Module number 2491




Database revision : gnsdb28.10
Date : Tue Feb 25 17:25:50 2003
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mPUB1:poly(A)+ RNA-binding protein,poly(A) binding protein,Null mu\ntant is viable\n mYDL237W:Unknown ,, Unknown\n Cond717:t2-SSD1\n mYGR026W:Unknown ,, Unknown\n mKRS1:lysyl-tRNA synthetase,lysine-tRNA ligase,Null mutant is invi\nable; mutants can show resistance to 5-methyltryptophan, 5-f\nluorotryptophan and canavanine; constitutive derepression an\nd slow growth; posttranscriptional increase in histidine bio\nsynthetic enzyme activity\n mHOM2:threonine and methionine pathway,aspartic beta semi-aldehyde\n dehydrogenase,Homoserine requiring\n mYJR001W:Unknown ,, Unknown\n mLYS20:homocitrate synthase, highly homologous to YDL131W,YDL131W (\nLYS21) homolog , homocitrate synthase,Null mutant is viable,\n is able to grow on minimal media, and exhibits reduced but \nsignificant homocitrate synthase activity\n mRPL7B:Homolog of mammalian ribosomal protein L7 and E. coli L30,ri\nbosomal protein L7B (L6B) (rp11) (YL8),Null mutant is viable\n; disruption of both RPL7A and RPL7B is lethal\n mCKA2:may have a role in regulation and/or execution of the eukary\notic cell cycle,casein kinase II alpha' subunit,Null mutant \nis viable, cka1 cka2 double deletion mutants are inviable; C\nells in which casein kinase II activity is depleted increase\n substantially in size prior to growth arrest, and a signifi\ncant fraction of the arrested cells exhibit a pseudomycelial\n morphology. Disruption of the activity also results in floc\nculation. Yeast strains lacking both endogenous catalytic su\nbunit genes can be rescued by expression of the alpha and be\nta subunits of Drosophila casein kinase II or by expression \nof the Drosophila alpha subunit alone\n Cond708:t0+SSD1\n Cond725:t4-SSD1,M31\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mTIR3:TIP1-related,cell wall mannoprotein,inviable under unaerobic\n conditions\n mYIL041W:Unknown ,, Unknown\n mYNL123W:Unknown ,, Unknown\n mGGA2:Golgi-localized, gamma-adaptin homology, Arf-binding,ARF-bin\nding protein,\n mSOL3:weak multicopy suppressor of los1-1,,Null mutant is viable\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n mRPL40A:Homology to rat L40,ribosomal protein L40A,Null mutant is vi\nable\n mPTM1:Putative membrane protein,membrane protein (putative),Null m\nutant is viable, no observable phenotype\n mARO2:Chorismate synthase,chorismate synthase,aromatic amino acid \nrequiring; lack of premeiotic DNA synthesis; blocked sporula\ntion in homozygous mutant\n mERG4:Sterol C-24 reductase,sterol C-24 reductase,Null mutant is v\niable\n mLYP1:lysine permease,lysine permease,\n Cond712:t4+SSD1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mIRA2:Negatively regulates cAPK by antagonizing CDC25,GTPase activ\nating protein , highly homologous to Ira1p , neurofibromin h\nomolog , GTPase activating protein , highly homologous to Ir\na1p , neurofibromin homolog,Null mutant is viable, exhibits \nincreased sensitivity to heat shock and nitrogen starvation,\n sporulation defects, and suppression of the lethality of a \ncdc25 mutants\n Cond319:37C_to_25C_shock_-_90_min\n mYIL090W:Unknown ,, Unknown\n mCYS4:Cystathionine beta-synthase,cystathionine beta-synthase,Null\n mutant is viable, exhibits vacuolar acidification defects; \ncys2 and cys4 mutations are linked together and co-operative\nly confer cysteine dependence\n mPRS5:Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyr\nophosphokinase),phosphoribosylpyrophosphate synthetase (ribo\nse-phosphate pyrophosphokinase),Null mutant is viable but re\nduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate s\nynthetase activity by 84%. prs5 mutations are synthetically \nlethal with mutations in prs1 or prs3.