Module number 2544




Database revision : gnsdb28.10
Date : Tue Feb 25 17:23:18 2003
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mSFB2:binds to Sed5p and Sec23p by distinct domains,zinc finger pr\notein (putative),\n mCIN2:involvement in microtubule function,tubulin folding cofactor\n C,Null mutant is viable but shows supersensitivity to benom\nyl and nocodazole, cold sensitivity, defects in karyogamy, a\nnd increased rates of chromosome loss; shows genetic interac\ntion with tubulin mutations\n mGUT2:glycerol-3-phosphate dehydrogenase, mitochondrial,glycerol-3\n-phosphate dehydrogenase,Null mutant is viable, unable to ut\nilize glycerol as a carbon source\n mTOS2:Hypothetical ORF,,\n mBNI4:bud neck involved,required to link Chs3p and Chs4p to the se\nptins,Null mutant is viable, shows delocalized chitin, elong\nated buds, enlarged bud necks\n mRTA1:involved in 7-aminocholesterol resistance,,Null mutant is vi\nable; overexpression confers resistance to 7-aminocholestero\nl\n mYAP3:bZIP protein; transcription factor,,\n mPAD1:Phenylacrylic acid decarboxylase,phenylacrylic acid decarbox\nylase,Null mutant is viable but is cinnamic acid-sensitive\n mHYR1:Hydroperoxide resistance conferring gene,glutathione-peroxid\nase (putative),Null mutant is hypersensitive to oxidative st\nress\n mINP54:INositol polyphosphate 5-Phosphatase, fourth one identified;\n has homology to Type I mammalian inositol polyphosphate 5-p\nhosphatases,inositol polyphosphate 5-phosphatase,\n Cond751: mHNT1:Hint homolog, member of the histidine triad superfamily of n\nucleotide-binding proteins,,\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mCWH41:Glucosidase I, involved in assembly of cell wall beta 1,6 gl\nucan; an ER type II integral membrane N-glycoprotein,glucosi\ndase I,Null mutant is viable, associated with K1 killer toxi\nn-resistant phenotype and a 50% reduction in the cell wall b\neta 1,6-glucan level\n mYGR154C:Unknown ,, Unknown\n mFUS1:cell-surface protein required for cell fusion,,Null mutant i\ns viable; in fus1 x fus1 matings there is an interruption of\n the mating process just before cytoplasmic fusion\n mIRR1:Irregular; involved in sister chromatid cohesion,cohesin com\nplex subunit,Null mutant is inviable; decreased transcriptio\nn of mutant causes irregularity of zygotes, colonies, decrea\nsed adhesion to solid supports\n mYJR054W:Unknown ,, Unknown\n mRNH35:RNase H(35), a 35 kDa ribonuclease H,,Null mutant is viable \nbut shows 75% reduction of RNase H activity in cell extracts\n mYDL163W:Unknown ,, Unknown\n Cond733: mCDC9:essential for mitosis and meiosis, dispensable for intrageni\nc recombination, but required for haploidization and spores,\nDNA ligase,cell division cycle blocked at 36 degrees, increa\nsed sensitivity to ultraviolet radiation and bleomycin; temp\nerature sensitive\n mYBL010C:Unknown ,, Unknown\n mSPH1:SPa2-Homolog; protein involved in shmoo formation and requir\ned for bipolar bud site selection (GB:AF008236).,Spa2p homol\nog,Null mutant is viable but results in defects in shmoo for\nmation.\n mPMS1:Required for mismatch repair in mitosis and meiosis, low lev\nels of postmeiotic segregation, and high spore viability, di\nspensable for homeologous recombination,mutL homolog , simil\nar to Mlh1p, associates with Mlh1p, possibly forming a heter\nodimer, Pms1p and Msh1p act in concert to bind to a Msh2p-he\nteroduplex complex containing a G-T mismatch,Null mutant is \nviable; postmeiotic segregation increased\n mJEM1:DnaJ-like protein of the endoplasmic reticulum membrane,,Nul\nl mutant is viable but has karyogamy defect; jem1 scj1 doubl\ne mutant is temperature sensitive\n mYKR077W:Unknown ,, Unknown\n mYDR279W:Unknown ,, Unknown\n mCTF3:Unknown ,, Unknown\n mYCL022C:Unknown ,, Unknown\n mYSY6:Protein that participates in secretory pathway,,\n mYGR151C:Unknown ,, Unknown\n mYCR007C:Unknown ,, Unknown\n Cond553:alpha14\n mYPS1:Gpi-anchored aspartic protease (Yapsin 1),GPI-anchored aspar\ntic protease,Null mutant is viable, defective in expression \nof somatostatin-28; yps1 mkc7 double disruptants are tempera\nture sensitive; yps1 mkc7 kex2 mutants are profoundly temper\nature sensitive and are cold sensitive\n mYJR030C:Unknown ,, Unknown\n mRDH54:genetic interaction with DMC1,helicase (putative) , similar \nto RAD54,Required for meiosis. Early meiotic induction of ge\nne conversion is wild-type in a tid1 deletion but mature cro\nssover products form slowly and cells block with single nucl\nei even though the spindle pole bodies duplicate and separat\ne twice, as if progressing to entry into the second meiotic \ndivision.