Module number 2605




Database revision : gnsdb28.10
Date : Tue Feb 25 17:21:18 2003
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Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond399:Nitrogen_Depletion_8_h\n Cond448:galactose_vs._reference_pool_car-1\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mSAM4:S-adenosylmethionine:homocysteine S-methyltransferase,,Slow \ngrowth on S-adenosylmethionine used as a sulfur source\n Cond301:Heat_Shock_10_minutes_hs-1\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond418:YPD_1_d_ypd-2\n mEGT2:cell-cycle regulation protein, may be involved in the correc\nt timing of cell separation after cytokinesis,,\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond913:(99i3)_S150-2B_YPD_NormInt\n Cond400:Nitrogen_Depletion_12_h\n mNEW1:This gene encodes a protein with an Q/N-rich amino terminal \ndomain that acts as a prion, termed [NU]+.,,Null mutant is v\niable\n Cond941:SK1_YPD\n Cond315:37C_to_25C_shock_-_15_min\n mCLU1:CLU1 is similar to the Dictyostelium cluA gene,translation i\nnitiation factor eIF3 subunit,Null mutant is viable, growth \nis normal, mitochondrial network is collapsed to one side of\n the cell\n mRPA135:135 kDa subunit of RNA polymerase I,RNA polymerase I subunit\n,suppression of rpb1, cold sensitive\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYDR119W:Unknown ,, Unknown\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mARO8:aromatic amino acid aminotransferase,aromatic amino acid ami\nnotransferase,Null mutant is viable\n Cond898:RPN4\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond719:t4-SSD1\n mPWP1:Protein with periodic trytophan residues that resembles memb\ners of beta-transducin superfamily because of presence of WD\n-40 repeats,,Null mutants are viable but show severely retar\nded growth\n Cond724:t4+SSD1,H44\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n mALR1:aluminium resistance ,ion transporter (putative),Null mutant\n is inviable; overexpression increases resistance to aluminu\nm and gallium toxicity\n Cond426:YPD_stationary_phase_1_d_ypd-1\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCSE1:Protein required for accurate mitotic chromosome segregation\n,,Null mutant is inviable\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond718:t4+SSD1wt\n Cond753: mSAC1:integral membrane protein localizing to the ER and Golgi,int\negral membrane protein,suppressor of actin mutations, suppre\nssor of sec14 alleles, inositol auxotrophy\n Cond420:YPD_3_d_ypd-2\n Cond404:Nitrogen_Depletion_5_d\n Cond709:t0+Vec\n Cond749: Cond449:glucose_vs._reference_pool_car-1\n mFKS1:Required for viability of calcineurin mutants,1,3-beta-D-glu\ncan synthase,Null mutant is viable, demonstrates slow growth\n, hypersensitivity to FK506 and cyclosporin A, sensitivity t\no echinocandin and a reduction in 1,3-beta-D-glucan synthase\n activity in vitro; sensitivity to papulacandin B\n mGCN1:translational activator of GCN4 through activation of GCN2 i\nn response to starvation,translational activator of GCN4 thr\nough activation of GCN2 in response to starvation,Null mutan\nt is viable and sensitive to 3-aminotriazole\n Cond452:sucrose_vs._reference_pool_car-1\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n mRRP5:Ribosomal RNA Processing,required for processing of pre-rRNA\n,Overexpression of RRP5 facilitates mitochondrial import of \nhydrophobic proteins; overexpression of an RRP5 mutant compl\nements the rRNA processing defect of the null alllele, but d\noes not facilitate mitochondrial import\n mHTS1:Nuclear gene that specifies two messages for cytoplasmic and\n mitochondrial forms,histidine-tRNA ligase,Certain mutations\n can be made to disrupt either cytoplasmic or mitochondrial \nform of Hts1p; loss of mitochondrial synthetase gives Pet- p\nhenotype; loss of cytoplasmic synthetase can result in letha\nlity or respiratory deficiency\n Cond914:(99i2)_S150-2B_YPGL+G_NormInt\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n Cond430:YPD_stationary_phase_7_d_ypd-1\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond450:mannose_vs._reference_pool__car-1\n Cond717:t2-SSD1\n Cond419:YPD_2_d_ypd-2\n Cond451:raffinose_vs._reference_pool_car-1\n mPMA1:major regulator of cytoplasmic pH,plasma membrane H+-ATPase,\ninviable; pma1 mutants are resistant to Dio-9, ethidium brom\nide and guanidine derivatives\n mMES1:methionyl tRNA synthetase,methionine-tRNA ligase,no