Module number 2726




Database revision : gnsdb28.10
Date : Tue Feb 25 17:27:39 2003
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mYBR022W:Unknown ,, Unknown\n mHSE1:Unknown ,, Unknown\n mYPR109W:Unknown ,, Unknown\n mMET30:F-box protein involved in sulfur metabolism and protein ubiq\nuitination,contains five copies of WD40 motif and interacts \nwith and regulates Met4p,Null mutant is inviable\n mCOS7:Protein with strong similarity to other subtelomerically-enc\noded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, C\nos8p, Cos6p, Cos9p,,\n mHAP5:Regulates respiratory functions; subunit of a heterotrimeric\n complex required for CCAAT binding,CCAAT-binding transcript\nion factor component (along with Hap2p and Hap3p),Null mutan\nt is viable\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYHR121W:Unknown ,, Unknown\n mVPS75:Unknown ,, Unknown\n mCEG1:mRNA guanylyltransferase (mRNA capping enzyme), alpha subuni\nt,mRNA capping enzyme alpha subunit , mRNA guanylyltransfera\nse,Null mutant is inviable\n mATE1:arginyl-tRNA-protein transferase,arginyl-tRNA-protein transf\nerase,Null mutant is viable, but unable to degrade substrate\ns of the N-end rule pathway that start with residues recogni\nzed by the Arg-transferase\n mYBL009W:Unknown ,, Unknown\n mSTE11:involved in the mating signalling pathway,,Null mutant is vi\nable but sterile\n mMOG1:Required for nuclear-protein import,nuclear protein that int\neracts with GTP-Gsp1p,Null mutant is viable, temperature sen\nsitive, exhibits defects in nuclear-protein import; MOG1 ove\nrexpression supresses the temperature sensitivity of gsp1 st\nrains; overexpression of NTF2 or GSP1 can suppress the ts ph\nenotype of mog1\n Cond711:t2+Vec\n mMUP3:methionine uptake,very low affinity methionine permease,\n mYDR115W:Unknown ,, Unknown\n mCLB4:Involved in mitotic induction,B-type cyclin,Null mutant is v\niable\n mMRPL38:mitochondrial ribosomal protein L14,ribosomal protein L14,\n mYLR077W:Unknown ,, Unknown\n mXPT1:Xanthine Phosphoribosyl Transferase,xanthine phosphoribosyl \ntransferase,Cannot utilize xanthine as a source of GMP\n mYEL015W:Unknown ,, Unknown\n mYGL085W:Unknown ,, Unknown\n mMSG1:Unknown ,, Unknown\n mMNN5:mannan synthesis,golgi alpha-1,2-mannosyltransferase (putati\nve),Null mutant is viable but defective in addition of the a\nlpha-1,3-linked mannose branch to the mannan structure found\n on N-linked glycans.\n mYKR051W:Unknown ,, Unknown\n mSPO7:dispensable for mitosis, but required for a normal mutation \nrate, required for premeiotic DNA synthesis, recombination, \nmeiosis I, meiosis II, glycogen degradation and spores,,Null\n mutant is viable, sporulation defective\n Cond719:t4-SSD1\n mSSP120:secretory protein,,Null mutant is viable\n mSNF4:involved in release from glucose repression, invertase expre\nssion, and sporulation,associates with Snf1p,Null mutant is \nviable, sucrose nonfermenting; high copy MSI1 and PDE2 parti\nally suppress sporulation defect\n mYGL024W:Unknown ,, Unknown\n Cond724:t4+SSD1,H44\n mYGL198W:Unknown ,, Unknown\n mYIR003W:Unknown ,, Unknown\n mARH1:adrenodoxin oxidoreductase homolog,adrenodoxin oxidoreductas\ne homolog,Null mutant is inviable\n mTAF10:TFIID subunit (TBP-associated factor) with predicted molecul\nar weight of 23 kD.,TFIID subunit,Null mutant is inviable\n Cond713:t4+Vec\n mYMR115W:Unknown ,, Unknown\n mHEM4:catalyzes the fourth step in the heme biosynthesis pathway,u\nroporphyrinogen III synthase,respiratory deficiency, accumul\nation of porphyrins, and heme auxotrophy\n mNUP84:component of nuclear pores; Part of complex with Nup120p, Nu\np85p, Sec13p, and