Module number 2722




Database revision : gnsdb28.10
Date : Tue Feb 25 17:27:29 2003
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mYNL010W:Unknown ,, Unknown\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mKRE27:Killer toxin REsistant,,K1 killer toxin resistance\n Cond944:SK1_ume6_YPA\n Cond887:t-BuOOH\n mDFG10:Protein required for filamentous growth, cell polarity, and \ncellular elongation,,Null mutant is viable and defective in \nfilamentous growth\n mTIR3:TIP1-related,cell wall mannoprotein,inviable under unaerobic\n conditions\n mTPI1:triosephosphate isomerase,triosephosphate isomerase,Null mut\nant is viable.\n mVMA21:Protein involved in vacuolar H-ATPase assembly or function,,\nNull mutant is viable but grows slowly and exhibits increase\nd calcium sensitivity. Null mutants also cannot grow on glyc\nerol or at pH 7.5\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mYHL039W:Unknown ,, Unknown\n mYHR133C:Unknown ,, Unknown\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n mSYS1:Multicopy suppressor of ypt6 null mutation,,Null mutant is v\niable. sys1 ypt6 double mutant displays enhanced defects in \nvacuolar sorting and cell growth\n Cond883:5\n mYMR071C:Unknown ,, Unknown\n mBUD32:Hypothetical ORF,,Diploid mutants exhibit random budding\n mPRS5:Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyr\nophosphokinase),phosphoribosylpyrophosphate synthetase (ribo\nse-phosphate pyrophosphokinase),Null mutant is viable but re\nduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate s\nynthetase activity by 84%. prs5 mutations are synthetically \nlethal with mutations in prs1 or prs3.\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mTFP3:vacuolar ATPase V0 domain subunit c' (17 kDa),vacuolar ATPas\ne V0 domain subunit c' (17 kDa) , vacuolar H(+) ATPase 17 kD\na subunit C , vacuolar ATPase V0 domain subunit c' (17 kDa) \n, vacuolar H(+) ATPase 17 kDa subunit C,Null mutant is viabl\ne, defective in vacuolar acidification, high copy TFP3 confe\nrs resistance to trifluoperazine\n mSNF4:involved in release from glucose repression, invertase expre\nssion, and sporulation,associates with Snf1p,Null mutant is \nviable, sucrose nonfermenting; high copy MSI1 and PDE2 parti\nally suppress sporulation defect\n mSCW4:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n Cond:\n mDCW1:Unknown ,, Unknown\n mAUR1:involved in phospolipid metabolism,,Null mutant is inviable;\n mutant exhibits dominant resistance to aureobasidin A. Wild\n type (sensitive) is recessive.\n Cond889:4NQO_2\n mLSM6:Like Sm-F protein,snRNP protein,Null mutant is viable but gr\nows slowly at 23deg and 30deg, and is required for growth at\n 37deg\n mGAS5:Unknown ,, Unknown\n mOLE1:delta-9-fatty acid desaturase,delta-9-fatty acid desaturase,\nThe null mutant is inviable but can be rescued by addition o\nf unsaturarted fatty acids to the growth medium. Some allele\ns are temperature-sensitive for growth and show defective in\ntracellular mitochondrial movement atthe non- permissive tem\nperature.\n mERG24:sterol C-14 reductase,sterol C-14 reductase,Null mutant appe\nars to be inviable in some genetic backgrounds and condition\nally lethal in others; erg24 mutations are suppessed by fen1\n and fen2 mutations\n mERG26:C-3 sterol dehydrogenase,C-3 sterol dehydrogenase,\n mYGR024C:Unknown ,, Unknown\n mYIL157C:Unknown ,, Unknown\n mSUA7:transcription factor TFIIB homolog,transcription factor TFII\nB homolog,Null mutant is inviable\n Cond888:MNNG_2\n Cond894:G2\n mMRPL44:Mitochondrial ribosomal protein MRPL44 (YmL44),ribosomal pro\ntein (YmL44),\n mBGL2:Cell wall endo-beta-1,3-glucanase,cell wall endo-beta-1,3-gl\nucanase,Null mutant is viable\n mYPR147C:Unknown ,, Unknown\n mERV41:ER vesicle protein,,Null mutant is viable.\n mTOM22:Translocase of Outer Mitochondrial membrane,mitochondrial im\nport receptor protein,Null mutant is inviable\n mTNA1:Transporter of Nicotinic Acid,high affinity nicotinic acid p\nlasma membrane permease,Null mutant is viable; the deletion \nof both YGR260W and YJR025C/BNA1 is lethal at low external n\nicotinic acid concentration\n mTOM7:Involved in mitochondrial protein import,translocase of the \nouter mitochondrial membrane,Null mutant is viable\n mALG9:catalyzes the transfer of mannose from Dol-P-Man to lipid-li\nnked oligosaccharides,mannosyltransferase,accumulation of li\npid-linked Man6GlcNAc2; hypoglycosylation of secreted protei\nns\n mPTR2:Functions in transport of small peptides into the cell,pepti\nde transporter,Null mutant is viable\n