\n mMSH2:Functions with Pms1p and Pms2/Mlh1p in a complex that intera\ncts with Pms3p/Msh6p to repair single-base and insertion-del\netion mispairs, or Msh3p to repair insertion-deletion mispai\nrs.,mutS homolog,Null mutant is viable. Haploid mutants disp\nlay an 85-fold increased rate of spontaneous mutation to can\navanine resistance. Mutants are defective for gene conversio\nn polarity gradients and high spore viability.\n mYOR055W:Unknown ,, Unknown\n mSER1:phosphoserine transaminase,phosphoserine transaminase,Null m\nutant is viable, serine-requiring\n mSHM2:serine hydroxymethyltransferase,,Null mutant is viable\n mPYK2:Pyruvate kinase, glucose-repressed isoform,,Null mutant is v\niable and shows no obvious phenotypes; however, a pyk1 pyk2 \ndouble-deletion mutant shows growth defects more pronounced \nthan in the pyk1 mutant strain\n mMSH6:Required for mismatch repair in mitosis & meiosis, low level\ns of postmeiotic segregation & high spore viability; forms c\nomplex with Msh2p to repair both single-base & insertion-del\netion mispairs; redundant with Msh3p in repair of in-dels,hu\nman GTBP protein homolog,Null mutant is viable, msh3 msh6 do\nuble deletion mutants exhibit microsatellite instability and\n mutability similar to that in a msh2 mutant\n mYCL069W:Unknown ,, Unknown\n mASF1:anti-silencing protein that causes depression of silent loci\n when overexpressed,,\n mASF2:anti-silencing protein that causes depression of silent loci\n when overexpressed,,\n mYCR076C:Unknown ,, Unknown\n mSIR1:repressor of silent mating loci,silent mating loci repressor\n,\n mERP3:Emp24p/Erv25p related protein 2,p24 protein involved in memb\nrane trafficking,viable\n mPSY3:Unknown ,, Unknown\n mYMR258C:Unknown ,, Unknown\n mMSP1:40 kDa putative membrane-spanning ATPase,40 kDa membrane-spa\nnning ATPase,Null mutant is viable, exhibits no observable g\nrowth defects\n mYOR284W:Unknown ,, Unknown\n mYBR071W:Unknown ,, Unknown\n Cond734: mCDC21:cell division cycle blocked at 36 degree C,thymidylate synth\nase,defective in continued replication during S phase of the\n cell cycle; temperature-sensitive thymidylate auxotroph\n mSWD1:YAR003W,,\n mYOL159C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond746: mKCC4:involved in septin organization,S. pombe Nim1 homolog , prot\nein kinase,Null mutant is viable\n mLPP1:Lipid phosphate phosphatase,lipid phosphate phosphatase,\n mPCL2:Interacts with cyclin-dependent kinase PHO85 to form kinase \ncomplex with G1-periodic activity involved in cell cycle pro\ngression,G1 cyclin,\n Cond554:alpha21\n Cond738:90\n mDPB2:DNA polymerase epsilon, subunit B,DNA polymerase epsilon sub\nunit B,Null mutant is inviable; conditional mutant shows def\nects in DNA replication\n mRSR1:Gtp-binding protein of the ras superfamily involved in bud s\nite selection,,random budding pattern\n mRDI1:Rho GDP dissociation inhibitor with activity toward Rho1p,,\n mTOS10:Hypothetical ORF,,\n mYER071C:Unknown ,, Unknown\n Cond737: Cond747: mCTS1:Endochitinase,endochitinase,Null mutant is viable; exhibits \na defect in cell separation\n mHSL1:Negative regulator of swe1 kinase (which regulates cdc28),pr\notein kinase (putative) , similar to S. pombe cdr1/nim1,Nul\nl mutant is viable; synthetically lethal with histone H3 mut\nations; G2 delay\n mYFL019C:Unknown ,, Unknown\n mDSE3:Hypothetical ORF,,\n mHXT12:High-affinity hexose transporter,hexose permease,\n Cond559:alpha56\n mRCE1:Protease involved in ras and a-factor terminal proteolysis,p\nrotease,Null mutant is viable, has defects in Ras localizati\non and signaling, and suppresses the activated phenotype of \nthe RAS2val19 allele\n mSWE1:protein kinase homolog,protein kinase homolog,Null mutant is\n viable\n mYOR053W:Unknown ,, Unknown\n mNRG2:homologue of NRG1,NRG1 homolog,Null mutant is viable with no\n detected phenotypes\n Cond750: mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n mYHL046C:Unknown ,, Unknown\n mMSH6 mPMS1 mMSH2
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Computational Genomics Lab, Tel-Aviv uniresity