Module number 2711




Database revision : gnsdb28.10
Date : Tue Feb 25 17:26:33 2003
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Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYDR100W:Unknown ,, Unknown\n mORM1:Product of gene unknown,,\n mHYR1:Hydroperoxide resistance conferring gene,glutathione-peroxid\nase (putative),Null mutant is hypersensitive to oxidative st\nress\n mSEC31:involved in protein transport from endoplasmic reticulum to \nGolgi,COPII coat of secretory pathway vesicles component (p1\n50),Null mutant is inviable\n mTIR3:TIP1-related,cell wall mannoprotein,inviable under unaerobic\n conditions\n mVCX1:Similar to sodium/calcium exchangers, including bovine Na+/C\na2+,K+ antiporter; putative vacuolar transmembrane protein,v\nacuolar H+/Ca2+ exchanger,Null mutant is viable, sensitive t\no high Ca2+ conditions\n mGGA2:Golgi-localized, gamma-adaptin homology, Arf-binding,ARF-bin\nding protein,\n mYGL245W:Unknown ,, Unknown\n mNPY1:hydrolyzes the pyrophosphate linkage in NADH and related nuc\nleotides,NADH pyrophosphatase 1,No readily detected phenotyp\ne\n mLAT1:Dihydrolipoamide acetyltransferase component (E2) of pyruvat\ne dehydrogenase complex,pyruvate dehydrogenase complex dihyd\nrolipoamide acetyltransferase component (E2),Null mutant is \nviable\n mENO1:enolase I,enolase I,Null mutant is viable\n Cond:\n Cond724:t4+SSD1,H44\n mGAS5:Unknown ,, Unknown\n mYNR021W:Unknown ,, Unknown\n mSSC1:Nuclear-encoded mitochondrial protein; member of the heat sh\nock protein 70 (HSP70) family; most similar to E. coli DnaK \nprotein; acts as a chaperone for protein import across the i\nnner membrane,SceI endonuclease subunit , mitochondrial matr\nix protein involved in protein import , SceI endonuclease su\nbunit , mitochondrial matrix protein involved in protein imp\nort,Null mutant is inviable; some alleles demonstrate effect\ns in sporulation and germination\n Cond873:10min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n Cond718:t4+SSD1wt\n mSTE24:zinc metallo-protease that catalyzes the first step of N-ter\nminal processing of the yeast a-factor precursor,zinc metall\no-protease,Null mutant is viable, exhibits a mating efficien\ncy of ~5% that of a wild-type strain and an a-factor process\ning defect\n Cond888:MNNG_2\n mYIL088C:Unknown ,, Unknown\n Cond852:30_min\n mSHM1:Serine hydroxymethyltransferase, mitochondrial,,Null mutant \nis viable.\n mCOQ5:co-enzyme Q deficient,C-methyltransferase (putative),Null mu\ntant is viable, respiratory deficient, petite.\n mPTR2:Functions in transport of small peptides into the cell,pepti\nde transporter,Null mutant is viable\n mADH3:alcohol dehydrogenase isoenzyme III,alcohol dehydrogenase is\noenzyme III,Null mutant is viable\n mCHO2:First step in the methylation pathway for phosphatidylcholin\ne biosynthesis,phosphatidyl-ethanolamine N-methyltransferase\n,Null mutant is viable and accumulates phosphatidylethanolam\nine and has reduced levels of phosphatidylcholine\n mADH4:Alcohol dehydrogenase type IV,alcohol dehydrogenase isoenzym\ne IV,Null mutant is viable\n mRCK2:Serine/threonine protein kinase,,Null mutant is viable\n Cond720:t0+SSD1,H44\n mCTR2:Putative low-affinity copper transport protein,,ctr2 mutants\n display a high level of resistance to toxic copper concentr\nations. CTR2 overexpression provides increased resistance to\n copper starvation and is also associated with an increased \nsensitivity to copper toxicity.\n mSRV2:70-kDa adenylyl cyclase-associated protein,70 kDa adenylyl c\nyclase-associated protein,Null mutant is inviable.