Module number 2720




Database revision : gnsdb28.10
Date : Tue Feb 25 17:27:21 2003
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mYNL010W:Unknown ,, Unknown\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mTKL1:Transketolase 1,transketolase 1,Null mutant is viable; growt\nh on fermentable carbon sources, but not gluconeogenic carbo\nn sources, is reduced; tkl1 tkl2 mutants are auxotrophic for\n aromatic amino acids\n mYLR179C:Unknown ,, Unknown\n mFPR1:FK506 binding protein; proline rotamase; rapamycin-binding p\nrotein,peptidyl-prolyl cis-trans isomerase (PPIase),Null mut\nant is viable but exhibits slow growth. Null mutant also exi\nbits partial resistance to FK506 and complete resistance to \nrapamycin.\n mTIR2:cold-shock induced protein of the Srp1p/Tip1p family of seri\nne-alanine-rich proteins,,Null mutant is viable.\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n mTIR3:TIP1-related,cell wall mannoprotein,inviable under unaerobic\n conditions\n Cond362:dtt_000_min__dtt-2\n mFET4:Putative transmembrane low-affinity Fe(II) transporter,low a\nffinity Fe2+ transport protein,Mutant lacks low affinity Fe(\nII) transport but has more active high affinity Fe(II) trans\nport activity\n mYHR045W:Unknown ,, Unknown\n mYDR492W:Unknown ,, Unknown\n mAAH1:adenine aminohydrolase (adenine deaminase),adenine aminohydr\nolase (adenine deaminase),Null mutant is viable\n mYHR133C:Unknown ,, Unknown\n mTUF1:Translation elongation factor Tu, mitochondrial,translation \nelongation factor Tu, mitochondrial,Null mutant is viable, b\nlocks mitochondrial translation and destabilizes mitochondri\nal genome.\n mENO1:enolase I,enolase I,Null mutant is viable\n Cond883:5\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSCS7:Required for the hydroxylation of the very long chain fatty \nacid (VLCFA), located in the endoplasmic reticulum,desaturas\ne , hydroxylase,Null mutant is viable, suppresses the Ca2+-s\nensitive phenotype of csg2 delta mutants\n Cond890:G1\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mHNM1:choline transport protein; may also control uptake of nitrog\nen mustard,transporter (permease) for choline and nitrogen m\nustard; share homology with UGA4,Null mutant is viable, but \nhyper-resistant to nitrogen mustard; ctr1,cho1 double null i\ns inviable\n mRHR2:DL-glycerol-3-phosphatase,DL-glycerol-3-phosphatase,\n Cond:\n mAUR1:involved in phospolipid metabolism,,Null mutant is inviable;\n mutant exhibits dominant resistance to aureobasidin A. Wild\n type (sensitive) is recessive.\n mGAS5:Unknown ,, Unknown\n mLSM6:Like Sm-F protein,snRNP protein,Null mutant is viable but gr\nows slowly at 23deg and 30deg, and is required for growth at\n 37deg\n mYNR021W:Unknown ,, Unknown\n mYPL245W:Unknown ,, Unknown\n mADO1:adenosine kinase,adenosine kinase,\n mCIS3:cik1 suppressor,similar to Hsp150p and Pir1p, Pir2p, and Pir\n3p,Null mutant is viable; CIS3 is a high copy suppressor of \ncik1 deletion mutants\n mRPS22A:Homology to rat S15a,ribosomal protein S22A (S24A) (rp50) (Y\nS22),\n Cond897:STATMMS\n Cond888:MNNG_2\n Cond894:G2\n mMRPL44:Mitochondrial ribosomal protein MRPL44 (YmL44),ribosomal pro\ntein (YmL44),\n mTAT2:Tryptophan permease, high affinity,tryptophan permease, high\n affinity,suppressor of chromosome segregation mutation\n mGIS2:GIG3 suppressor,,\n mRTN1:Unknown ,, Unknown\n mYOL092W:Unknown ,, Unknown\n mSPE2:S-adenosylmethionine decarboxylase,,Null mutant is viable un\nder anaerobic conditions, under aerobic conditions, spe2 nul\nl mutants demonstrate an absolute requirement for polyamines\n for growth and exhibit increase in cell size, a marked