mADH3:alcohol dehydrogenase isoenzyme III,alcohol dehydrogenase is\noenzyme III,Null mutant is viable\n mCAX4:CAX4p contains 3 short stretches of amino acids that are cha\nracteristic for a wide variety of phosphatases, including li\npid phosphatases and a protein phosphatase.,contains 3 short\n stretches of amino acids that are characteristic for a wide\n variety of phosphatases, including lipid phosphatases and a\n protein phosphatase,Null mutant is viable with severely aff\nected growth rate, hypo-N-glycosylation of secretory protein\ns, and severely reduced levels of dolichol-linked oligosacch\narides in the endoplasmic reticulum. Exhibits defective acti\nn organization and calcofluor white hypersensitivity. Synthe\ntically lethal with a temperature sensitve allele of CMD1\n mCHO2:First step in the methylation pathway for phosphatidylcholin\ne biosynthesis,phosphatidyl-ethanolamine N-methyltransferase\n,Null mutant is viable and accumulates phosphatidylethanolam\nine and has reduced levels of phosphatidylcholine\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mYMR210W:Unknown ,, Unknown\n mYGR257C:Unknown ,, Unknown\n Cond895:G2MMS\n mERP4:Emp24p/Erv25p related protein 4,p24 protein involved in memb\nrane trafficking,viable\n mSEC14:Required for vesicle budding from the Golgi,phosphatidylinos\nitol transfer protein,Null mutant is inviable; other mutatio\nns are temperature sensitive\n mYIL121W:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCHS7:The seventh gene identified that is involved in chitin synth\nesis; involved in Chs3p export from the ER,,Null mutant is v\niable but exhibit reduced chitin synthesis due to a severe r\neduction of Chitin Synthase III activity.\n Cond877:MMS\n mEMP24:type I transmembrane protein, component of COPII-coated, ER-\nderived transport vesicles,type I transmembrane protein,Null\n mutant is viable\n mERV14:ER-derived vesicles,14 kDa protein found on ER-derived vesic\nles,Null mutant is viable but exhibits defects in sporulatio\nn (diploids) and bud site selection (haploids). Null mutants\n also retain the bud site selection marker, Axl2p, in the ER\n and exhibit slow recovery from selective to rich media.\n Cond886:g-ray\n mYOL101C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mOST1:Oligosaccharyltransferase catalyzes the transfer of oligosac\ncharide from dolichol-oligosaccharide donor to consensus gly\ncosylation acceptor sites (asparagines) in newly synthesized\n proteins in ER lumen,64 kDa, alpha subunit of oligosacchary\nltransferase complex; homologous to mammalian ribophorin I,N\null mutant is inviable; temperature-sensitive mutants show p\nleiotropic underglycosylation of soluble and membrane-bound \nglycoproteins\n mOST4:May be subunit or accessory component of oligosaccharyltrans\nferase,3.6 kDa protein, probably membrane-located,Null mutan\nt is viable but is cold- and heat-sensitive; vanadate-resist\nant, hygromycin B-sensitive; defective in oligosaccharyltran\nsferase activity in vivo and in vitro\n Cond876:zero2\n mYPT7:Gtp-binding protein of the rab family; required for homotypi\nc fusion event in vacuole inheritance, for endosome-endosome\n fusion, and for fusion of endosomes to vacuoles when expres\nsed from high copy plasmid,GTP-binding protein , rab family \n, GTP-binding protein , rab family,Null mutant is viable, ch\naracterized by highly fragmented vacuoles and differential d\nefects of vacuolar transport and maturation\n Cond885:20\n mMRP2:14 kDa mitochondrial ribosomal protein; homologous to E. col\ni S14 protein,14 kDa mitochondrial ribosomal protein , simil\nar to E. coli S14 protein,defective mitochondrial protein sy\nnthesis; absence of a and b type cytochromes; reduced levels\n of mitochondrial 15 S rRNA; defective processing of apocyto\nchrome b intron; convert to rho- and rho0 at high frequency\n mYGR033C:Unknown ,, Unknown\n mYGL080W:Unknown ,, Unknown\n mYGR106C:Unknown ,, Unknown\n mYMR295C:Unknown ,, Unknown\n mERV25:COPII coat component of certain ER-derived vesicles,vesicle \ncoat component,Null mutant is viable, displays a selective d\nefect in transport of secretory proteins from the ER to Golg\ni complex.\n mLCB2:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Auxotrophic for long\n-chain component of sphingolipids; some mutations can suppre\nss the Ca2+-sensitive mutant csg2\n mYJL178C:Unknown ,, Unknown\n mYGR182C:Unknown ,, Unknown\n Cond884:10\n mTOM7 mTOM22
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Computational Genomics Lab, Tel-Aviv uniresity