Module number 2703




Database revision : gnsdb28.10
Date : Tue Feb 25 17:25:26 2003
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mHSE1:Unknown ,, Unknown\n mYPR109W:Unknown ,, Unknown\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mCEG1:mRNA guanylyltransferase (mRNA capping enzyme), alpha subuni\nt,mRNA capping enzyme alpha subunit , mRNA guanylyltransfera\nse,Null mutant is inviable\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mURE2:Nitrogen catabolite repression regulator that acts by inhibi\ntion of GLN3 in good nitrogen source. Altered form of Ure2p\n creates [URE3] prion.,glutathione transferase (putative) , \nprion , transcriptional regulator,Null mutant is viable but \nexhibits defects in nitrogen catabolite repression (NCR), an\nd null mutant diploids are defective in pseudohyphal growth \nand display an increased incidence of random bud patterns.\n mYGR223C:Unknown ,, Unknown\n mEMP47:47 kDa type I transmembrane protein localized to the Golgi,4\n7 kDa type I transmembrane protein localized to the Golgi,Nu\nll mutant is viable\n mPEX10:C3HC4 zinc-binding integral peroxisomal membrane protein,C3H\nC4 zinc-binding integral peroxisomal membrane protein,mutant\n lacks morphologically recognizable peroxisomes and shows cy\ntosolic mislocalization of peroxisomal matrix proteins\n Cond892:S\n Cond573:cdc15_80\n mRPB4:fourth-largest subunit of RNA polymerase II,RNA polymerase I\nI fourth largest subunit,Null mutant is viable, rbp4 mutants\n are heat and cold sensitive, exhibit slow growth at interme\ndiate temperatures\n mYOR131C:Unknown ,, Unknown\n mYTA12:Mitochondrial ATPase (similar to E. coli FtsH protein) that \nresides in the innner mitochondrial membrane,ATPase , CDC48/\nPAS1/SEC18 (AAA) family,Null mutant is viable, petite grossl\ny deficient in mitochondrial respiratory and ATPase complexe\ns, yet synthesizes all proteins encoded by mitochondrial DNA\n mVPS45:Protein of the Sec1p family essential for vacuolar protein s\norting,,Null mutant is viable, defective in the segregation \nof vacuolar material into the developing daughter cell, has \nlarge central vacuoles\n Cond943:SK1_YPA\n Cond872:Zero1\n Cond889:4NQO_2\n mTAF10:TFIID subunit (TBP-associated factor) with predicted molecul\nar weight of 23 kD.,TFIID subunit,Null mutant is inviable\n mRNA15:Protein with a role in mRNA stability and/or poly(A) tail le\nngth,cleavage and polyadenylation factor CF I component invo\nlved in pre-mRNA 3'-end processing,Null mutant is inviable\n mNMD4:putative Upf1p-interacting protein,,\n mYMR115W:Unknown ,, Unknown\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSTS1:restores protein transport when overexpressed and rRNA stabi\nlity to a sec23 mutation,,Null mutant is inviable\n mIWS1:Interacts with Spt6,,Null: Null Mutant is Lethal.\n mMRPL40:Mitochondrial ribosomal protein MRPL40 (YmL40),ribosomal pro\ntein (YmL40),\n mAEP1:Requried for the translation of OLI1 mRNA.,basic hydrophilic\n 59 kDa protein,permanently respiratory defective; unable to\n translate OLI1 transcripts\n mCST6:Chromosome STability; contains an ATF/CREB-like bZIP domain;\n transcriptional activator,basic leucine zipper (bZIP) trans\ncription factor,Overexpression of CSTs induces chromosome lo\nss\n Cond897:STATMMS\n Cond937:t=0\n Cond894:G2\n mYME1:Mitochondrial protein of the CDC48/PAS1/SEC18 family of ATPa\nses,,Null mutant is viable, exhibits an elevation in the rat\ne at which copies of TRP1 and ARS1, integrated into the mito\nchondrial genome, escape to the nucleus; a heat-sensitive re\nspiratory-growth defect; a cold-sensitive growth defect on r\nich glucose medium; and synthetic lethality in rho- (cytopla\nsmic petite) cells; yme1 (osd1) mutants fail to degrade newl\ny synthesized subunits of cytochrome c\n mYGR165W:Unknown ,, Unknown\n mMRPL49:mitochondrial ribosomal protein of the large subunit,ribosom\nal protein large subunit,\n Cond893:SMMS\n mNIT2:Nit protein, nitrilase superfamily member,,\n mYJR088C:Unknown ,, Unknown\n mMAS1:mitochondrial processing protease subunit,mitochondrial proc\nessing protease subunit,Null mutant is inviable; Elevated mi\ntotic recombination and chromosomal missegregation when over\nproduced\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mYNL335W:Unknown ,, Unknown\n mRSM24:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,\n mTLG2:member of the syntaxin family of t-SNAREs,tSNARE that affect\ns a late Golgi compartment,Null mutant is viable in SEY6210,\n