decr\nease in budding, accumulation of vesicle-like bodies, absenc\ne of specific localization of chitin-like material, and abno\nrmal distribution of actin-like material; in addition, spe2 \nnull mutants are associated with a marked elevation in +1 bu\nt no change in -1 ribosomal frameshifting\n mLHP1:Protein homologous to human La (SS-B) autoantigen,,Null muta\nnt is viable\n mSPE3:biosynthesis of spermidine,putrescine aminopropyltransferase\n (spermidine synthase),Null mutant is viable, has no spermid\nine synthase activity, requires spermine or spermidine for g\nrowth\n mPMP3:plasma membrane protein involved in salt tolerance,hypotheti\ncal transmembrane protein,Null mutant is viable and sensitiv\ne to cations such as sodium\n Cond879:MMC\n mYLR413W:Unknown ,, Unknown\n mYHR214W:Unknown ,, Unknown\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n mPAU7:similar to Pau3, member of Pau1 family,,\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n mELO1:elongation enzyme 1, required for the elongation of the satu\nrated fatty acid tetradecanoic acid (14:0) to that of hexade\ncanoic acid (16:0),,Null mutant is viable, but shows no grow\nth on media supplemented with less than 16-C saturated fatty\n acid in a fatty acid synthase minus background\n mSEC53:involved in synthesis of GDP-mannose and dolichol-phosphate-\nmannose; required for protein assembly in endoplasmic reticu\nlum,phosphomannomutase,null is inviable; ts mutant is defect\nive in glycosylation, accumulating inactive and incompletely\n glycosylated forms of secretory proteins within the ER lume\nn\n mYOL101C:Unknown ,, Unknown\n mRPL33B:Homology to rat L35a,ribosomal protein L33B (L37B) (rp47) (Y\nL37),Null mutant is viable.\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mRPL26B:Homology to rat L26,ribosomal protein L26B (L33B) (YL33),\n mCYS3:cystathionine gamma-lyase,cystathionine gamma-lyase,Null mut\nant is viable, cysteine auxotroph\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPRY3:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n Cond891:G1MMS\n mYGL080W:Unknown ,, Unknown\n mYGR106C:Unknown ,, Unknown\n Cond881:4NQO\n mTIF2:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mERV25:COPII coat component of certain ER-derived vesicles,vesicle \ncoat component,Null mutant is viable, displays a selective d\nefect in transport of secretory proteins from the ER to Golg\ni complex.\n mRPL34B:Homology to rat L34,ribosomal protein L34B,\n mLCB2:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Auxotrophic for long\n-chain component of sphingolipids; some mutations can suppre\nss the Ca2+-sensitive mutant csg2\n mYJL178C:Unknown ,, Unknown\n mRPL1A:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1B (Ssm2p),ribosomal protein L\n1A, forms part of the 60S ribosomal subunit,Null mutant is v\niable; shows double mutant lethality with rpl1b (ssm2b) null\n mutants\n mRPE1:D-ribulose-5-Phosphate 3-epimerase,D-ribulose-5-Phosphate 3-\nepimerase,Null mutants are viable but show no ribulose-5-pho\nsphate epimerase activity, cannot grow on D-xylulose, and ar\ne sensitive to hydrogren peroxide\n mPUB1:poly(A)+ RNA-binding protein,poly(A) binding protein,Null mu\ntant is viable\n mERG10:acetoacetyl CoA thiolase,acetoacetyl CoA thiolase,Nul mutant\n is inviable; other mutants are ergosterol biosynthesis defe\nctive or nystatin resistant\n mKRE27:Killer toxin REsistant,,K1 killer toxin resistance\n mTOS6:Hypothetical ORF,,\n mRPL20B:Homology to rat L18a,ribosomal protein L20B (L18B),\n mTPI1:triosephosphate isomerase,triosephosphate isomerase,Null mut\nant is viable.