Module number 2721




Database revision : gnsdb28.10
Date : Tue Feb 25 17:27:24 2003
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Cond899:RPN4_MMS__\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mKRE27:Killer toxin REsistant,,K1 killer toxin resistance\n mTKL1:Transketolase 1,transketolase 1,Null mutant is viable; growt\nh on fermentable carbon sources, but not gluconeogenic carbo\nn sources, is reduced; tkl1 tkl2 mutants are auxotrophic for\n aromatic amino acids\n mTIR2:cold-shock induced protein of the Srp1p/Tip1p family of seri\nne-alanine-rich proteins,,Null mutant is viable.\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n mRAS1:ras proto-oncogene homolog,ras homolog,\n mTPI1:triosephosphate isomerase,triosephosphate isomerase,Null mut\nant is viable.\n Cond362:dtt_000_min__dtt-2\n mFET4:Putative transmembrane low-affinity Fe(II) transporter,low a\nffinity Fe2+ transport protein,Mutant lacks low affinity Fe(\nII) transport but has more active high affinity Fe(II) trans\nport activity\n mECM1:putative transmembrane domain protein involved in cell wall \nbiogenesis,,A Tn3 insertion into ECM1 causes hypersensitivit\ny to the cell surface polymer perturbing agent calcofluor wh\nite.\n mAAH1:adenine aminohydrolase (adenine deaminase),adenine aminohydr\nolase (adenine deaminase),Null mutant is viable\n mRPS25A:Homology to rat S25,ribosomal protein S25A (S31A) (rp45) (YS\n23),\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mYJR116W:Unknown ,, Unknown\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n Cond892:S\n Cond883:5\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSCS7:Required for the hydroxylation of the very long chain fatty \nacid (VLCFA), located in the endoplasmic reticulum,desaturas\ne , hydroxylase,Null mutant is viable, suppresses the Ca2+-s\nensitive phenotype of csg2 delta mutants\n mYDR116C:Unknown ,, Unknown\n Cond454:YP_fructose_vs_reference_pool_car-2\n Cond890:G1\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mHNM1:choline transport protein; may also control uptake of nitrog\nen mustard,transporter (permease) for choline and nitrogen m\nustard; share homology with UGA4,Null mutant is viable, but \nhyper-resistant to nitrogen mustard; ctr1,cho1 double null i\ns inviable\n Cond872:Zero1\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond889:4NQO_2\n mGAS5:Unknown ,, Unknown\n Cond310:Heat_Shock_000_minutes_hs-2\n mRPS11A:Homology to rat S11, human S11, and E. coli S17,ribosomal pr\notein S11A (S18A) (rp41A) (YS12),Null mutant is viable\n mRPP2A:Homology to rat P2, human P2, and E.coli L12eIB,60S acidic r\nibosomal protein P2A (L44) (A2) (YP2alpha),Null mutant is vi\nable\n mDAN1:Delayed Anaerobic,cell wall mannoprotein , induced during an\naerobic growth,Null mutant is viable\n mRPA12:A12.2 subunit of RNA polymerase I,RNA polymerase I A12.2 sub\nunit,Null mutant is viable but is temperature sensitive; syn\nthetically lethal with RPA14\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n mDPH5:diphthamide biosynthesis,,Null mutant is viable\n mRPL21B:Homology to rat L21,ribosomal protein L21B,\n Cond894:G2\n mCAF20:binds to eIF4E, the mRNA cap-binding protein, and represses \ncap-dependent translation initiation by interfering with the\n interaction of eIF4E and eIF4G,20 kDa subunit , mRNA cap bi\nnding protein eIF-4F , 20 kDa subunit , mRNA cap binding pro\ntein eIF-4F,Null mutant is viable and grows faster; deletion\n of CAF20 partially suppresses mutations in translation init\niation factors; overexpression of CAF20 causes slower growth\n and enhances translation mutation phenotypes\n mYOR175C:Unknown ,, Unknown\n mBGL2:Cell wall endo-beta-1,3-glucanase,cell wall endo-beta-1,3-gl\nucanase,Null mutant is viable\n Cond459:YP_sucrose_vs_reference_pool_car-2\n