\n Cond708:t0+SSD1\n mFUM1:Fumarase converts l-malate to fumarate as part of the TCA cy\ncle,fumarase (fumarate hydralase),respiratory defective\n Cond422:YPD_stationary_phase_2_h_ypd-1\n mSBA1:SBA1p binds to Hsp90 and is important for pp60v-src activity\n in yeast, shows similarity to the mammalian P-Twenty-Three \nproteins,HSP90 associated co-chaperone,Null mutant is viable\n, exhibits slow growth at 18 degrees and 37 degrees; synthet\nic growth defects in SBA1-1/sti1-1 double mutant\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond874:30min\n mOST3:Catalyzes the transfer of oligosaccharide from dolichol-olig\nosaccharide donor to consensus glycosylation acceptor sites \n(asparagines) in newly synth. proteins - ER lumen; may enhan\nce oligosacch. transfer to subset of acceptor substrates,oli\ngosaccharyl transferase glycoprotein complex 34 kDa gamma su\nbunit,Null mutant is viable but shows underglycosylation of \nsoluble and membrane-bound glycoproteins and contains less o\nligosaccharyltransferase activity in vitro\n mIDH2:NAD+-dependent isocitrate dehydrogenase,NAD-dependent isocit\nrate dehydrogenase,Null mutant is viable\n mGSF2:Glucose Signaling Factor,,A Tn3 insertion into this gene cau\nses hypersensitivity to the cell surface polymer perturbing \nagent calcofluor white; Defective in glucose repression; mut\nants decrease transcriptional repression by MIG1; alter gluc\nose-regulated subunit interactions within the Snf1 protein k\ninase complex; the effects of eff1 and eff2 on SUC2 repressi\non are strongly synergistic.\n mGRX5:Member of a glutaredoxin subfamily in Sc together with GRX3 \n& GRX4. Significant sequence diff. with the other glutaredox\nin subfamily, formed by the previously described GRX1 & GRX2\n glutaredoxins (Luikenhuis MBC 9:1081, 1998),glutaredoxin,Nu\nll mutant is viable and shows high sensitivity to oxidative \nstress and increased sensitivity to osmotic stress, and incr\neased oxidation levels of cell proteins; grx5 is synthetical\nly lethal with grx2.\n Cond714:t0+SSD1wt\n mYHR113W:Unknown ,, Unknown\n mDOT5:Derepression Of Telomeric silencing,,\n mZRT3:Hypothetical ORF,,\n mKTR1:mannosyltransferase involved in O- and N-linked glycosylatio\nn,type II transmembrane protein,Null mutant is viable\n mYMR298W:Unknown ,, Unknown\n mIDP1:Mitochondrial form of NADP-specific isocitrate dehydrogenase\n,NADP-dependent isocitrate dehydrogenase,Null mutant is viab\nle\n mRSC9:Remodels the Structure of Chromatin,,Null: Lethal.\n mSWP1:oligosaccharyl transferase glycoprotein complex, delta subun\nit,oligosaccharyl transferase glycoprotein complex, delta su\nbunit,lethal\n mATP15:nuclear gene for ATP synthase epsilon subunit,ATP synthase e\npsilon subunit , nuclear encoded,unable to grow on glycerol \nmedium; no detectable oligomycin-sensitive ATPase activity; \noligomycin-sensitive uncoupling of the mitochondrial respira\ntion rate\n mATP16:ATP synthase delta subunit,ATP synthase delta subunit,cells \nare entirely cytoplasmic petite\n mPRC1:dispensable for haploidization and sporulation, but required\n for full protein degradation during sporulation,carboxypept\nidase Y (proteinase C),Null mutant is viable,proteinase C de\nficient\n mLCB2:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Auxotrophic for long\n-chain component of sphingolipids; some mutations can suppre\nss the Ca2+-sensitive mutant csg2\n mERV29:ER Vesicle protein of 29 kDa (apparent MW),ER-Golgi transpor\nt vesicle protein,Null mutant is viable.\n mAPE3:Aminopeptidase yscIII,aminopeptidase yscIII,Null mutant is v\niable but exhibited reduced vacuolar aminopeptidase activiti\nes and could not hydrolyze Lys-Ala-MCA to Lys and Ala-MCA.