growth a\nt 36 degrees C\n Cond431:YPD_stationary_phase_13_d_ypd-1\n mYLR413W:Unknown ,, Unknown\n Cond708:t0+SSD1\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond882:zero3\n mSPT16:global regulator of transcription,,suppression of Ty inserti\non mutations\n mSTT3:Required for protein glycosylation,integral ER membrane prot\nein , oligosaccharyltransferase complex subunit (putative),N\null mutant is inviable. sst3 mutants are defective in protei\nn glycosylation, sensitive to hygromycin B, and resistant to\n sodium orthovanadate. Depletion of the STT3 protein results\n in loss of oligosaccharyl transferase activity in vivo and \na deficiency in the assembly of oligosaccharyl transferase c\nomplex.\n mIMD1:IMP dehydrogenase homolog,IMP dehydrogenase homolog,\n mPMT4:Transfers mannose residues from dolichyl phosphate-D-mannose\n to specific serine/threonine residues of proteins in the se\ncretory pathway,dolichyl phosphate-D-mannose:protein O-D-man\nnosyltransferase,Null mutant is viable but shows under glyco\nsylation of chitinase; pmt2 pmt3 pmt4 triple mutant is invia\nble\n mILV1:threonine deaminase,threonine deaminase,Isoleucine-plus-vali\nne requiring\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mUTP10:Unknown ,, Unknown\n Cond945:W303_YPD\n mUBA1:ubiquitin activating enzyme, similar to Uba2p,ubiquitin acti\nvating enzyme, similar to Uba2p,Null mutant is inviable\n Cond712:t4+SSD1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond403:Nitrogen_Depletion_3_d\n Cond746: mADE6:5'-phosphoribosylformyl glycinamidine synthetase,5'-phosphor\nibosylformyl glycinamidine synthetase,Adenine requiring\n Cond402:Nitrogen_Depletion_2_d\n mCDC60:cytosolic leucyl tRNA synthetase,leucine--tRNA ligase,arrest\n at START point of cell cycle upon shift to restrictive temp\nerature\n mNCP1:NADP-cytochrome P450 reductase,NADP-cytochrome P450 reductas\ne,Null mutant is viable\n mSES1:seryl-tRNA synthetase,serine-tRNA ligase,Null mutant is invi\nable.\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond876:zero2\n Cond682:MHY1_(crt1)_vs_CRY1_(wild_type)\n Cond401:Nitrogen_Depletion_1_d\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mGCN20:Positive effector of the EIF-2-alpha kinase activity of GCN2\n; component of a heteromeric complex that includes GCN1 and \nGCN20,ATP-binding cassette (ABC) family,Null mutant is viabl\ne and shows impaired derepression of GCN4 translation and re\nduced levels of eIF-2 alpha phosphorylation\n mSUN4:Protein involved in the aging process,,\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSEC21:non-clathrin coat protein involved in transport between ER a\nnd Golgi,PEST sequence-containing protein , non-clathrin coa\nt protein,Null mutant is inviable\n mSXM1:Suppressor of mRNA export mutant; Importin-beta like gene,ka\nryopherin beta family member,Null mutant is viable, does not\n exhibit growth defects at any temperature examined or exhib\nit marked defects in tRNA processing\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mHXT2:hexose transporter,high affinity hexose transporter-2,Null m\nutant is viable\n mBAT1:branched-chain amino acid transaminase, highly similar to ma\nmmalian ECA39, which is regulated by the oncogene myc,branch\ned-chain amino acid transaminase , highly similar to mammali\nan ECA39, which is regulated by the oncogene myc , branched-\nchain amino acid transaminase , highly similar to mammalian \nECA39, which is regulated by the oncogene myc,Null mutant is\n viable; ILV auxotrophy in bat1 bat2 double mutant\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond973:WT_vs_F82G_1\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n Cond421:YPD_5_d_ypd-2\n mYGR265W:Unknown ,, Unknown\n mPOM152:May be involved in duplication of nuclear pores and nuclear \npore complexes during S-phase,membrane glycoprotein , nuclea\nr pore complex subunit,Null mutant is viable; overproduction\n inhibits cell growth; synthetically lethal with NUP170 and \nNUP188\n mYOR108W:Unknown ,, Unknown\n mUTP21:Unknown ,, Unknown\n Cond671:DES459_(mec1)_-_mock_irradiation_-_30_min\n Cond710:t2+SSD1\n Cond428:YPD_stationary_phase_3_d_ypd-1\n mYOL098C:Unknown ,, Unknown\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond660:DES460_(wt)_-_mock_irradiation_-_60_min\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mGCN20 mGCN1
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Computational Genomics Lab, Tel-Aviv uniresity