing agent calcofluor wh\nite.\n mYKL056C:Unknown ,, Unknown\n mRPS25A:Homology to rat S25,ribosomal protein S25A (S31A) (rp45) (YS\n23),\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mRPS18A:Homology to rat S18 and E. coli S13,ribosomal protein S18A,\n mHIP1:histidine permease,histidine permease,requires supplementati\non with large amounts of histidine for growth\n mRPL42B:Homology to rat L36a and human L36a,ribosomal protein L42B (\nYL27) (L41B) (YP44),Deficient in maintenance of killer\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n Cond892:S\n mVRG4:May regulate Golgi function and glycosylation in Golgi,,Null\n mutant is inviable; mutants exist with defects in Golgi-spe\ncific glycosylation, resistance to vanadate, sensitivity to \naminoglycosides, and sporulation defects\n Cond745: mPRS5:Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyr\nophosphokinase),phosphoribosylpyrophosphate synthetase (ribo\nse-phosphate pyrophosphokinase),Null mutant is viable but re\nduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate s\nynthetase activity by 84%. prs5 mutations are synthetically \nlethal with mutations in prs1 or prs3.\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond463:29_deg_growth_ct-1\n Cond323:heat_shock_29_to_37,_20_minutes\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond872:Zero1\n Cond940:6h\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond889:4NQO_2\n mOLE1:delta-9-fatty acid desaturase,delta-9-fatty acid desaturase,\nThe null mutant is inviable but can be rescued by addition o\nf unsaturarted fatty acids to the growth medium. Some allele\ns are temperature-sensitive for growth and show defective in\ntracellular mitochondrial movement atthe non- permissive tem\nperature.\n Cond426:YPD_stationary_phase_1_d_ypd-1\n mYPR063C:Unknown ,, Unknown\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n mCAF20:binds to eIF4E, the mRNA cap-binding protein, and represses \ncap-dependent translation initiation by interfering with the\n interaction of eIF4E and eIF4G,20 kDa subunit , mRNA cap bi\nnding protein eIF-4F , 20 kDa subunit , mRNA cap binding pro\ntein eIF-4F,Null mutant is viable and grows faster; deletion\n of CAF20 partially suppresses mutations in translation init\niation factors; overexpression of CAF20 causes slower growth\n and enhances translation mutation phenotypes\n Cond934:8h\n Cond322:heat_shock_25_to_37,_20_minutes\n Cond459:YP_sucrose_vs_reference_pool_car-2\n Cond420:YPD_3_d_ypd-2\n Cond857:pm38-gtoe\n Cond893:SMMS\n mYPR114W:Unknown ,, Unknown\n mRPS19A:Homology to rat S19,ribosomal protein S19A (S16aA) (rp55A) (\nYS16A),\n mRPS19B:Homology to rat S19,ribosomal protein S19B (rp55B) (S16aB) (\nYS16B),\n Cond379:1M_sorbitol_-_30_min\n mSUI2:Translation initiation factor eIF-2 alpha subunit,,suppressi\non of initiator codon mutations\n mRPL36A:Homology to rat L36,ribosomal protein L36A (L39) (YL39),\n mRPO26:subunit common to RNA polymerases I, II, and III,RNA polymer\nases I, II, and III subunit,Null mutant is inviable\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n RapamycinDip.dip_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n Cond434:DBY7286_37degree_heat_-_20_min\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond419:YPD_2_d_ypd-2\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond783:Peroxide_60'\n Cond878:MNNG\n Cond895:G2MMS\n mSEC14:Required for vesicle budding from the Golgi,phosphatidylinos\nitol transfer protein,Null mutant is inviable; other mutatio\nns are temperature sensitive\n Cond882:zero3\n Cond877:MMS\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n Cond417:YPD_12_h_ypd-2\n Cond946:W303ume6_YPD\n Cond886:g-ray\n mYHM2:Yeast suppressor gene of HM mutant (abf2),DNA binding protei\nn , mtDNA stabilizing protein, mitochondrial inner membrane \nprotein with low homology to RIM2,Null mutant is viable but \nshows slow growth in the presence of non-fermentable carbon \nsources; mutant