Module number 2746




Database revision : gnsdb28.10
Date : Tue Feb 25 17:29:56 2003
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mSPC1:Homolog of the SPC12 subunit of mammalian signal peptidase c\nomplex. Protein is important for efficient signal peptidase \nactivity.,,Null mutant is viable; synthetically lethal with \na conditional mutation in sec11; high copy Spc1 suppresses t\nhe conditional sec11 mutation\n Cond899:RPN4_MMS__\n mERG10:acetoacetyl CoA thiolase,acetoacetyl CoA thiolase,Nul mutant\n is inviable; other mutants are ergosterol biosynthesis defe\nctive or nystatin resistant\n mTIM17:Mitochondrial inner membrane protein involved in protein imp\nort,16.5 kDa inner membrane protein required for import of m\nitochondrial precursor proteins,Null mutant is inviable\n mYNL010W:Unknown ,, Unknown\n mYGR131W:Unknown ,, Unknown\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mERG13:involved in mevalonate synthesis,3-hydroxy-3-methylglutaryl \ncoenzyme A synthase,\n mSSB1:Stress-Seventy Subfamily B; involved in translation, perhaps\n by guiding the nascent chain through the ribosome,HSP70 fam\nily,null mutant is viable but cold-sensitive\n mRPP1B:Homology to rat P1, human P1, and E. coli L12eIIB,ribosomal \nprotein P1B (L44') (YP1beta) (Ax),Null mutant is viable\n mDFG10:Protein required for filamentous growth, cell polarity, and \ncellular elongation,,Null mutant is viable and defective in \nfilamentous growth\n mRPB10:RNA polymerase II subunit,RNA polymerase II core subunit,Nul\nl mutant is inviable\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n mTIF34:p39 subunit of translation initiation factor eIF3,translatio\nn initiation factor eIF3 p39 subunit,Null mutant is inviable\n mTPI1:triosephosphate isomerase,triosephosphate isomerase,Null mut\nant is viable.\n mYHR045W:Unknown ,, Unknown\n mYDR492W:Unknown ,, Unknown\n mRPA43:DNA-dependent RNA polymerase I subunit A43,DNA dependent RNA\n polymerase I subunit A43,Null mutant is inviable\n mRPS25A:Homology to rat S25,ribosomal protein S25A (S31A) (rp45) (YS\n23),\n mVMA21:Protein involved in vacuolar H-ATPase assembly or function,,\nNull mutant is viable but grows slowly and exhibits increase\nd calcium sensitivity. Null mutants also cannot grow on glyc\nerol or at pH 7.5\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mXPT1:Xanthine Phosphoribosyl Transferase,xanthine phosphoribosyl \ntransferase,Cannot utilize xanthine as a source of GMP\n mHIP1:histidine permease,histidine permease,requires supplementati\non with large amounts of histidine for growth\n mYHR133C:Unknown ,, Unknown\n mRPA135:135 kDa subunit of RNA polymerase I,RNA polymerase I subunit\n,suppression of rpb1, cold sensitive\n mTUF1:Translation elongation factor Tu, mitochondrial,translation \nelongation factor Tu, mitochondrial,Null mutant is viable, b\nlocks mitochondrial translation and destabilizes mitochondri\nal genome.\n mRKI1:Ribose-5-phosphate ketol-isomerase,ribose-5-phosphate ketol-\nisomerase,Null mutant is inviable\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n Cond892:S\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n mPRS5:Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyr\nophosphokinase),phosphoribosylpyrophosphate synthetase (ribo\nse-phosphate pyrophosphokinase),Null mutant is viable but re\nduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate s\nynthetase activity by 84%. prs5 mutations are synthetically \nlethal with mutations in prs1 or prs3.\n mSCS7:Required for the hydroxylation of the very long chain fatty \nacid (VLCFA), located in the endoplasmic reticulum,desaturas\ne , hydroxylase,Null mutant is viable, suppresses the Ca2+-s\nensitive phenotype of csg2 delta mutants\n mPIS1:phosphatidylinositol synthase,phosphatidylinositol synthase,\nNull mutant is inviable\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n mDYS1:Deoxyhypusine synthase carries out the first step in hypusin\ne biosynthesis, converting lysine and spermidine into deoxyh\nypusine.,deoxyhypusine synthase,Null mutant is inviable\n Cond890:G1\n mHNM1:choline transport protein; may also control uptake of nitrog\nen mustard,transporter (permease) for choline and nitrogen m\nustard; share homology with UGA4,Null mutant is viable, but \nhyper-resistant to nitrogen mustard; ctr1,cho1 double null i\ns inviable\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mRSM19:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,\n Cond:\n mAUR1:involved in phospolipid metabolism,,Null mutant is inviable;\n mutant exhibits dominant resistance to aureobasidin A. Wild\n type (sensitive) is recessive.