\n mBMH2:Brain Modulosignalin Homolog,member of conserved eukaryotic \n14-3-3 gene family,Null mutant is viable; bmh1 bmh2 double m\nutant is inviable; (in strain Sigma-1278b, required for pseu\ndohyphal development but not for viability)\n mYIL039W:Unknown ,, Unknown\n mATP1:mitochondrial F1F0-ATPase alpha subunit,F1F0-ATPase alpha su\nbunit,null mutant is viable; grows slowly on fermentable car\nbon sources; exhibits delayed kinetics of protein import for\n several mitochondrial precursors\n mATP2:F(1)F(0)-ATPase complex beta subunit, mitochondrial,F(1)F(0)\n-ATPase complex beta subunit,Mutant displays a growth defect\n on glycerol\n mCOS3:Protein with strong similarity to subtelomerically-encoded p\nroteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, \nCos6p, Cos9p (COS3 and YBR302C code for identical proteins),\n,\n Cond423:YPD_stationary_phase_4_h_ypd-1\n mYPR098C:Unknown ,, Unknown\n mRPT5:Probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable\n mERG10:acetoacetyl CoA thiolase,acetoacetyl CoA thiolase,Nul mutant\n is inviable; other mutants are ergosterol biosynthesis defe\nctive or nystatin resistant\n mNAS6:Interaction with the 19S regulatory particle of the 26S prot\neasome detected by coimmunoprecipitation.,26S proteasome int\neracting protein,Null mutant is viable.\n mERG12:mevalonate catabolism,mevalonate kinase,Null mutant is invia\nble and unable to grow vegetatively or germinate spores; mut\nants exhibit increased mitotic stability of plasmids with we\nak ARS elements.\n mYGR026W:Unknown ,, Unknown\n mSKN1:Involved in (1->6)-beta-glucan biosynthesis,highly homologou\ns to Kre6p , type II membrane protein (putative),Null mutant\n is viable; exhibits no alterations in killer sensitivity, g\nrowth, or (1->6)-beta-glucan levels; skn1 kre6 double deleti\non mutants show a dramatic reduction in both (1-->6)-beta-gl\nucan levels and growth rate compared with either single disr\nuptant\n mTRR1:Thioredoxin reductase,thioredoxin reductase,Null mutant is v\niable but grow slowly; trr1 mutations are sensitive to hydro\ngen peroxide and activate Mlu1 cell cycle box (MCB)- and Swi\n4/Swi6 cell cycle box (SCB)-dependent reporter genes in swi6\n null mutants.\n RapamycinHap.hap_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n Cond887:t-BuOOH\n mLAP3:aminopeptidase of cysteine protease family; bleomycin hydrol\nase,aminopeptidase of cysteine protease family,Null mutant i\ns viable with no obvious growth defects but is leucine amino\npeptidase deficient and hypersensitive to bleomycin; overexp\nression confers resistance to bleomycin\n mPTM1:Putative membrane protein,membrane protein (putative),Null m\nutant is viable, no observable phenotype\n mHIP1:histidine permease,histidine permease,requires supplementati\non with large amounts of histidine for growth\n Cond892:S\n mERG9:squalene synthetase,squalene synthetase,Null mutant is invia\nble\n mTFP1:Encodes a protein with three regions (ABC) that is spliced t\no yield the extein AC & the intein B; AC is a 69K vacuolar (\nH+)-ATPase & B is a 50K site-specific endonuclease named VDE\n (PI-SceI) that is homologous to HO,protein with three regio\nns (ABC) that are spliced to yield the extein AC and the int\nein B; AC is a 69K vacuolar (H+)-ATPase, and B is a 50K site\n-specfic endonuclease named VDE (PI-SceI) that is homologous\n to HO. Cleavage is meiosis-specific and induces gene conver\nsion at the TFP1 locus. , site-specific endonuclease VDE (PI\n-SceI) , vacuolar ATPase V1 domain subunit A (69 kDa) , prot\nein with three regions (ABC) that are spliced to yield the e\nxtein AC and the intein B; AC is a 69K vacuolar (H+)-ATPase,\n and B is a 50K site-specfic endonuclease named VDE (PI-SceI\n) that is homologous to HO. Cleavage is meiosis-specific and\n induces gene conversion at the TFP1 locus. , site-specific \nendonuclease VDE (PI-SceI) , vacuolar ATPase V1 domain subun\nit A (69 kDa),Null mutant is viable, resistant to trifluoper\nazine, grows slowly under non-acidic conditions and on glyce\nrol and is cold, temperature, and cation-sensitive\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mNCE102:involved in secretion of proteins that lack classical secret\nory signal sequences,,An uncharacterized allele exhibits def\nects in the export of the mammalian protein galectin-1.