shows mitochondrial genome unstability\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mUTP13:Unknown ,, Unknown\n Cond415:YPD_8_h_ypd-2\n mRPS6A:Homology to rat, mouse, and human S6,ribosomal protein S6A (\nS10A) (rp9) (YS4),\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n Cond319:37C_to_25C_shock_-_90_min\n Cond402:Nitrogen_Depletion_2_d\n Cond811:Na60'\n mUTP19:Unknown ,, Unknown\n Cond876:zero2\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond401:Nitrogen_Depletion_1_d\n mRPL4A:Homology to rat L4, Xenopus L1, Drosophila L1,ribosomal prot\nein L4A (L2A) (rp2) (YL2),\n Cond885:20\n mPFK2:phosphofructokinase beta subunit,phosphofructokinase beta su\nbunit,Null mutant is viable but exhibits slow growth and dec\nreased efficiency of glucose utilization.\n mMRP2:14 kDa mitochondrial ribosomal protein; homologous to E. col\ni S14 protein,14 kDa mitochondrial ribosomal protein , simil\nar to E. coli S14 protein,defective mitochondrial protein sy\nnthesis; absence of a and b type cytochromes; reduced levels\n of mitochondrial 15 S rRNA; defective processing of apocyto\nchrome b intron; convert to rho- and rho0 at high frequency\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mEGD1:beta subunit of the nascent-polypeptide-associated complex (\nNAC); homologous to human BTF3b; GAL4 enhancer protein,pol I\nI transcribed genes regulator,Null mutant is viable; reduced\n induction of galactose-regulated genes upon shift from gluc\nose to galactose\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond815:Na+FK60'\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mYAR075W:Unknown ,, Unknown\n mSUR4:Required for conversion of 24-carbon fatty acids to 26-carbo\nn species,,Null mutants is viable, not sensitive to UV or ga\nmma radiation. sur4 mutants suppress rad3, rvs161 delta, and\n rvs167 mutations. sur4 fen1 mutants and sur4 elo2 mutants a\nre inviable.\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n mRPP0:Homology to rat P0, human P0, and E. coli L10e,ribosomal pro\ntein P0 (A0) (L10E),Null mutant is inviable\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mRPL16A:Homology to rat L13a,ribosomal protein L16A (L21A) (rp22) (Y\nL15),\n Cond421:YPD_5_d_ypd-2\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n mRPL16B:Homology to rat ribosomal protein L13a,ribosomal protein L16\nB (L21B) (rp23) (YL15),\n mRPC19:subunit common to RNA polymerases I (A) and III (C),RNA poly\nmerases I (A) and III (C) subunit,Null mutant is inviable\n mCDC33:Required for START A of cell cycle and sporulation,mRNA cap \nbinding protein eIF-4E,Null mutant is inviable. cdc33 mutant\ns arrest at G(sub)1. cdc33 has normal cAMP pools and is not \nsuppressed by cAPK mutants, suggesting sporulation is indepe\nndent of the cAMP pathway\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Cond304:Heat_Shock_30_minutes_hs-1\n mFAA4:acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatt\ny acid activator 2), activates imported fatty acids and prov\nides substrates for N-myristoylation,long chain fatty acyl:C\noA synthetase , long-chain fatty acid:CoA ligase,Not essenti\nal for vegetative growth when fatty acid synthase (fas) is a\nctive\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n mARC1:associated with tRNA and amino acyl-tRNA synthetases; has af\nfinity for quadruplex nucleic acids,,Null mutant is viable, \nleads to slow growth and reduced MetRS activity; arc1- mutan\nts are synthetic lethals and are complemented by the genes f\nor methionyl-tRNA and glutamyl-tRNA synthetase.\n mRPS7A:Homology to human S7 and Xenopus S8,ribosomal protein S7A (r\np30),Null mutant is viable\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond884:10\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n Cond958:t0.5_g/r_ratio\n mRPP1A mRPP0 mTIF6 mTIF2 mSUI2 mPFK2 mCDC33 mFAA4 mCAF20 mRPA12 mRPC19
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Computational Genomics Lab, Tel-Aviv uniresity