a Sec13p homolog,similar to mammalian Nup1\n07p,Null mutant is viable but has defects in nuclear membran\ne and nuclear pore complex organization and in poly(A)+ RNA \ntransport\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mNUP85:Protein in nuclear pore complex; may function in nuclear env\nelope integrity; may also be involved in tRNA biogenesis,,Nu\nll mutant is viable but is temperature-sensitive; at nonperm\nissive temperature, null mutant accumulates poly(A)+ RNA and\n has fragmented nucleolus; at permissive temperature, nuclea\nr envelope of null mutant detaches from nucleus\n mTAF14:Protein required for actin cytoskeleton assembly or function\n,transcription initiation factor TFIIF small subunit,Null mu\ntant is viable but has a depolarized actin cytoskeleton.\n mSEY1:Unknown ,, Unknown\n mYLR252W:Unknown ,, Unknown\n mYPT32:probably involved in intra-Golgi transport or in the formati\non of transport vesicles at the most distal Golgi compartmen\nt,GTPase , YPT31 homolog , ras homolog,Null mutant is viable\n; ypt31 ypt32 double deletion mutants are inviable\n mCKB1:beta (38kDa) subunit of casein kinase II (CKII),casein kinas\ne II beta subunit,Null mutant is viable, exhibits salt sensi\ntivity specific to NaCl and LiCl\n mCKB2:Casein kinase II, beta' subunit,Casein kinase II beta' subun\nit,Null mutant is viable\n mMRPL40:Mitochondrial ribosomal protein MRPL40 (YmL40),ribosomal pro\ntein (YmL40),\n mMRP51:Mitochondrial Ribosomal Protein,mitochondrial ribosome small\n subunit component,Null mutant is viable, exhibits completel\ny blocked mitochondrial gene expression; missense mutations \nsuppress 5'-UTL mutations in at least 2 mitochondrial mRNAs\n Cond718:t4+SSD1wt\n mMRPS5:Probable mitochondrial ribosomal protein S5,ribosomal protei\nn S5 (putative),\n mSIF2:Sir4p-Interacting Factor,,Null mutant is viable, exhibits in\ncreased telomeric silencing\n mYGL082W:Unknown ,, Unknown\n mYNL026W:Unknown ,, Unknown\n mYME1:Mitochondrial protein of the CDC48/PAS1/SEC18 family of ATPa\nses,,Null mutant is viable, exhibits an elevation in the rat\ne at which copies of TRP1 and ARS1, integrated into the mito\nchondrial genome, escape to the nucleus; a heat-sensitive re\nspiratory-growth defect; a cold-sensitive growth defect on r\nich glucose medium; and synthetic lethality in rho- (cytopla\nsmic petite) cells; yme1 (osd1) mutants fail to degrade newl\ny synthesized subunits of cytochrome c\n mYGR165W:Unknown ,, Unknown\n mMUB1:Homolog of samB gene of Aspergillus nidulans (deletion of sa\nmB results in mislocalization of septa,,Null mutant is viabl\ne but shows multi-budding\n mYDR061W:Unknown ,, Unknown\n mHRB1:an ORF of unknown function located in a centromeric region d\nuplicated between chromosomes III and XIV,hypothetical RNA-b\ninding protein,\n Cond709:t0+Vec\n mPPG1:Serine/threonine protein phosphatase involved in glycogen ac\ncumulation,,Null mutant is viable but accumulates less glyco\ngen\n mYGR111W:Unknown ,, Unknown\n mYLR031W:Unknown ,, Unknown\n mUBS1:General positive regulator of CDC34; Suppress some cdc34 mut\nations when over-expressed,,Null mutant is viable but exhibi\nts a synthetic phenotype with temperature-sensitive alleles \nof cdc34.\n mYNL335W:Unknown ,, Unknown\n mYGR031W:Unknown ,, Unknown\n mRET3:vesicle coat component,vesicle coat component,ret3-1 mutant \nis thermosensitive and shows defects in retrieval of dilysin\ne-tagged proteins from the Golgi back to the ER\n mSEC4:Involved in transport and fusion of post-Golgi secretory ves\nicles to the plasma membrane,ras homolog , small GTP binding\n protein,null is inviable; conditional mutants show defects \nin secretion and accumulation of post-Golgi vesicles under n\non-permissive conditions\n mARE2:Acyl-CoA cholesterol acyltransferase (sterol-ester synthetas\ne),acyl-CoA cholesterol acyltransferase (sterol-ester synthe\ntase),Null mutant is viable; greatly reduces in vivo and in \nvitro ergosterol esterification (to 15 - 35 % of wild-type).