\n mERG20:May be rate-limiting step in sterol biosynthesis pathway,far\nnesyl diphosphate synthetase (FPP synthetase),Null mutant is\n inviable\n Cond889:4NQO_2\n mYLR241W:Unknown ,, Unknown\n mTSA1:antioxidant enzyme that provides protection against oxidatio\nn systems capable of generating reactive oxygen and sulfur s\npecies,thioredoxin-peroxidase (TPx); reduces H2O2 and alkyl \nhydroperoxides with the use of hydrogens provided by thiored\noxin, thioredoxin reductase, and NADPH,Null mutant is viable\n, grows slower than wild-type under aerobic conditions\n mAYR1:Subcellular location of Ayr1p: lipid particles and endoplasm\nic reticulum of the yeast,1-acyl dihydroxyacetone phosphate \nreductase,Null mutant is viable\n mHEM15:Performs last step in heme biosynthesis pathway, inserting f\nerrous iron into protoporphyrin IX,ferrochelatase (protoheme\n ferrolyase),Null mutant is inviable in certain genetic back\ngrounds\n mTOM20:Translocase of Outer Mitochondrial membrane,20 kDa mitochond\nrial outer membrane protein import receptor,Null mutant is v\niable but respiration deficient; defective in import of mito\nchondrial preproteins\n mYMR148W:Unknown ,, Unknown\n mCCC1:Functions in the homeostasis of both calcium and manganese i\nons,transmembrane Ca2+ transporter (putative),Wild-type comp\nlements csg1 (calcium sensitive-group) mutants when overexpr\nessed\n mGLN1:glutamine synthetase,glutamine synthetase,Glutamine syntheta\nse non-derepressible\n mTOM22:Translocase of Outer Mitochondrial membrane,mitochondrial im\nport receptor protein,Null mutant is inviable\n mYMR010W:Unknown ,, Unknown\n mHXK2:Glucose phosphorylation,hexokinase II (PII) (also called hex\nokinase B),Null mutant is viable and can ferment fructose, b\nut fails to show glucose repression at SUC2, CYC1, GAL10. hx\nk1, hxk2 double null mutant cannot ferment fructose\n mCPR3:cyclophilin-3 (cyclosporin-sensitive proline rotamase-3),cyc\nlophilin , peptidyl-prolyl cis-trans isomerase (PPIase),Null\n mutant is viable, unable to grow on L-lactate at 37 degrees\n C\n mPRE5:alpha-type of subunit of 20S proteasome,20S proteasome alpha\n-type subunit,Null mutant is inviable\n Cond717:t2-SSD1\n Cond424:YPD_stationary_phase_8_h_ypd-1\n mUGP1:Uridinephosphoglucose pyrophosphorylase,uridinephosphoglucos\ne pyrophosphorylase,Null mutant is inviable, probably due to\n inability to properly form the cell wall\n mYJR001W:Unknown ,, Unknown\n Cond725:t4-SSD1,M31\n mLSC1:alpha subunit of succinyl-CoA ligase (synthetase; ATP-formin\ng), a mitochondrial enzyme of the TCA cycle,,Null mutant is \nviable but grows slowly on minimal glycerol or pyruvate; mut\nant suppresses idh2 null mutants for growth on glycerol\n mSEC14:Required for vesicle budding from the Golgi,phosphatidylinos\nitol transfer protein,Null mutant is inviable; other mutatio\nns are temperature sensitive\n Cond882:zero3\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYNL045W:Unknown ,, Unknown\n mDPM1:dolichol phosphate mannose synthase,dolichol phosphate manno\nse synthase,Null mutant is inviable\n mASN2:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n mYHR181W:Unknown ,, Unknown\n mUBA1:ubiquitin activating enzyme, similar to Uba2p,ubiquitin acti\nvating enzyme, similar to Uba2p,Null mutant is inviable\n mYFR006W:Unknown ,, Unknown\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n mUBP6:deubiquitinating enzyme (putative),,\n Cond723:t2-SSD1,M31\n mYNL190W:Unknown ,, Unknown\n mSED1:putative cell surface glycoprotein,cell surface glycoprotein\n (putative),Null mutant is viable; during stationary phase, \nnull mutants exhibit increased sensitivity to Zymolyase.