\n mRPL13B:Homology to rat L13,ribosomal protein L13B,\n mRPS25A:Homology to rat S25,ribosomal protein S25A (S31A) (rp45) (YS\n23),\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mHIP1:histidine permease,histidine permease,requires supplementati\non with large amounts of histidine for growth\n mYNL211C:Unknown ,, Unknown\n mRPA49:49-kDa alpha subunit of RNA polymerase A,RNA polymerase A 49\n kDa alpha subunit,Null mutant is viable but grows slowly an\nd is temperature or cold sensitive; synthetically lethal wit\nh RPA14\n mYJR116W:Unknown ,, Unknown\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n mPRS5:Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyr\nophosphokinase),phosphoribosylpyrophosphate synthetase (ribo\nse-phosphate pyrophosphokinase),Null mutant is viable but re\nduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate s\nynthetase activity by 84%. prs5 mutations are synthetically \nlethal with mutations in prs1 or prs3.\n Cond898:RPN4\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n mTFP3:vacuolar ATPase V0 domain subunit c' (17 kDa),vacuolar ATPas\ne V0 domain subunit c' (17 kDa) , vacuolar H(+) ATPase 17 kD\na subunit C , vacuolar ATPase V0 domain subunit c' (17 kDa) \n, vacuolar H(+) ATPase 17 kDa subunit C,Null mutant is viabl\ne, defective in vacuolar acidification, high copy TFP3 confe\nrs resistance to trifluoperazine\n Cond872:Zero1\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mECM39:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n Cond889:4NQO_2\n mERG24:sterol C-14 reductase,sterol C-14 reductase,Null mutant appe\nars to be inviable in some genetic backgrounds and condition\nally lethal in others; erg24 mutations are suppessed by fen1\n and fen2 mutations\n mERG25:C-4 sterol methyl oxidase,C-4 sterol methyl oxidase,Null mut\nant is inviable\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n mMIR1:Product of gene unknown,,Null mutant is viable on glucose co\nntaining media, but is unable to grow on a non-fermentable c\narbon source, shows reduced levels of mitochondrial proteins\n mBGL2:Cell wall endo-beta-1,3-glucanase,cell wall endo-beta-1,3-gl\nucanase,Null mutant is viable\n mCAF20:binds to eIF4E, the mRNA cap-binding protein, and represses \ncap-dependent translation initiation by interfering with the\n interaction of eIF4E and eIF4G,20 kDa subunit , mRNA cap bi\nnding protein eIF-4F , 20 kDa subunit , mRNA cap binding pro\ntein eIF-4F,Null mutant is viable and grows faster; deletion\n of CAF20 partially suppresses mutations in translation init\niation factors; overexpression of CAF20 causes slower growth\n and enhances translation mutation phenotypes\n mYOL002C:Unknown ,, Unknown\n Cond459:YP_sucrose_vs_reference_pool_car-2\n mTOM20:Translocase of Outer Mitochondrial membrane,20 kDa mitochond\nrial outer membrane protein import receptor,Null mutant is v\niable but respiration deficient; defective in import of mito\nchondrial preproteins\n mYPR114W:Unknown ,, Unknown\n mTOM22:Translocase of Outer Mitochondrial membrane,mitochondrial im\nport receptor protein,Null mutant is inviable\n Cond893:SMMS\n mTOM6:involved in supporting the cooperativity between receptors a\nnd the general insertion pore and facilitating the release o\nf preproteins from import components,associates with TOM40 ,\n protein translocation complex component , associates with T\nOM40 , protein translocation complex component,Null mutant i\ns viable, associated with a delay of import of preproteins, \nstabilization of preprotein binding to receptors and the gen\neral insertion pore, and destabilization of the interaction \nbetween receptors and the general insertion pore; tom6 tom40\n double mutants are inviable.