exhibits endocytosis defect and loss of Kex2p\n mMDR1:Mac1-dependent regulator,GTPase activating protein (GAP) fo\nr Ypt6,Null mutant is viable\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mNHP10:Non-Histone Protein 10,HMG1-box containing protein,null muta\nnt is viable and has normal growth rate\n mIST1:Similar to Nuf1p (spindle pole body component),,\n mSMY1:not believed to act as a kinesin, colocalizes with Myo2p,kin\nesin heavy chain homolog,high copy suppressor of myosin\n mSEC6:cytoplasmic protein involved in fusion of post-Golgi vesicle\ns with the plasma membrane. The Exocyst complex is required \nfor exocytosis.,exocyst complex 88 kDa component,lethal\n mAAD14:aryl-alcohol dehydrogenase located on chromosome 14,aryl-alc\nohol dehydrogenase (putative),\n mNMT1:N-myristoyl transferase,N-myristoyl transferase,Null mutant \nis inviable\n mYPL260W:Unknown ,, Unknown\n mSEC9:Putative t-SNARE of the plasma membrane,t-SNARE (putative),A\nn uncharacterized allele accumulates 100nm secretory vesicle\ns and berkeley bodies and is defective in proteint transport\n to the cell surface. The sec9-4 allele has diploid-specific\n bud site selection defects.\n mENT5:Unknown ,, Unknown\n Cond895:G2MMS\n mMRPL10:Mitochondrial ribosomal protein MRPL10 (YmL10),ribosomal pro\ntein (YmL10),\n mGLC8:Homolog of mammalian protein phosphatase inhibitor 2,protein\n phosphatase 1 (Glc7p) regulator,Null mutant is viable; dele\ntion of glc8 suppresses phenotypes of ipl1 and glc7 mutants\n mSEC12:Required for recruitment of Sar1p and vessicle formation at \nthe endoplasmic reticulum.,guanine nucleotide exchange facto\nr for Sar1p,Null mutant is inviable. Defective in endoplasmi\nc reticulum to Golgi transport.\n Cond882:zero3\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond877:MMS\n Cond886:g-ray\n mYPR148C:Unknown ,, Unknown\n mYKL195W:Unknown ,, Unknown\n Cond945:W303_YPD\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPDX1:Plays a structural role in pyruvate dehydrogenase complex,py\nruvate dehydrogenase complex protein X component,Null mutant\n is viable\n mCTK3:CTD kinase-I gamma subunit,RNA polymerase II C-terminal doma\nin kinase gamma subunit, similar to cyclin-dependent kinase,\nNull mutant is viable, displays slow growth and cold sensiti\nve phenotypes in combination with ctk1 and ctk2 null mutants\n Cond885:20\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond891:G1MMS\n mPBS2:Involved in osmoregulation, member of the HOG1 mitogen-activ\nated protein kinase (MAPK) cascade,MAP kinase kinase (MEK) ,\n may act as a scaffolding protein for Sho1p, Ste11p, and Hog\n1p , MAP kinase kinase (MEK) , may act as a scaffolding prot\nein for Sho1p, Ste11p, and Hog1p , MAP kinase kinase (MEK) ,\n may act as a scaffolding protein for Sho1p, Ste11p, and Hog\n1p,Null mutant is viable, sensitive to high osmolarity, sens\nitive to the antibiotic polymyxin B; shows marked decreased \ninduction of transcription by osmotic stress that is mediate\nd by stress response elements; a deletion in RGA1 and PBS2 a\nctivates the pheromone-dependent signal transduction pathway\n independently of the G protein\n mUFE1:t-SNARE that resides on the endoplasmic reticulum and mediat\nes retrograde traffic from the Golgi complex,t-SNARE (ER),Nu\nll mutant is inviable\n mMRP7:Mitochondrial ribosomal protein MRP7 (YmL2) (E. coli L27),ri\nbosomal protein (YmL2) (E. coli L27),Null mutant is viable\n mMTR2:mRNA transport regulator,mRNA transport regulator,Null mutan\nt is inviable; mtr2 mutants exhibit nuclear mRNA accumulatio\nn and nucleolar fragmentation\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n mSRP68:part of the signal recognition particle (SRP) ribonucleoprot\nein (RNP) complex that functions in protein targeting to the\n endoplasmic reticulum (ER) membrane,signal recognition part\nicle component,Null mutant is viable, associated with slow c\nell growth and inefficient protein translocation across the \nER membrane\n mYGL161C:Unknown ,, Unknown\n mPHB2:Possible role in aging,mammalian BAP37 and S. cerevisiae Phb\n1p homolog , prohibitin homolog,Null mutant is viable, exhib\nits a slightly decreased lifes span; phb1 phb2 double deleti\non mutants exhibit a more decreased replicative lifespan and\n a defect in mitochondrial membrane potential\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n Cond884:10\n mVPS45 mTLG2
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Computational Genomics Lab, Tel-Aviv uniresity