\n Deletion of both ARE1 and ARE2 completely eliminates in viv\no and in vitro ergosterol esterification\n mMNS1:specific alpha-mannosidase,alpha-mannosidase,Null mutant is \nviable\n mNUP53:Component of karyopherin docking complex of the nuclear pore\n complex,karyopherin docking complex component of the nuclea\nr pore complex,Null mutant is viable but disrupts Kap121 loc\nalization to the nuclear envelope.\n mYMR210W:Unknown ,, Unknown\n mRSM27:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,\n mYPL144W:Unknown ,, Unknown\n Cond717:t2-SSD1\n mSIN4:involved in positive and negative regualtion of transcriptio\nn, possibly via changes in chromatin structure,RNA polymeras\ne II holoenzyme/mediator subunit,Null mutant is viable, temp\nerature sensitive, displays defects in both positive and neg\native regulation of transcription, suppresses Ty insertion m\nutations (Spt-), exhibits decreased superhelical density of \ncircular DNA molecules, exhibits expression from promoters l\nacking UAS elements; associated with a defect in RME1-depend\nent repression and a methionine or cysteine requirement, exh\nibits flocculant/lacy colony morphology, suppressor of snf/s\nwi mutations\n mCPR8:Shows similarity to the secretory pathway cyclophilin Cpr4,c\nyclophilin , peptidyl-prolyl cis-trans isomerase (PPIase),Nu\nll mutant is viable\n mSSU72:functionally related to TFIIB, affects start site selection \nin vivo,,Null mutant is inviable\n mREX3:RNA EXonuclease; member of 3'->5' exonuclease family. See Mo\nser et al. 1997 Nucleic acids Res. 25:5110-5118,,Mutants exh\nibit RNase MRP RNA processing defect; functions redundantly \nwith REX1 and REX2 in U5 snRNA and RNase P RNA processing\n mYLR224W:Unknown ,, Unknown\n mYFL046W:Unknown ,, Unknown\n Cond878:MNNG\n mYOR291W:Unknown ,, Unknown\n mSEC11:signal peptidase subunit,,Null mutant is inviable\n Cond716:t2+SSD1wt\n mYBR206W:Unknown ,, Unknown\n mCHS5:Involved in chitin synthase III activity, also required for \nhomozygosis in the first stages of mating,,Null mutant is vi\nable, cells exhibit a strong mating defect; sensitive to Cal\ncofluor, reduced amount of chitin in the cell wall\n Cond708:t0+SSD1\n Cond725:t4-SSD1,M31\n mYPR100W:Unknown ,, Unknown\n mYLR253W:Unknown ,, Unknown\n mYDR287W:Unknown ,, Unknown\n mMNN10:Required for mannan synthesis and for polarized growth and b\nud emergence,galactosyltransferase,Null mutant is viable, is\n larger than wild-type cells, is deficient in bud emergence,\n and depends upon an intact morphogenesis checkpoint control\n to survive\n mCBC2:cap binding complex,nuclear cap binding complex subunit,muta\nnts exhibit promiscuous 3'-end formation; sae-1 mutation cau\nses temporary cell cycle arrest in meiotic prophase\n mYOR223W:Unknown ,, Unknown\n Cond712:t4+SSD1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mMTF1:Mitochondrial RNA polymerase specificity factor,mitochondria\nl RNA polymerase specificity factor,Null mutant is viable, d\nefective in respiration, and lacks mtDNA.