\n Cond889:4NQO_2\n mYNR021W:Unknown ,, Unknown\n mERG24:sterol C-14 reductase,sterol C-14 reductase,Null mutant appe\nars to be inviable in some genetic backgrounds and condition\nally lethal in others; erg24 mutations are suppessed by fen1\n and fen2 mutations\n mERG25:C-4 sterol methyl oxidase,C-4 sterol methyl oxidase,Null mut\nant is inviable\n mERG26:C-3 sterol dehydrogenase,C-3 sterol dehydrogenase,\n mCIS3:cik1 suppressor,similar to Hsp150p and Pir1p, Pir2p, and Pir\n3p,Null mutant is viable; CIS3 is a high copy suppressor of \ncik1 deletion mutants\n mYPR063C:Unknown ,, Unknown\n mACC1:acetyl-CoA carboxylase,acetyl CoA carboxylase,acc1 spores fa\nil to enter vegetative growth\n Cond888:MNNG_2\n Cond894:G2\n mCAF20:binds to eIF4E, the mRNA cap-binding protein, and represses \ncap-dependent translation initiation by interfering with the\n interaction of eIF4E and eIF4G,20 kDa subunit , mRNA cap bi\nnding protein eIF-4F , 20 kDa subunit , mRNA cap binding pro\ntein eIF-4F,Null mutant is viable and grows faster; deletion\n of CAF20 partially suppresses mutations in translation init\niation factors; overexpression of CAF20 causes slower growth\n and enhances translation mutation phenotypes\n mHEM13:Oxygen-repressed, sixth step in heme biosynthetic pathway,co\nproporphyrinogen III oxidase,Null mutant is viable; auxotrop\nh for heme and methionine\n mMRPL44:Mitochondrial ribosomal protein MRPL44 (YmL44),ribosomal pro\ntein (YmL44),\n mTOM20:Translocase of Outer Mitochondrial membrane,20 kDa mitochond\nrial outer membrane protein import receptor,Null mutant is v\niable but respiration deficient; defective in import of mito\nchondrial preproteins\n mERV41:ER vesicle protein,,Null mutant is viable.\n mSSZ1:DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a \nribosome-associated complex (RAC) that is bound to the ribos\nome via the Zuo1p subunit,HSP70 family,Null mutant is viable\n, cold sensitive; SSZ1 overexpression causes increased expre\nssion of some PDR genes\n Cond893:SMMS\n mTOM22:Translocase of Outer Mitochondrial membrane,mitochondrial im\nport receptor protein,Null mutant is inviable\n mRPS19B:Homology to rat S19,ribosomal protein S19B (rp55B) (S16aB) (\nYS16B),\n mYMR010W:Unknown ,, Unknown\n mTOM7:Involved in mitochondrial protein import,translocase of the \nouter mitochondrial membrane,Null mutant is viable\n mSUI1:translation initiation factor 3 (eIF3),translation initiatio\nn factor 3 (eIF3),Null mutant is inviable\n mCPR3:cyclophilin-3 (cyclosporin-sensitive proline rotamase-3),cyc\nlophilin , peptidyl-prolyl cis-trans isomerase (PPIase),Null\n mutant is viable, unable to grow on L-lactate at 37 degrees\n C\n mADH4:Alcohol dehydrogenase type IV,alcohol dehydrogenase isoenzym\ne IV,Null mutant is viable\n mRSM26:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,\n mSPT4:Zn-finger protein, transcriptional regulator,transcriptional\n regulator , zinc finger protein,Null mutant is viable, exhi\nbits suppression of Ty insertion mutations\n mEFB1:Translation elongation factor EF-1beta, GDP/GTP exchange fac\ntor for Tef1p/Tef2p,translation elongation factor EF-1beta, \nGDP/GTP exchange factor for Tef1p/Tef2p,Null mutant is invia\nble\n mMRPL9:Mitochondrial ribosomal protein MRPL9 (YmL9) (E. coli L3) (h\numan MRL3),ribosomal protein (YmL9) (E. coli L3) (human MRL3\n),Null mutant is viable\n mTIF11:Translation initiation factor eIF1A,translation initiation f\nactor eIF1A,Null mutant is inviable\n Cond878:MNNG\n Cond895:G2MMS\n mSEC11:signal peptidase subunit,,Null mutant is inviable\n Cond879:MMC\n mERP4:Emp24p/Erv25p related protein 4,p24 protein involved in memb\nrane trafficking,viable\n mSEC14:Required for vesicle budding from the Golgi,phosphatidylinos\nitol transfer protein,Null mutant is inviable; other mutatio\nns are temperature sensitive\n mYDR367W:Unknown ,, Unknown\n mYIL121W:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond882:zero3\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n Cond877:MMS\n mSCM4:Protein that suppresses ts allele of CDC4 when overexpressed\n,,viable, suppressor of cdc4ts allele\n Cond875:60min\n mCBR1:cytochrome b reductase,cytochrome b reductase,\n mERV14:ER-derived vesicles,14 kDa protein found on ER-derived vesic\nles,Null mutant is viable but exhibits defects in sporulatio\nn (diploids) and bud site selection (haploids). Null mutants\n also retain the bud site selection marker, Axl2p, in the ER\n and exhibit slow recovery from selective to rich media.