\n Cond723:t2-SSD1,M31\n mYHR020W:Unknown ,, Unknown\n Cond719:t4-SSD1\n mRHR2:DL-glycerol-3-phosphatase,DL-glycerol-3-phosphatase,\n Cond724:t4+SSD1,H44\n Cond714:t0+SSD1wt\n mSPF1:Sensitivity to a killer toxin (SMK toxin) produced by Pichia\n farinosa,P-type ATPase,The null mutant is viable and resist\nant to the SMK toxin, but grows slowly and has glycosylation\n defects.\n mHEM1:First enzyme in heme biosynthetic pathway,5-aminolevulinate \nsynthase,Null mutant is viable; auxotroph for heme and methi\nonine\n mGAS5:Unknown ,, Unknown\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mGCD11:Negative regulator of GCN4 expression,translational initiati\non factor eIF-2 gamma subunit,Null mutant is inviable, gcd11\n mutants have slower growth rate under nonstarvation conditi\nons\n mTHR1:homoserine kinase,homoserine kinase,Null mutant is viable, t\nhreonine auxotroph\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n mRPP2A:Homology to rat P2, human P2, and E.coli L12eIB,60S acidic r\nibosomal protein P2A (L44) (A2) (YP2alpha),Null mutant is vi\nable\n mSXM1:Suppressor of mRNA export mutant; Importin-beta like gene,ka\nryopherin beta family member,Null mutant is viable, does not\n exhibit growth defects at any temperature examined or exhib\nit marked defects in tRNA processing\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mTHR4:threonine synthase,threonine synthase,threonine requiring\n mCKB2:Casein kinase II, beta' subunit,Casein kinase II beta' subun\nit,Null mutant is viable\n Cond718:t4+SSD1wt\n mSTE24:zinc metallo-protease that catalyzes the first step of N-ter\nminal processing of the yeast a-factor precursor,zinc metall\no-protease,Null mutant is viable, exhibits a mating efficien\ncy of ~5% that of a wild-type strain and an a-factor process\ning defect\n mFRS1:Phenylalanyl-tRNA synthetase, alpha subunit, cytoplasmic,phe\nnylalanine-tRNA ligase subunit,\n Cond722:t2+SSD1,H44\n mCAF40:Hypothetical ORF,,Null mutant is viable\n Cond709:t0+Vec\n mRIM101:Rim101p is similar to the Aspergillus Phenotype-response reg\nulator PacC and the Yarrowia proteinase YlRim1010p; transcri\nptional activator required for entry into meiosis,,Poor grow\nth at low temperature, altered colony morphology, inefficien\nt sporulation due to reduced expression of the meiotic activ\nator IME1, and defective invasive growth\n Cond710:t2+SSD1\n mCCT2:cytoplasmic chaperonin of the Cct ring complex related to Tc\np1p; subunit beta,,Null mutant is inviable; some mutant alle\nles exhibit defects in microtubule and actin assembly.\n mAPE3:Aminopeptidase yscIII,aminopeptidase yscIII,Null mutant is v\niable but exhibited reduced vacuolar aminopeptidase activiti\nes and could not hydrolyze Lys-Ala-MCA to Lys and Ala-MCA.\n mARC1:associated with tRNA and amino acyl-tRNA synthetases; has af\nfinity for quadruplex nucleic acids,,Null mutant is viable, \nleads to slow growth and reduced MetRS activity; arc1- mutan\nts are synthetic lethals and are complemented by the genes f\nor methionyl-tRNA and glutamyl-tRNA synthetase.\n mUTH1:Youth, involved in determining yeast longevity,,extension of\n yeast lifespan\n mCKB2 mCKA2
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Computational Genomics Lab, Tel-Aviv uniresity