\n mYPR140W:Unknown ,, Unknown\n mFOL1:folic acid synthesis,dihydro-6-hydroxymethylpterin pyrophosp\nhokinase , dihydroneopterin aldolase , dihydropteroate synth\netase,essential, induces pseudohyphal growth\n mVPS24:involved in secretion,,Null mutant missorts vacuolar hydrola\nses and accumulates a late endosomal compartment; Class E vp\ns mutant\n mRFC1:RFC is a DNA binding protein and ATPase that acts as a proce\nssivity factor for DNA polymerases delta and epsilon and loa\nds proliferating cell nuclear antigen (PCNA) on DNA,replicat\nion factor C subunit 1 , similar to human RFC 140 kDa subuni\nt,Null mutant is inviable, rfc1 conditional mutants arrest b\nefore mitosis\n mYHR192W:Unknown ,, Unknown\n mGLO2:Cytoplasmic glyoxylase-II,glyoxylase-II,Null mutant is viabl\ne but shows increased sensitivity to methylglyoxal\n mYKL123W:Unknown ,, Unknown\n mPHO86:May collaborate with Pho87p and Pho84p in phosphate uptake,i\nnorganic phosphate transporter (putative),Null mutant is via\nble and expresses repressible acid phosphatase in high phosp\nhate medium; pho86 pho87 double mutant and pho86 pho88 doubl\ne mutant constituvely synthesize repressible acid phosphatas\ne and are arsenate-resistant; pho84 pho86 pho87 triple mutan\nt grows more slowly than pho84 mutant\n Cond723:t2-SSD1,M31\n mMRL1:Mannose 6-phosphate Receptor Like,,\n mGRX5:Member of a glutaredoxin subfamily in Sc together with GRX3 \n& GRX4. Significant sequence diff. with the other glutaredox\nin subfamily, formed by the previously described GRX1 & GRX2\n glutaredoxins (Luikenhuis MBC 9:1081, 1998),glutaredoxin,Nu\nll mutant is viable and shows high sensitivity to oxidative \nstress and increased sensitivity to osmotic stress, and incr\neased oxidation levels of cell proteins; grx5 is synthetical\nly lethal with grx2.\n mTAF9:TFIID subunit (TBP-associated factor) with predicted molecul\nar weight of 17 kD.,TFIID subunit,Null mutant is inviable\n mMRP1:shows allele-specific genetic interactions with pet122 and p\net123,37 kDa mitochondrial ribosomal protein,defective mitoc\nhondrial protein synthesis; absence of a and b type cytochro\nmes; reduced levels of mitochondrial 15 S rRNA; defective pr\nocessing of apocytochrome b intron; convert to rho- and rho0\n at high frequency\n mSEH1:Nuclear pore protein, homologous to sec13,,\n mKTR3:Putative alpha-1,2-mannosyltransferase,alpha-1,2-mannosyltra\nnsferase (putative),\n mNVJ1:Vac8p binding protein; nucleus-vacuole junction,,Null mutant\n is viable; cells do not form nucleus-vacuole junctions\n mPSK1:contains serine/threonine protein kinase domain and shows ho\nmology with the SNF1 serine/threonine protein kinase,,Null m\nutant is viable\n mUFE1:t-SNARE that resides on the endoplasmic reticulum and mediat\nes retrograde traffic from the Golgi complex,t-SNARE (ER),Nu\nll mutant is inviable\n mRVB2:RUVB-like protein, TIP49b Homologue,transcriptional regulato\nr,Null mutant is inviable\n mUSA1:Identified by its interaction with the U1 snRNP-specific pro\ntein, Snp1p.,pre-mRNA splicing factor (putative),\n mYMR160W:Unknown ,, Unknown\n mPNG1:de-N-glycosylation enzyme,peptide:N-glycanase,Null mutant is\n viable and shows no growth or viability defect under experi\nmental conditions\n mMAK32:Protein necessary for structural stability of L-A double-str\nanded RNA-containing particles,,\n mYGR011W:Unknown ,, Unknown\n mPTP1:phosphotyrosine-specific protein phosphatase,phosphotyrosine\n-specific protein phosphatase,viable\n Cond710:t2+SSD1\n mYKL033W:Unknown ,, Unknown\n mYSP3:subtilisin-like protease III,subtilisin-like protease III,\n mMSY1:Tyrosyl-tRNA synthetase,tyrosine-tRNA ligase,\n mYBR178W:Unknown ,, Unknown\n mNUP84 mSEH1 mPHO86 mNUP85 mTAF10 mTAF9 mTAF14 mYEL015W mMET30 mMNS1 mCKB1 mCKB2
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Computational Genomics Lab, Tel-Aviv uniresity