\n Cond886:g-ray\n mHPT1:enzyme involved in de novo purine biosynthesis,hypoxanthine \nguanine phosphoribosyltransferase,Null mutant is viable; mut\nants show resistance to 8-azaguanine\n mDPM1:dolichol phosphate mannose synthase,dolichol phosphate manno\nse synthase,Null mutant is inviable\n mYOL101C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCOX5A:One of two genes (COX5A and COX5B, both nuclear-encoded) cod\ning for subunit V of cytochrome c oxidase; COX5A gene produc\nt is the predominantform of subunit V found in holocytochrom\ne c oxidase under normal growth conditions,cytochrome c oxid\nase chain Va,Null mutant is viable, respires at 10-15% of th\ne wild-type rate due to the presence of COX5B; cox5a cox5b d\nouble deletion mutants are completely non-respiratory\n Cond874:30min\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n mYPR021C:Unknown ,, Unknown\n Cond876:zero2\n mARF1:implicated in signal transduction and intracellular protein \ntransport to or within the Golgi apparatus,ADP-ribosylation \nfactor,Null mutant is viable and shows slow growth, cold sen\nsitivity and sensitivity to normally sublethal concentration\ns of fluoride ion in the medium.\n Cond885:20\n mRPS31:Homology to rat S27a,ribosomal protein S31 (S37) (YS24),Null\n mutant is viable\n mPFK2:phosphofructokinase beta subunit,phosphofructokinase beta su\nbunit,Null mutant is viable but exhibits slow growth and dec\nreased efficiency of glucose utilization.\n mSHR3:Protein required for appearance of amino acid permeases on t\nhe cell surface,ER integral membrane component,Null mutants \nare viable, specifically accumulate amino acid permeases in \nthe endoplasmic reticulum\n mMRP2:14 kDa mitochondrial ribosomal protein; homologous to E. col\ni S14 protein,14 kDa mitochondrial ribosomal protein , simil\nar to E. coli S14 protein,defective mitochondrial protein sy\nnthesis; absence of a and b type cytochromes; reduced levels\n of mitochondrial 15 S rRNA; defective processing of apocyto\nchrome b intron; convert to rho- and rho0 at high frequency\n Cond891:G1MMS\n mIMP1:Inner membrane protease (mitochondrial protein),inner membra\nne protease,petite; unable to grow on non-fermentable carbon\n sources\n mKTR1:mannosyltransferase involved in O- and N-linked glycosylatio\nn,type II transmembrane protein,Null mutant is viable\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mEGD1:beta subunit of the nascent-polypeptide-associated complex (\nNAC); homologous to human BTF3b; GAL4 enhancer protein,pol I\nI transcribed genes regulator,Null mutant is viable; reduced\n induction of galactose-regulated genes upon shift from gluc\nose to galactose\n mYAR075W:Unknown ,, Unknown\n Cond881:4NQO\n mFCY1:cytosine deaminase highly homologous to Candida albicans cyt\nosine deaminase,cytosine deaminase,Mutant is resistant to 5-\nfluorocytosine and shows total loss of cytosine deaminase ac\ntivity\n mTIF1:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mTIF2:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mRCE1:Protease involved in ras and a-factor terminal proteolysis,p\nrotease,Null mutant is viable, has defects in Ras localizati\non and signaling, and suppresses the activated phenotype of \nthe RAS2val19 allele\n mRPL16B:Homology to rat ribosomal protein L13a,ribosomal protein L16\nB (L21B) (rp23) (YL15),\n mTIF6:similar to human translation initiation factor 6 (eIF6); how\never, TIF6 does not act as a true translation initiation fac\ntor.The protein may be involved in the biogenesis and or sta\nbility of the 60S ribosomal subunits,,Null mutant is inviabl\ne; cells are depleted of 60S ribosomal subunits, translation\n initiation is inhibited, and cells arrest in G1\n mGUA1:GMP synthase,GMP synthase,Null mutant is viable but is a gua\nnine auxotroph\n mLCB2:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Auxotrophic for long\n-chain component of sphingolipids; some mutations can suppre\nss the Ca2+-sensitive mutant csg2\n mCDC33:Required for START A of cell cycle and sporulation,mRNA cap \nbinding protein eIF-4E,Null mutant is inviable. cdc33 mutant\ns arrest at G(sub)1. cdc33 has normal cAMP pools and is not \nsuppressed by cAPK mutants, suggesting sporulation is indepe\nndent of the cAMP pathway\n mRPL1A:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1B (Ssm2p),ribosomal protein L\n1A, forms part of the 60S ribosomal subunit,Null mutant is v\niable; shows double mutant lethality with rpl1b (ssm2b) null\n mutants\n Cond884:10\n mEFB1 mTEF4 mADH4 mSUI1 mSSZ1 mTIF34 mERG10 mTOM20 mTOM7 mTOM22 mTIF2 mPFK2 mCDC33 mCAF20
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Computational Genomics Lab, Tel-Aviv uniresity