\n mTNA1:Transporter of Nicotinic Acid,high affinity nicotinic acid p\nlasma membrane permease,Null mutant is viable; the deletion \nof both YGR260W and YJR025C/BNA1 is lethal at low external n\nicotinic acid concentration\n mTOM7:Involved in mitochondrial protein import,translocase of the \nouter mitochondrial membrane,Null mutant is viable\n mKES1:Homologous to human oxysterol-binding protein; implicated in\n ergosterol biosynthesis and regulation of Golgi-derived tra\nnsport vesicle biogenesis,,Pleiotropic sterol-related phenot\nypes\n mARX1:Unknown ,, Unknown\n Cond895:G2MMS\n Cond878:MNNG\n mERP4:Emp24p/Erv25p related protein 4,p24 protein involved in memb\nrane trafficking,viable\n mNDE1:Unknown ,, Unknown\n Cond882:zero3\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYIL121W:Unknown ,, Unknown\n Cond877:MMS\n Cond886:g-ray\n mYJL122W:Unknown ,, Unknown\n mHPT1:enzyme involved in de novo purine biosynthesis,hypoxanthine \nguanine phosphoribosyltransferase,Null mutant is viable; mut\nants show resistance to 8-azaguanine\n mLAC1:Longevity-assurance gene 1 cognate (LAG1 cognate),LAG1 longe\nvity gene homolog,Null mutant is viable but exhibits synthet\nic lethality with mutations in lag1.\n mCOX5A:One of two genes (COX5A and COX5B, both nuclear-encoded) cod\ning for subunit V of cytochrome c oxidase; COX5A gene produc\nt is the predominantform of subunit V found in holocytochrom\ne c oxidase under normal growth conditions,cytochrome c oxid\nase chain Va,Null mutant is viable, respires at 10-15% of th\ne wild-type rate due to the presence of COX5B; cox5a cox5b d\nouble deletion mutants are completely non-respiratory\n mRPS6A:Homology to rat, mouse, and human S6,ribosomal protein S6A (\nS10A) (rp9) (YS4),\n Cond319:37C_to_25C_shock_-_90_min\n mYNL190W:Unknown ,, Unknown\n Cond876:zero2\n Cond885:20\n mPFK1:phosphofructokinase alpha subunit,phosphofructokinase alpha \nsubunit,Null mutant is viable, accumulates fructose-6-phosph\nate, glucose-6-phosphate, and sedoheptulose-7-phosphate, exh\nibits decreased levels of fructose-1,6-bisphosphate; pfk1 pf\nk2 double deletion mutants fail to grow on 2% glucose\n mYMR157C:Unknown ,, Unknown\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mEGD1:beta subunit of the nascent-polypeptide-associated complex (\nNAC); homologous to human BTF3b; GAL4 enhancer protein,pol I\nI transcribed genes regulator,Null mutant is viable; reduced\n induction of galactose-regulated genes upon shift from gluc\nose to galactose\n mYOR246C:Unknown ,, Unknown\n mFCY1:cytosine deaminase highly homologous to Candida albicans cyt\nosine deaminase,cytosine deaminase,Mutant is resistant to 5-\nfluorocytosine and shows total loss of cytosine deaminase ac\ntivity\n mHMG1:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is\nozyme,3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduct\nase isozyme,Null mutant is viable, sensitive to compactin, a\n competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 doubl\ne deletion mutants are inviable\n mSRL1:Suppressor of rad53 lethality,,\n mFAA4:acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatt\ny acid activator 2), activates imported fatty acids and prov\nides substrates for N-myristoylation,long chain fatty acyl:C\noA synthetase , long-chain fatty acid:CoA ligase,Not essenti\nal for vegetative growth when fatty acid synthase (fas) is a\nctive\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n mYGR182C:Unknown ,, Unknown\n Cond884:10\n mTOM20 mTOM7 mTOM22
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Computational Genomics Lab, Tel-Aviv uniresity