\n mYPT7:Gtp-binding protein of the rab family; required for homotypi\nc fusion event in vacuole inheritance, for endosome-endosome\n fusion, and for fusion of endosomes to vacuoles when expres\nsed from high copy plasmid,GTP-binding protein , rab family \n, GTP-binding protein , rab family,Null mutant is viable, ch\naracterized by highly fragmented vacuoles and differential d\nefects of vacuolar transport and maturation\n mYNK1:Nucleoside diphosphate kinase,nucleoside diphosphate kinase,\nNull mutant is viable, exhibits no defects in growth rate, s\npore formation, mating ability, or morphology\n mVMA4:vacuolar ATPase V1 domain subunit E (27 kDa),E subunit of V1\n sector , vacuolar ATPase V1 domain subunit E (27 kDa) , vac\nuolar H(+) ATPase 27 kDa subunit,Null mutant is viable, slow\n growing, cold-sensitive, thermo-sensitive, and exhibits poo\nr growth on glycerol; fails to grow on media supplemented wi\nth 100 mM CaCl2 or ZnCl2\n mVMA5:42 kDa subunit of V1 sector,V1 sector hydrophilic subunit C \n, vacuolar ATPase V1 domain subunit C (42 kDa) , vacuolar H-\nATPase , V1 sector hydrophilic subunit C , vacuolar ATPase V\n1 domain subunit C (42 kDa) , vacuolar H-ATPase,Null mutant \nis viable; certain vma5 mutations show allele-specific synth\netic lethality with cdc24-ls mutants\n mTPD3:protein phosphatase 2A regulatory subunit A,protein phosphat\nase 2A regulatory subunit A,Null mutant is viable, defective\n in cytokinesis at reduced temperatures, defective in transc\nription by RNA polymerase III at elevated temperatures; noco\ndazole sensitive and exhibits phenotypes of previously ident\nified kinetochore/spindle checkpoint mutants\n mKRE6:cell wall beta-glucan assembly,beta-glucan synthase (putativ\ne),Null mutant is viable, slow growing, killer toxin-resista\nnt, possesses half the normal level of wild-type cell wall (\n1-->6) beta-glucan)\n mWTM1:WD repeat containing transcriptional modulator 1,transcripti\nonal modulator,Null mutant is viable\n mKRE9:cell wall beta-glucan assembly,,Null mutant is viable, assoc\niated with growth defects, altered cell wall, aberrant multi\nply budded morphology, mating defects; exhibits double mutan\nt lethality in combination with knh1, kre1, kre6, or kre11 m\nutants; killer toxin resistant; reduction in cell wall (1---\n-6)-beta-glucan\n mSUR7:Multicopy suppressor of rvs167 mutation,integral membrane pr\notein (putative),Null mutant is viable, exhibits no growth d\nefects on non-fermentable carbon sources or sensitivites to \n3-AT or high salt\n mMDL1:ATP-binding cassette (ABC) transporter family member,,Null m\nutant is viable\n mGDI1:Regulates vesicle traffic in secretory pathway by regulating\n dissociation of GDP from Sec4/Ypt/rab family of GTP-binding\n proteins,GDP dissociation inhibitor,Null mutant is inviable\n mTOM40:Translocase of Outer Mitochondrial membrane,forms the outer \nmembrane import channel , mitochondrial outer membrane prote\nin , forms the outer membrane import channel , mitochondrial\n outer membrane protein,Null mutant is inviable; cells accum\nulate uncleaved mitochondrial precursor proteins\n mGDI1 mYPT7
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Computational Genomics Lab, Tel-Aviv uniresity