mALG5:UDP-glucose:dolichyl-phosphate glucosyltransferase,UDP-gluco\nse:dolichyl-phosphate glucosyltransferase,underglycosylation\n of carboxypeptidase Y\n mSSZ1:DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a \nribosome-associated complex (RAC) that is bound to the ribos\nome via the Zuo1p subunit,HSP70 family,Null mutant is viable\n, cold sensitive; SSZ1 overexpression causes increased expre\nssion of some PDR genes\n mRPL38:Homology to rat L38,ribosomal protein L38,\n Cond893:SMMS\n mYPR114W:Unknown ,, Unknown\n mCOQ2:para hydroxybenzoate: polyprenyl transferase,para hydroxyben\nzoate: polyprenyl transferase,Null mutant is viable but is r\nespiratory defective and lacks PHB:polyprenyltransferase act\nivity\n mALG8:adds glucose to the dolichol-linked oligosaccharide precurso\nr prior to transfer to protein,glycosyl transferase,Null mut\nant is viable, secretes under-glycosylated proteins\n mTOM7:Involved in mitochondrial protein import,translocase of the \nouter mitochondrial membrane,Null mutant is viable\n mRPL18B:Homology to rat ribosomal protein L18,ribosomal protein L18B\n (rp28B),\n mGIS2:GIG3 suppressor,,\n mPMP3:plasma membrane protein involved in salt tolerance,hypotheti\ncal transmembrane protein,Null mutant is viable and sensitiv\ne to cations such as sodium\n Cond895:G2MMS\n Cond879:MMC\n mRPL7B:Homolog of mammalian ribosomal protein L7 and E. coli L30,ri\nbosomal protein L7B (L6B) (rp11) (YL8),Null mutant is viable\n; disruption of both RPL7A and RPL7B is lethal\n mYLR413W:Unknown ,, Unknown\n Cond882:zero3\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n Cond877:MMS\n mEMP24:type I transmembrane protein, component of COPII-coated, ER-\nderived transport vesicles,type I transmembrane protein,Null\n mutant is viable\n mPAU7:similar to Pau3, member of Pau1 family,,\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n Cond886:g-ray\n mHPT1:enzyme involved in de novo purine biosynthesis,hypoxanthine \nguanine phosphoribosyltransferase,Null mutant is viable; mut\nants show resistance to 8-azaguanine\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond319:37C_to_25C_shock_-_90_min\n mOST4:May be subunit or accessory component of oligosaccharyltrans\nferase,3.6 kDa protein, probably membrane-located,Null mutan\nt is viable but is cold- and heat-sensitive; vanadate-resist\nant, hygromycin B-sensitive; defective in oligosaccharyltran\nsferase activity in vivo and in vitro\n Cond876:zero2\n Cond885:20\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond891:G1MMS\n mPHO11:Acid phosphatase, secreted,acid phosphatase,phosphatase defi\ncient\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mEGD1:beta subunit of the nascent-polypeptide-associated complex (\nNAC); homologous to human BTF3b; GAL4 enhancer protein,pol I\nI transcribed genes regulator,Null mutant is viable; reduced\n induction of galactose-regulated genes upon shift from gluc\nose to galactose\n mYGL080W:Unknown ,, Unknown\n mYGR106C:Unknown ,, Unknown\n Cond881:4NQO\n mYOR246C:Unknown ,, Unknown\n mFCY1:cytosine deaminase highly homologous to Candida albicans cyt\nosine deaminase,cytosine deaminase,Mutant is resistant to 5-\nfluorocytosine and shows total loss of cytosine deaminase ac\ntivity\n mRPS17A:Homology to rat S17,ribosomal protein S17A (rp51A),Null muta\nnt is viable and grows slowly; rps17A rps17B double null mut\nant is inviable\n mLCB2:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Auxotrophic for long\n-chain component of sphingolipids; some mutations can suppre\nss the Ca2+-sensitive mutant csg2\n mYJL178C:Unknown ,, Unknown\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n Cond884:10\n
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Computational Genomics Lab, Tel-Aviv uniresity